4 Best Noopept Stacks: Better Focus, Creativity & Mood

Updated on June 16, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Given the option of improving your cognitive performance using a Noopept stack, would you not give in to it?

Noopept is a cognitive enhancement supplement that has been clinically tested to boost memory and learning capacity.

Not only is it gaining popularity among students and middle-aged people. A review showed that it is popular among the old ones as well.

They believe in the long term effect of Noopept in the brain.

Time and again, we have found how stacking nootropics can maximize its effect.

However, searching for the best stack depends on the preference of a person. What works with one may not work with the other.

best noopept stack featured image

In this post, we are giving you our recommended Noopept stacks that you can try for yourself. But first, let us recall how Noopept works.

Benefits & How Noopept Works

Noopept (N-Phenylacetyl- l-prolylglycine ethyl ester) increases intelligence and perceptual awareness. It is referred to as one of the top smart drugs in the nootropic community.

noopept benefits effects

Studies have shown how efficient Noopept is when it comes to improved memory and increased cognitive function. It works similarly with the other racetams like Oxiracetam or Piracetam, but this drug is said to be 1000 times stronger.

Other than its cognitive effects, these are its noted benefits:

  • Removes brain fog
  • Alleviates stress
  • Boosts focus
  • Helps prevent neurodegenerative diseases
  • Increases levels of nerve growth factor (NGF)
  • Increases levels of brain-derived neurotrophic factor (BDNF)

Noopept is a fast-acting compound that is metabolized in the liver and rapidly absorbed by the digestive system.

It immediately crosses the blood-brain barrier carrying more oxygen into the brain. Once in the bloodstream, it interacts with the glutamatergic system, which is intrinsically connected with cognitive processes.

This nootropic has a sensitizing effect on acetylcholine processes. Acetylcholine is a neurotransmitter responsible for cognition and learning. While in the brain, Noopept increases the neural response to acetylcholine.

It also affects the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are vital neuroproteins for cognition.

Noopept Dosage & Interactions

Since Noopept is a nootropic closely related to Piracetam, they are structurally similar only that Noopept is 1000 times more potent.

This nootropic may give optimal results or a bad reaction depending on the dosage.

To achieve outstanding effects in the body, you should follow the recommended way of its administration and dosage, especially if you are new to nootropics and learn exactly how to take Noopept.

The typical dose is between 10mg to 40mg taken three times daily.

To know what dosage is best for you, start with a small amount first and gradually work your way to a higher dose if you did not feel any improvement with the 10mg dose.

Noopept is not recommended for more prolonged use since it quickly builds up a tolerance, contributing to dependence.

Other users find this nootropic less attractive because of its short half life.

Most researchers have found that it is easily broken down in the body within 30-60 minutes. However, this does not mean that you will no longer feel any effects after that. Besides, this has been dubbed as the best nootropic for its longer positive effects on the brain.

The 4 Best Noopept Stacks

Gaining extra advantages is the purpose of using the best nootropic stacks. It synergizes the pathways of the different compounds allowing additional benefits for the user.

the 5 best noopept stacks

You can use Noopept with other nootropics to optimize its effects.

Here is a list of the nootropic stack for Noopept.

Focus & Concentration Stack

Piracetam and Alpha GPC: These two work synergically with Noopept. Alpha GPC is a choline supplement that helps prevent headaches caused by taking nootropics. The combination of Piracetam and Noopept results in better cognition. While Piracetam works on the neurotransmitter acetylcholine, Noopept targets glutamate. This action improves memory formation and number abilities.

focus and concentration stack

Huperzine A: This is another choline supplement that works as an acetylcholinesterase inhibitor, meaning it enhances the acetylcholine activity.

Creativity Stack

Sulbutiamine and Aniracetam: Sulbutiamine is derived from vitamin B that is also proven to enhance memory. When stacked with Noopept, there is a boost in imagination, and focus is improved simultaneously. On the one hand, Aniracetam is an anxiety reducer. It relaxes the mindstate keeping you mentally and psychologically calm. With this, you don’t have to squeeze out the creativity in you as it will naturally come out.

Mood Enhancement Stack

Aniracetam: Aniracetam and Noopept are considered as the foundation of all other stacks. Working together, these can already provide a fantastic effect for better cognitive function, social fluidity, mood, and memory. It gives an overall feeling of wellness while experiencing a sharper mental performance.

Memory & Learning Ability Stack

Alpha GPC: Alpha GPC is a stabilizer, and it works wonders in maximizing the brain-boosting effect of Noopept. This happens when the body converts it into acetylcholine and improves all other brain functions, especially those necessary for memory formation, learning, and recall.

How to Design Your Noopept Stacks?

The good thing about stacking is that you can design your Noopept stack according to your preference. Of course, this precedes thorough research from your end to prevent adverse side effects that may hinder you from getting the nootropic benefits.

Before looking at the nootropic stacks list, the first thing you have to do is to identify your goals and learn about buying Noopept from a trusted source only. Why do you want to take brain-boosting drugs such as Noopept?

Aside from improving your cognition by taking Noopept, what else do you think you need for the best nootropic stacks?

Answer these two primary questions to spend less time identifying the class or family of supplements to choose from.

Now proceed to analyze which design option to use. One is you can choose a supplement from the existing racetams and add it to your Noopept dosage. Users who posted their stack reviews often choose among the following: Aniracetam, Oxiracetam, Piracetam, and Pramiracetam.

Know that the racetams have similar effects on memory and cognition. If you choose this option, your goal is to maximize the use of Noopept by supporting it with another smart drug.

The second option is using an unrelated supplement to get a wider array of benefits. Unrelated supplements work entirely differently from Noopept but enhance the benefits of the product and reduce side effects.

For one, L theanine, which is an amino acid, reduces mental fatigue and stress. Stack your Noopept with this, and you will surely experience mental alertness without feeling burnt out.

L theanine has a significant effect on alleviating mental stress that complements the increased cognitive activity targeted by nootropics such as Noopept.

Choosing the second option is a bit tricky. You have to analyze the different mechanisms of the supplements to ensure that one does not get in the way of the other. Apart from that, you have to do diligent research on the possible effects that you may experience.

Again, small doses are recommended when trying out which stack works for you. Your base guide is your goal. You have to keep in mind what your goal is and do trial and error.

Yes, trial and error, because there is no exact dose to ensure an improved focus or increased alertness. The dose depends on the body’s reaction, but you have to keep it within the recommended dose.

Observe its reactions to your body. It should not take several days to experience its effects as it usually kicks in a few minutes after the dosage. If it works, then stick to it. If not, try another stack.

Noopept Stacks Cycle

Noopept stack cycle is the process of using the stack in straight days then taking some days off. The reason is that the human body is very adaptive.

Prolonged use of any supplement for that matter may soon diminish its effects, even if you're considering a Noopept megadose.

What is the best thing to do? Do the cycle.

Use Noopept as your base nootropic but not for long. You can alter it with Oxiracetam or any nootropic with similar effects.

One recommended cycle is using a Noopept stack for one week then have five days off. You can continue using it for another three straight days but with two days off.

For easier cycles, you can simply create your own. You can follow a uniform pattern like seven days of use and five days off and change it once in a while.

The ultimate goal is not to let the effects of Noopept diminish by not allowing the body to adapt to it.


Noopept is already a very potent nootropic, but the purpose of stacks is to use to your advantage the effects of other supplements to enhance Noopept’s effects and synergize with each other for admirable results.

Stacks are meant to produce a combination of supplements that will positively react with the body. Choose your preferred stack and take only small doses.

With proper administration, you will reap the fruits of carefully choosing the most suitable stack for you.