8 Best Nootropic Stimulants in 2023 (Tested & Reviewed)

Updated on January 5, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Are you looking for a way to supercharge your productivity and focus?

If so, nootropic stimulants might be just what you need.

In this guide, we’ll look at the best nootropic stimulants[1] to help you get the most out of your day.

1. Vyvamind

Vyvamind is one of the best nootropic stimulants available today. It's a fast-acting, non-addictive nootropic supplement that helps improve focus, drive, and concentration. It contains 6 natural ingredients that provide a safe and effective way to increase energy and cognitive performance.

It is similar to Vyvanse, a prescription stimulant, but without the addiction and unpleasant side effects. Vyvamind is an excellent choice for those looking for a natural way to boost their mental performance and energy levels.

2. Modafinil

Modafinil is one of the most popular nootropic stimulants on the market today. It has a wide range of applications, from treating ADD and narcolepsy to boosting mental performance. The drug works by targeting the wakefulness-promoting areas of the brain and enhancing them to keep you alert and focused.

It is widely considered to be the best alternative to other stimulants due to its low risk of side effects and its effectiveness. Although it does carry some risk of side effects, such as insomnia, headaches, and nausea, these can be minimized by following the correct dosage instructions.

3. Phenylpiracetam

Phenylpiracetam is one of the most popular and powerful nootropic stimulants available. It increases cognitive ability and alertness by promoting an increase in dopamine and norepinephrine levels in the brain[2]. This can result in improved concentration, focus, and mental acuity. It also increases physical performance, endurance, and strength by boosting the body's metabolism and providing more energy.

Phenylpiracetam is also known to boost mood, reduce anxiety, and improve stress levels. It is generally considered safe, but some users may experience side effects such as headaches, anxiety, or insomnia. It is important to speak with a doctor before taking this nootropic stimulant to ensure it is suitable for your individual needs.

4. Caffeine

Caffeine is one of the most well-known nootropic stimulants, and is commonly used to boost energy and alertness. It works by blocking the effects of adenosine, a neurotransmitter that helps regulate sleep, and increasing the production of dopamine and norepinephrine, both of which are associated with increased alertness and focus[3].

Caffeine is especially effective when combined with L-theanine, an amino acid found naturally in tea leaves that can help to reduce the jittery side effects of caffeine while also providing its own mental and physical benefits.

5. Methylliberine

Methylliberine is a naturally-occurring stimulant that has been studied for its potential nootropic effects. This compound has been found to have a stimulating effect on the brain, as well as a calming effect on the body. It has been studied for its ability to improve cognitive performance, reduce fatigue, and increase focus and alertness[4]. Additionally, methyliberine has also been studied for its potential to improve mood and reduce stress levels.

This compound is found in some plants, such as guarana, and is available as a dietary supplement. As with any nootropic stimulant, it is important to research and understand the potential risks and side effects before taking this supplement.

6. Sulbutiamine

Sulbutiamine is a synthetic derivative of thiamine or vitamin B1. It was created in Japan in the 1970s and was designed to help treat fatigue[5]. It works by increasing the concentration of thiamine in the brain. Research has shown that it can improve alertness, energy levels, and mental clarity. It is also thought to help with memory and focus. In addition, some studies have suggested that it can help people who suffer from depression and anxiety. However, more research needs to be done in this area.

Sulbutiamine is considered to be safe and well-tolerated with no serious side effects, although some people may experience mild nausea, headaches, or insomnia. It is important to consult your doctor before taking any supplement, especially if you are taking other medications, or have any pre-existing medical conditions.

7. Alpha GPC

Alpha GPC is a natural nootropic that is becoming increasingly popular among people looking to improve their cognitive performance and stimulate their minds. This supplement is derived from the choline molecule and is naturally found in the human body, but is also found in many foods such as organ meats, egg yolks, and spinach. Alpha GPC works to increase acetylcholine levels in the brain, which is a neurotransmitter responsible for memory and learning.

Alpha GPC has been shown to improve cognitive performance, increase energy levels, and even enhance mood. It is also known to have positive effects on physical performance, such as reducing fatigue and increasing muscle strength. Alpha GPC is a great natural nootropic for anyone looking to boost their mental performance and stimulate their minds.

8. Citicoline

Citicoline, also known as CDP-choline, is a natural nootropic commonly used to boost cognition and mental performance. It helps to increase the production of neurotransmitters, which are essential for brain health and cognitive functioning. It also helps to reduce inflammation and improve memory, focus, and concentration. Citicoline is a great choice for those looking for a natural, safe, and effective nootropic stimulant.

Citicoline has minimal side effects, and unlike some of the more powerful stimulants, it does not create a jittery or anxious feeling. Additionally, it may help to improve mood and reduce fatigue. For those looking for an all-natural approach to cognitive enhancement, citicoline is a great option.

How Can Nootropics Help with Stimulation?

Nootropics, also known as smart drugs, are substances that are designed to improve cognitive performance. They are used to enhance concentration and focus, improve memory, and increase motivation and creativity.

Nootropics can also be used to improve stimulation, as they are known to help increase alertness, energy, and productivity. Stimulation is an important part of cognitive performance, as it can help us to stay focused and motivated while working or studying. Nootropics can help us to achieve this state by providing us with an extra boost that we may need.

The Benefits of Nootropic Stimulants

Nootropics have been used for centuries as a way to naturally boost mental performance and energy. By taking natural substances, such as those in Vyvamind, users can experience improved alertness and concentration. Stimulants such as phenylpiracetam, caffeine, modafinil, and nicotine are popular nootropics that can help to enhance cognitive function.

best nootropic stimulant

These stimulants work by increasing the release of certain neurotransmitters and hormones in the brain, such as dopamine and serotonin. This can result in improved mood, focus, and concentration, as well as increased energy levels. Additionally, they can also help to reduce stress and anxiety, while also aiding in better sleep quality.

The benefits of taking nootropic stimulants don’t stop there. They can also help to improve memory and learning abilities, as well as help to prevent age-related cognitive decline. Furthermore, these compounds can also help to boost creativity and motivation, making them a great choice for those looking to take their productivity to the next level.

The Safety and Side Effects of Taking Nootropic Stimulants

When taking any type of stimulant, whether it be a nootropic or otherwise, it is important to be aware of the potential safety and side effects. Stimulants can have a variety of effects on the body and brain, ranging from mild to severe. Some of the most common nootropic stimulants and their associated side effects include:

  • Vyvamind: Vyvamind has been associated with increased energy, improved focus, and enhanced mood. However, it can also cause anxiety, insomnia, headaches, and jitters.
  • Modafinil: Modafinil is a strong nootropic and wakefulness-promoting agent that can be used to treat ADD and narcolepsy. Its side effects can range from mild to severe, and can include nausea, headache, diarrhea, and skin rash.
  • Phenylpiracetam: Phenylpiracetam is a powerful stimulant that can boost mental performance and increase energy levels. Its side effects include anxiety, insomnia, irritability, and headaches.
  • Caffeine: Caffeine and L-theanine is a popular combination for cognitive enhancement. However, it can cause restlessness, insomnia, and nausea.
  • Methylliberine: Methylliberine is a milder stimulant that is thought to improve focus and alertness. However, it can also cause headaches, nausea, and irritability.
  • Sulbutiamine: Sulbutiamine is another mild stimulant that can help improve energy levels and mood. It can also cause headaches, insomnia, and anxiety.

Tips on Choosing the Right Nootropic for Stimulation

Choosing the right nootropic stimulant is a matter of understanding your own mental needs and body chemistry, as well as the different effects of each nootropic. It is important to know that the effects of these stimulants are dose-dependent, so start with the lowest dose and work your way up. Some nootropics, such as caffeine, may require a higher dose to achieve the desired effect, while others, such as acetyl-L-carnitine, may require a lower dose.

It is also important to use natural nootropics such as Bacopa monnieri, L-theanine, caffeine, CDP-choline (citicoline), ginkgo biloba, and acetyl-L-carnitine in order to avoid the risk of side effects associated with synthetic stimulants. Finally, be sure to consult with a doctor before starting any supplement, as some of these nootropic stimulants may interact with prescription medications. With the right information, you can find the right nootropic stimulant to help you reach your mental goals.

Conclusion: The Pros and Cons of Taking Nootropic Stimulants

Nootropic stimulants have the potential to provide enhanced mental performance, increased focus, and improved alertness. While the effects of nootropics vary from person to person, their overall benefits are undeniable. However, it is important to be aware of the potential risks and side effects of taking nootropics, particularly when they are taken in large doses or for an extended period of time.

When deciding if nootropic stimulants are the right choice for you, it is important to consider the pros and cons before taking them. On the plus side, nootropic stimulants can offer a range of benefits such as improved concentration, focus, and energy levels. On the other hand, they can also cause side effects such as anxiety, insomnia, and headaches. Taking nootropic stimulants safely requires careful consideration and research.

To ensure you get the most out of your nootropic stimulant, it is important to choose the right one for your needs. Research various brands and dosages before taking any nootropic stimulants to ensure you get the desired effects. Additionally, it is important to monitor your body’s response so that you can adjust your dosage accordingly.

By following these steps, you can maximize the potential benefits of nootropics and minimize any associated risks. Ultimately, nootropic stimulants can be an effective way to improve mental performance and focus, when used safely and responsibly.


1Repantis, Dimitris et al. “Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.” Psychopharmacology vol. 238,2 (2021): 441-451. doi:10.1007/s00213-020-05691-w
2Bobkov, Iu G et al. “Farmakologicheskaia kharakteristika novogo fenil'nogo analoga piratsetama--4-fenilpiratsetama” [Pharmacological characteristics of a new phenyl analog of piracetam--4-phenylpiracetam]. Biulleten' eksperimental'noi biologii i meditsiny vol. 95,4 (1983): 50-3.
3Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655
4Tartar, Jaime L et al. “A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers.” Cureus vol. 13,12 e20534. 20 Dec. 2021, doi:10.7759/cureus.20534
5Sevim, Serhan et al. “Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis.” Multiple sclerosis and related disorders vol. 16 (2017): 40-43. doi:10.1016/j.msard.2017.05.010