5 Best Nootropics for Adrenal Fatigue in 2023 (Tested & Reviewed)

Updated on April 6, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
best nootropics for adrenal fatigue

What are the best nootropics for adrenal fatigue?

Adrenal fatigue is a common condition caused by chronic stress, leading to exhaustion and other symptoms that can significantly impact an individual's quality of life.

Fortunately, natural remedies such as nootropics can help manage its symptoms, promoting optimal mental and physical well-being. By incorporating these nootropics into their lifestyle, individuals with adrenal fatigue can take steps toward improving their energy levels, mood, cognitive function, and overall health.

In this article, we will explore some of the best nootropics that can assist in managing adrenal fatigue symptoms for optimal well-being without the use of harsh chemicals or hazardous drugs.

Best Nootropics for Adrenal Fatigue

  • Nooceptin — Great for improving focus
  • Semax — Best cognitive-enhancing effects, including improved focus, memory, and mood
  • Sulbutiamine — Great for boosting energy and alleviating fatigue
  • Ashwagandha — Best adaptogen for stress relief and cognitive enhancement
  • Rhodiola Rosea — Best for boosting energy and endurance

1. Nooceptin

Nooceptin is a natural nootropic that has been shown to improve cognitive abilities such as focus, memory retention, mental clarity, and overall cognitive performance, making it an excellent choice for those looking to combat mental fatigue and brain fog.

This product contains 7 natural ingredients that work together to support optimal brain function, including bacopa monnieri, lion's mane mushroom, and panax ginseng, all of which have been shown to enhance energy levels and promote mental clarity.(1)


  • Promotes cognitive function and improves memory retention
  • Helps reduce stress levels and anxiety
  • Increases focus and attention span


  • May not be safe for all types of individuals
  • May cause insomnia or sleep disturbances if taken in large doses

What makes nooceptin significant is its precise formulation, which supports nervous system health. This in turn diminishes adrenal fatigue symptoms like anxiety, brain fog, and low energy levels. Plus, Nooceptin uses high-quality ingredients, ensuring you get the best possible product.

2. Semax

Semax is a popular nootropic that can help with cognitive enhancement. As a synthetic peptide drug, it has neuroprotective and neurogenic properties that make it useful for treating anxiety and depression. Semax is an analog of adrenocorticotropic hormone (ACTH), and modified to enhance its effectiveness and reduce its side effects.(2) This leads to a host of benefits, including improved memory and focus, reduced fatigue, and increased motivation.


  • Increases cognitive function and improves focus
  • Reduces stress and anxiety
  • Improves memory retention and recall


  • Can cause headaches, or dizziness
  • May cause irritation or a burning sensation around the nasal area

Semax is often used together with other nootropics to provide a comprehensive approach to managing adrenal fatigue. With its proven effectiveness and wide range of benefits, semax is definitely a nootropic worth considering for anyone looking to improve their cognitive function and overall well-being.

3. Sulbutiamine

Sulbutiamine, a nootropic that has been found to improve mood and memory, is also known to have an effect on energy levels. This makes it a prime candidate for those suffering from adrenal fatigue, which can result in a depletion of energy.(3) Along with other energy-enhancing nootropics like rhodiola rosea and acetyl-l-carnitine, it can provide a boost of mental and physical energy to those who need it most.


  • Improves cognitive function and memory retention
  • Reduces fatigue and increases energy levels
  • Stimulates dopamine receptors, leading to mood improvements


  • May not be safe for certain individuals

With scientific evidence on its side and positive user reviews, sulbutiamine is a solid choice for those seeking to combat fatigue and improve their mental performance.

4. Ashwagandha

This medicinal adaptogenic herb is often referred to as Indian ginseng and has been used in Eastern medicine for over 3,000 years. Ashwagandha helps your body with hormone production and is effective in regulating cortisol levels and reducing stress and anxiety.(4) It is also known for its ability to support the sleep-wake cycle, which may help individuals suffering from adrenal dysfunction.


  • Reduces stress and anxiety levels
  • Improves cognitive function and memory retention
  • Anti-inflammatory and immune-boosting properties


  • High doses may cause stomach upset or liver damage

Ashwagandha has strong scientific evidence and has been shown in studies to offer anti-inflammatory, antioxidant, immunomodulatory, neuro-regenerative, and nootropic properties. Overall, it is a highly recommended nootropic supplement for individuals looking to support their adrenal function and immune health.

5. Rhodiola Rosea

Rhodiola rosea has been used for centuries to treat various health issues, including anxiety, chronic stress, and depression. As an adaptogen, it may help increase attention and endurance to burnout.(5) Rhodiola root extract alleviates the effects of stress. Its supplementation with other neuroenhancers helps counteract the effects of ongoing stress, promoting mental and physical well-being.


  • Reduces stress and anxiety levels
  • Helps boost energy and increase endurance
  • Improves cognitive function


  • May cause some side effects
  • Long-term use may lead to a tolerance build-up

By taking its potency and effectiveness into account, rhodiola rosea can be considered one of the top nootropics that can help with stress relief and support adrenal health.

How We Picked the Top Nootropics for Adrenal Fatigue

By evaluating various factors, we've determined that these selected supplements can support the health of your adrenal glands, help reduce stress levels, and improve energy levels. By taking these supplements regularly, you may experience improved mental acuity and reduced symptoms associated with chronic conditions like adrenal fatigue.


The aforementioned products are effective in improving brain function, regulating hormones, reducing fatigue and stress, and promoting healthy communication between the brain and other organs.

Nootropics work by boosting the brain's cognitive functions, which in turn helps manage symptoms of adrenal fatigue. By improving energy levels, and promoting healthy brain activity, nootropics can help alleviate the symptoms of adrenal fatigue and improve overall well-being.


The ingredients used in a product can make or break its effectiveness. That’s why our team of experts carefully researched and analyzed the ingredients of each product before choosing the best ones. We selected nootropics that contain responsibly sourced, high-quality ingredients.

These ingredients have been shown to support brain function, reduce stress and anxiety, and improve overall cognitive performance, making them perfect for individuals struggling with adrenal fatigue. By taking these factors into account, we can confidently recommend the best nootropics for adrenal fatigue.

Scientific Evidence

The best herbal supplements are those that have undergone extensive research and clinical trials to establish their effects. Ashwagandha and rhodiola rosea, for instance, have been extensively studied for their stress-reducing effects, and many studies have found them to be effective in reducing anxiety, fatigue, and brain fog.(6)

Nooceptin, semax, and sulbutiamine are also promising nootropics for adrenal fatigue. They can help balance hormone levels and support the thyroid, as well as boost immune function respectively.


A good supplement is safe to use and has minimal side effects. When picking the products for this blog, safety was a key consideration. It is important to only use nootropics that are manufactured in facilities that follow strict quality control and safety standards.

Additionally, it is important to always follow the recommended dosages for each product and not exceed the recommended amounts. By choosing safe and effective products, individuals will be able to support their body's stress response system without risking their health.

Brand Reputation

When it comes to choosing the best nootropics for adrenal fatigue, brand reputation is an important factor to consider. A reputable brand takes the quality of its products seriously, using only high-quality, safe ingredients that are backed by clinical studies. It also ensures transparency in its product information and provides clear instructions on how to use its products.

In addition, a reputable brand has a strong following and positive user reviews, indicating that its products are effective in addressing adrenal fatigue. When choosing the best nootropics for adrenal fatigue, it's crucial to choose a brand with a solid reputation to ensure you're getting a product that is both safe and effective.

Product Transparency

Consumers want to know exactly what they are putting into their bodies and the dosage of each ingredient. It is important for brands to clearly list their ingredients and provide information on the sourcing and manufacturing processes. Transparency builds trust with consumers and shows a commitment to quality.

Additionally, it allows consumers to make informed choices and avoids any potential health risks. It is crucial to consider brands that prioritize product transparency. This ensures that the consumer is able to make informed decisions and experience their full benefits.

User Reviews

User reviews can provide valuable insights into the effectiveness of different nootropics for adrenal fatigue. When looking at reviews, it's important to pay attention to the dosage, duration of use, overall rating, and number of reviews. User reviews also give valuable insights into the delivery process, customer service, and overall satisfaction with the product.

Reviews from users with similar symptoms and concerns can also be helpful in making an informed decision. While user reviews can be a helpful resource when selecting the best nootropic for adrenal fatigue, it's also important to remember that everyone's experience is unique.

How Do Nootropics for Adrenal Fatigue Work?

Nootropics for adrenal fatigue work by helping to regulate the body's stress response system, which is crucial for managing adrenal fatigue. They can also provide much-needed energy support and promote better sleep quality.

Nootropics achieve this by targeting specific neurotransmitters in the brain, such as dopamine and acetylcholine, that are responsible for cognitive function and mood regulation.(7) By improving these neurotransmitters, nootropics can help reduce the symptoms of adrenal fatigue.

The best dietary supplements for adrenal support are those that help regulate the body's immune response and cortisol production and provide natural support for the body's energy needs.

Nootropics for Adrenal Fatigue FAQs

Can nootropics actively work on one's adrenals?

No, while nootropics promote brain health, they do not directly work on the adrenals. However, they do indirectly help by alleviating some of the symptoms by promoting optimal adrenal function and hormone regulation.

How long does it take for nootropics to work for adrenal fatigue?

The timeline for when nootropics start working for adrenal fatigue can vary depending on the individual and the specific nootropic being used. Some nootropics may take time to build up in the system, while others may have a more immediate effect.

Are nootropics safe for people with adrenal fatigue?

It depends on the individual and the specific nootropic being used. Some nootropics may interact with medications or exacerbate certain symptoms of adrenal fatigue.

Can nootropics be taken alongside other medications for adrenal fatigue?

It depends on the specific supplement or medication being taken. Some nootropics may interact with certain medications or supplements, so it's important to speak with a healthcare professional beforehand.


Adrenal fatigue is a prevalent health condition triggered by prolonged stress, leading to exhaustion and other symptoms that can significantly affect an individual's quality of life.

However, natural remedies such as nootropics can help alleviate its symptoms and promote optimal mental and physical well-being. Some of the best nootropics for adrenal fatigue include nooceptin, semax, sulbutiamine, ashwagandha, and rhodiola rosea. These nootropics are effective, safe, and backed by scientific evidence and brand reputation.

Incorporating these nootropics into a daily routine can help individuals with adrenal fatigue enhance their energy levels, mood, cognitive function, and overall health without relying on harsh chemicals or harmful drugs.