7 Best Nootropics for Long-Term Use in 2023 (Tested & Reviewed)

Updated on August 23, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
best nootropics for long term use

What are the best nootropics for long-term use?

As our lives become more and more fast-paced, we are constantly searching for ways to increase our productivity and improve our cognitive abilities. This need has led to the rising popularity of nootropics, or cognitive enhancers.

While many people turn to these supplements for short-term benefits, more and more are also seeking out options for long-term use. In this post, we'll explore the best nootropics for those looking for sustained cognitive enhancement over time. From natural substances to synthetic compounds, these options offer a range of benefits for those seeking to boost their brain function in the long run.

So, whether you're a student looking to improve your academic performance or a professional seeking to stay sharp at work, read on to discover the top nootropics for long-term use.

Best Nootropics for Long-Term Use

1. Mind Lab Pro

Mind Lab Pro appears at the top of most lists of the best nootropic supplements. Its formula contains 11 scientifically proven brain-boosting substances, including some of the market's most powerful and efficient nootropics. The combination of ingredients enhances brain pathways, making it a universal nootropic that can support both short-term and long-term memory and mental wellness.(1) Unlike other similar choices on the market, Mind Lab Pro targets different brain processes to deliver a more well-rounded increase in cognitive ability and energy levels. It contains no severe stimulants, making it perfect for individuals of various ages to take without becoming jittery or suffering other major side effects.



  • May cause nausea or bloating in some users

Additionally, the mix is non-GMO and vegan, making it a perfect choice for individuals looking for a non-toxic nootropic combination. All the substances combined in a single blend make Mind Lab Pro a strong nootropic pill that can assist a variety of cognitive processes and pathways. Mind Lab Pro is marketed as a high-performance nootropic that can considerably improve mental function.

2. NooCube

NooCube is a nootropic supplement that aims to improve cognitive function by using a blend of essential vitamins and amino acids. It is carefully formulated by neuroscientists to aid in brain health and improve memory and concentration. NooCube also enhances multitasking skills, social strength, and mental energy to assist with daily tasks. The supplement is backed by scientific research and contains no harmful chemicals or toxins. NooCube contains ingredients like Alpha GPC, Huperzine A, Cat's claw, Bacopa Monnieri, oat straw, L-Theanine, and L-Tyrosine that help improve focus and memory retention and prevent cognitive diseases like Alzheimer's and ADHD.(2) The supplement is free of caffeine and GMOs.


  • Enhances brain function and cognitive ability
  • Improves memory and concentration
  • Increases mental agility and productivity
  • Safe and effective


  • Not suitable for pregnant or nursing women or anyone under 18 years of age
  • May cause side effects such as headaches, nausea, or insomnia

NooCube improves the release of neurotransmitters in the brain, which are responsible for communication between different organs, and repairs damaged neurons.(3) It is an effective way to enhance cognitive function and long-term brain health.

3. Pine Bark Extract

Pine bark extract is a natural brain supplement that has received attention for its potential cognitive benefits. It is derived from the bark of the French maritime pine tree and is rich in antioxidants. These antioxidants, also known as flavonoids, promote healthy blood flow and protect the brain from oxidative stress, which can lead to cognitive decline. Additionally, pine bark extract has been found to enhance memory and attention span. One study found that individuals who took the supplement showed improved memory recall and increased attention span compared to the placebo group. Furthermore, it is suggested that pine bark extract reduces the risk of developing cognitive disorders such as Alzheimer's disease.


  • Contains potent antioxidants
  • Can improve heart health and circulation
  • Can boost cognitive function and memory
  • Can reduce inflammation and stress
  • Enhances cognitive energy


  • May cause side effects such as headaches, stomach upset, and dizziness
  • May interact with certain medications

Overall, pine bark extract is considered a safe and natural supplement that may provide cognitive benefits with long-term use. However, it is important to consult with a healthcare professional before adding any new supplements to your daily regimen.

4. Lion's Mane Mushroom

Lion's mane mushroom is a natural supplement that has been used for centuries in traditional Chinese medicine for its various health benefits. It is also known as hericium erinaceus, yamabushitake, or monkey head mushroom. One of the most notable benefits of Lion's Mane mushroom is its ability to enhance cognitive function and brain health.

Lion's Mane mushroom contains compounds that stimulate the production of nerve growth factor (NGF), a protein that supports the growth, maintenance, and survival of neurons.(4) NGF also promotes the formation of new synapses, the connections between neurons that enable communication and learning. By increasing NGF levels in the brain, Lion's Mane mushroom may improve memory, learning, attention, and creativity.


  • Improves memory and cognitive function
  • Promotes brain plasticity and regeneration
  • Can boost mental clarity and overall brain health
  • Can help alleviate symptoms of anxiety and depression


  • May cause side effects such as upset stomach and allergic reactions
  • May interact with certain medications

Lion's mane mushroom also protects the brain from degeneration and damage caused by aging, stress, toxins, or diseases. It may prevent or delay the onset of cognitive impairment and dementia, such as Alzheimer's disease and Parkinson's disease. It also helps repair damaged nerves and restore neurological functions.

5. Citicoline

Citicoline is a nootropic that has been extensively researched for its benefits for long-term brain health. It is a natural compound found in the body and can also be derived from certain foods. Citicoline has the potential to enhance cognitive function, improve memory, and protect the brain from age-related decline. It works by increasing acetylcholine levels, which is a neurotransmitter that is important for learning and memory.(5) Additionally, citicoline has been shown to improve blood circulation to the brain and may even reduce the risk of stroke. Studies have also suggested that citicoline can protect the brain from damage caused by environmental toxins and may even have neuroprotective and neuroregenerative properties.(6)


  • Optimizes brain pathways
  • Boosts neural regeneration and brain energy
  • Improves attention, focus, memory, and learning
  • Helps treat some neurological disorders


  • May cause side effects like headaches, nausea, and insomnia
  • May interact with certain medications

Citicoline is safe for long-term use, and there have been no serious adverse effects reported in clinical trials. Overall, citicoline has a promising track record of promoting long-term brain health and may be a valuable addition to a nootropic stack for those interested in enhancing their cognitive performance.

6. Bacopa Monnieri

Bacopa Monnieri is a natural nootropic that has been used for centuries in Ayurvedic medicine to enhance cognitive function. It works by increasing blood flow to the brain and promoting the growth of new neurons. Bacopa Monnieri has been proven to improve memory, learning, and attention span, making it an excellent choice for long-term use. Studies have shown that Bacopa Monnieri can help prevent cognitive decline and even reduce symptoms of anxiety and depression.(7) However, it is important to note that the effects of Bacopa Monnieri are not immediate and may take several weeks to become noticeable. For optimal results, it should be taken consistently over an extended period of time.


  • Promotes retention of new knowledge
  • Supports brain chemical synthesis and blood flow
  • Improves cognitive function and memory
  • Reduces anxiety and depression symptoms


  • May cause side effects such as upset stomach or dry mouth
  • May interact with certain medications

Bacopa Monnieri is also often combined with other natural nootropics, such as Ginkgo Biloba and Phosphatidylserine, to create a more comprehensive brain-boosting stack. Overall, Bacopa Monnieri is an excellent natural nootropic that can help you improve your cognitive function and maintain long-term brain health.

7. Phosphatidylserine

Phosphatidylserine is a nootropic supplement that has been gaining popularity in recent years for its cognitive benefits. It is a phospholipid that is found in the brain and is essential for healthy brain function. Phosphatidylserine improves cognitive function and memory by increasing the production of acetylcholine, a neurotransmitter that is important for learning and memory. It also helps reduce stress and improve mood by regulating the production of cortisol, a stress hormone. Phosphatidylserine has been shown to be effective in improving cognitive function in older adults with cognitive impairment as well as alleviating symptoms of ADHD. It has also been shown to enhance cognitive performance in athletes and individuals under stress.


  • Promotes fluid and flexible brain cell membranes
  • Supports long-term brain health
  • Can improve cognitive function and overall brain health


  • May cause side effects such as upset stomach and insomnia

Phosphatidylserine is generally safe and well tolerated, but individuals with bleeding disorders or taking blood-thinning medications should consult their healthcare provider before taking it. Overall, phosphatidylserine is a promising nootropic that can provide long-term cognitive benefits with minimal side effects.

How Do Nootropics for Long-Term Use Work?

When it comes to long-term brain health, natural nootropics are the way to go. These cognitive enhancers improve daily performance in pursuit of better brain health tomorrow without compromising long-term brain health. Some nootropics only work for short-term cognitive concerns, while others may enhance brain function over time with perpetual use. Certain nootropics work only under certain conditions, such as sleep deprivation, traumatic brain injury, and catecholamine depletion.

On the other hand, chronic nootropics work all the time, especially when supplemented daily for a long period. They do so by improving acetylcholine levels, decreasing oxidative stress, protecting and improving mitochondrial health, and improving neuron growth and repair. While some of these long-acting nootropics may lack the appeal of fast-acting cognitive enhancers, their protective and regenerative benefits can help eliminate the need for quick-fix boosters in the future.

In general, nootropics come with long-term health advantages, and although they may possess some safety concerns, natural nootropics are backed by scientific research, contain no harmful chemicals or toxins, and offer customer satisfaction guarantees.

How We Picked the Best Nootropics for Long-Term Use

Our comprehensive review process helped us identify the top nootropics suitable for long-term use. We factored in effectiveness, ingredients, safety, brand reputation, transparency, manufacturing process, user feedback, price, and value to compile a reliable list of nootropics that can be used consistently without concern.


We examined the long-term cognitive benefits of each nootropic, focusing on sustained improvement in focus, memory, and mental clarity.


We investigated the components of each formula, with an emphasis on safe, evidence-supported, and high-quality ingredients that provide consistent cognitive enhancement.

Scientific Evidence

We consulted peer-reviewed research and meta-analyses to substantiate the long-term efficacy of key ingredients in supporting cognitive function.


We evaluated optimal dosage levels and ingredient ratios, ensuring they were in line with established research for consistent effectiveness over time.


We verified the safety profile of each ingredient, considering long-term use, potential side effects, and interactions, as well as compliance with regulatory guidelines. Priority was given to nootropics containing FDA-approved ingredients.

Brand Reputation

We assessed the credibility and reliability of each brand through customer reviews, expert recommendations, and company background.

Product Transparency

We emphasized the importance of full ingredient disclosure, including sources, quantities, and concentrations, in order to facilitate informed consumer choices.

Manufacturing Process

We evaluated manufacturing standards, giving preference to products produced in certified facilities that adhere to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, placing particular importance on testimonials reporting sustained cognitive benefits and long-term improvements.


We compared product prices, ensuring that they were competitive while reflecting the quality and effectiveness of each nootropic.


We assessed the overall value of each nootropic, taking into account the balance of price, quality, and long-term effectiveness to guarantee the best return on investment.

Nootropics for Long-Term Use FAQs

Are nootropics safe when used recurringly?

Generally, yes. However, as with any supplement, it's important to do your research before taking any nootropic. Look for products that have been scientifically tested for safety and efficacy and consult with a healthcare professional if you have any concerns.

Can nootropics improve brain function for life?

Nootropics have the potential to improve brain function, including memory and focus, over the long term when used consistently and as part of a healthy lifestyle. However, individual results may vary.

Are synthetic nootropics as effective in the long run as natural ones?

Synthetic nootropics are more potent and fast-acting than their natural counterparts. While natural nootropics are safer and have fewer side effects than synthetic nootropics.

Can I combine different nootropics for long-term use?

Yes, different types of nootropics have different effects and they can be combined to acquire their collective benefits. But you must do research to find the best nootropics to stack together and consult a healthcare professional.


The demand for long-term cognitive enhancement has led to the emergence of a wide range of nootropics that offer sustained benefits for improving brain function. These dietary supplements, containing natural ingredients, have shown promising results in enhancing memory, focus, and overall brain health.

When selecting the best nootropics for long-term use, several factors were taken into consideration, including their effectiveness, ingredients, safety profile, and user feedback. The chosen options encompass a variety of mechanisms to support brain function, such as optimizing energy production, promoting neuroregeneration, and improving neurotransmitter activity.

Mind Lab Pro, a popular nootropic stack, targets different brain processes to provide comprehensive cognitive support, while NooCube stands out for its ability to elevate energy levels and enhance brain function. Natural supplements like pine bark extract, Lion's Mane mushroom, and Bacopa Monnieri offer additional benefits such as boosting working memory, enhancing focus and concentration, and improving long-term memory. Citicoline and phosphatidylserine are recognized for their potential for long-term brain health by optimizing neural pathways and supporting brain cell membranes.

These nootropics, with their natural composition, offer a safe and effective solution for individuals seeking sustained cognitive enhancement. Incorporating these supplements into a balanced lifestyle and consulting with healthcare professionals can help individuals make informed decisions about their cognitive health.