5 Best Nootropics for the Hippocampus in 2023 (Tested & Reviewed)

Updated on July 27, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
best nootropics for hippocampus

What are the best nootropics for hippocampus?

Are you looking for ways to improve your memory, focus, and overall cognitive function? Look no further than the hippocampus, the part of the brain responsible for long-term memory and spatial navigation.

To boost your hippocampal function, you may want to consider taking nootropics – compounds that enhance brain performance. In this blog post, we will explore some of the best nootropics for the hippocampus and how they benefit your brain health. From natural herbs to synthetic compounds, there's a range of options to explore.

So, read on to discover the top nootropics for enhancing your hippocampus function!

Best Nootropics for Hippocampus

  • Nooceptin — Best for improving neuroplasticity and enhancing working memory
  • Semax — Best for improving cognitive performance and mood
  • L-Theanine — Great for reducing anxiety and promoting relaxation
  • Modafinil — Best to boost wakefulness, alertness, and motivation
  • Phosphatidylserine — Great for enhancing energy metabolism in brain

1. Nooceptin

Nooceptin is a highly effective nootropic supplement that has a range of beneficial effects on the brain, especially the hippocampus. Produced by the reputable company SAP Nutra, Nooceptin offers seven natural ingredients that support different areas of brain function, including memory, learning, focus, and stress reduction. This nootropic stack is designed to provide fast and consistent results, although it should be used consistently for up to 90 days to experience all its benefits.

Nooceptin has gained popularity as a natural nootropic supplement due to its potent natural ingredients that improve cognitive performance, treat cognitive impairment, and enhance brain function. It helps increase levels of acetylcholine, the neurotransmitter responsible for memory formation and recall. It also helps to increase levels of dopamine, which plays a vital role in motivation and reward-seeking behavior.


  • Promotes brain cell health by increasing oxygen and nutrient delivery
  • Neuroprotectant for better memory and cognitive performance
  • Improves cognitive function and suppresses stress
  • Elevates levels of concentration and attention


  • May not be suitable for everyone as individual responses vary
  • May have contraindications for certain health conditions

Furthermore, Nooceptin increases blood flow to the brain, enhancing concentration and focus while reducing fatigue. Together, its ingredients make it an effective supplement for boosting brain health and performance.

2. Semax

Semax is a popular nootropic supplement that has been shown to boost cognitive function and enhance intelligence. It works by increasing levels of important brain chemicals like dopamine and serotonin, which are responsible for regulating mood, motivation, and cognitive performance. Semax has also been found to improve memory retention and recall, making it a great option for those looking to enhance their learning and memory abilities.

In addition, Semax has neuroprotective properties that help protect against age-related cognitive decline and boost overall brain health. It also enhances mood and reduces anxiety and depression, making it a great option for people who experience these symptoms. However, Semax requires intranasal administration, which may not be comfortable for everyone. Also, there is potential for adverse effects such as nasal irritation or allergic reactions.


  • Improves cognitive performance including attention and concentration
  • Enhances mood and reduces anxiety and depression
  • Has anti-inflammatory effects


  • Requires intranasal administration which may not be comfortable for everyone
  • Potential for adverse effects such as nasal irritation or allergic reactions

Therefore, it is important to speak with a healthcare professional before starting any new supplement regimen or making significant changes to your current routine. Semax is a powerful tool for unlocking greater mental clarity and focus, but its effects may vary for every individual.

3. L-Theanine

L-Theanine is a naturally occurring nootropic amino acid found in tea leaves and some mushroom species. It is known to reduce anxiety, promote relaxation, and improve sleep quality without causing drowsiness. L-Theanine has been shown to increase alpha brain waves, which are associated with relaxation and creativity.(1) It has also been found to improve memory and attention, making it a popular ingredient in nootropic supplements.

L-Theanine is often combined with caffeine to enhance its cognitive benefits. Some studies suggest that the combination of L-Theanine and caffeine improve focus, alertness, and attention while reducing the jitters and anxiety commonly associated with caffeine consumption. L-Theanine is generally considered safe, with no reported side effects at the recommended dosage.


  • Boosts mental alertness
  • Reduces stress and anxiety
  • Helps improve sleep quality
  • Promotes relaxation without drowsiness


  • Limited research on long-term effects
  • May interact with certain medications

However, high doses may cause headaches, dizziness, and gastrointestinal discomfort. It is important to check with a healthcare provider before taking any new supplements, including L-Theanine, especially if you have any underlying medical conditions or are taking medication.

4. Modafinil

Modafinil is a pharmaceutical substance that enhances cognitive functions and memory, making it easier to stay energized and focused throughout the day. It's considered to be the best hardcore product for enhancing mental performance and productivity. Modafinil is a prescription drug that's typically regulated to prove its safety and effectiveness. It can be taken individually or in combination with other nootropics to achieve its effects. Modafinil is available in capsule, powder, or liquid form, and it's best to consult a physician before taking it as a supplement.

Modafinil works by modulating neurotransmitters such as dopamine and serotonin or by increasing blood flow to the brain, improving focus, memory, and vigilance.(2)(3) Additionally, it reduces fatigue and enhances motivation, making it a popular choice for people who need to stay alert and productive for long periods.



  • May have side effects for some users
  • Potential for abuse and addiction

It's important to note that even the best nootropic supplements will not fully provide critical benefits if you are not maintaining a healthy lifestyle. Adding nootropic supplements to your diet can help you reach optimal results, but it's always best to speak with your doctor before taking any new supplement regimen if you are taking other medications.

5. Phosphatidylserine

Phosphatidylserine is a popular nootropic supplement that is commonly used by athletes and bodybuilders. It is also known to have benefits for brain function, particularly in the hippocampus. The hippocampus is a region of the brain that plays a crucial role in memory, learning, and spatial orientation.

Research has shown that Phosphatidylserine supplementation improves cognitive function, especially in tasks that require short-term memory and intelligence.(4) It has also been found to have a protective effect on the brain, particularly against neurodegenerative diseases.

Furthermore, Phosphatidylserine is known to improve energy metabolism in the brain, leading to increased ATP production and higher energy levels. This enhances mental performance and reduce fatigue, which is particularly useful during demanding cognitive tasks.(5) It may also improve mood and reduce symptoms of depression and anxiety.


  • Improves physical performance during high-intensity exercise
  • Supports cognitive function and memory
  • Helps with depression and fatigue


  • May cause digestive issues in some users

If you are considering taking Phosphatidylserine as a nootropic supplement, it is recommended to start with a low dose and gradually increase it over time. Make sure to consult with your doctor before starting any new supplement regimen, especially if you have any pre-existing medical conditions.

How Do Nootropics for Hippocampus Work?

When it comes to nootropics for the hippocampus, it's important to understand what this part of the brain does. The hippocampus is responsible for forming new memories and spatial navigation. It's also one of the few areas of the brain where neurogenesis, or the creation of new brain cells, can occur in adulthood. Nootropics for the hippocampus work in a variety of ways to support brain health and function.

Some nootropics for the hippocampus work by boosting levels of brain-derived neurotrophic factor (BDNF), which is a protein that promotes the growth and survival of neurons. This helps support neurogenesis and improve memory function. Other nootropics can increase blood flow to the brain or enhance the activity of neurotransmitters involved in memory and learning. Some nootropic stacks are also known to increase acetylcholine levels in the brain, which is a neurotransmitter essential for memory and learning. These dietary supplements support healthy brain pathways to boost problem-solving skills, increase attention, reduce stress, improve focus, and boost brain power.

These natural compounds help improve cognitive function by supporting the growth and maintenance of brain cells. However, it's important to remember that nootropics are not a substitute for a healthy lifestyle and should be used in combination with a balanced diet, regular exercise, and plenty of sleep. By incorporating nootropics for the hippocampus into a comprehensive brain health plan, individuals may be able to improve their memory, focus, and overall cognitive function.

How We Picked the Best Nootropics for Hippocampus Health

Our selection process for the top nootropics promoting hippocampus health involved an in-depth evaluation of multiple factors. These included effectiveness, ingredients, scientific evidence, safety, brand reputation, product transparency, manufacturing methods, user reviews, pricing, and overall value. Our comprehensive approach allowed us to present a credible and well-rounded list of the best hippocampus-supporting nootropics to our readers.


We examined clinical studies and user experiences to determine the impact of nootropics on hippocampus health, with a focus on neurogenesis, memory consolidation, and spatial learning.


We carefully assessed each formula, giving priority to natural, high-quality, and evidence-based ingredients that contribute to hippocampal health and function.

Scientific Evidence

We consulted peer-reviewed research and meta-analyses to confirm the effectiveness of key ingredients in supporting hippocampus health and cognitive functions.


We evaluated optimal dosages and ingredient ratios, ensuring their alignment with established research for maximum efficacy and safety.


We confirmed the safety of each ingredient, accounting for possible side effects, interactions, and compliance with regulatory guidelines. Priority was given to FDA-approved ingredients.

Brand Reputation

We assessed the credibility and trustworthiness of each brand through customer feedback, expert opinions, and the company's track record.

Product Transparency

We valued comprehensive ingredient information, including their sources and concentrations, to enable informed decision-making by consumers.

Manufacturing Process

We investigated manufacturing standards, giving preference to products made in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, placing importance on testimonials that specifically address improvements in hippocampus-related cognitive functions.


We compared product prices to ensure their competitiveness while taking into account the quality and effectiveness of the nootropic.


We evaluated the overall value of each nootropic, considering the balance between price, quality, and effectiveness to guarantee the best return on investment for our readers.

Nootropics for Hippocampus FAQs

Can nootropic supplements help with age-related memory loss?

Yes, using these supplements may help improve age-related memory loss and other forms of cognitive decline.

How long do nootropic supplements take to affect memory?

It varies depending on the individual and the nootropic, but most people experience improvements in cognitive function within a few weeks to a few months of regularly taking the supplements.

Can nootropics be taken with other medications to improve learning abilities?

Some nootropic stacks may interact with medications. It is crucial to consult with a healthcare professional before taking any new supplement to ensure it is safe to use alongside your current medications.

Are there any dietary or lifestyle changes that might complement these learning nootropics?

A well-balanced diet, regular exercise, and sufficient sleep are essential for optimal brain health. Engaging in cognitive training exercises, such as puzzles or memory games, may also enhance the effects of these nootropics.


The hippocampus is a vital part of the brain that is involved in memory, learning, and spatial navigation. To enhance brain function and support healthy brain cells, individuals may want to consider taking nootropics for the hippocampus. These are compounds that boost levels of brain chemicals, increase blood flow to the brain, or stimulate brain activity. Some examples of natural nootropics for the hippocampus are Nooceptin, Semax, L-Theanine, Modafinil, and Creatine.

These supplements may help to improve cognitive performance, reduce brain fog, and protect against age-related cognitive decline. However, nootropics are not magic brain pills and should be used with caution and under medical supervision. They should also be combined with a healthy lifestyle that includes a balanced diet, regular exercise, and adequate sleep.

By following these tips, individuals may be able to optimize their hippocampal function and enjoy better mental clarity and focus.