Do Nootropics Raise Blood Pressure?

Updated on August 28, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
do nootropics affect blood pressure

Do nootropics really raise blood pressure?

Nootropics, also known as cognitive enhancers or smart drugs, are substances that are believed to improve various aspects of cognitive function, such as memory, focus, and mental clarity. As their popularity continues to rise, many individuals are curious about the potential effects of these substances on their overall health, including their blood pressure levels.

Nootropics, also known as "smart drugs", potentially lead to an increase in blood pressure.

In this article, we will explore everything you need to know about how to enhance your cognitive abilities and enjoy the benefits of nootropics, whilst being responsible about maintaining healthy blood pressure levels!

Understanding Nootropics and Their Effects

Nootropics encompass a wide range of substances,(1) including both natural compounds(2) and synthetic drugs.

They are taken with the aim of enhancing cognitive performance and promoting brain health. While the specific mechanisms of action may vary depending on the type of nootropic used, they work by influencing neurotransmitters, blood flow, and brain energy metabolism.

Commonly used terms to describe nootropics include "brain boosters," "memory enhancers," and "neuroenhancers." These substances have gained attention for their potential to improve cognitive abilities, especially in individuals facing cognitive impairment due to conditions such as Alzheimer's disease,(3) attention deficit hyperactivity disorder (ADHD),(4) or age-related cognitive decline.(5)

These supplements offer a wide range of benefits that can help individuals improve their memory, focus, attention, and overall brain health.

Here are 5 incredible benefits of incorporating nootropics into your daily routine:

  1. Enhanced Memory Function: One of the most sought-after benefits of nootropics is their ability to improve memory and enhance learning capabilities. Nootropics such as Piracetam have been shown to increase the synthesis of acetylcholine, a neurotransmitter essential for memory formation and retrieval. By optimizing acetylcholine levels, nootropics can enhance long-term memory, working memory, and the ability to retain and recall information.
  2. Increased Focus and Attention: Nootropics can also significantly improve focus and attention span, making it easier to concentrate on tasks and perform at optimal levels. Compounds like Rhodiola Rosea and Bacopa Monnieri have been shown to increase the production of dopamine and serotonin, neurotransmitters responsible for regulating mood, motivation, and focus. By balancing these brain chemicals, nootropics can enhance cognitive performance and promote better mental clarity.
  3. Boosted Brain Energy: Nootropics are known to increase brain energy and combat mental fatigue, making them ideal for individuals looking to enhance productivity and combat mental exhaustion. These supplements work by improving blood flow to the brain, supplying it with essential nutrients like glucose and oxygen for optimal functioning. Nootropics like Alpha-GPC and CDP-Choline support brain cell metabolism and can help neutralize mental fatigue, leading to improved alertness and overall cognitive performance.
  4. Stress Reduction and Mood Enhancement: High levels of stress and poor mood can negatively impact cognitive function. Nootropics such as L-Theanine and Bacopa Monnieri have been shown to have calming effects on the brain, reducing anxiety and stress levels. These compounds work by modulating neurotransmitters, promoting a relaxed state without sedative side effects. By reducing stress and improving mood, nootropics can enhance overall cognitive well-being and productivity.
  5. Brain Health and Neuroprotection: Nootropics also offer long-term benefits for brain health and neuroprotection. Compounds like Lion's Mane Mushroom and Maritime Pine Bark Extract have potent antioxidant and anti-inflammatory properties that protect brain cells from oxidative stress and age-related damage. By improving blood flow, increasing neurotrophic factors, and stimulating neuronal growth, these nootropics support brain health and help prevent cognitive decline.

The Connection Between Nootropics and Blood Pressure

The effect of nootropics on blood pressure can be variable, depending on the specific substance and individual factors. Some nootropics have been associated with changes in blood pressure, both increases, and decreases, while others may have a minimal impact.

It is essential to understand these effects and consider them when using nootropics, particularly for individuals with pre-existing cardiovascular conditions.

Several studies have investigated the relationship between nootropics and blood pressure. Stimulant-based nootropics with properties like caffeine have been shown to increase blood pressure levels in some individuals.

These substances exert their effects by stimulating the central nervous system, which can lead to vasoconstriction and higher blood pressure.

On the other hand, various other nootropics have been associated with potential blood pressure-lowering effects. 

These compounds may promote vasodilation and improve cardiovascular health, leading to lower blood pressure levels.

Nootropics That May Raise Blood Pressure

While it is crucial to note that individual responses may vary, here are some nootropics that have been reported to potentially raise blood pressure levels:

  • Caffeine: Found in coffee, tea, and many energy drinks, caffeine is a stimulant that can increase blood pressure temporarily.
  • Adderall: A prescription medication typically used to treat ADHD, Adderall is a potent stimulant that can significantly elevate blood pressure.
  • Ritalin: Another prescription medication for ADHD, Ritalin can also increase blood pressure due to its stimulant effects.
  • Modafinil: Used primarily for narcolepsy and sleep disorders, Modafinil can stimulate the nervous system and may lead to elevated blood pressure levels.
  • Ephedrine: Although primarily used as a decongestant, ephedrine has stimulant properties that can cause an increase in blood pressure.

It is crucial to exercise caution when using these substances, especially if you have a history of hypertension or cardiovascular issues. 

Nootropics That May Lower Blood Pressure

Conversely, some nootropics have been associated with potential blood pressure-lowering effects. It is important to note that individual responses to these compounds may vary.

Here are a few examples:

  • Ginkgo Biloba: This herbal extract has vasodilatory properties that may help promote healthy blood flow and lower blood pressure.
  • Omega-3 Fatty Acids: These essential fatty acids, commonly found in fish, have been associated with cardiovascular benefits, including blood pressure regulation.
  • Resveratrol: This compound, found in red wine and grapes, may have antioxidant and anti-inflammatory effects that could contribute to lower blood pressure levels.

Nootropics That May Not Affect Blood Pressure

Certain nootropics, particularly those with no stimulant effect on the central nervous system, are less likely to have a significant impact on blood pressure levels. Some examples include:

  • L-Theanine: This amino acid, commonly found in tea, is known for its calming and focusing effects and is not associated with noticeable changes in blood pressure.
  • Bacopa Monnieri: A plant-derived nootropic, Bacopa Monnieri has been used traditionally for its cognitive-enhancing properties, with no significant effects on blood pressure reported.(6)

While these substances may not directly affect blood pressure, individual responses can still vary.

Managing Nootropic Use to Maintain Healthy Blood Pressure

To ensure the responsible use of nootropics and maintain healthy blood pressure levels, consider the following strategies:

  1. Consult with a healthcare professional: Obtain professional advice before starting any new supplementation regimen, particularly if you have a history of cardiovascular conditions or blood pressure issues.
  2. Monitor your blood pressure regularly: Keep track of your blood pressure levels using a reliable blood pressure monitor. This can help you gauge the effects of nootropics on your blood pressure over time.
  3. Practice dosage control: Use nootropics according to recommended dosages and guidelines. Avoid exceeding recommended limits, as higher doses may increase the likelihood of adverse effects on blood pressure.
  4. Make lifestyle changes: Focus on maintaining a healthy lifestyle by incorporating regular exercise, a balanced diet, stress management techniques, and sufficient sleep. These factors play a vital role in blood pressure regulation.
  5. Consider individual sensitivity: Remember that individual responses can vary, and what works for one person may not work the same way for another. Monitor your body's response to different nootropics and adjust your usage accordingly to avoid issues with high blood pressure from nootropics.

Factors Affecting Blood Pressure Response to Nootropics

  • Individual physiology: Each person's body reacts differently to substances, including nootropics. Some individuals may be more susceptible to blood pressure changes than others.
  • Existing medical conditions: Pre-existing cardiovascular conditions, such as hypertension or hypotension, can influence how your body responds to nootropics. Individuals with these conditions should exercise caution and seek professional advice.
  • Genetic factors: Genetic variations can also play a role in determining how a person responds to certain substances, including nootropics. Some individuals may have genetic factors that make them more prone to blood pressure fluctuations.
  • Dosage and frequency: The dosage and frequency of nootropic use can affect blood pressure response. Higher doses or more frequent usage may increase the likelihood of blood pressure changes.
  • Other medications and supplements: Concurrent use of other medications or supplements can interact with nootropics and impact blood pressure levels. It is important to consider potential drug interactions and consult with healthcare professionals.


In summary, the impact of nootropics on blood pressure varies depending on the specific substance or compound being used, as well as individual factors. 

While some nootropics have been associated with an increase in blood pressure, others may have potential blood pressure-lowering effects. There is a variety of different types of nootropics to explore, so be sure to find the one that works the best for you and your lifestyle goals.

It is crucial to consult with a healthcare professional, monitor your blood pressure regularly, and use nootropics responsibly to maintain healthy blood pressure levels.