F-Phenibut Review: Effects, Dosage & Where to Buy

F-Phenibut carries the tag that says, “feel happy and relaxed.”

If you want to exactly feel that way, with the bonus of stomach butterflies like you have just been promoted at work, then this substance might be the one for you.

Let us look into this Fluorophenibut review to find out.

What is F-Phenibut?

F-Phenibut (Fluoro Phenibut, 4 Fluorophenyl, 4 amino 3) [R] is a central nervous system depressant and a GABA B receptor agonist that is more potent than the GABA derivative, Phenibut.


Fluorophenyl butanoic acid is a depressant belonging to the chemical class of Gabapentinoid that has similar tranquilizing effects to other nootropics and has a five to ten-fold higher potency making it a viable option.

Phenibut powder interacts with the central nervous system and lowers the over-excitement levels in the brain.

Although Fluorophenibut works similarly to Phenibut, it has a shorter duration in the body compared to Phenibut half-life. It is a derivative substance of GABA B only that it can cross the blood-brain barrier because of the phenyl ring.

The substance is formed into crystals and is water-soluble in its form. It can also be compared to Baclofen since they have identical chemical structure, except for the fluorine that replaces chlorine atoms in the para-position of the phenyl group.

What Does It Do?

Fluorophenibut is likewise similar to depressants like gabapentin and pregabalin, but it is best preferred as there are speculations that it may reduce excitatory neurotransmitters.

f phenibut featured image

GABA or aminobutyric acid is the chief inhibitory neurotransmitter. On one hand, GABA’s receptor agonist, Fluorophenibut is modulated producing the calming and sedating effects on the central nervous system.

Unlike Phenibut powder, there is a little human study on the use of 4 Fluorophenyl, so there are only intelligent assumptions about its pharmacology and significance as a depressant.

Effects & Benefits

Among other nootropics, 4 Fluorophenyl (4 amino 3) is less stimulating and has a faster onset. At times when the voltage gated calcium channels are over-stimulated, the right amount of depressant provides a relaxing effect.

fluorophenibut effects benefits

Based on research, the right dosage has favorable physical and cognitive effects.

  • Sedation. When used in small amounts, it can induce sleep giving the feeling of a full rest upon waking.
  • Wakefulness. On the contrary, a higher dose stimulates the brain and increases productivity and mental alertness.
  • State of euphoria. This feeling of pleasure is felt similarly during a state of excitement or love. It can suppress anxiety and just feel good while the drug is in effect.
  • Enhanced appetite. At the right dose, a person’s appetite is stimulated enhancing food consumption.
  • Entactogenic effects. Moderate doses can increase friendliness and empathy inducing fewer social inhibitions and emotional openness.

How Long Does it Take to Feel it?

Other nootropics take a while to kick in while 4 Fluorophenyl takes only 20 minutes to take effect. For others, it takes up to 60 minutes before they feel any difference.

The effect can be felt within 6 to 8 hours.

Dosage & How to Take

There is not enough research stating the recommended dose, but for starters, it is best to take lower doses to help the body adjust to its effects.

The threshold is at 50 mg while light doses are between 100 mg to 150 mg. The users who testified on this drug shared that taking 250 mg to 400 mg is just enough to feel the effects.

The strong dose is between 400 mg to 600 mg while the heavy dose is at 600 mg to 100g.

Keep a 4-hour window before taking another dose and cycle it up every 2 weeks of daily intake.

As a precaution, if you are pregnant or lactating, consult your doctor before taking this or any other nootropics.

The suggested doses are just speculations from previous users since there is not enough research about the product yet.

Side Effects

The exact toxic dosage is unknown since there is very little history of human usage to study. However, early reports stated that higher doses may have adverse effects that can lead to serious injury or even death.

Evidence from people who have tried it in moderate doses and used it occasionally suggests that there seem to be no negative side effects, but for those who are not used to it may experience the following:

  • Nausea
  • Stomach cramps
  • Loss of motor control
  • Sweating
  • Dehydration
  • Headaches
  • Muscle cramps
  • Frequent urination
  • Amnesia
  • Depression
  • Shortness of breath
  • Compulsive redosing

Experiences Shared on Reddit

Here are experiences shared by the users.

According to edifice98:

“I received 5 grams of this yesterday and my first impression is good…It took between 3 to 4 hours to feel the full effects. So far, I am a fan.. I will probably take it for several days in a row to see if my tolerance goes up or not… for science!”

According to 2c-wasted:

“ I'd highly recommend this substance over regular Phenibut for it's quicker onset time and increased potency. I also like that it doesn't seem to have residual effects the next day because of its shorter duration. Overall a great substance…”

Where to Buy F-Phenibut?

There is F-Phenibut for sale from various online vendors.

Buy Phenibut from a trusted website that has a proven track record of selling supplements.

SwissChems is the best Phenibut HCL source. It has an independent lab testing verification that assures you the quality of products you are buying from them.

Frequently Asked Questions (FAQ)

Let us answer your questions here.

Is it Safe?

The substance is safe to use in moderation. Its rapid onset may allow compulsive redosing leading to tolerance.

Make a diligent research before taking it with other substances to avoid dangerous and life-threatening effects.

What is the Difference Between F-Phenibut and Baclofen?

Fluorophenibut is a more potent GABA B receptor agonist than Phenibut but is less potent than Baclofen.

It has a similar pharmacological structure to Baclofen.It is used to treat alcoholism and drug dependence.

Between the two, Fluorophenibut HCL is more effective as a nootropic and neuroprotective compound.

However, it has more abuse potential. In one case study, Baclofen was even used to treat Phenibut dependence.


Fluorophenibut is a modified version of Phenibut and is suggested to be better than most other nootropics when it comes to acute effects.

A moderate use promises a balanced central nervous system by lowering the levels of over-excitement and enhancing the feeling of pleasure. With more research, this might be the next level of nootropic in the market.