NMN supports cardiovascular and cognitive health, as well as increase energy production.
It also improves retinal and bone health.
It furthermore may promote DNA repair and activate SIRTUIN genes resulting in anti-aging effects.
Available through our partner Double Wood Supplements.
The aging process is inevitable and NMN might be the supplement that will bring you the elusive Fountain of Youth.
As you age, your physical, mental, and physiological health also decline. What's worse is that it may happen together with some chronic diseases.
However, no hope is lost as there are anti-aging supplements that claim to reverse the signs of aging and make you feel young again.
NMN in its powder form is advertised as the Fountain of Youth. Its formulation is to prevent chronic diseases, combat the evident signs of aging, and increase strength. Enjoying the golden years of adulthood is its utmost priority.
With these heavy claims to regain your youthful days, does it live up to the hype? Is it really the miracle drug that people are asking for?
Read more to learn and discover nicotinamide mononucleotide.
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound derived from vitamin B3. It exists in every cell of various organisms, including humans.
The molecule is essential in various bodily functions like self-repair. It is found in the food that we eat like broccoli, cucumber, tomatoes, cabbage, and avocados.
Some of our body's enzymes use it to produce another compound, nicotinamide adenine dinucleotide (NAD). It is used as a metabolite for maintaining normal NAD levels.
At this stage, it helps to regulate physiology and alleviate symptoms connected to nutrient depletion. Helping to prevent any disease and pathologies remains its goal.
After being metabolized, the product is reused by the body. This is a vital part of human rejuvenation as scientists discovered its certain anti aging effects.
Nicotinamide mononucleotide products have a role in DNA repair and allow regrowing function in the cell. Nicotinamide Mononucleotide also supports the activation of the Sirtuin genes which are thought to help in healthy aging.
Dr. David Sinclair, a Professor of Genetics at Harvard Medical School, is one of the leading researchers in the rejuvenation field. He is known for his work on various molecules such as Resveratrol and Sirtuins.
David Sinclair continues to work on NMN and resveratrol and the analogs of it. It is directed to understand aging and how to reverse it through activating pathways to improve our body’s defenses against it.
This was elaborated in his book Lifespan, where he discusses his research examining Nicotinamide Mononucleotide in mice to observe if it helps in their life extension.
David Sinclair describes how NMN is related to NR (Nicotinamide Riboside). NR is known to increase the levels of NAD. However, we gradually lose NAD as we age, having only half of it by the time we enter our 50s.
As of now, Nicotinamide Mononucleotide research is still in its infancy. The first study in humans was published this year and is still in Phase 1.
Other recent studies are also taking place to fully understand the effects of taking the supplement products.
Nicotinamide Mononucleotide supplements raise NAD levels not just to ensure its anti-aging effects but also to improve overall health to relieve physiological declines due to age.
With NMN, anti-aging effects are definitely on the table. Aside from combating aging, what’s good about it is it has additional effects in alleviating chronic diseases, although not independently, to ensure longevity.
It is important to note that this is not intended to diagnose, treat, cure or prevent diseases.
There are different ways to use NMN products.
The pure form in a bulk powder can be taken raw, mixed with yogurt or water, or it can be taken as a sublingual.
However, this dietary supplement has not yet been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
Since NMN is not yet approved and evaluated by the Food and Drug Administration, there is no official dosage recommendation. The supplement manufacturers have only established doses bases on trial and error.
To avoid complications, consult your doctor for the right drug administration.
In the study of 50 women, the dosage tested is 125 mg of the product twice a day over 8 weeks.
Dr. Sinclair, the Professor who publicly announced his usage of NMN for good health, reportedly takes 1 gram of pure NMN daily, together with 1 gram of resveratrol in the mornings consumed with yogurt.
In a specific product, Double Wood Supplements, their recommended dosage of Nicotinamide Mononucleotide is between 250-1500 mg per day.
It is not advised to take the entire day’s dose in a single consumption but to take 8 doses of 125 mg around 1.5 hours. Their product contains 30 grams of the powder.
Consuming this product in short dosages will cause NAD+ levels to be elevated all day long. It is used widely because of the free shipping promos being offered on websites.
Although the research for Nicotinamide Mononucleotide is still ongoing, the studies that were conducted so far have shown no signs of toxicity with no adverse effects.
The first phase of the scientific study which began in 2016, was focused on assessing the safety of NMN and its time course in the blood.
While another recent study is evaluating the effect of the supplement in a group of 50 older women diagnosed with high blood triglycerides, blood glucose, and BMI.
There are still some rare reactions reported from the products like itchiness, sweating, and nausea.
To be safe, please consult your doctor first before taking this.
To ensure the highest quality and get the intended results, you need to know the best NMN out there.
You should check NMN Bulk Powder by Double Wood Supplements.
You can purchase their product for a price of $129.95 or $116.96 if you subscribe to the product.
To know the experiences of those who have tried pure products, here are some of the best NMN supplement reviews on Reddit:
“I’ve been using Alive By Nature’s nicotinamide mononucleotide for nearly a year. Spent 14 years in the dietary supplement industry, this outfit appears to do a good job. Bio hack: I hold the salivary-dissolved powder under my tongue for 30+ seconds to permit sublingual absorption. This helps avoid first pass liver degradation, potentially maximizing the effectiveness of this form of NAD. Good luck.”
“I think Uthever NMN is great. After taking it, I feel more comfortable and can sleep well. I joined an activity in their company and they offered me free nicotinamide mononucleotide for 30 days. They are NMN raw material manufacturer.”
You may find the answers to your questions here.
Although these supplements are not yet FDA approved, it can be used as a substitute for a NAD supplement.
Animal studies indicate that using NMN (a precursor for NAD) can increase NAD+ levels and prolong the life of worms and mice. It can also improve muscle generation, metabolism, and cardiovascular function.
However, it is crucial to know that animal findings don’t necessarily translate to the effectivity on humans.
The efficacy of it in humans is still unclear as human trials are still ongoing at Brigham and Women’s Hospital in Boston.
The study will help find out how this product is processed by the body at different dosages.
The study which is published in Endocrine Journal has recently concluded the safety of NMN supplements that work for mitigating aging-related signs and diseases in humans [R].
According to the trial that involves 10 healthy Japanese men, a single sublingual administration was safe and effectively metabolized without any significant adverse effects. Thus, the oral administration of nicotinamide mononucleotide was found to be safe and well-tolerated.
Nicotinamide mononucleotide has proven to be effective in reversing the aging effects and DNA repair in animal studies.
The first study in humans was published in 2020 and showed that a single dose of 500 mg of the supplement is tolerable with no deleterious effects.
However, there is still insubstantial scientific information on whether this is indeed effective in humans as the trials are yet to be concluded.
Although the supplement might help in preventing certain pathologies, it should not be solely used to address these.
Pure NMN products are not intended to diagnose, treat, cure, or prevent any diseases.