Noopept And Phenibut: Stack, Facts, & Dangers

Updated on April 24, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

If you are looking for a trick, whether to boost your memory, improve your mood, fight anxiety, or simply make your brain relaxed from a busy schedule, a stack of nootropics like Noopept and Phenibut would do the magic.

Well, I guess you will agree that the idea of taking these pills to increase your brainpower somehow brings you a “why not” moment.

This post will give you a deeper understanding of these two nootropics in terms of its benefits, dosage, and side effects, so take the time to read and discover what could be in store for you.

Both Phenibut and Noopept are often tagged as smart drugs as they are known to be effective cognitive enhancers.

They are clinically used to fight common and acute neurological disorders such as mood disorders, dementia, Alzheimer’s disease, and cerebrovascular disorders that affect the brain’s blood vessels and supply.

noopept and phenibut featured image

To give you a brief history of the two and our experience with Noopept, both were synthetically developed in Russia. Phenibut was initially created as an anti-anxiety (anxiolytic) drug in the 1960s. At that time, it gained popularity with its claim of also boosting memory recall.

On the other hand, Noopept was later introduced in 1996 to support cognitive function. Despite similar usage, their mechanisms and results may vary.

Noopept Overview

The nootropic Noopept is also known as Omberacetam. The use of this synthetic nootropic enhances cognitive impairments and allows neurofunction protection.

It heightens brain alpha wave function that enables users to become efficient problem-solvers, quickly encodes memory, and recall previous learnings. This is possible due to its reactions to brain receptors stimulation that revolve around focus, memory, impulse control, and learning.

Taking it opens neurotransmissions channels that stimulate the transmission of signals which reconcile thought processes and focus. To simply put it in words, Noopept improves communication between brain neurons.

noopept overview

Research has verified that the effects Noopept has for patients with organic brain disorders are enhanced mood, sleep quality, and daytime wakefulness. Now, who wouldn’t want that?

Other cool benefits you’ll gain if you are taking Noopept as a nootropics supplement is that it combats depression.

The other effect that was usually recorded is that it may result in a feeling of being clear-headed. Users may feel brighter. Noopept generally fights social anxiety, making a person confident in social settings.

The results it generally brings are positivity and well-being. Wouldn't it be lovely if people are less prone to irritation over minor issues?

In case you’re wondering if its effects are the same for all, well, it’s not for everyone. Moreover, if it’s to compare with Phenibut nootropic in terms of anxiety reduction, Noopept may be a bit more subtle and it's better to mix those two than Noopept with alcohol.

Phenibut Overview

Phenibut has been known since the 1960s as a supplement for insomnia and mood disorders. Taking Phenibut nootropic triggers calming effects on users. Since that time in the 60s until now, it is known to contain sedation side effects that are usually present in today’s similar medications.

Phenibut is commonly used to treat PTSD symptoms and alcohol withdrawal syndrome since it imitates GABA-like influences promoting anxiety relief.

Research also shows that Phenibut can stimulate dopamine receptors. It became famous for people to consume as an off-label nootropic agent for recreational purposes.

phenibut overview

Phenibut has GBA-line influences. To give you a brief background about it, GABA means gamma-aminobutyric acid that is the brain’s inhibitory chemical.

The nootropic is an amino acid with the general function of a neurotransmitter for normal brain regulation that intercepts the nerve cells from getting overexcited and reduces the number of stress-stimulus.

It also provides the same response as the GABA that promotes the effects of calming sensations. The only thing for you to remember is that it has higher effects than the GABA supplements due to its greater capacity to reach its targets as it easily crosses blood-brain barriers.

Every drug has its limitations. Phenibut receptors are somehow similar to alcohol influences on the brain and benzodiazepines (psychoactive drugs), and baclofen (muscle relaxer and spasm reliever agent).

It has the same side effects as the GABA if Phenibut is misused. Taking Phenibut nootropic in a high dose can cause side effects such as withdrawal symptoms, a psychosis-like condition, and it also includes overdose.

Noopept vs. Phenibut

If we are to differentiate Noopept from Phenibut, it is given that they are distinct substances from each other. Here’s why: Noopept is created for cognitive function stimulation, and Phenibut is mainly for battling anxiety.

They are both nootropics with similar capabilities to enhance mood and relieve anxiety, but they are differentiated in terms of their GABA-like influences.

Noopept nootropics have some stimulant-like effects but don’t bind with GABA receptors. Meanwhile, Phenibut nootropics have GABA receptor activation and binding that produces anxiolytic effects, and it is possible to have sedation outcomes.

For research, both are subject to studies for treating degenerative brain disorders of cognitive dysfunction. In particular, Noopept nootropics may have an edge through its benefits of protecting the brain against toxicity and the decrease of tau phosphorylation that contributes to the brain’s disruption, which involves diseases like dementia.

Concerning this disease, dementia patients may show symptoms of nervousness, agitation and may often be paranoid. Phenibut nootropics may provide some calming consequences.

For recreational purposes that are off-label, Phenibut nootropics produce a relaxation experience and mental calmness, but these are susceptible to harmful side effects, as earlier mentioned.

Noopept + Phenibut Stack

The Phenibut Noopept stack came to the surface as a combo of nootropic supplements that can be considered a social stack. Its known benefits are euphoria stimulation in socializing, enhancing memory, triggering focus, clarity, and alertness.

Like any other supplement, users with health conditions need to first consult their doctors before taking a stack of Phenibut and Noopept. The use of these substances daily or in high doses, may not be recommended and it's always a good idea to stack Noopept and Choline.


As mentioned earlier, if you take Noopept, it will contribute to your increased feelings of well-being. You will also notice that Noopept reduces your stress and anxiety.

Reviews about Noopept have also mentioned that if you take it on a daily schedule, there's a cumulative result of enhancing your senses and levels up your memory.

On the other hand, you’ll be surprised that the use of Phenibut is not only to fight anxiety or depression. Some bodybuilders also utilize it to increase hormone secretion and maintain muscle oxygen levels.

Combining Noopept with Phenibut into a proper dosage stack is proven beneficial, with people claiming its positive effect on their mood, memory, sociability, and alertness.

Noopept is indeed a match for Phenibut as its use is to give clarity and focus while the latter’s use is for sociability and positive mood.

Another treat is that these nootropics also allow the brain to recover after a person quits smoking.

Dosage and How Much to Take

Noopept has common forms of crystal powder and capsules. Noopept capsules range from 10 mg to 20 mg, and 30 mg. It’s typically to be taken daily for one capsule only.

dosage and how much to take

Meanwhile, for Phenibut, it is recommended to take between 250 mg and 1000 mg dosage of the supplement. Since this nootropic has a high potency, it is mostly discouraged to be taken daily. Twice per week is enough to experience results.

These could also mean that you need to start taking these supplements in lower dosages to observe how your body reacts. Also, it’s better to avoid drinking alcohol if you’re using Phenibut as your nootropic.

Side Effects

Like any other substance, Noopept user may experience the following:

  • Headaches
  • Potential irritability
  • Restlessness
  • Brain fog
  • Change in appetite

These might not be the same as other users since most of them did not experience any serious health risks.

For Phenibut, the following are possible complications:

  • Dizziness
  • Stomach cramps
  • Lack of energy or enthusiasm
  • Potential dependence

Self-administration of dosages is highly discouraged due to possible risks.


In case you might be asking yourself some questions, here are some clarifications.

Are Phenibut and Noopept the Same Thing?

Both are smart drugs or synthetic substances consumed to improve a healthy person’s mental performance. Although they have the same nature, the benefits, dosage, and effects vary.

Is Noopept Phenibut Safe Together?

Yes, they are safe together if taken in the proper dosage. If your brain needs a boost, both effectively improve memory, focus, and energy while it reduces depression simultaneously.

Users usually take 250 mg Phenibut and 10 to 30 mg Noopept but again, take the time to consult a doctor to identify your required dosage.

Keep in mind maintaining a low dosage of Phenibut when being used as an additive to avoid overdose risks and drug tolerance.

How Long is the Duration of Effects?

Noopept is believed to have a 2 to 3 hours half-life. The concentration of Noopept will decrease to half of its starting dose in the body in 2 to 3 hours.

Studies show that for continued use in 2 to 3 weeks, there’s a significant improvement in one’s senses and cognitive function.

Meanwhile, reports stated that Phenibut outcomes begin in 60 to 90 minutes and last for 4 to 10 hours.


Noopept alone is an effective nootropic for improving the brain’s cognitive function. Phenibut as well has positive cognitive influences and is much proven to be efficient in fighting anxiety.

When Noopept is combined with Phenibut in recommended dosages, you can attain the two substances’ magic trick as you improve your focus, memory and feel euphoric with reduced depression.