If you’re thinking of taking nootropics, you’ve probably come across Noopept.
As an all-around cognitive enhancer and mood booster, Noopept is a way for many adults to improve memory consolidation and function more effectively in everyday life.
Before you start taking Noopept, though, you should have more information on what it is, how it works, its benefits, and its possible side effects.
Here, I’ve done the research for you.
What Is Noopept?
Noopept is the brand name of supplement manufacturers for N-Phenylacetyl L Prolylglycine Ethyl Ester, a chemical that stimulates the production of NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) in the hippocampus.
N-Phenylacetyl L Prolylglycine Ethyl Ester also activates AMPA and NMDA receptors, which facilitate transmission between neurons.
Since these neurotrophins and glutamate receptors are actively involved in the growth and survival of neurons, they help improve memory, focus, and cognitive performance.
As part of the racetam family, Noopept and Piracetam are also often compared to each other.
Although they share similar mechanisms of action, the former is much more potent, so treatment starts at much lower doses compared to Piracetam. People also experience fewer issues when using Noopept.
Besides the brand name Noopept, N-Phenylacetyl L Prolylglycine Ethyl Ester is sometimes called by its dipeptide code name, GVS-111.
With other variations of Noopept, ingredients may be added to create a ready-made supplement stack.
How Does Noopept Work?
Find out below.
Long Term Effects
Because Noopept easily crosses the blood-brain barrier, it’s considered a fast-acting drug that takes immediate effect in your body.
While it is usually taken for its quick results, research shows it has a long-lasting effect on your cognitive health too.
Over time, it increases NGF/BDNF levels and reduces oxidative stress, which is essential for good cognitive function.
Research is also being conducted on the nootropic as a treatment for different types of disorders including Alzheimer’s Disease, Parkinson’s Disease, and dementia, among others.
Since it has a reparative effect, it may alleviate and improve mild cognitive damage.
Is Noopept safe to use?
Because not many long-term studies have been conducted on the nootropic, you cannot be 100% certain of its health risks.
However, based on information from published literature and user reviews, it is generally safe, with minimal side effects.
With that said, it’s important to purchase from trusted supplement manufacturers to make sure you’re getting quality Noopept pills.
Before consumption, you can review your medical history and information with your doctor too, if you want to be extra safe.
One last tip is to research online and read about different users’ experiences, as these can vary from person to person.
It’s useful to consider multiple sources of information, so you can really decide if it’s the right supplement for you.
How long does Noopept last?
Well, fast-acting substances usually have very short half-lives. Noopept half-life is just 60 to 90 minutes, which means that an average person can fully process half of the dose in that period of time.
However, one thing to remember is that a drug with a shorter half-life can cause withdrawal problems, as its effect wears off quite rapidly. Therefore, you should always be careful not to be too dependent on it.
Side Effects & Dangers
It’s very important to have information on any drug or supplement’s side effects before consuming it.
While many people use it without any issues, you should know that Noopept dangers include headaches and fatigue for some users.
Research shows that a Noopept headache is usually caused by low levels of acetylcholine [R].
To counter this, users stack Noopept capsules with a choline source such as Alpha GPC.
If you’re still experiencing headaches, I’d also recommend lowering your dose, as the nootropic may be too powerful for you.
Noopept tolerance can also occur if you’re constantly taking high amounts of the supplement without incorporating breaks in between.
While Noopept effects may feel good, it’s best to be safe and avoid a tolerance buildup.
With that said, you should start with the lowest dose of 10mg and gradually add 5mg per week, only if needed. Most users don’t even need the largest dose of 30mg!
Although it is primarily known for its positive effect on cognitive activity, memory consolidation, and health, this nootropic also has a number of additional benefits.
Now, what does Noopept do?
With Noopept, anxiety can be reduced. Since it affects benzodiazepine receptors that are associated with lowering stress levels, taking it can improve your mood and feel better overall.
In a study involving patients with mild cognitive disorders, 10mg of the nootropic used twice daily had an anxiolytic effect.
Another one of the benefits of Noopept is it supposedly helps clear mental fog [R]. Because it targets your focus, memory, and learning capabilities, your mind should feel sharper and clearer after consumption.
However, you may have to study your individual reaction to the drug, as some users actually experience Noopept brain fog as a side effect of taking it.
Research on mental fog isn’t the most comprehensive either, as it can be quite subjective.
One interesting study showed that among those who took Noopept, depression symptoms actually decreased.
Because the nootropic deals with anxiety, stress, and low motivation, it may also help with elevating your mood in the long-term.
There’s minimal research regarding this, but anecdotal reports usually indicate that it helps with depression.
Is there such a thing as a Noopept high?
The answer is no. Contrary to popular belief, it does not make you feel euphoric or high, unlike other psychostimulant drugs.
It doesn’t increase physiological or central nervous system activity—all it does is enhance cognitive function.
What Reddit Users Say
Based on my research, many Reddit users have good experiences with the nootropic, as it really helps with a variety of cognitive issues.
Generally, they recommend starting with the lowest dosage possible, as the effects are powerful and immediate.
New users, in particular, may feel over-stimulated, especially when taking a large amount. When this happens, it may be beneficial to incorporate a supplement such as Choline to calm the mind.
After taking the nootropic, users feel very focused, energized, and positive—they feel more ready to take on whatever comes their way, and some become more proactive than usual.
For those who experience constant mood swings, this could also help with stabilizing their emotions.
Most importantly, it helps you process information better, in a more organized and analytical manner. This is extremely helpful for those wanting to use it as a safer “study drug” [R].
However, it’s also vital to note that this nootropic can make it difficult for some people to relax.
To counteract this, you should take a low dosage earlier in the day or supplement with drugs that have an anxiolytic effect.
Another thing you should be careful of is the potential of withdrawal symptoms.
Once you become dependent on the nootropic, you may feel worse when you don’t have access to it. Thus, it’s important to have a good cycle to prevent this from occurring.
What’s A Good Noopept Cycle?
A typical dosage is 10-30mg, depending on your body weight, but it’s always best to start on the lower end of the range for safety purposes.
This can be taken every day for up to 60 days, with the treatment split into three or more equal parts.
The sublingual method of administration is preferred because this allows you to feel its full effect.
Research shows this bypasses metabolic and digestive processes, so the chemical isn’t broken down by the time it enters your bloodstream.
Keep in mind you should increase intake slowly and gradually to prevent dependency and any other problems.
As much as possible, stick to a low dosage as this nootropic is very potent. You should also take a break from it for a few months after every 60 days of using it.
When taking Noopept, examine the effect on your body and discontinue use if something feels wrong. After all, your health is most important!
Among the different nootropics, Noopept is one of the best because of its all-around effects on your mind and body.
Whether you’re a student preparing for a big test or someone trying to counteract the effects of aging, it’s a good option to heighten your mental functions.
Just remember to be safe and use it wisely!