10 Best Supplements to Take With Adderall in 2024 (Science-Backed Vitamins, Minerals & Natural Herbs)

Updated on February 4, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Science-backed vitamins, minerals, and natural herbs to take with Adderall for cognitive and health enhancement.

Adderall, an ADHD medication often utilized for its cognitive-enhancing properties, can be complemented effectively with the right vitamins and supplements.

But it’s crucial to know which ones work in synergy with Adderall and which should be avoided due to potential interactions.

This article delves into the world of dietary supplements and natural nootropics that can aid in Adderall recovery and enhance the benefits of Adderall use.

We’ve sifted through the science to bring you a list of the best supplements to take with Adderall, helping you make informed decisions about your health regimen.

Key Supplements Compatible with Adderall

  • Vyvamind — Enhances stimulant and cognitive effects
  • B Vitamins (B6, B12, Folate) — Supports brain health and function
  • Omega-3 Fatty Acids — Improves mood and cognitive health
  • Magnesium — Reduces tolerance and muscle tension
  • Vitamin C — Accelerates Adderall clearance, aids in sleep
  • L-Tyrosine — Replenishes neurotransmitters, like dopamine
  • L-Theanine — Reduces anxiety and jitteriness
  • Zinc — Potentially enhances ADHD medication effectiveness
  • Coenzyme Q10 (CoQ10) — Protects against oxidative stress
  • Ashwagandha — Counteracts stress and anxiety side effects

1. Vyvamind

Vyvamind is a nootropic supplement often used with Adderall to boost brain function and mental clarity.

What is Vyvamind?

Vyvamind, a smart drug, is known for its cognitive-enhancing properties. It’s a natural nootropic supplement that many people take alongside Adderall, a popular stimulant.

Ingredients in Vyvamind

This supplement contains several potent ingredients that work together to support brain health. These include caffeine, L-tyrosine, L-theanine, and citicoline.

  • Caffeine: Known for boosting alertness.
  • L-Tyrosine: An amino acid that helps produce dopamine, a neurotransmitter involved in mood regulation.
  • L-Theanine: Another amino acid that promotes relaxation without causing drowsiness.
  • Citicoline: Supports memory and cognitive function.

In addition to these primary ingredients, Vyvamind also contains vitamins B6 and B12.

Role of Vitamins B6 and B12

The vitamin complex of B6 and B12 in Vyvamind plays an essential role in promoting overall brain health. When used alongside stimulants like Adderall, these vitamins can help maintain optimal brain function by supporting the nervous system and aiding the production of serotonin – a neurotransmitter responsible for mood regulation.

Using Vyvamind with Adderall

Many individuals take Vyvamind as an adjunct to their regular Adderall medication. The combination helps enhance the effects of Adderall while potentially reducing some side effects associated with long-term use of such medications. For instance:

  • Enhanced mental clarity
  • Improved focus
  • Reduced anxiety
  • Decreased insomnia

It’s important to note that everyone’s body responds differently to supplements and medications. Therefore, it’s always advisable to consult your healthcare provider before starting any new supplement regimen, especially when combining it with other medications like Adderall.

2. B Vitamins (B6, B12, Folate)

B vitamins are crucial nutrients that play a significant role in brain health. Specifically, vitamins B6 and B12 have been found to enhance the effects of Adderall.

Essential Nutrients and Brain Health

These vitamins support the production of neurotransmitters, proteins that transmit signals between nerve cells. In other words, they facilitate communication within our brains. This is particularly important for those using medications like Adderall as these drugs can impact neurotransmitter levels.

A study conducted by the National Institute of Health demonstrated that vitamin B supplementation can improve cognitive function in individuals with nutrient deficiencies. This shows how vital these nutrients are for maintaining optimal brain health.

The Role of Folate

Folate, another member of the vitamin B complex family, also plays a key role in supporting brain health while on Adderall. It aids in maintaining balanced serotonin and dopamine levels.

Serotonin and dopamine are neurotransmitters responsible for feelings of happiness and pleasure. Medications like Adderall can affect their levels within our brains. By ensuring adequate folate intake through diet or supplements, we can help maintain these critical neurotransmitter balances.

Nootropic Supplements: A Synergistic Approach

Nootropic supplements containing amino acids and fatty acids can work synergistically with B vitamins to support overall brain health while using drugs like Adderall.

For example, Omega-3 fatty acids found in fish oil supplements have been shown to boost cognitive function when combined with B vitamins.

3. Omega-3 Fatty Acids

Omega-3 fatty acids, commonly found in fish oil, are vital nutrients that can enhance the effectiveness of Adderall.

Enhancing Adderall Effectiveness

Omega-3 fatty acids are known for their role in improving brain function. When taken with Adderall, these fatty acids can potentially increase the medication’s effectiveness. They do this by enhancing the communication between nerve cells in your brain.

  • Omega-3 is a type of polyunsaturated fat
  • It’s found in various foods including fish, walnuts and flaxseeds
  • Fish oil supplements are a popular source of omega-3

Balancing Mood Swings

Adderall users often experience mood swings as a side effect of the medication. However, omega-3 fatty acids can help counteract this problem by promoting serotonin production.

Serotonin is a neurotransmitter that plays an essential role in regulating mood, sleep and appetite. By increasing serotonin levels in your body, omega-3 supplements can help you maintain balanced emotional health while using Adderall.

Boosting Cognitive Function

Pairing omega-3 supplements with magnesium could have impressive cognitive benefits. Magnesium is another nutrient that promotes brain health and mental clarity.

Together, these two nutrients could potentially:

  1. Improve memory
  2. Increase focus
  3. Enhance learning capabilities

However, more research is needed to fully understand these effects.

Supporting Brain Health

As natural nootropics or “brain boosters”, both omega-3 and magnesium play crucial roles in maintaining overall brain health when taken with Adderall.

These supplements provide key nutrients your brain needs to function optimally:

  • Omega-3: Supports cell membrane health and reduces inflammation
  • Magnesium: Helps regulate neurotransmitters, promoting better focus and mental clarity

4. Magnesium

Magnesium plays a key role in maintaining dopamine balance, which is often disrupted by the use of Adderall.

The Role of Magnesium in Dopamine Balance

Dopamine, a neurotransmitter responsible for transmitting signals in the brain and other vital areas, is crucial for your mood, sleep, learning, and concentration.

  • Studies show that magnesium supplementation can help increase dopamine levels.
  • This can be beneficial for people taking Adderall as it may enhance the drug’s effectiveness.

Synergistic Effects with Vitamins B6 and Zinc

Next up is the synergistic relationship between magnesium, vitamin B6 and zinc. These nutrients work together to amplify the benefits of Adderall.

  • Vitamin B6 aids in the absorption of magnesium.
  • Zinc increases the effectiveness of both magnesium and vitamin B6.
  • Together they form a powerful trio that helps maximize the effects of Adderall.

Serotonin Production Boosted by Magnesium

Another important aspect to consider is how magnesium aids serotonin production. Serotonin is another neurotransmitter that regulates mood and sleep patterns.

  • Increased serotonin levels can lead to improved mood stability and better sleep quality.
  • This can be particularly beneficial for those using Adderall as it tends to disrupt normal sleep cycles.

To summarize:

  1. Regular intake of dietary supplements containing magnesium can aid in balancing dopamine levels which are often disrupted by Adderall use.
  2. The nutrient works hand-in-hand with vitamins B6 and zinc to enhance the effectiveness of Adderall.
  3. By aiding in serotonin production, magnesium plays an essential role in regulating mood swings and ensuring healthy sleep patterns.

These points highlight why many health experts recommend including dietary supplements like magnesium when taking Adderall.

5. Vitamin C

Vitamin C is a crucial dietary supplement. It enhances the absorption of iron in the body when taken with Adderall.

Mood and Social Behavior Regulator

This essential vitamin plays a significant role in producing serotonin. Serotonin is a neurotransmitter that helps regulate mood and social behavior.

Comparison with Nootropic Supplements

Unlike nootropic supplements like Vyvamind or citicoline, Vitamin C does not directly boost cognitive function. However, it contributes significantly to overall brain health.

Timing Intake for Optimal Benefits

High doses of Vitamin C may decrease Adderall’s effectiveness due to its acid content. Therefore, timing your intake is crucial for optimal benefits.

Here are some tips:

  1. Try taking Adderall on an empty stomach.
  2. Wait at least one hour before consuming foods or supplements high in Vitamin C.

Remember, every individual’s body reacts differently to supplements and medications. What works best for one person may not work as effectively for another.

6. L-Tyrosine

L-Tyrosine, a beneficial amino acid, replenishes tyrosine reserves that Adderall depletes. It might also boost dopamine levels, counteracting Adderall’s effects on this neurotransmitter.

What is L-Tyrosine?

L-Tyrosine is an amino acid that your body naturally produces. It plays a significant role in producing neurotransmitters, chemicals that transmit signals in your brain.

Tyrosine Reserves and Adderall

Adderall, a medication often prescribed for attention deficit hyperactivity disorder (ADHD), can deplete the body’s tyrosine reserves. This depletion may result in decreased mental alertness and increased fatigue.

Dopamine Boost

Dopamine is one of the neurotransmitters produced by L-Tyrosine. By boosting dopamine levels, this supplement could potentially offset some of the effects of Adderall on this important neurotransmitter.

The Role of Vitamins B6 and Zinc

Vitamins B6 and zinc play crucial roles in aiding the effectiveness of L-Tyrosine. These supplements enhance its function by supporting the conversion process from L-tyrosine to dopamine.

  • Vitamin B6: This vitamin acts as a coenzyme in converting L-tyrosine into dopamine.
  • Zinc: This mineral enhances the activity of dopamine neurons.

Combining Supplements: A Potential Solution

Combining L-Tyrosine with vitamins B6 and zinc could increase its effectiveness significantly. Here’s why:

  1. Increased Conversion Rate: The combination might enhance the conversion rate from L-tyrosine to dopamine.
  2. Enhanced Effectiveness: The synergy between these supplements might lead to improved cognitive function.
  3. Counteract Depletion: This combination could help offset tyrosine depletion caused by Adderall use.

7. L-Theanine

L-Theanine, a natural nootropic supplement, can balance the stimulating effects of Adderall. This smart drug enhances serotonin production, promoting calming effects and reducing anxiety.

Balancing Adderall’s Effects with L-Theanine

Adderall is known for its stimulating effects. These are beneficial in many ways but can sometimes lead to unwanted side effects such as restlessness or insomnia. Enter L-Theanine, a nootropic supplement that has been shown to counterbalance these stimulating effects.

  • It does this by enhancing the production of chemical serotonin in the brain.
  • Serotonin is a neurotransmitter associated with feelings of well-being and happiness.
  • By boosting serotonin levels, L-Theanine promotes calming effects and reduces anxiety.

Combining L-Theanine with Other Supplements

While L-Theanine on its own is effective, combining it with other supplements can boost its effectiveness even further.

  1. One such supplement is ashwagandha, an ancient medicinal herb known for its stress-reducing properties.
  2. Another one is zinc, an essential mineral that plays a crucial role in neurotransmission and nerve signaling.
  3. Lastly, curcumin – the main active ingredient in turmeric – has potent anti-inflammatory and antioxidant benefits which can support overall brain health when taken alongside L-Theanine.

Safer Long-Term Use Compared to Serotonergic Drugs

One key advantage of dietary supplements like L-theanine over serotonergic drugs lies in their safety profile.

  • Unlike serotonergic drugs which often come with a host of side effects (including but not limited to nausea, dry mouth, drowsiness), dietary supplements like L-theanine have fewer side effects.
  • This makes them safer for long-term use especially considering the chronic nature of conditions that necessitate the use of Adderall such as ADHD or narcolepsy.

8. Zinc

Zinc, a vital mineral, can help balance Adderall’s effects. It enhances the benefits and reduces potential side effects.

The Role of Zinc

Zinc is an essential nutrient that plays a crucial role in our bodies. It aids in cell growth, DNA synthesis, immune function, and metabolism. Zinc can be a game-changer.

It helps mitigate some of the common side effects associated with Adderall such as loss of appetite and sleep disturbances. It may enhance the drug’s positive effects like improved focus and decreased impulsivity.

Combining Zinc with Other Minerals

Combining zinc with other minerals like magnesium and iron can lead to better overall nutrient absorption. This combination optimizes the effectiveness of Adderall.

  • Magnesium: This mineral has been shown to reduce tolerance to Adderall. It also helps manage some side effects like anxiety and insomnia.
  • Iron: Iron deficiency can exacerbate symptoms of ADHD (which is often why people take Adderall). Proper iron supplementation alongside zinc can therefore improve outcomes for those using this medication.

9. Coenzyme Q10 (CoQ10)

Coenzyme Q10, often abbreviated as CoQ10, is a dietary supplement that can enhance the effects of Adderall. It supports energy production and cognitive function while also providing protection against potential oxidative damage.

The Energy Booster

CoQ10 plays a critical role in our body’s energy production process. This attribute makes it an ideal supplement for those using Adderall, which often leads to fatigue. Regular intake of CoQ10 helps counteract this tiredness by boosting your body’s energy levels.

  • Aids in mitochondrial ATP synthesis
  • Helps maintain optimal physical performance

Brain Health Support

Beyond its role in energy production, CoQ10 is also essential for brain health and cognitive function. Its antioxidant properties help protect the brain from oxidative stress, enhancing mental clarity and focus.

  • Supports neuronal health
  • Enhances cognitive performance

Antioxidant Effects

As a potent antioxidant, CoQ10 works synergistically with other supplements such as zinc, magnesium, and vitamin B6 to protect against potential oxidative damage from Adderall use. This combined effect ensures your body remains healthy even while on medication.

  • Protects cells from oxidative damage
  • Works well with other antioxidants like vitamin B6 and zinc

Synergy With Other Supplements

The beauty of CoQ10 lies in its ability to work synergistically with other supplements to maximize their benefits. When taken alongside zinc, magnesium or vitamins B6 – all known for their beneficial impact on the human body – the effectiveness of these supplements can be significantly enhanced.

10. Ashwagandha

Ashwagandha is a natural nootropic supplement that might be beneficial for those taking Adderall. It can potentially reduce anxiety and symptoms of hyperactivity disorder.

Natural Nootropic

Natural nootropics, like Ashwagandha, have been used in traditional medicine for centuries. They offer a range of health benefits, including improved cognitive function and reduced stress levels.

  • For instance, Ashwagandha has shown promising results in reducing anxiety and managing ADHD symptoms.
  • This makes it an excellent supplement to consider alongside Adderall.

Calming Effects of Ashwagandha

The calming effects of this supplement are well-documented.

  • Research shows that it can help manage stress by lowering cortisol levels.
  • This makes it particularly useful for individuals dealing with the side effects of Adderall usage.

Pairing with Other Supplements

Combining Ashwagandha with other supplements may enhance its effectiveness.

  1. Curcumin, derived from turmeric, is known for its anti-inflammatory properties.
  2. Melatonin is often used to regulate sleep cycles disrupted by stimulant medications like Adderall.
  3. When paired with these supplements, Ashwagandha’s calming effects may be amplified.

Managing Adderall-Induced Stress and Sleep Disorders

Adderall can cause various side effects, including increased stress levels and sleep disorders.

  • As a natural adaptogen, Ashwagandha helps the body cope better under stress.
  • Its potential ability to regulate serotonin levels could help alleviate sleep issues associated with Adderall use.

Supplement Comparison

SupplementPotential BenefitHow it May Help with Adderall UseRecommended DosagePrecautions
VyvamindCognitive enhancement, increased focus and energyMay provide a balanced stimulation to complement Adderall’s effects1 capsule dailyMay interact with stimulant medications; consult a healthcare provider before use
B Vitamins (B6, B12, Folate)Energy metabolism, brain functionSupports overall brain health, possibly countering long-term stimulant use effectsVaries per specific B vitamin; follow recommended daily allowanceExcessive intake can cause nerve damage (B6) and unmask B12 deficiency
Omega-3 Fatty AcidsSupports brain health and anti-inflammatory benefitsMay aid in improving mood and cognitive function possibly reduced by long-term stimulant use1,000-2,000 mg dailyFish oil supplements can interact with certain medications and conditions; check with healthcare provider if on blood thinners
MagnesiumNervous system support, muscle relaxationMay reduce tolerance and muscle tension associated with Adderall use200-400 mg dailyHigh doses may cause diarrhea; consult with a doctor if using magnesium oxide as it can interfere with Adderall absorption
Vitamin CImmune support, antioxidant propertiesCan acidify the urine which may help clear Adderall from the system more quickly, reducing its effects at night for better sleep. Take it after the last dose of Adderall.500-1000 mg post-Adderall useHigh doses can cause stomach upset and diarrhea; can increase acidity of urine which may affect medication excretion rates
L-TyrosineNeurotransmitter synthesisMay replenish dopamine levels potentially depleted by Adderall use500-2000 mg taken before or between Adderall dosesMay increase blood pressure; avoid taking it late in the day as it can affect sleep
L-TheaninePromotes relaxation without sedationMay help to mitigate anxiety or jitteriness caused by stimulants like Adderall100-200 mg up to twice dailyGenerally well-tolerated but could potentially lower blood pressure too much in combination with Adderall
ZincImmune function, enzyme reactionsCan enhance the effectiveness of ADHD medications like Adderall for some individuals15-30 mg dailyTaking zinc in high doses can lead to copper deficiency and other side effects; always adhere to recommended dosages
Coenzyme Q10 (CoQ10)Antioxidant, supports cellular energyMay protect against oxidative stress caused by stimulants100-200 mg dailyGenerally well-tolerated; consult a doctor if on blood-thinning medications
AshwagandhaStress relief, hormonal balanceMay counteract stress and anxiety side effects of Adderall300-500 mg dailyMay lower blood pressure; consult a healthcare provider if pregnant or breastfeeding

Minerals and Vitamins Avoid During Adderall Treatment

Not all vitamins and minerals play nice with Adderall. Here are a few you might want to avoid:

  • Calcium: This mineral can make it harder for your body to absorb Adderall. If you need to take calcium, try to do it a few hours apart from your medication.
  • Vitamin B12: This vitamin can increase the stimulant effects of Adderall. If you’re feeling jittery or having trouble sleeping, you might want to cut back on B12.

Here’s how these two stack up:

Mineral/VitaminEffectsWhen to Avoid
CalciumInterferes with Adderall absorptionWhen taking Adderall
Vitamin B12May increase stimulationIf experiencing side effects

Remember, everyone’s body is different. What works for one person might not work for another. It’s all about finding what works best for you.

Addressing Potential Nutrient Deficiencies from Stimulant Use

Stimulants, like Adderall, have been known to lead to nutrient deficiencies. This is because they can suppress appetite and disrupt normal eating patterns.

For instance, a study published in the Journal of Attention Disorders found that children with ADHD who take stimulants tend to consume fewer calories and less zinc, iron, and magnesium than those who do not take these medications. This suggests that individuals using Adderall might need additional nutrients to maintain balance.

Supplements for Adderall Recovery

Dietary supplements can play a significant role in Adderall recovery. They work by replenishing essential nutrients depleted due to stimulant use.

Nootropic supplements are particularly beneficial as they can enhance brain function. For example, Ashwagandha is a natural nootropic known for its ability to reduce anxiety and improve focus – two areas often affected by attention deficit hyperactivity disorder (ADHD) and stimulant use.

Vitamins B6 also plays a crucial role in neurotransmitter production, which can be helpful for those recovering from stimulant use. A 2014 study published in the Journal of Clinical Biochemistry and Nutrition found that vitamin B6 supplementation improved ADHD symptoms in affected children.

However, it’s important to remember that while dietary supplements can support recovery from Adderall use, they should not replace traditional treatment methods or be used without medical supervision.

Drug Interactions with Supplements

Understanding potential drug interactions is crucial when incorporating vitamins and supplements into an Adderall treatment plan. Some substances may interact negatively with the medication or diminish its effectiveness.

For instance, Vitamin C can increase the acidity of urine which may speed up the excretion of Adderall from your body thus reducing its effectiveness.

On the other hand, some nootropic supplements such as L-Tyrosine may enhance the effects of Adderall.

Pros and Cons of Taking Supplements With ADHD Drugs

While it’s true that certain supplements may enhance the effectiveness of ADHD drugs like Adderall, it’s crucial to understand that they are not a magic solution and should always be taken under the guidance of a healthcare professional.

Interaction Between Adderall and Dietary Supplements

ADHD medications like Adderall can interact with dietary supplements. This interaction could heighten side effects or diminish the medication’s efficacy. For example, certain supplements may increase heart rate, a common side effect of stimulant medications.

  • Increased Heart Rate: Stimulants like caffeine found in some supplements might amplify this effect.
  • Reduced Efficacy: Some minerals such as calcium or magnesium present in dietary supplements can interfere with the absorption of ADHD medications.

Nootropic Supplements Enhance Cognitive Benefits

Nootropic supplements may boost the cognitive benefits of Adderall treatment. They could improve focus and memory in individuals with attention deficit hyperactivity disorder (ADHD).

  • Improved Focus: Nootropics such as L-Theanine can enhance concentration levels, complementing the effects of Adderall.
  • Enhanced Memory: Certain nootropics, including Bacopa Monnieri, have shown potential to improve memory function.

Natural Nootropics Support during Adderall Recovery

The use of natural nootropics can help manage withdrawal symptoms during Adderall recovery. They also support brain health by mitigating neurotoxicity associated with long-term stimulant use.

  • Withdrawal Symptoms Management: Rhodiola Rosea is a natural adaptogen that may alleviate fatigue and depression related to Adderall withdrawal.
  • Support Brain Health: Lion’s Mane mushroom has neuroprotective properties that could support brain health during recovery from stimulant use.

Negative Side Effects from Supplement Use

While there are potential benefits, taking supplements with ADHD drugs might also introduce negative side effects. It’s crucial to consult a medical professional before starting any supplemental regimen.

  • Potential Adverse Reactions: Combining serotonergic drugs like St John’s Wort with ADHD medications could increase the risk of serotonin syndrome.
  • Increased Anxiety: Adding certain supplements, such as caffeine or guarana, can exacerbate feelings of anxiety and restlessness when taken with ADHD medications.

Conclusion: Managing Side Effects and Optimizing ADHD Treatment with Supplements

Navigating the world of ADHD treatment can be complex. It’s important to understand that while Adderall is a powerful tool, it doesn’t work in isolation. By incorporating supplements like Vyvamind, B Vitamins, Omega-3 Fatty Acids, and others mentioned above into your routine, you may mitigate some side effects and bolster the drug’s effectiveness. However, always consult with a healthcare professional before starting any new supplement regimen.

We’ve discussed various supplements that might complement an Adderall treatment plan, potential nutrient deficiencies stemming from stimulant use, and pros and cons of combining supplements with ADHD drugs. This information aims to empower you in making informed decisions about your health.

Now it’s time for action! Start by identifying which supplements resonate with your needs and discuss them with your doctor today. Remember, optimizing your ADHD treatment is a journey worth taking for improved quality of life.


What supplements can I take with Adderall?

There are several supplements that can be taken with Adderall to help manage its side effects and enhance its benefits. These include Magnesium, Vitamin C, Zinc, L-Tyrosine, and Fish Oil.

Can these supplements reduce the side effects of Adderall?

Yes, some supplements like Magnesium may help mitigate some of the common side effects of Adderall such as insomnia and anxiety. Vitamin C can aid in reducing appetite suppression caused by Adderall. But remember, results can vary from person to person.

How do these supplements enhance the effectiveness of Adderall?

Supplements like L-Tyrosine may improve the effectiveness of Adderall by replenishing the brain’s dopamine levels which is often depleted by regular use of this medication. Zinc has been shown to increase the potency of Adderall, potentially allowing for lower doses.

When should I take these supplements in relation to my dosage of Adderall?

The timing depends on the specific supplement. For instance, Vitamin C should be taken after your last dose of the day as it can speed up excretion and decrease effectiveness if taken too close together.

Are there any risks associated with taking these supplements along with my medication?

While generally safe for most people when used appropriately, all supplements carry potential risks such as allergic reactions or interactions with medications. It is critical to discuss any new supplement regimen with a healthcare provider first.