9-Me-BC Review: Nootropic Benefits, Dosage, & Side Effects

Updated on January 3, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

In this 9-Me-BC review, we'll take an in-depth look at this popular nootropic. We'll also go over how 9-Me-BC works in the brain, provide information about the benefits, side effects, and where you can buy it online.

9-Me-BC, also known as 9-Methyl-β-carboline, is a member of the β-carboline family. It's an intriguing heterocyclic amine that has caught researchers' attention.

Its unique chemical structure makes it a promising candidate for use in cognitive enhancement. Today, we'll examine how it works and if it's really worth using as a nootropic supplement.

So without further ado, let's get to it.

9-Me-BC Review Summary

9-Me-BC is a unique, methylated version of β-carboline that has been studied for its neuroprotective and regenerative effects in dopaminergic neurons. It may be beneficial in treating neurological conditions such as Parkinson's and Alzheimer's due to its ability to reduce inflammation and promote the regeneration of neurons.

9-me-BC improves cognitive function by increasing dopamine levels in the brain, which leads to improved focus, memory, mood, and overall brain health. For optimal cognitive enhancement, it should be ingested orally with or without food at a 10 - 30 mg daily dosage range; cycling off after extended use is recommended if side effects occur.

Pros

  • It helps to protect and regenerate dopaminergic neurons
  • Restores normal dopamine levels
  • Aids in preventing neurological conditions
  • Improves focus, memory, and mood

Cons

  • The clinical research is still in its early stages
  • Hard to find high-quality 9-Me-BC online

What Is 9-Me-BC?

9-Me-BC is a unique, methylated version of β-carboline (BC) with an exciting molecular formula consisting of 12 carbon atoms and 10 hydrogen molecules (C12H10N2).

what is 9 me bc

β-Carboline, or norharmane, can be synthesized through the Eschweiler–Clarke reaction process: an organic chemical procedure. 9-Me-BC is synthesized from this process, as it can take the form of both its methylated and nonmethylated forms.

Recent studies have revealed that 9-Me-BC can stimulate, protect and regenerate neuro pathways, as well as reduce inflammation. Even more impressive is its capability to increase dopaminergic neuron growth without requiring dopamine uptake into those neurons [1].

Imagebuying 9-me-bc
Name9-Me-BC
ClassNootropic
EffectsIncreases euphoria, acts as a cognitive enhancer, memory retention
Potential Side EffectsPossible DNA damage if exposed to a lot of sunlight
Half-Life15 - 24 hours
Common Dosage15 - 30 mg daily
Content500 mg
Price$49.99
Money Back GuaranteeCase-by-case
Rating⭐⭐⭐⭐☆ 4.4/5
Best VendorClick Here ›

9-Me-BC is also known as:

  • 9-Methylnorharman
  • 9-MBC
  • N-Methyl-β-carboline

9-Me-BC has also caused a wave of excitement among scientists due to its potential as an inhibitor of monoamine oxidase A and B, which may result in possible remedies for those with Parkinson's disease (PD).

How Does 9-Me-BC Work In The Brain?

9-Me-BC is a compound that has been studied for its neuroprotective and regenerative effects in dopaminergic neurons.

It does this by upregulating the expression of essential proteins like tyrosine hydroxylase and transcription factors associated with differentiation and promoting neurite outgrowth [2].

Additionally, it reduces the inflammatory cytokines released by damaged neurons and inhibits the oxidation of neurotoxin precursor MPTP into its more harmful form, MPP+ (1-methyl-4-phenylpyridinium).

By acting on several different pathways simultaneously, 9-Me-BC helps to protect cells from damage and can stimulate new growth. This could benefit various neurological disorders associated with neuron damage or dysfunction.

9 me bc featured image

It is still unclear exactly how 9-Me-BC works at the molecular level, but given its ability to increase neuron survival and promote regeneration, it can be useful in treating diseases such as Parkinson's, where neuronal degeneration is a major factor [3].

Additionally, the anti-inflammatory properties of 9-Me-BC may prove beneficial in other inflammatory conditions associated with cognitive decline.

What Is 9-Me-BC Used For?

9-Me-BC is used for its potential brain-boosting effects and dopamine-restoring effects. It may also be beneficial in treating neurological conditions such as Parkinson's and Alzheimer's due to its ability to reduce inflammation and promote the regeneration of neurons.

9 me bc benefits effects

9-Me-BC improves cognitive function by increasing dopamine levels in the brain, which leads to improved focus, memory, mood and overall brain health.

It may also be useful for treating depression, as it can reduce levels of monoamine oxidase, an enzyme that breaks down the neurotransmitter serotonin. By reducing the activity of this enzyme, serotonin levels in the brain increase, and symptoms of depression may decrease [4].

In an extensive study, 9-Me-BC demonstrated incredible efficacy in primary mesencephalic dopaminergic neuron cell cultures. It promoted the differentiation of dopaminergic neurons and activated higher levels of transcription factors associated with their development [5].

Additionally, it inhibited oxidation in MPTP to prevent its conversion into the harmful neurotoxin MPP+. Thus, 9-Me-BC helps protect the brain from neurotoxin damage and promotes neuronal regeneration.

What Are The Benefits Of 9-Me-BC For Cognition?

9-me-BC has multiple benefits for cognitive performance, and its impact is linked to its ability to induce neuroprotection, neurorestorative, anti-inflammation, and an enhancement of hippocampal dopamine levels [6].

Gruss, Michael et al. assert that this nootropic compound not only influences neural pathways but also actively encourages the proliferation of dendrites and synapses in the hippocampus.

This indicates that 9-me-BC goes beyond affecting neural pathways, as it modulates neuron morphology by enabling changes in their structure.

Moreover, these effects can be beneficial for maintaining neuronal networks implicated in memory and learning processes. The observed stimulation of hippocampal dopamine is especially important as it is a major neurotransmitter involved in cognition, reward, and motivation.

Thus, 9-me-BC appears to act upon multiple mechanisms to modulate cognitive function, which provides promising evidence for its application as a cognitive enhancer.

Where To Buy 9-me-BC Online?

We recommend purchasing 9-me-BC from a trusted vendor such as Chemyo. Chemyo offers 9-me-BC in 500 mg powder form for $49.99 (USD).

They also provide third-party lab tests for all their products, ensuring quality and purity. Additionally, they provide a 100% satisfaction guarantee or your money back.

Plus, enjoy the convenience of free shipping when you spend over US $100 domestically or international orders above $275.

You can order 9-me-BC online here:

What Do People Say About 9-me-BC On Reddit?

Let's take a look at what Reddit users have to say about 9-me-BC.

AnyVisual states:

"I've been using 9-me-BC for several weeks now and I'm definitely noticing an increase in energy and focus. I'm also sleeping better, which has been fantastic."

BubbleBuddy32 goes on to say:

"It has provided me with a significant boost in motivation. I am a lot more interested in my work and life in general…However, I have not been able to experience an increase in cognition, which is described in the literature. I might be able to remember stuff slightly easier, but it is just really hard to quantify."

Htred4 adds:

"Definitely feel more focus and concentration. It feels like my brain is performing at near-peak performance. There's not a high or euphoria (maybe 40%), but there's a definite impact on cognition and mental sharpness. Excellent stuff, and I like it much more than amphetamines. No highs, no lows. Just clear results on myself."

How Do You Take 9-me-BC For Cognitive Enhancement?

For optimal cognitive enhancement, 9-me-BC should be ingested orally in its powdered form with or without food. We recommend you begin with a minimal dosage and then slowly increase it until you reach your desired result.

Most people prefer taking 9-me-BC on an empty stomach first thing in the morning for faster absorption. It's also a good idea to have a choline source (such as Alpha GPC) to help increase the efficacy of the nootropic.

You can also cycle 9-me-BC. Some people prefer taking it for a few weeks, then taking a break for the same amount of time before resuming use.

Others take it every day or once every few days. Everyone reacts differently to 9-me-BC, so you'll need to experiment and decide what works best for you.

The recommended 9-Me-BC dosage for cognitive enhancement is 10 to 30 mg daily, taken in one or two separate doses.

It's important to note that 9-Me-BC has a relatively long half-life (15 - 24 hours), which means it can take up to a full day for its effects to be fully felt.

This is also why some people take it for an extended period to let the nootropic effects compound over time.

What Are The Side Effects Of 9-Me-BC?

According to the available scientific literature, the most common side effects of 9-Me-BC are headaches, nausea, and stomach discomfort. That said, anecdotal reports from Reddit suggest that 9-Me-BC can cause anhedonia at high doses.

Anhedonia is a condition where you experience a reduced ability to feel pleasure from activities or events that would normally be enjoyable. So if you're taking 9-Me-BC, it's important to stick to the recommended dosage and cycle off when necessary.

There are also a couple of Reddit users who experienced sensitivity to the sun. DNA damage after UVA rays exposure is possible due to photosensitivity. To avoid this, it is advised to keep away from direct sun when under the influence of carboline 9.

It's also worth noting that 9-Me-BC has the potential to sensitize individuals' skin when exposed to UVA rays from direct sunlight, resulting in DNA damage [7].

To prevent this reaction and maintain healthy cells, it is best for those who have taken 9-Me-BC to stay out of direct UV light exposure.

What Nootropics Are Similar To 9-Me-BC?

Nootropics that are similar to 9-Me-BC include Bromantane (Ladasten) and Centrophenoxine (Meclofenoxate):

  • Bromantane stands out among psychostimulants and anxiolytics, given that it is part of the adamantane family related to amantadine and memantine. In Russia, this drug has been found to be effective in managing neurasthenia and anxiety disorders [8].
  • Centrophenoxine is a powerful choline-derivative that combines dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA) to form an ester. It boosts acetylcholine levels (ACh) by releasing more of this neurotransmitter and is used to improve memory, focus, and clarity. It also has neuroprotective benefits that help protect the brain from damage [9].

Like 9-Me-BC, Centrophenoxine is an MAO inhibitor. It can help treat depression and similar mental health issues [10].

The biggest difference between Bromanatane, Centrophenoxine, and 9-Me-BC is their available literature and research. As 9-Me-BC is a relatively new addition to the nootropic scene, the available research is limited and not as robust as those for Bromantane and Centrophenoxine.

What Brain Supplements Can 9-Me-BC Be Stacked With?

The best nootropics to stack with 9-Me-BC are Piracetam, Alpha GPC, and Sulbutiamine.

Piracetam (2-oxo-1-pyrrolidine-acetamide) is the most well-known of all nootropic drugs, which are cyclic derivatives derived from gamma-aminobutyric acid (GABA). Through its use, individuals can experience vast improvements in their learning capacity and memory retention and an increase in overall brain metabolism. When stacked with 9-Me-BC, this combination can enhance focus, attention, and memory recall and relieve stress and anxiety.

Alpha GPC (L-alpha glycerylphosphorylcholine) is a natural choline source that helps increase levels of acetylcholine (ACh), an important neurotransmitter involved in learning memory formation and recall. When stacked with 9-Me-BC, Alpha GPC can help boost cognitive abilities and overall brain performance.

Sulbutiamine (Arcalion/Enerion) is a synthetic form of thiamine that increases dopamine and glutamate transmission in the brain. It has been found to be effective in treating chronic fatigue syndrome, depression, anxiety, and other neuropsychiatric disorders. When stacked with 9-Me-BC, Sulbutiamine can help improve memory formation and recall and increase focus and concentration.

If you don't want to buy each nootropic separately or are unsure where to start, we highly recommend staking 9-Me-BC with a nootropic blend like NooCube, using that as your foundation. NooCube contains 13 science-backed ingredients, including Alpha GPC, Huperzine A, and Bacopa Monnieri. These ingredients work together to support cognitive function and overall brain health.

Stack this with 9-Me-BC to create a powerful combination that can help improve productivity and lower stress while providing neuroprotection. You can read more about NooCube here:

Frequently Asked Questions (FAQ)

Let's answer some commonly asked questions about 9-Me-BC.

Is 9-Me-BC Legal?

Yes, 9-Me-BC is legal in the United States and most other countries. It's considered a research chemical and is currently not regulated by the FDA.

Is 9-Me-BC Safe?

9-Me-BC is a novel nootropic, and limited research is available on its long-term safety profile. Caution is advised to consumers as there is still a lack of human trials to determine its safety and potency.

How Long Does It Take For 9-Me-BC To Work?

Numerous animal studies demonstrate that 9-me-BC can elevate dopamine levels in the hippocampus after 10 days. Most people, however, report feeling the effects of 9-Me-BC within 1-3 days.

How Does 9-Me-BC Make You Feel?

9-Me-BC makes you feel alert and focused. It may also help reduce stress, anxiety, and depression. Some users report feeling euphoric after taking 9-Me-BC.

What's The Half-Life Of 9-Me-BC?

The half-life of 9-Me-BC is approximately 15-24 hours. This means that it will take 24 hours for half of the drug to be eliminated from the bloodstream. This is important to note when deciding on dosage and timing.

Is 9-Me-BC Addictive?

9-Me-BC is not considered addictive and does not possess any of the typical characteristics of an addictive substance. However, it is important to note that some people may develop a tolerance to the drug if used over an extended period.

Conclusion

So what do we know about 9-Me-BC?

9-Me-BC is a novel nootropic that can increase dopamine levels in the brain. It has been linked to increased focus, attention, memory recall, and even enhanced mood. It is considered legal in most countries, but there is still a lack of research on its long-term safety profile, so caution should be taken when using this drug.

When stacked appropriately with other nootropics like Piracetam, Sulbutiamine, NooCube, and Alpha GPC, 9-Me-BC can be a powerful supplement to help improve cognitive abilities and overall brain performance. It has a relatively long half-life of 15-24 hours and is not considered addictive when used as directed.

Overall, 9-Me-BC may be useful for those looking to increase focus, concentration, and productivity. However, it is important to use caution when considering any new supplement and consult with a medical professional before beginning supplementation.

We hope this article has been informative in helping you understand the potential benefits, dosage, and side effects of 9-Me-BC. As always, stay safe and good luck on your nootropic journey!

References

References
1Keller, Sebastian et al. “9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes.” Journal of neural transmission (Vienna, Austria : 1996) vol. 127,7 (2020): 999-1012. doi:10.1007/s00702-020-02189-9
2Polanski, Witold, et al. “The Exceptional Properties of 9-Methyl-β-Carboline: Stimulation, Protection and Regeneration of Dopaminergic Neurons Coupled with Anti-Inflammatory Effects.” Journal of Neurochemistry, 2010, https://doi.org/10.1111/j.1471-4159.2010.06725.x.
3panelJulianeHamannaCatrinWernickebJochenLehmanncHeinzReichmannaHansRommelspacherb1GabrieleGillea1PersonEnvelope, Author links open overlay, et al. “9-Methyl-β-Carboline up-Regulates the Appearance of Differentiated Dopaminergic Neurones in Primary Mesencephalic Culture.” Neurochemistry International, Pergamon, 4 Sept. 2007, https://www.sciencedirect.com/science/article/abs/pii/S0197018607002483?via%3Dihub. 
4Culpepper, Larry. “Reducing the Burden of Difficult-to-Treat Major Depressive Disorder: Revisiting Monoamine Oxidase Inhibitor Therapy.” The primary care companion for CNS disorders vol. 15,5 (2013): PCC.13r01515. doi:10.4088/PCC.13r01515
5Herraiz, Tomás, and Hugo Guillén. “Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.” Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol. 49,8 (2011): 1773-81. doi:10.1016/j.fct.2011.04.026
6Gruss, Michael et al. “9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation.” Journal of neurochemistry vol. 121,6 (2012): 924-31. doi:10.1111/j.1471-4159.2012.07713.x
7Vignoni, Mariana et al. “Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines.” Organic & biomolecular chemistry vol. 11,32 (2013): 5300-9. doi:10.1039/c3ob40344k
8Oliynyk, Sergiy, and Seikwan Oh. “The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.” Biomolecules & therapeutics vol. 20,5 (2012): 446-56. doi:10.4062/biomolther.2012.20.5.446
9Georgiev, V et al. “Effect of centrophenoxine on acetylcholine release in perfused cerebral ventricles of cats under dynamic electrophysiological control.” Acta physiologica et pharmacologica Bulgarica vol. 5,3 (1979): 59-66.
10Stancheva, S L, and L G Alova. “Vliianie tsentrofenoksina, piratsetamai aniratsetama na monoaminoksidaznuiu aktivnost' v razlichnykh strukturakh mozga krys” [Effect of centrophenoxine, piracetam and aniracetam on the monoamine oxidase activity in different brain structures of rats]. Farmakologiia i toksikologiia vol. 51,3 (1988): 16-8. 
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