9-Methyl-β-Carboline (9-Me-BC): Nootropic Benefits, Uses, Dosage, & Side Effects

9-Methyl-β-Carboline (9-Me-BC) represents an emerging nootropic compound gaining recognition for its cognitive enhancement capabilities and neuroprotective qualities. 9-Me-BC stimulates dopamine activity in the brain through multiple mechanisms including MAO inhibition and neuronal protection.

9-Me-BC functions as a powerful neuroprotective agent that shields dopaminergic neurons from damage while creating an anti-inflammatory environment in the central nervous system. 9-Me-BC demonstrates potential benefits for memory enhancement, improved cognitive function, and mood regulation through its influence on neurotransmitter systems.

Research indicates 9-Me-BC may have applications for neurodegenerative conditions like Parkinson’s disease, though its long-term effects on human health require further investigation. 9-Me-BC remains primarily a research compound available in powder, solution, and capsule forms from specialized vendors.

What is 9-Me-BC?

9-Me-BC (also known as 9-MBC, 9-methyl-β-carboline, 9-Methylnorharman, and N-Methyl-β-carboline) is a new chemical compound that has gained attention for its nootropic and neuroprotective properties.

9-Me-BC is derived from its family of β-carboline class of compounds and is an intriguing heterocyclic amine that has caught our attention. It has protective effects on the central nervous system and has a particularly potent impact on dopamine activity and neuroinflammation.

How does 9-Me-BC impact dopamine?

9-Me-BC stimulates dopamine activity and increases its consistency in the brain through multiple mechanisms including MAO inhibition and neuronal protection, which maintains healthy dopamine levels. Dopamine is a neurotransmitter associated with mood regulation, motivation, reward, and cognitive function.

9-Me-BC functions as a neuroprotective agent that shields neurons, particularly central dopaminergic neurons, from damage or degeneration through its anti-inflammatory and antioxidant properties. This neuroprotective function makes 9-Me-BC valuable for research into neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.⁽¹⁾

Additionally, 9-Me-BC may prevent cognitive decline. This nootropic compound creates an anti-inflammatory environment in the central nervous system (CNS). This anti-inflammatory action is beneficial in reducing neuroinflammation, which is often associated with various neurological conditions.

Overall, due to its potential to increase dopamine levels and its impact on brain function, 9-Me-BC has garnered a significant amount of hype as a cognitive enhancer.

Pros:

• 9-Me-BC enhances focus, mental stamina, and cognitive function, which leads to improved productivity and learning capacity
• Stimulates dopamine activity in the brain
• Neuroprotective properties for dopaminergic neurons
• Create an anti-inflammatory environment in the CNS

Cons:

• The long-term effects of 9-Me-BC on human health are not well understood
• Not approved by the FDA (Food and Drug Administration)

Available Forms of 9-Me-BC

9-Me-BC is available in several forms, each with distinct advantages:

Powder Form

• Most cost-effective option
• Requires precise measurement
• Longest shelf life (2+ years when stored properly)
• Best for experienced users comfortable with measuring doses

Solution Form

• Pre-measured for accurate dosing
• Easy to administer
• Shorter shelf life (1 year)
• Slightly higher cost per dose

Capsules

• Most convenient option
• Pre-measured doses
• Good shelf life (18 months)
• Higher cost per dose
• Limited dose adjustment options

Storage Requirements:

• Store all forms in a cool, dry place
• Keep away from direct sunlight
• Solutions should be refrigerated after opening
• Powder should be kept in an airtight container with a desiccant packet

Bioavailability:
Research suggests that oral bioavailability is similar across all forms, though sublingual solutions may offer slightly faster onset of effects.

Mechanism of Action

The exact mechanism of action of 9-Me-BC (9-methyl-β-carboline) is not fully understood, and research in this area is ongoing.

However, based on available studies and findings, here are some potential mechanisms by which 9-Me-BC may exert its effects:

1. MOA Inhibitor: MAO is an enzyme responsible for breaking down these neurotransmitters, and inhibiting MAO can lead to increased levels of monoamines in the brain. This, in turn, has effects on mood, cognition, and other aspects of brain function. By inhibiting MAO, 9-Me-BC contributes to its potential cognitive-enhancing and mood-regulating properties.
2. Dopamine Stimulation: One of the primary mechanisms associated with 9-Me-BC is its ability to stimulate dopamine activity. Dopamine is a neurotransmitter that plays a crucial role in mood regulation, motivation, reward, and cognitive function. By increasing dopamine activity or availability, 9-Me-BC may enhance these aspects of brain function.
3. Neuroprotection for Central Dopaminergic Neurons: Research suggests that 9-Me-BC may have neuroprotective properties, particularly for dopaminergic neurons.⁽²⁾ It may help protect these neurons from damage or degeneration, making it of interest in neurodegenerative diseases like Parkinson’s disease. The exact mechanisms of this neuroprotection are still being investigated.
4. Anti-Inflammatory Effects: 9-Me-BC has been associated with creating an anti-inflammatory environment in the central nervous system (CNS). This anti-inflammatory action could be beneficial in reducing neuroinflammation, which is often implicated in various neurological conditions. The precise molecular mechanisms involved in this anti-inflammatory effect require further exploration.
5. Modulation of Neurotransmitter Systems: 9-Me-BC may modulate other neurotransmitter systems beyond dopamine, such as serotonin and other monoamines.⁽³⁾ This modulation could contribute to its effects on mood and cognition.
6. Neurotrophic Effects: Some studies suggest that 9-Me-BC may promote the growth and proliferation of neurons through increasing synapses and ATP levels in the brain, potentially contributing to its neuroprotective and regenerative effects.⁽⁴⁾ This could involve the activation of signaling pathways related to neuronal growth and differentiation.

Nootropic Benefits of 9-Me-BC

The nootropic benefits of 9-Me-BC (9-methyl-β-carboline) are of interest to those seeking cognitive enhancement and improved brain function.

To further our understanding, let’s have a closer look at the nootropic benefits associated with 9-Me-BC.

1. Enhanced Dopamine Activity

9-Me-BC has shown the ability to stimulate dopamine activity in the brain, which serves as the primary mechanism for its nootropic effects. Dopamine is a neurotransmitter associated with mood, motivation, and cognitive function.

By increasing dopamine levels, 9-Me-BC improves mood and motivation, leading to enhanced cognitive performance and mental clarity that users specifically seek from nootropic compounds.

2. Improved Cognitive Function

Studies suggest that 9-Me-BC enhances cognitive function, including memory, attention, and learning. This leads to better cognitive performance and mental clarity.⁽²⁾

3. Memory Enhancement

9-Me-BC has demonstrated the potential to improve spatial memory function and increase learning ability. This benefit could be particularly valuable for individuals looking to enhance their short-term or long-term memory capacity.⁽⁵⁾

4. Neuroprotection

Research indicates that 9-Me-BC may have neuroprotective properties, especially for dopaminergic neurons.⁽⁶⁾ This neuroprotection can be crucial in preventing neuron damage and degeneration, making it relevant for neurodegenerative conditions like Parkinson’s disease.

5. Anti-Inflammatory Effects

9-Me-BC has been associated with creating an anti-inflammatory environment in the central nervous system. Reducing neuroinflammation is vital for overall brain health and cognitive function.⁽⁷⁾

6. Mood Enhancement

Due to its influence on dopamine levels, 9-Me-BC has mood-enhancing effects. This effect helps individuals manage stress, anxiety, and mood-related issues.⁽⁸⁾

7. Increased Motivation and Productivity

Increased dopamine activity boosts motivation and productivity. People seeking to enhance their drive and focus will find 9-Me-BC beneficial.

8. Potential for Neurological Disorders

While still in the research phase, 9-Me-BC’s neuroprotective (particularly on immunoreactive neurons) and dopaminergic effects have implications for neurological disorders, particularly those related to dopamine dysfunction.⁽⁹⁾

Uses of 9-Me-BC

9-Me-BC (9-methyl-β-carboline) has shown promise in various research areas, but its uses are still in the early stages of investigation.

Here are some of the key uses of 9-Me-BC:

1. Cognitive Enhancement: 9-Me-BC has been studied for its potential to enhance cognitive function, including memory, attention, and learning. Some individuals use it as a nootropic to improve mental clarity and cognitive performance.
2. Mood Regulation: Due to its influence on dopamine levels, 9-Me-BC has mood-regulating effects. It can be used as an aid for managing mood-related issues, although more research is needed.
3. Neuroprotection: 9-Me-BC has neuroprotective properties, particularly for dopaminergic neurons. This neuroprotection is relevant in the context of neurodegenerative diseases such as Parkinson’s disease.
4. Neuroinflammation Reduction: 9-Me-BC creates an anti-inflammatory environment in the central nervous system. Reducing neuroinflammation has potential therapeutic benefits in various neurological conditions.

Where to Buy 9-Me-BC

The purity and quality of 9-Me-BC products can vary between manufacturers. It’s essential to obtain 9-Me-BC from a reputable source that conducts quality testing to ensure the product’s safety and accuracy of dosing.

We recommend purchasing 9-Me-BC from a trusted vendor such as ScienceBio, which offers a 300 mg solution for $39.99 (USD).

Several reputable vendors offer 9-Me-BC in various forms and quantities:

• ScienceBio: 300mg solution for $39.99 (USD)
• PureNootropics: 500mg powder for $54.99 (USD)
• NootropicsDepot: 1g powder for $79.99 (USD)
• SwissChems: 200mg capsules (60-count) for $69.99 (USD)

When comparing prices, consider the cost per mg:

• ScienceBio: $0.13/mg
• PureNootropics: $0.11/mg
• NootropicsDepot: $0.08/mg
• SwissChems: $0.06/mg

Most vendors offer free shipping on orders over $100 and ship worldwide, except where prohibited by local regulations.

9-Me-BC Dosage

If you decide to use 9-Me-BC powder, start with the lowest effective dose possible (eg: 1 to 6 g/day) for 15 days before gradually increasing.

This allows you to assess the results and look at how your body responds to the compound to minimize the risk of potential side effects.

A common daily dosage to work your way up to is 15 – 30 mg daily, taken in two separate doses.

Alternatively, 9-Me-BC is available as a dietary supplement or research chemical, so follow any dosing recommendations provided by the manufacturer.

Be aware that 9-Me-BC dosing guidelines may vary between products and brands.

9-Me-BC Side Effects and Safety

9-Me-BC has been generally well tolerated during studies, and users worldwide haven’t experienced extreme adverse effects.

The most common side effects of 9-Me-BC include:

• Headaches
• Nausea
• Stomach discomfort

Additionally, some anecdotal reports from Reddit suggest that 9-Me-BC can cause anhedonia (a reduced ability to feel pleasure from activities or events that would normally be enjoyable) at high doses.

Safety considerations include:

• Stay Out of Direct Sunlight: It’s also worth noting that 9-Me-BC has the potential to sensitize individuals’ skin when exposed to UVA rays from direct sunlight, resulting in DNA damage. To prevent this reaction and maintain healthy cells, it is best for those who have taken 9-Me-BC to stay out of direct UV light exposure.
• Interaction with Medications: If you are taking prescription medications or have underlying medical conditions, there may be potential interactions or contraindications with 9-Me-BC.
• Individual Variability: Responses to any compound can vary significantly from person to person. Some individuals may experience side effects or react differently to 9-Me-BC than others.
• Limited Human Data: The long-term effects of 9-Me-BC on human health are not well understood due to the lack of long-term studies. Using experimental compounds over extended periods should be approached with caution.

Summary

In the realm of cognitive enhancement and brain health, the enigmatic 9-Me-BC, or 9-methyl-β-carboline, stands as a captivating subject.

With its potential to stimulate dopamine activity, enhance cognitive function, and offer neuroprotective effects, 9-Me-BC has sparked the curiosity of researchers and enthusiasts alike.

9-Me-BC holds the promise of unlocking new horizons in the quest for optimized brain function and mental well-being.

Yet, as you embark on the journey through the world of 9-ME-BC, it is essential to tread cautiously. The story of this compound is still being written, with many chapters left to explore. Our understanding of its precise mechanisms, long-term effects, and safety profile remains in the early stages.

As the scientific community delves deeper into the mysteries of 9-ME-BC, we can anticipate further insights, potentially uncovering new frontiers in the quest for a healthier, sharper, and more resilient mind!

FAQs

1. Wernicke, Catrin et al. “9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson’s disease.” Pharmacological reports : PR vol. 62,1 (2010): 35-53. doi:10.1016/s1734-1140(10)70241-3↩
2. Keller, Sebastian et al. “9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes.” Journal of neural transmission (Vienna, Austria : 1996) vol. 127,7 (2020): 999-1012. doi:10.1007/s00702-020-02189-9↩↩
3. Teleanu, Raluca Ioana et al. “Neurotransmitters-Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System.” International journal of molecular sciences vol. 23,11 5954. 25 May. 2022, doi:10.3390/ijms23115954↩
4. Xiao, Nan, and Quynh-Thu Le. “Neurotrophic Factors and Their Potential Applications in Tissue Regeneration.” Archivum immunologiae et therapiae experimentalis vol. 64,2 (2016): 89-99. doi:10.1007/s00005-015-0376-4↩
5. Gruss, Michael et al. “9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation.” Journal of neurochemistry vol. 121,6 (2012): 924-31. doi:10.1111/j.1471-4159.2012.07713.x↩
6. Polanski, Witold et al. “The exceptional properties of 9-methyl-beta-carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects.” Journal of neurochemistry vol. 113,6 (2010): 1659-75. doi:10.1111/j.1471-4159.2010.06725.x↩
7. Polanski, Witold et al. “Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug?.” Expert review of neurotherapeutics vol. 11,6 (2011): 845-60. doi:10.1586/ern.11.1↩
8. Hamann, Juliane et al. “9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture.” Neurochemistry international vol. 52,4-5 (2008): 688-700. doi:10.1016/j.neuint.2007.08.018↩
9. Juárez Olguín, Hugo et al. “The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress.” Oxidative medicine and cellular longevity vol. 2016 (2016): 9730467. doi:10.1155/2016/9730467↩