7 Best Nootropics 2023 (Smart Drugs & Nootropic Supplements)

Q: Can I combine different nootropics?

Yes, many people create " nootropic stacks " to achieve specific cognitive goals. Be sure to research potential interactions and consult a qualified medical professional for personalized advice on stacking.

Updated on November 19, 2023

by Jacob Kovacs — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

What are the best nootropics?

This list covers the top nootropic supplements and smart drugs for your brain, how they work, and what their pros and cons are.

Nootropics are a new class of brain enhancers that can increase focus and productivity, enhance memory, and improve mood.

There are several good cognitive enhancers and smart drugs that have been proven to increase mental performance, cognitive function, and mental health and help you reach your brain optimization goals.

But how do you know which are the most effective nootropics on the market today?

We’ve compiled a list of the most powerful brain-boosting nootropics that will help you achieve excellent results.

Table of Contents show

Best Nootropic Supplements

NooCube — Top nootropic supplement overall
Vyvamind — Good nootropic stimulant for ADHD
Mind Lab Pro — Good nootropic stack for brain health
Nooceptin — Good for memory and recall
Feedamind — Good for focus and energy
Performance Lab Mind — Great nootropic for athletes
Qualia Mind — Good for learning and creativity

1. NooCube

NooCube is a highly effective nootropic supplement with a unique and potent blend of scientifically supported natural ingredients. It is specifically designed to enhance cognitive function, improve learning abilities, and help with memory formation and retention. NooCube is the perfect choice for anyone looking to improve memory recall and their overall cognitive performance, from students to professionals and even athletes.

What makes NooCube stand out from the rest is its formulation, which is both potent and safe. NooCube is caffeine-free, making it a great natural alternative to stimulants like Adderall. Overall, NooCube is a top-tier nootropic supplement that delivers on its promises, making it one of the top options available on the market.

What it's good for: NooCube is good for anyone who wishes to enhance their brain function and improve their mental performance. It works effectively to improve focus, memory, and problem-solving skills.

Who it's good for: NooCube is an excellent choice for anyone looking to enhance their cognitive function and brain performance. It is especially beneficial for those who struggle with concentration, memory, and multitasking and is suitable for students, athletes, professionals, and anyone who wants to achieve their optimum.

Pros

Improves communication between healthy brain cells
Improves memory and overall cognition
Protects your brain from oxidative damage
Repairs damaged neurons
Promotes new brain cell generation
Decreases stress levels, anxiety, and fatigue
Contains B vitamins important for the human brain

Cons

Might be too pricey if you're on a budget
Takes time to work

Active Ingredients

Bacopa Monnieri Extract 12:1 (20% Bacosides) — 250mg
L-Tyrosine — 250mg
Oat Straw Extract 10:1 (Avena Sativa Straw) — 150mg
Cat's Claw Extract 4:1 (Uncaria Tomentosa Bark) — 175mg
Huperzia Serrata (0.5% Huperzine-A) — 20mg
L-Theanine — 100mg
Lutemax 2020® — 20mg
Alpha GPC (Glycerylphosphorylcholine) — 50mg
Resveratrol 99% — 14.3mg
Pterostilbene — 140mcg
Vitamin B1 (Thiamine Hydrochloride) — 1.1mg
Vitamin B7 (Biotin) — 50mcg
Vitamin B12 (Cyanocobalamin) — 2.5mcg

2. Vyvamind

Vyvamind is an effective and fast-acting nootropic supplement that can help increase energy and motivation, and reduce brain fog and fatigue. Its unique blend of caffeine and l-theanine⁽¹⁾ offers a smoother energy boost compared to low-quality alternatives. It also contains citicoline, a potent nootropic that helps increase mental energy, improve mental processing speeds, and support brain health and functioning.⁽²⁾

What sets Vyvamind apart from other brain supplements is its ability to provide top-to-bottom brain support when you need it most. By taking just one capsule a day, you can experience the benefits of improved mental performance, focus, and overall improved cognitive function.

This makes it an excellent choice for anyone looking to improve their focus and concentration or combat brain fog and fatigue for faster and clearer thinking. It's also a safe and effective over-the-counter substitute for smart drugs and attention deficit hyperactivity disorder (ADHD) prescription drugs.

While there are some cons to Vyvamind, such as its slightly high price point and potential for causing jitters in some users, overall, it is a top choice for anyone looking for a powerful nootropic supplement. Overall, Vyvamind is undoubtedly one of the most effective nootropic supplements available on the market today.

What it's good for: As a complete nootropic supplement, Vyvamind provides top-to-bottom brain support to improve processing speeds and overall brain health. It's highly effective for increasing mental energy, boosting productivity, and enhancing cognitive abilities, which leads to optimal performance in work and daily life.

Who it's good for: Vyvamind is an ideal supplement for high-performing adults who work demanding jobs, study for exams, or train for a competition. It is also useful for individuals who feel mentally drained and need an extra push to stay productive.

Pros

Scientifically proven to increase mental energy levels
Keeps you alert throughout the day
Strengthens mental performance under stress
Boosts your motivation and focus similar to Adderall

Cons

Can cause headaches in high dosages
May not be suitable for people sensitive to caffeine

Active Ingredients

Caffeine Anhydrous — 75mg
L-Theanine — 150mg
Citicoline (CDP Choline) — 200mg
L-Tyrosine — 300mg
Vitamin B6 (Pyridoxine HCL) — 2.5mg
Vitamin B12 (Methylcobalamin) — 50mcg

3. Mind Lab Pro

Mind Lab Pro® claims to be the world's first Universal Nootropic™, which aims to deliver a host of cognitive benefits without targeting a specific area of the brain. It enhances focus and memory, alleviates mental tiredness, and prevents brain cell degeneration.

It's safe to say that Mind Lab Pro is one of the finest nootropics money can buy. This supplement contains 11 organic ingredients that target four brain pathways, resulting in improved cognitive and mental abilities throughout. Mind Lab Pro is great for fighting brain fog, improving memory, and experiencing general cognitive enhancement. It's recommended to take 2-4 capsules daily, with 2 in the morning for the best results.

While the price point may be high, the benefits are worth it for those looking to optimize their brain function. Overall, Mind Lab Pro is a highly recommended supplement for anyone looking to enhance their peak cognitive performance naturally.

What it's good for: Mind Lab Pro is unexcelled for improving greater cognitive function and brain health. The carefully selected ingredients in Mind Lab Pro work together to optimize the human brain, resulting in improved memory, focus, attention, and overall mental performance.

Who it's good for: Mind Lab Pro is designed to improve cognitive performance and brain function in all kinds of people, making it a superb choice for anyone looking to enhance their daily brainpower and protect their long-term healthy function. Whether you're a busy professional, a student, an athlete, a senior, or someone simply looking for a mental edge in life, Mind Lab Pro can help.

Pros

Enhances cognitive function and fights age-related cognitive decline
Helps produce alpha brain waves for better concentration
Long-term brain health benefits
Contains no stimulants

Cons

It may take some time to see results
May not be effective for everyone

Active Ingredients

Citicoline (CDP Choline) — 250mg
Bacopa Monnieri Extract (24% Bacosides) — 150mg
Lion's Mane Mushroom — 500mg
Sharp-PS® Green Phosphatidylserine (Sunflower Lecithin) — 100mg
N-Acetyl L-Tyrosine — 175mg
Suntheanine® L-Theanine — 100mg
Rhodiola Rosea (3% Rosavins, 1% Salidrosides) — 50mg
Maritime Pine Bark Extract (95% Proanthocyanidins) — 75mg
Vitamin B6 — 2.5mcg
Vitamin B9 — 100mcg
Vitamin B12 — 7.5mcg

4. Nooceptin

Nooceptin is an excellent nootropic supplement that has gained attention for its ability to improve cognitive health, short- and long-term memory, and enhance mental performance. The popular nootropic formula boasts a unique blend of combined natural ingredients, backed by solid scientific research, that can benefit cognition, memory retention, inflammation, heart health, immunity, and mental wellbeing.

Based on our thorough research and its well-studied ingredients, such as Lion's Mane mushroom⁽³⁾, Bacopa Monnieri,⁽⁴⁾ and Rhodiola Rosea,⁽⁵⁾ it's definitely one of the most powerful nootropics currently available on the market. Overall, Nooceptin is a highly effective all-in-one daily nootropic that is suitable for anyone looking to boost their peak mental performance.

What it's good for: Nooceptin is optimally suited to optimize brain health and enhancing cognitive function. The natural nootropic supplement aims to boost memory, improve mental focus, and learning, among other benefits.

Who it's good for: Nooceptin is especially beneficial for those who struggle with day-to-day motivation and learning, such as students or individuals with demanding jobs.

Pros

Effectiveness of ingredients scientifically proven by 20 studies
Reduces tension and anxiety while improving attention
Improves memory and recall in the long term
Helps with brain cell regeneration

Cons

Slow shipping because of the high demand
Expensive for people on a tight budget

Active Ingredients

Citicoline (CDP Choline) — 200mg
Rhodiola Rosea Extract (3% Rosavins, 1% Salidroside) — 150mg
Bacopa Monnieri Extract (40% Bacosides) — 150mg
L-Theanine — 200mg
Ginkgo Biloba Extract (24% Flavone Glycosides, 6% Terpene Lactones) — 100mg
Lion's Mane Mushroom Extract (30% Polysaccharides) — 400mg
Panax Ginseng Extract — 200mg

5. Feedamind

Feedamind is one of the best nootropic supplements on the market because of its unique blend of 16 natural ingredients that work in synergy to deliver powerful results, including boosting mental performance and energy. The inclusion of special ingredients like Chocamine® Plus and Dynamine™ gives Feedamind an edge over other natural nootropic supplements.⁽⁶⁾

Overall, Feedamind is still highly effective and safe, making it a go-to choice for those seeking to enhance their cognition and motivation.

What it's good for: Feedamind is most effective for boosting mental performance and energy, as well as improving mental function, focus, and memory function.

Who it's good for: Feedamind is perfect for individuals seeking to boost their focus, energy, mental capacities, and cognitive ability to function in both the short and long term.

Pros

Helps improve mental performance
Increases energy
Short- and long-term cognitive enhancement

Cons

Suboptimal amounts of some ingredients
Potential for mild side effects

Active Ingredients

Chocamine® Plus — 500mg
N-Acetyl-L-Tyrosine (NALT) — 250mg
Bacopa Monnieri Extract (40% Bacosides) — 125mg
Alpha GPC (L-Alpha-Glycerylphosphorylcholine) — 100mg
L-Theanine — 50mg
Dynamine™ (Methylliberine) — 50mg
Pterostilbene — 46.7mg
Cat's Claw Extract (Uncaria Tormentosa) — 20mg
Oat Straw Extract — 20mg
Resveratrol — 14.3mg
Lutein — 6mg
Marigold Flower Extract (Tagetes Erecta L.) — 6mg
Vitamin B1 (Thiamin) — 1.1mg
Vitamin B6 — 1.5mg
Vitamin B7 (Biotin) — 5mg
Vitamin B12 (Methylcobalamin) — 100mcg

6. Performance Lab Mind

Performance Lab Mind is one of the most effective nootropics on the market today. This supplement enhances cognitive performance through its stream-lined and targeted formula. It boosts energy levels, mental alertness, logical thinking, memory retention, and concentration, including no stimulants like caffeine or others. Performance Lab Mind is suitable for anyone looking to improve their brain function, energy, and general well-being.

What sets this supplement apart is that it focuses on enhancing dopamine, which is a crucial brain chemical for memory retention. Performance Lab Mind strengthens mitochondria and increases cerebral blood flow, making it an ideal dietary supplement for burnout resistance.

What it's good for: Performance Lab Mind is good for people who want to improve their memory retention, logical thinking, and concentration while reducing brain fog and enhancing clarity of thought.

Who it's good for: Performance Lab Mind is a fantastic supplement suitable for anyone who wants to enhance cognitive function, improve memory retention, and boost brain energy without relying on stimulants.

Pros

High-quality, clinically studied ingredients
Does not contain any stimulants
Suitable for vegetarians and vegans

Cons

Only available for purchase online
Can be more expensive than other options

Active Ingredients

Cognizin® Citicoline — 250mg
Sharp-PS® Green Phosphatidylserine — 100mg
Ajipure® L-Tyrosine — 250mg
Maritime Pine Bark Extract (Pinus Pinaster, 95% Proanthocyanidins) — 75mg

7. Qualia Mind

Qualia Mind is a powerful nootropic supplement that contains a complex blend of 28 nootropic compounds that target vital chemical messengers and other signaling systems in the brain. The premium supplement by Neurohacker Collective is designed to enhance brain function, promote focus, support energy, mood, creativity, and mental clarity.

However, some ingredients are well-dosed, while others are not. Qualia Mind also isn't very convenient, as it requires taking seven capsules in one serving. Overall, Qualia Mind is one of the most advanced and top-rated brain supplements for enhancing brain capacity and offering cognitive benefits. It may not be suitable for everyone because of its dosing and complexity.

What it's good for: With its powerful blend of nootropic ingredients, choline donors, amino acids, neuro-vitamins, minerals, adaptogenic extracts, and neuro-antioxidants, Qualia Mind supports long-term healthy brain function.

Who it's good for: Qualia Mind is perfect for individuals who are seeking a comprehensive cognitive boost. It is especially helpful for those who need to focus for prolonged periods of time, as it helps to eliminate brain fog and keeps the mind sharp.

Pros

Boosts brain power, focus, memory, and mental clarity
Supports neural pathways important for optimal brain function
Contains a staggering 28 clinically proven cognitive-enhancing ingredients
Amplifies drive, productivity, and creativity

Cons

Hefty price tag
Recommended dosages are high
Serving size of seven capsules
May take several weeks before users notice any significant improvements

Active Ingredients

Vitamin C — 100mg
Vitamin D3 (Cholecalciferol) — 25mcg
Thiamine (Thiamine HCI) — 50mg
Niacin (Niacinamide) — 50mg
Vitamin B6 (Pyridoxal 5'-Phosphate) — 20mg
Vitamin B12 (Methylcobalamin) — 1,000mcg
Pantothenic Acid (Calcium Pantothenate) — 50mg
Acetyl-L-Carnitine HCI (ALCAR) — 500mg
Artichoke Leaf Extract (4% Cynarin and related flavonoids) — 500mg
Bacopa Monnieri Leaf Extract — 300mg
Rhodiola Rosea Root Extract (3% Rosavins, 1% Salidrosides) — 300mg
DL-Phenylalanine — 300mg
Uridine-5'-Monophosphate Heptahydrate Disodium (UMP) — 250mg
N-Acetyl-L-Tyrosine (NALT) — 250mg
Taurine — 200mg
L-Theanine — 200mg
Alpha-Glycerylphosphorylcholine (Alpha GPC) — 200mg
Cognizin® (Citicoline) — 150mg
Organic Coffeeberry® (90mg Caffeine) Whole Coffee Fruit Extract — 129mg
Velvet Bean (Mucuna Pruriens) Seed Extract — 100mg
Phosphatidylserine (from Sunflower Lecithin) — 100mg
Theobromine — 100mg
DHA (Docosahexaenoic Acid from Algae) — 80mg
Celastrus Paniculatus Seed Extract — 60mg
Ginkgo Biloba Leaf Extract (24% Glycosides) — 50mg
Coleus Forskohlii Root Extract (20% Forskolin) — 20mg
Pyrroloquinoline Quinone Disodium (PQQ) — 10mg
Huperzia Serrata Leaf Extract (7% Huperzine A) — 5mg

How We Picked the Top Nootropics

To determine the top-quality nootropics on the market, we employed a thorough testing and review process encompassing effectiveness, ingredients, brand reputation, transparency, production method, user feedback, price, and value. This approach allowed us to present readers with a credible and comprehensive list of top-notch nootropics.

Numerous products did not make it on this list, including but not limited to:

Onnit Alpha Brain
Hunter Focus
Focus Factor
Thesis Nootropics
Elm & Rye
Brainzyme Focus Pro
L-655,708
Methylphenidate
Nicotine

Effectiveness

We explored clinical trials and user experiences, focusing on cognitive enhancement, mental clarity, and improved focus and performance.

Ingredients

We carefully examined each formula, placing emphasis on evidence-supported, natural, and high-quality ingredients that may improve your cognitive function.

Scientific Evidence

We consulted peer-reviewed studies and meta-analyses to confirm the effectiveness of key ingredients that boost cognitive performance.

Dosage

We evaluated the optimal dosages and ingredient ratios, making sure they correspond with established human research for maximum efficacy.

Safety

We ensured the safety of each ingredient, considering possible side effects and interactions, and verifying compliance with regulatory guidelines. We gave preference to FDA-approved ingredients.

Brand Reputation

We assessed brands' credibility and trustworthiness by examining customer reviews, expert endorsements, and company history.

Product Transparency

We valued comprehensive ingredient disclosure, including sources and concentrations, empowering consumers to make informed decisions.

Manufacturing Process

We investigated manufacturing standards, giving priority to products made in certified facilities adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, emphasizing testimonials that highlighted cognitive enhancement and mental performance improvements.

Price

We compared product prices, confirming they were competitive and proportional to the quality and effectiveness of the supplement.

Value

We evaluated overall value, weighing the balance of price, quality, and effectiveness of each brain pill to guarantee an optimal return on investment.

Best Nootropic Ingredients

Ingredient	Effects
Bacopa Monnieri	Enhances memory, learning, and cognitive function through neuroprotective and antioxidant properties.
CDP Choline	Boosts focus and mental clarity by increasing choline and uridine levels, supporting the synthesis of brain cell membranes.
Lion's Mane Mushroom	Promotes neurogenesis and neural plasticity and brain-derived neurotrophic factor (BDNF), improving memory and cognitive function.
L-Theanine	Induces relaxation without drowsiness, improving focus and attention span by modulating neurotransmitters, and can help improve sleep.
Rhodiola Rosea	Reduces stress and fatigue, increasing mental endurance and cognitive performance.
L-Tyrosine	Improves working memory and stress resilience by increasing the production of catecholamine neurotransmitters.
Caffeine	Enhances alertness, attention, and cognitive function by blocking adenosine receptors in the brain.
Ginkgo Biloba	Increases blood flow to the brain, improving memory and cognitive function through antioxidant and anti-inflammatory properties.
Noopept	Enhances cognitive function, memory, and learning by modulating neurotransmitter systems and neuroplasticity.
Piracetam	Improves learning and memory by increasing cell membrane fluidity and promoting neuronal communication.
Modafinil	Increases wakefulness, alertness, and cognitive function by modulating neurotransmitter systems, particularly dopamine and norepinephrine.
Vinpocetine	Improves cerebral blood flow and metabolism, enhancing memory and cognitive function through neuroprotective effects.
Panax Ginseng	Boosts cognitive performance, reduces mental fatigue, and improves mood through adaptogenic and antioxidant properties.
Ashwagandha	Reduces stress and anxiety, supporting cognitive function and memory through adaptogenic and neuroprotective effects.
Pramiracetam	Enhances memory and cognitive function by increasing high-affinity choline uptake and promoting efficient brain cell communication.
Oxiracetam	Improves memory, learning, and cognitive function by modulating neurotransmitter release and stimulating neuronal plasticity.
Picamilon	Reduces anxiety and stress while increasing GABA, cerebral blood flow, improving cognitive function and mental clarity.
Aniracetam	Enhances memory, learning, and creativity by modulating glutamate receptors and stimulating the release of acetylcholine.
Phenylpiracetam	Increases cognitive function, memory, and mental energy by modulating neurotransmitter levels and improving brain cell communication.
Sulbutiamine	Boosts energy, focus, and mood by increasing thiamine levels and enhancing the synthesis of neurotransmitters.
Unifiram	Enhances memory, learning, and cognitive function by modulating AMPA receptors and increasing synaptic plasticity.
Sunifiram	Improves memory and cognitive performance by modulating AMPA receptors and stimulating the release of acetylcholine.
9-Me-BC	Supports cognitive function and memory by promoting the growth and maintenance of dopaminergic neurons and protecting against neurotoxicity.
Omega-3 Fatty Acids	Promote brain health, cognitive function, and memory by reducing inflammation, promoting neuronal growth, and maintaining cell membrane fluidity.
Creatine	Enhances cognitive performance, particularly in tasks requiring short-term memory, low reaction times, and quick thinking, by increasing cellular energy production in the brain.
B Vitamins	Support cognitive function, brain health, and energy production by contributing to neurotransmitter synthesis, DNA repair, and cellular metabolism.

How Do Nootropics and Smart Drugs Work?

Nootropics are substances that can improve cognitive function, memory, and focus.⁽⁷⁾ They may also help to increase intelligence and creativity. Some people use them to boost their productivity, while others take them to enhance their mood or reduce stress levels. Many nootropic herbs are also used in Ayurvedic medicine.

There are many potential benefits to using nootropics, also known as “smart drugs.”⁽⁸⁾ They are thought to work by modulating neurotransmitter systems in the brain. This can lead to increased concentration and optimize brain function. Also, they may help protect the brain from damage caused by free radicals and other toxins.

While more research is needed to substantiate the claims about the efficacy of some nootropics, there is evidence to suggest that these substances can boost brain function.

Some benefits of using nootropics include:

Improved memory
Enhanced focus
Increased concentration
Improved brain function
Protection from brain damage
Reduced stress and anxiety
Enhanced mood
Increased intelligence
Creativity boost

Nootropics FAQs

What are nootropics?

Nootropics are natural or synthetic substances that enhance cognitive functions, such as memory, creativity, and motivation. They work through various mechanisms, including boosting neurotransmitters, protecting brain cells, and improving blood flow to the brain.

How do I choose the right nootropic for me?

Consider your specific goals, such as memory enhancement or reducing anxiety. Research various nootropics to identify potential benefits and side effects.

Are nootropics safe?

Most nootropics have low toxicity and are safe for the human body when used appropriately. However, it is crucial to follow recommended dosages and assess any potential risks or interactions with medications.

Can I combine different nootropics?

Yes, many people create "nootropic stacks" to achieve specific cognitive goals. Be sure to research potential interactions and consult a qualified medical professional for personalized advice on stacking.

How quickly will I see results from using nootropics?

The effects of nootropics may vary. Some may produce immediate results, while others take weeks or longer to show noticeable improvements. Consistency and proper dosage are key to experiencing benefits.

Are nootropic effects permanent?

The benefits of nootropics are not permanent, and users typically need to continue supplementation to maintain improvements in cognitive performance. However, some compounds promote long-term brain health.

Are there any long-term risks associated with nootropic use?

There are potential long-term risks associated with their use. Taking higher than recommended doses can be toxic to the brain and lead to headaches, brain fog, confusion, loss of focus and motivation, lethargy, mental fatigue, migraines, stomach cramps, diarrhea, and constipation. There is also some evidence that people who take prescription nootropics to improve brain function may have a higher risk of impulsive behavior.

Can nootropics help manage conditions like dementia and Alzheimer's disease?

Clinical studies have found that natural nootropics and brain-enhancing supplements may help manage cognitive decline and depression. They are also used for other conditions related to cognitive deficits, such as Alzheimer's disease or dementia.

Can I take nootropics if I have a medical condition?

Consult your healthcare provider before taking nootropics if you have a pre-existing medical condition or take medications. They can potentially interfere with medications or worsen specific health conditions.

Can nootropics improve brain function?

Yes, they can help improve brain function by enhancing cognitive abilities such as memory, focus, and creativity.

Are natural nootropics better than synthetic ones?

It depends on the individual's needs and preferences. Natural nootropics may have lesser side effects, but synthetic ones may be more potent.

Can nootropics support healthy brain cells?

Yes, certain nootropics can help support healthy brain cells by reducing oxidative stress and inflammation in the brain.

Are nootropics drugs or supplements?

Nootropics can be both drugs or supplements, depending on their categorization and intended use.

Summary

There are many good nootropic supplements on the market to choose from. However, not all these natural supplements are created equal. Some brain health supplements may be more potent than others, and some may have more side effects.

We found that the most effective and top-rated blends on the market are NooCube, Vyvamind, and Mind Lab Pro. These supplements contain a blend of high-quality nootropic ingredients that are research-backed and have been clinically proven to boost cognitive function and reduce mild cognitive impairment. These best nootropics are well-tolerated and have minimal side effects.