If you're familiar with nootropics, then you've probably heard of N-phenylacetyl-L-prolylglycine ethyl ester or its brand name, Noopept.
Despite being one of the more reasonably priced supplements in the market, Noopept offers superb cognitive-enhancing results with minimal side effects.
This explains why it's popular among the young looking for a quick and effective brain boost and among the elderly who are seeking to reverse cognitive decline.
Now, what is Noopept, how do you use Noopept, and what should you expect after taking Noopept?
What Is Noopept?
Noopept is the brand name of supplement manufacturers for N-Phenylacetyl L Prolylglycine Ethyl Ester, a chemical that stimulates the production of NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) in the hippocampus.
N-Phenylacetyl L Prolylglycine Ethyl Ester also activates AMPA and NMDA receptors, which facilitate transmission between neurons.
Since these neurotrophins and glutamate receptors are actively involved in the growth and survival of neurons, they help improve memory, focus, and cognitive performance.
As part of the racetam family, Noopept and Piracetam are also often compared to each other.
Although they share similar mechanisms of action, the former is much more potent, so treatment starts at much lower doses compared to Piracetam. People also experience fewer issues when using Noopept.
Besides the brand name Noopept, N-Phenylacetyl L Prolylglycine Ethyl Ester is sometimes called by its dipeptide code name, GVS-111.
With other variations of Noopept, ingredients may be added to create a ready-made supplement stack.
How Does Noopept Work?
Find out below.
Long Term Effects
Because Noopept easily crosses the blood-brain barrier, it's considered a fast-acting drug that takes immediate effect in your body.
While it is usually taken for its quick results, research shows it has a long-lasting effect on your cognitive health too.
Over time, it increases NGF/BDNF levels and reduces oxidative stress, which is essential for good cognitive function.
Research is also being conducted on the nootropic as a treatment for different types of disorders including Alzheimer's Disease, Parkinson's Disease, and dementia, among others.
Since it has a reparative effect, it may alleviate and improve mild cognitive damage.
Although it is primarily known for its positive effect on cognitive activity, memory consolidation, and health, this nootropic also has a number of additional benefits.
Now, what does Noopept do?
With Noopept, anxiety can be reduced. Since it affects benzodiazepine receptors that are associated with lowering stress levels, taking it can improve your mood and feel better overall.
In a study involving patients with mild cognitive disorders, 10mg of the nootropic used twice daily had an anxiolytic effect.
Another one of the benefits of Noopept is it supposedly helps clear mental fog [R]. Because it targets your focus, memory, and learning capabilities, your mind should feel sharper and clearer after consumption.
However, you may have to study your individual reaction to the drug, as some users actually experience Noopept brain fog as a side effect of taking it.
Research on mental fog isn't the most comprehensive either, as it can be quite subjective.
One interesting study showed that among those who took Noopept, depression symptoms actually decreased.
Because the nootropic deals with anxiety, stress, and low motivation, it may also help with elevating your mood in the long-term.
There's minimal research regarding this, but anecdotal reports usually indicate that it helps with depression.
Is there such a thing as a Noopept high?
The answer is no. Contrary to popular belief, it does not make you feel euphoric or high, unlike other psychostimulant drugs.
It doesn't increase physiological or central nervous system activity—all it does is enhance cognitive function.
How to Take Noopept
There are many ways to take Noopept—you can opt for oral, sublingual, or even intranasal administration.
Oral Noopept usually involves pills or capsules. For first-time users, this is often the best method of administration because it's easy, convenient, and safe.
First, the dose is already measured out for you, so you won't have to weigh it out yourself.
There's no bitter aftertaste when you swallow the pills too, which minimizes discomfort. Another plus is that they're long-lasting and not difficult to store.
If you're just trying out the product, and you aren't ready to make a commitment yet, then this is a great option for you.
Now, how to take Noopept powder? There are two ways:
Sublingual Noopept is when you dissolve Noopept powder under your tongue.
This is preferred by some users because it bypasses metabolic and digestive processes, which means that it isn't broken down by the time it enters your bloodstream.
This makes for a much more potent result compared to the oral route, where digestive enzymes start to process the nootropic before it can take full effect.
However, because it's in powder form, it can taste unpleasant for some people.
Moreover, its faster rate of absorption may lead to a higher risk of side effects manifesting, especially if you aren't used to taking Noopept.
Intranasal Noopept involves snorting it in powder form. Like the sublingual method, intranasal administration has a much more powerful effect on the brain because it doesn't get digested and metabolized by your body.
However, it enters via nasal mucus instead of the salivary glands.
Again, inhaling powder can be uncomfortable, so you should definitely choose a different method if you find this difficult to do.
It can also be inconvenient for you to measure out the exact Noopept dose every time, so keep that in mind.
How Much Noopept to Take
Noopept dosing can be confusing, especially for beginners, but here's a quick and easy guide to help you out.
Remember, while Noopept is often compared to Piracetam, it's actually up to 1000 times more potent than Piracetam!
With that said, don't use the same amount that you would normally do with Piracetam or even with other nootropics with similar effects.
As a general rule, you should also spread out one dose throughout the day and take a break after every two months for safety purposes.
The recommended dosage for an adult is 10-30 mg, depending on your weight. However, it's always best to start with just 10 mg to assess the effect on your body.
After all, you can always increase the dose afterward.
Capsules come in a variety of sizes, so be sure to check the label properly before purchasing a bottle.
Take only the minimum amount you need for your safety. This will also help prevent you from building a tolerance to the drug.
For sublingual dosage, you should start a bit lower, at around 5 mg.
Since it has quicker and more potent results, you should observe how you react to this method before increasing to the standard 10 mg dose.
It's very important to accurately measure the amount of powder you need. High doses could lead to problematic Noopept side effects, so be extra careful!
Snorting Powder Dosage
Similar to sublingual dosage, snorting powder dosage should be quite low.
While it's generally safe to take 10-30 mg in any form, Noopept may cause headaches, fatigue, and nausea, so always err on the side of caution.
If a typical dose is 10 to 30 milligrams, a Noopept megadose is a whopping 50 to 100 milligrams. Some people even take amounts greater than 100 mg!
A megadose is used when you want to see a dramatic improvement in your memory, learning, intelligence, and overall cognitive skills.
This should only be done once a week at most, as continuous use could make it less effective in the long-term.
Additionally, this can be extremely dangerous for some people, so make sure you're fully aware of your own tolerance level before attempting this.
How long does Noopept last?
Well, fast-acting substances usually have very short half-lives. Noopept half-life is just 60 to 90 minutes, which means that an average person can fully process half of the dose in that period of time.
However, one thing to remember is that a drug with a shorter half-life can cause withdrawal problems, as its effect wears off quite rapidly. Therefore, you should always be careful not to be too dependent on it.
Duration of Effects
Like most chemicals with fast-acting effects, Noopept has a short half-life. This means that while you feel it working right away, it also wears off quickly.
Typically, Noopept duration of effects is a little over an hour for most users. This is already longer than other nootropics such as Piracetam.
If you want to maximize this, you can divide your dose into smaller quantities and take them more frequently so you'll feel focused and alert all throughout the day.
This can also help with anti-anxiety and mood improvement.
For your safety, make sure not to exceed the recommended amount, though!
While there isn't much research on its long-term effect, some Noopept reviews indicate that it may be used for improving overall brain health.
In fact, it is sometimes used to treat cognitive disorders such as Alzheimer's Disease and Parkinson's Disease.
Side Effects of Noopept
Is Noopept safe to use?
Because not many long-term studies have been conducted on the nootropic, you cannot be 100% certain of its health risks.
However, based on information from published literature and our Noopept review, it is generally safe, with minimal side effects.
With that said, it's important to purchase from trusted supplement manufacturers to make sure you're getting quality Noopept pills.
Before consumption, you can review your medical history and information with your doctor too, if you want to be extra safe.
One last tip is to research online and read about different users' experiences, as these can vary from person to person.
It's useful to consider multiple sources of information, so you can really decide if it's the right supplement for you.
Research shows that a Noopept headache is usually caused by low levels of acetylcholine [R].
To counter this, users stack Noopept capsules with a choline source such as Alpha GPC.
If you're still experiencing headaches, I'd also recommend lowering your dose, as the nootropic may be too powerful for you.
One good tip is to drink lots of water in case you accidentally take too much Noopept too.
Before you buy Noopept, it's best to consult your doctor, especially if you have any existing medical conditions. He'll help confirm if it's safe for you to consume the nootropic!
What Reddit Users Say About Their Experiences
Based on my research, many Reddit users have good experiences with the nootropic, as it really helps with a variety of cognitive issues.
Generally, they recommend starting with the lowest dosage possible, as the effects are powerful and immediate.
New users, in particular, may feel over-stimulated, especially when taking a large amount. When this happens, it may be beneficial to incorporate a supplement such as Choline to calm the mind.
After taking the nootropic, users feel very focused, energized, and positive—they feel more ready to take on whatever comes their way, and some become more proactive than usual.
For those who experience constant mood swings, this could also help with stabilizing their emotions.
Most importantly, it helps you process information better, in a more organized and analytical manner. This is extremely helpful for those wanting to use it as a safer "study drug" [R].
However, it's also vital to note that this nootropic can make it difficult for some people to relax.
To counteract this, you should take a low dosage earlier in the day or supplement with drugs that have an anxiolytic effect.
Another thing you should be careful of is the potential of withdrawal symptoms.
Once you become dependent on the nootropic, you may feel worse when you don't have access to it. Thus, it's important to have a good cycle to prevent this from occurring.
What's A Good Noopept Cycle?
A typical dosage is 10-30mg, depending on your body weight, but it's always best to start on the lower end of the range for safety purposes.
This can be taken every day for up to 60 days, with the treatment split into three or more equal parts.
The sublingual method of administration is preferred because this allows you to feel its full effect.
Research shows this bypasses metabolic and digestive processes, so the chemical isn't broken down by the time it enters your bloodstream.
Keep in mind you should increase intake slowly and gradually to prevent dependency and any other problems.
As much as possible, stick to a low dosage as this nootropic is very potent. You should also take a break from it for a few months after every 60 days of using it.
When taking Noopept, examine the effect on your body and discontinue use if something feels wrong. After all, your health is most important!
Noopept tolerance can also occur if you're constantly taking high amounts of the supplement without incorporating breaks in between.
While Noopept effects may feel good, it's best to be safe and avoid a tolerance buildup.
With that said, you should start with the lowest dose of 10mg and gradually add 5mg per week, only if needed. Most users don't even need the largest dose of 30mg!
Noopept Review Conclusion
Whether you're starting to experience cognitive decline or you just want to perform at your best, Noopept is an excellent option for you.
Overall, I'd recommend taking this instead of Piracetam if you want something safe, effective, and affordable!