Phosphatidylserine: Review of Nootropic Benefits, Side Effects, & Dosage

Updated on March 7, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Are you looking for ways to improve your cognitive performance?

Have you heard of phosphatidylserine, a nootropic that is known to improve memory, concentration and focus?

In this article, we'll explore how phosphatidylserine can enhance your mental performance and provide tips on how to use it safely.

What is Phosphatidylserine?

Phosphatidylserine (PS) is a phospholipid found in cell membranes. It is a vital component for proper cell functioning and is found in high concentrations in the brain. PS is essential for cognition, memory, and learning(1) and supports the release of neurotransmitters like acetylcholine and dopamine.

As a nootropic, it has been shown to improve cognitive performance, memory, mood, and stress management. Studies have also shown that PS can reduce age-related cognitive decline and help protect against brain diseases like Alzheimer’s and dementia(2).

How Does Phosphatidylserine Work?

Phosphatidylserine is made up of several fatty acids, including linoleic acid, oleic acid, palmitic acid, and stearic acid. It helps in the maintenance of cell structure and is a major component of the cell membrane. It is important for the proper functioning of the brain and is involved in the transmission of signals between neurons.

phosphatidylserine nootropic review

Phosphatidylserine also helps to regulate the release of neurotransmitters such as dopamine and serotonin. In addition, it helps to regulate energy metabolism, reduce stress, and decrease inflammation. By helping to keep cell membranes healthy, phosphatidylserine helps to promote optimal brain functioning.

Benefits of Phosphatidylserine

Phosphatidylserine has been found to have many benefits for cognitive performance. Studies have shown that it can improve memory, focus and concentration. It can also help with mood and stress management, as well as cardiovascular health.

It is believed that phosphatidylserine can also reduce age-related cognitive decline. It has been found to be especially helpful for those with mild memory problems or those who have difficulty focusing. Furthermore, it can also be beneficial for those who are looking for a natural way to boost their brain power and performance.

1. Brain Function

Phosphatidylserine has been linked to several cognitive benefits, especially when it comes to brain function. Studies have shown that it can improve memory recall and learning, as well as increase focus and concentration. It is also thought to help protect against age-related cognitive decline and improve overall cognitive performance.

Phosphatidylserine also has neuroprotective properties, which means it can help protect the brain from damage due to stress or other environmental factors. Additionally, it can help reduce stress levels, improve mood, and promote better sleep quality. It can even help improve cardiovascular health, as it can help reduce inflammation and cholesterol levels.

2. Cognitive Performance

When it comes to cognitive performance, Phosphatidylserine is a powerhouse nootropic. Studies have shown that it can improve memory, reduce age-related cognitive decline, and even increase IQ scores. It is believed to be effective due to its ability to increase the production of neurotransmitters in the brain, which are essential for memory formation and recall.

It has also been shown to increase the density of the neuronal synapses and to reduce the amount of stress hormone cortisol, which can impair cognitive performance.

3. Mood and Stress Management

Mood and stress management is another area where phosphatidylserine nootropic supplements have been found to be effective. Studies have found that supplementation with phosphatidylserine can reduce symptoms of stress in those suffering from chronic fatigue syndrome, as well as reduce feelings of depression and anxiety. In addition, this supplement has been found to reduce the psychological effects of stress, such as irritability, fatigue, and difficulty sleeping.

Furthermore, phosphatidylserine has been found to improve cognitive functioning, which can lead to improved mood and stress management. By improving cognitive functioning, phosphatidylserine supplementation can provide relief from cognitive issues, allowing for better focus and concentration. This, in turn, can lead to improved mood and stress management, as well as improved overall mental and physical health.

4. Cardiovascular Health

Cardiovascular health is yet another area that may benefit from phosphatidylserine supplementation. Studies have shown that phosphatidylserine may help reduce levels of lipoprotein(a) in the blood, which is a marker of heart disease risk.

Additionally, phosphatidylserine has been shown to reduce the risk of arrhythmias and improve blood flow in the heart, both of which can be beneficial for cardiovascular health.

Side Effects of Phosphatidylserine

When it comes to side effects, phosphatidylserine is generally considered to be safe and well tolerated. However, some people may experience mild digestive issues such as bloating, gas, nausea, or loose stools when taking a phosphatidylserine supplement. If this happens, it is recommended to start with a lower dose and gradually increase it over time.

It is also important to note that phosphatidylserine should be used cautiously in individuals with pre-existing medical conditions such as hypertension, diabetes, and thyroid disorders, as well as those taking medications that affect blood sugar levels. Additionally, pregnant and breastfeeding women should avoid using phosphatidylserine supplements.

Dosage and Timing of Phosphatidylserine

When it comes to dosage and timing, the optimal amount of phosphatidylserine to take depends on your individual needs. Generally, the recommended dose is 100-400 mg daily, in divided doses. It is best taken with meals for better absorption.

To experience the full benefits of phosphatidylserine, it is important to take it consistently for several weeks. It is also important to note that phosphatidylserine is fat-soluble and should be taken with fatty acids, such as fish oil, to enhance absorption.

Types of Phosphatidylserine Supplements

Phosphatidylserine supplements come in a variety of forms, from capsules and tablets to powders and liquid forms. Each form has its own advantages, making it easier for consumers to find the most suitable form for their needs.

  • Capsules and tablets are the most popular forms, as they are easy to store and take on-the-go. They also come in a variety of strengths and doses, so you can easily find the right supplement for your needs.
  • Powders are great for mixing into smoothies, shakes, or other drinks, while liquid forms are great for those who have difficulty swallowing pills or capsules.

Stacking Phosphatidylserine with Other Nootropics

Stacking Phosphatidylserine with other nootropics can help to further enhance its effects. For example, combining phosphatidylserine with Ginkgo biloba can help to improve mental clarity and focus. Similarly, pairing it with Bacopa monnieri can help to boost memory recall and learning.

Additionally, stacking it with Citicoline can help to improve cognitive performance, making it a great option for those who are looking to get the most out of their nootropic supplement routine. It is important to note that before stacking any nootropics, including phosphatidylserine, it is recommended to consult with a doctor to ensure that any potential interactions are known and monitored.

Using Phosphatidylserine for Optimal Cognitive Performance

Phosphatidylserine can be used for optimal cognitive performance by increasing the effectiveness of other cognitive enhancers when stacked. When taken in combination with other nootropics, such as omega-3 fatty acids and choline, phosphatidylserine can help to improve focus, memory and concentration.

The combination of these supplements can also help to reduce stress and anxiety, which can help to improve cognitive performance. Phosphatidylserine can also be taken on its own to help improve cognitive performance, memory, focus and concentration.

Food Sources of Phosphatidylserine

Phosphatidylserine is a naturally occurring phospholipid found in animal and plant foods, but the body can also produce it.

Some of the best food sources of phosphatidylserine include:

  • Organ meats such as liver and kidney
  • Egg yolks
  • Fish like anchovies, herring, and salmon

Phosphatidylserine is also found in small amounts in certain vegetables like broccoli and spinach. While these food sources may provide some phosphatidylserine, it's usually not enough to provide the desired nootropic effects. For this reason, many people prefer to take a phosphatidylserine supplement for greater potency and convenience.

Why Choose Phosphatidylserine as a Nootropic?

Phosphatidylserine is a natural nootropic that can be used to improve mental performance. With the ability to improve memory, focus, and attention, phosphatidylserine is a great choice for those looking to enhance their cognitive performance.

Phosphatidylserine is also known to have a positive effect on mood and stress levels, making it a great option for those looking to manage their stress levels. Additionally, phosphatidylserine has been shown to have positive effects on cardiovascular health, making it a great option for those looking to maintain their overall health.

With the wide range of benefits associated with using phosphatidylserine as a nootropic, it is no wonder so many people are choosing it as their go-to supplement for cognitive enhancement.