Oxiracetam: Review of Effects, Dosage & Where to Buy

Looking to tap into the wonder of nootropics and unlock your brain's full potential?

Oxiracetam is one nootropic supplement that might do the job.

But how safe and effective is it?

In this review we’ll answer these questions and more by explaining how it works, its side effects, and more.

What Is Oxiracetam?

oxiracetam structure

Oxiracetam is a supplement developed in the 1950s, and research found it to be effective in enhancing cognition. Oxiracetam works by activating the Glutamate receptor.

As an amino acid derivative, it helps neurotransmitters to bind to their receptors. It also delays the breakdown of other neurotransmitters like serotonin and dopamine.

Oxiracetam is used to enhance mental ability, boost intellectual function, improve reasoning skills, and restore attention span.

Oxiracetam [R] is a popular supplement with clinical therapeutic effects that people have been using for years to boost their brain's performance. Like many more popular nootropics, this one is a member of the Racetam family, a synthetic drug that increases cognitive function, focus, and overall brain health.

Imageoxiracetam
NameOxiracetam
ClassNootropic
EffectsImproves memory, brain protection, memory retention, focus, better creativity
Potential Side EffectsHeadache and insomnia
Half-Life5 hours
Common Dosage800 - 1,600 mg daily
Content50 g
Price$24.99
Money Back Guarantee30 days
Rating⭐⭐⭐⭐⭐ 4.8/5
Best VendorClick Here ›

Since it's a water-soluble nootropic, it can be taken orally or sublingually. Aside from boosting cognitive processes, it may also improve your verbal fluency and act as a mild stimulant to keep you energized and alert.

Mechanism of Action

Oxiracetam's mechanism of the action revolves around its ability to increase cholinergic neurotransmission.

Choline is an essential precursor in the synthesis of acetylcholine, and this supplement stimulates nerve impulses which can improve mental ability, learning, and concentration levels. It also enhances metabolic activity through phospholipid metabolism and glucose consumption or uptake.

Glutamate receptors or ionotropic glutamate receptors (specifically AMPA and kainite) are stimulated by this supplement, resulting in increased alertness, focus, attention span, learning capacity, and speed of recall.

Oxiracetam is absorbed in the intestines and is then distributed throughout various body tissues. Some of it will be metabolized into choline which can cross the blood-brain barrier resulting in higher acetylcholine levels due to cholinergic transmission and cerebral blood flow.

The brain's cerebral cortex, hippocampus, thalamus, basal forebrain, caudate nucleus are areas where Oxiracetam increases memory retention processes.

It has been established that older people tend to have lower concentrations of neurotransmitters like dopamine and serotonin. This drug also stimulates the release of dopamine, leading to increased attentiveness and focus and enhanced moods, which help treat depression.

As mentioned earlier, the supplement increases synaptic plasticity through glutamate release. It also increases NMDA receptors, creating more binding sites for glutamate, resulting in improved information processing capacity. This, in turn, will improve learning capacity as well as attention span over time.

Choline is broken down into acetylcholine, which is vital for cognitive function. It allows nerve impulses to be transmitted by neurons leading to focus, attentiveness, memory retention or recall, moods, and sleep patterns.

Acetylcholine levels increase when this drug acts on cholinergic neurotransmission through various mechanisms like speeding up enzyme reactions that result in the synthesis of acetylcholine, leading to increased activity of cholinergic neurons.

What Is It Used For?

Like every other Racetam that you know, it effectively boosts the brain's new memory-forming capability. That makes it a powerful study aid for patients who need to do some serious cramming. It also helps with brain damage.

In this review, we'll answer these questions by explaining how it works, its side effects, and more.

What Is Oxiracetam?

Oxiracetam is a drug developed in the 1950s, and research found it to be effective in enhancing alertness. Oxiracetam works by activating the Glutamate receptor.

As an amino acid derivative, it helps neurotransmitters to bind to their receptors. It also delays the breakdown of other neurotransmitters like serotonin and dopamine.

Oxiracetam is used to enhance mental ability, boost intellectual function, improve reasoning skills, and restore attention span.

Oxiracetam [R] is a popular supplement with nootropic effects that people have been using for years to boost their brain's performance. Like many more popular nootropics, this one is a member of the Racetam family, a synthetic drug that increases cognitive function, focus, and overall brain health.

Since it's a water-soluble nootropic, it can be taken orally or sublingually. Aside from boosting cognitive processes, it may also improve your verbal fluency and act as a mild stimulant to keep you energized and alert.

Mechanism of Action

Oxiracetam's mechanism of the action revolves around its ability to increase cholinergic neurotransmission.

Choline is an essential precursor in the synthesis of acetylcholine, and this drug stimulates nerve impulses which can improve mental ability, learning, and concentration levels. It also enhances metabolic activity through phospholipid metabolism and glucose consumption or uptake.

Glutamate receptors or ionotropic glutamate receptors (specifically AMPA and kainite) are stimulated by this drug, resulting in increased alertness, focus, attention span, learning capacity, and speed of recall.

Oxiracetam is absorbed in the intestines and is then distributed throughout various body tissues. Some of it will be metabolized into choline which can cross the blood-brain barrier resulting in higher acetylcholine levels due to cholinergic transmission and cerebral blood flow.

The brain's cerebral cortex, hippocampus, thalamus, basal forebrain, caudate nucleus are areas where Oxiracetam increases memory retention processes.

It has been established that older people tend to have lower concentrations of neurotransmitters like dopamine and serotonin. This drug also stimulates the release of dopamine, leading to increased attentiveness and focus and enhanced moods, which help treat depression.

As mentioned earlier, the drug increases synaptic plasticity through glutamate release. It also increases NMDA receptors, creating more binding sites for glutamate, resulting in improved information processing capacity. This, in turn, will improve learning capacity as well as attention span over time.

Choline is broken down into acetylcholine, which is vital for cognitive function. It allows nerve impulses to be transmitted by neurons leading to focus, attentiveness, memory retention or recall, moods, and sleep patterns.

Acetylcholine levels increase when this drug acts on cholinergic neurotransmission through various mechanisms like speeding up enzyme reactions that result in the synthesis of acetylcholine, leading to increased activity of cholinergic neurons.

What Is It Used For?

Like every other Racetam that you know, it effectively boosts the brain's new memory-forming capability. That makes it a powerful study aid for people who need to do some serious cramming. It also helps with brain damage.

oxiracetam review

This one distinguishes itself from most other Racetams because of its ability to serve as both a brain booster and a mild stimulant, simultaneously increasing thinking prowess and improving focus.

Its stimulant properties are similar to that of Phenylpiracetam, meaning the nootropic drug is potent enough to keep you awake. But unlike caffeine and other stimulants that promote wakefulness, Oxiracetam doesn't leave you feeling wired or restless.

Aside from boosting the mental performance of healthy people, several human research has tested its viability for treating cognitive impairment induced by cognitive decline, dementia, and memory loss. The focus of such research has been people with neurological conditions like Alzheimer's or dementia.

Based on a double-blind, placebo-controlled study, multi-infarct dementia treatment and memory restoration in aged patients with dementia can work with Oxiracetam [R]. Further research also indicates that it is safe and suitable for long-term therapy, especially for improving and preserving brain health in the elderly.

While there is evidence regarding the beneficial effects of Oxiracetam in treating older people with dementia, documented research regarding young, healthy people using the supplement is lacking. Nonetheless, many young people use it recreationally and claim it heightens their learning and mental ability, and more.

Effects & Benefits

Even though the FDA doesn't approve its use, it works and offers various nootropic benefits.

It's especially popular for the following benefits:

Improving Memory

Oxiracetam works by increasing two of the body's most important chemicals for learning: acetylcholine and glutamate.

An increase in these neurotransmitters has been shown to help with everything from speech clarity to problem-solving skills.

These positive effects allow people suffering from neurodegenerative conditions like Alzheimer's Disease or dementia to experience more brain activity than they would have otherwise had if their situation remained unaltered.

Its benefits are wide-ranging, but it's most famous for enhancing cognitive formation and retention, as well as improving your speed of recall. These nootropic effects are by far the most studied in both animal and human tests, all of which indicate that it improves memory.

Learning Enhancement

Oxiracetam can stimulate glutamate receptors along with other receptors associated with learning. Increases in these chemicals have been shown to improve problem-solving skills, reasoning, coordination between senses, speaking clarity, and mental ability.

By taking this substance, consumers can retain information that they otherwise would not be able to after ingesting just a placebo.

oxiracetam benefits

Anecdotal evidence indicates that Oxiracetam may boost students' learning who need to cram for exams more than similar drugs. It can also promote analytical thinking, making it ideal for students who are tackling logic-intensive research.

These are all possible because of their effect on the brain's ability to form new memories and recall information. It speeds up both processes, making learning new things faster and more effective.

While no clinical studies involving young people prove this claim, animal studies‍ and research involving dementia patients‍ have promising data.

Enhancing Verbal Fluency

Oxiracetam has become one of the most common prescriptions to improve verbal fluency. This is because it works on glutamate receptors, which make up a large part of language comprehension.

Many users report vast improvements in their vocabulary, as well as an increase in word recall. Interestingly, these benefits are commonly seen after short-term use.

Some users believe that this substance may be more effective when taken at shorter intervals.

Want to sound more intelligent and more eloquent? Several clinical studies indicate Oxiracetam can boost verbal fluency. Verbal fluency connects to your ability to retrieve information from your brain quickly. It will help you speak with greater eloquence by sharpening your mind.

That means no more pausing mid-sentence to find the right words to most effectively convey your message. Proof of its effectiveness is evident in the clinical trials involving individuals with dementia or age-related cognitive decline, dementia, and cognitive impairment.

Because the drug also boosts cognitive formation and recall, it'll be helpful to those who are trying to learn a new language and not just to those with cognitive impairment or dementia.

Memory Retention

Oxiracetam's ability to block PDE4 enzymes allows it to prevent the breakdown of acetylcholine and dopamine, two chemicals associated with memory retention and recall capabilities.

By blocking these enzymes, consumers experience improved recall and learning capacity. Additionally, it has been shown to potentiate other nootropics, making their effects more potent when taken with this substance especially by people with dementia.

Boosting Concentration and Focus

Oxiracetam has been shown to have significant effects on the neurotransmitter Acetylcholine, which is responsible for attention and focus.

Studies have demonstrated that participants experience increased concentrations while taking this nootropic. This effect becomes more pronounced at multiple-dose administration, leading people to focus on one task for more extended periods.

If you struggle with focusing on tasks, it can help by increasing your overall concentration. The more focused you are, the more time you can spend studying or completing tasks without your mind wandering and becoming distracted.

Brain Protection

As a neuroprotectant, it may prevent Alzheimer's disease, dementia, and other forms of dementia from forming or progressing. There's evidence of this effect in studies involving animals with impaired memory formation. Other tests also indicate that it can alleviate blood-brain barrier dysfunction and protect against stroke.

Many users report having improved brain plasticity when taking this nootropic. This means that neurons, the building blocks of the human brain, are more capable of growing and dividing.

This has a significant impact on a person's ability to recover from traumatic injuries or other issues causing cognitive disabilities or even dementia.

Better Creativity

Oxiracetam is known for its ability to boost creativity. It has been shown to increase dopamine levels in the brain, which helps people get past mental roadblocks and get into a creative mindset.

In clinical studies, many participants reported increased creativity while using this drug at various dosage levels.

In addition, it may allow consumers to see different sides of an issue or problem, which can be highly beneficial in creative professions.

Several users report having an easier time synthesizing information and coming up with new ideas when taking this drug.

Brain Blood Flow

Oxiracetam has been shown to increase cerebral blood flow in the brain. It is believed that this increased cerebral blood flow creates more energy for people, allowing them to complete tasks that they might otherwise struggle with.

This increase in mental energy also helps people stay awake and alert for more extended periods. Users have reported improved concentration, as well as a decrease in impulsivity.

Many athletes use this supplement because it allows them to train harder and recover faster. Because of its cognitive benefits may also be used as a nootropic supplement by those who want to achieve their full potential with physical training.

The addition of Oxiracetam into a brain health regimen can be highly beneficial when enhancing alertness, focus, and attention levels.

Stay Awake and Alert

Always dozing at the wrong times? Oxiracetam is a mild psycho-stimulant that can inhibit sleep and keep you awake by increasing cerebral blood flow within the brain. So, if you need to pull an all-nighter, this nootropic can help.

Oxiracetam has been shown to increase alertness and wakefulness significantly. Many people use this supplement when they need to be more productive throughout the day, whether at work or school.

It is also used by many athletes who want to train harder and push themselves further than usual. This effect can decrease mental fatigue, allowing patients to think more clearly and concentrate on tasks for more extended periods.

Dosage

Oxiracetam is a synthetic compound. As a dietary supplement, you can find it in the form of a water-soluble powder, tablets, or capsules that you can take orally or sublingually.

Since the supplement is unregulated, general guidelines regarding its dosage are unavailable.

If it's your first time using it, we recommend starting at the lowest effective dose and working your way up as necessary to meet your needs.

Since there are no reports of adverse effects from using it in high doses or multiple-dose administration, there isn't much cause for concern.

In human clinical trials, patients took multiple-dose administration per day for a combined 700 - 2,400 mg per day.

Never take more than the limit of 4,000mg daily to avoid overdose. Depending on your personal preference, you may take it either on its own or mix it with juice or water.

Please do not drink alcohol within 24 hours after taking this supplement, as it may diminish its effects. If you choose to take Oxiracetam as a nootropic, experts recommend taking it in the early mornings for maximum positive impact and results.

As a drug used for the treatment of myoclonus (uncontrollable muscle twitching), lower doses are taken during the day before bedtime, which can be up to 2,400 mg per day, divided into three doses.

Regular users tend to take Oxiracetam in cycles which means taking it simultaneously every day for 2-3 months, followed by a month-long break or lower dosage before resuming usage again.

This is done to avoid developing tolerance against its effects because of harmful feedback mechanisms in the brain when taken nonstop. If you wish to experience the clinical therapeutic effects of this drug, do not exceed 800mg per day because higher doses do not give better results.

If using a similar dose, make sure your second dose is less than half of your first dose and taken by early afternoon. Using the drug any later could lead to its stimulant properties disrupting your sleep cycles.

For the best results, take your dose an hour before your study or other intended activity.

Remember that Oxiracetam is for short-term use only; don't use it every day continuously for more than three months.

It's not advisable to take this drug during pregnancy or breastfeeding since its effects on unborn/nursing babies are still unknown at this point. Patients who have kidney problems should also avoid taking this drug as a precaution.

How to Take Oxiracetam for Best Results?

This drug is available in powder form that can either be white or cream-colored. Users may take it with or without food. If you're taking choline supplemental drugs like Alpha GPC, make sure to space them out properly to diminish their effectiveness.

how to take oxiracetam powder

These supplemental drugs are fat-soluble, which means they need certain enzymes (lipase) to break them down before they are absorbed into the body. Without adequate lipase production within the liver, these supplements might get stored as fat.

Oxiracetam is water-soluble so mixing it with other liquids is recommended. Some patients place this powder directly under their tongue, but others suggest mixing it with either plain water or juice to help the powder quickly be absorbed by your body without having to taste it.

The typical dosage for adults is between 800 milligrams and 1,600 milligrams per day, but make sure you don't go over this limit unless you must do so by a doctor.

While most patients start out taking low doses of each supplement, they stack together. Some decide that they can handle higher levels of Oxiracetam on their own, depending on how well they know their tolerance levels.

However, remember that most nootropics work best when both drugs are taken at similar dosages to avoid unwanted side effects, so do not take more than the recommended dosage.

Just as you would with any other nootropic, start out taking low doses of both supplements and work your way up over time.

If you experience any adverse reactions after taking these two supplemental drugs together, then consider slowly lowering your dosage or switching to a different stack that might work better for you.

While this process will take some trial and error, it should help you optimize the clinical therapeutic effects of taking Oxiracetam alone or in combination with other nootropics.

Side Effects

According to research, there are no adverse effects from using Oxiracetam in standard or large doses. The compound is generally well tolerated by the human body, and there are no reports of severe side effects.

That said, first-timers that take higher-than-necessary doses may experience headaches or restlessness. The headaches occur due to Oxiracetam exhausting your brain's reserves of choline while delivering its desired effects. You can counteract such problems by using supplemental choline drugs alongside Oxiracetam.

oxiracetam side effects

Alternatively, you could eat more foods that contain choline, such as peanuts, eggs, and liver.

Some users also experience insomnia or restlessness. That's due to using this late in the day, leading to its mild stimulant effect disrupting regular sleep patterns.

Oxiracetam Experiences Shared on Reddit

Here's feedback from real people on Reddit:

According to Psycho_student:

"...Today, I absolutely smashed my Psychology exam on Oxiracetam and I just want to share my experience with this noot because I noticed so much difference in my cognition, especially memory, verbal comprehension, and verbal fluency!!! I just can't help it… I studied for this exam for only three days and a significant amount of information I memorized was in the last 5 hours before the exam! It's so much easier than at my baseline memory."

According to LosBuratnos:

"…I had six days to write 10,000 words on Chechen terrorism… Working 7-8 hours a day, for 6 days, I did my dissertation and got a B1 (equivalent 17/20 points). The funniest thing is, right now, if I read it, it makes a lot of sense and is actually a pretty interesting piece of research…Oxi gave me a significant increase in focus, to the point where I could work for 2-3 hours without even checking Facebook. I was just reading/writing all the time. It's something that I could NEVER experience in real life. Would top it up with occasional Red Bull and a sandwich. The focus was just laser-sharp. It also helped me with memory (was clearly retaining more info in both short-term and long-term)…"

Possible Oxiracetam Stacks

It's easy to see that Oxiracetam has some benefits. You can take this supplement alone to get the energy and focus you need, but it is often much more effective to stack different supplements together for more significant effects.

The most common reason why patients choose to stack supplemental drugs like this is that nootropics work in synergy with one another when they are combined.

This means that when several similar chemicals or ingredients are taken simultaneously, each substance enhances the positive aspects of the others until their effects combine into something more significant than the individual parts.

This is especially true in cases where two or more nootropics share similar mechanisms in affecting brain functions, cognitive improvement levels, and mood enhancement.

While there are hundreds of different nootropics, a few are well suited to be stacked together.

Stacking them with other nootropics amplifies the effects of Racetams. If you want the best results from using this as a cognitive enhancer and mild stimulant, you are better off stacking it with other nootropics. Here are some impressive nootropic stacks to try:

Choline + Oxiracetam = The Ultimate Racetam Stack

The primary benefit of this nootropics stack is eliminating its mild potential side effects. That's because a shortage of choline in the body causes them.

One of the easiest stacks you can make is between Choline and Oxiracetam. Choline supplements like Alpha GPC or Citicoline increase acetylcholine levels in your brain, an essential neurotransmitter for memory formation and recall.

When increased levels of this chemical are present, your mind's ability to process information and retain memories improves.

At the same time, the active ingredients in Oxiracetam work with these chemicals to improve cognitive function on both short term and long term scales.

One may use 750 mg Oxiracetam and 300 mg Alpha GPC one to two times per day for optimal effect.

Citicoline + Oxiracetam = Improved Attention Span

Another excellent supplement stack is between Citicoline and Oxiracetam. The most common types of Citicoline include cytidine diphosphate choline (CDP Choline), which is known as CDP-Choline or simply citicoline, plus cytoplasmic acid, which is also known as DiCytidine 5'-Ophosphate or cytidine 5'-monophosphate.

When combined with supplemental drugs like Oxiracetam, these supplements can help you enjoy increased concentration levels throughout the day without causing oxidative stress induced by medications on your mental functions.

Besides making it easier for you to focus on tasks, Citicoline can also improve your mental energy levels, allowing you to work at a faster pace during the day.

There are many types of nootropics that patients use in an attempt to increase their mental energy levels. Still, citicoline is one of the few which can give you all-day coverage without worrying about side effects or harmful consequences.

Oxiracetam + Aniracetam = Improved Memory Formation

Taking it with Aniracetam will boost your learning and mood while lessening anxiety. The result is feeling sharper and pleasant, yet relaxed.

In addition to being used in combination with other drugs, many patients have found that taking nootropics like Oxiracetam on its own also helps improve their cognitive formation and recall functions.

Some supplement stacks were explicitly designed to be taken together, including this same pairing between Oxiracetam and Aniracetam.

Besides improving your mental abilities, Oxiracetam can also help you think more quickly, concentrating better in short bursts without making the mental strain obvious.

These benefits make this one of the most popular racetams on the market, especially among college students looking for ways to improve their intelligence and increase their chances of graduating.

Aniracetam, in turn, can help you think more quickly because it enhances specific brain receptors known as AMPA receptors. These receptors are often increased in size when people age, which is why older patients have a more challenging time concentrating than younger adults do.

The same benefits can occur even without aging when you take nootropics like Oxiracetam in combination with drugs that work best when boosting your cognitive functions.

The nootropics stack works best with 750 mg of Oxiracetam and Aniracetam once or twice daily.

Oxiracetam + Adrafinil = Fewer Side Effects

One exception to this rule is when using Adrafinil with Oxiracetam. Although these supplements were designed to be taken together, they do not always mix well. There are necessary precautions that both users and healthcare professionals should take before trying this combination.

While both Adrafinil and Oxiracetam are considered part of the racetam family, they have some critical differences.

For example, Adrafinil is known as hepatic-friendly, which means that it does not put extra stress on your liver as other supplements do. This makes it great for patients who already suffer from liver problems or want to improve their overall health by avoiding unnecessary strain on their body's most important muscle.

On the other hand, although this supplement is designed to give you all-day mental energy, it can cause some users' side effects like headaches, jitteriness, and nausea.

Oxiracetam + Noopept = Improved Memory Functions

By stacking the Oxiracetam and Noopept supplements together, you can use small doses of both instead of large amounts of either one alone. This helps prevent these issues so that you can enjoy all the benefits each supplement has to offer without worrying about adverse reactions or putting your health at risk.

The positives offered by this combination certainly outweigh its negatives for many patients. Not only will combining these two nootropics help improve memory formation, but it can also increase concentration levels while reducing fatigue.

Some research even shows that this pairing could enhance focus span and physical stamina during periods where mental energy must be sustained over long durations, making it particularly popular among students who need to concentrate for hours on end.

Many of the benefits you will experience when using this pairing include the nootropic effects that each supplement can offer on its own.

Oxiracetam is known to increase your memory formation capabilities, helping you remember information more quickly and accurately than you usually would. Noopept, meanwhile, enhances brain processes to make it easier for you to recall memories, especially those associated with new experiences.

Where to Buy Oxiracetam, Online or Physical Store?

As always, it's vital to purchase your nootropics from a reputable vendor. The best way to buy nootropics is online, so you can compare prices and find the best deal on both supplements before deciding which one to use.

You can buy Oxiracetam online from several vendors. But if you want a safe product that delivers the best results, buy from a reputable vendor with a track record for selling genuine nootropics.

Science.bio is a nootropics vendor, and they offer high-quality products at competitive prices.

How Much Does it Cost?

As with any nootropic, there's no telling how long Oxiracetam will remain popular, which could change the price of this supplement at any time.

When it is still easy to find in stores, you might be able to get a bottle for around $25. However, if this supplement grows in popularity and begins selling like hotcakes, expect its price point to increase eventually.

Frequently Asked Questions (FAQ)

Your most pressing questions answered.

Are Racetams Safe?

Racetams are generally safe as long as you use them in proper doses. Even when used in higher doses, the side effect is usually minor.

How Much Oxiracetam Should I Take?

Because it's unregulated, there are no fixed guidelines regarding its dose. Human clinical trials indicate using 700 - 2,400 mg per day split into two doses. Start at the lowest effective dose and work your way up as necessary to meet your needs.

Is Oxiracetam a Stimulant?

As a cholinergic, it releases acetylcholine in the brain. It's a neurotransmitter that works as a mild psycho-stimulant.

What is Oxiracetam's Half-Life?

Oxiracetam has a half-life of 5 hours which means it takes about 5 hours before being eliminated from your system after ingestion.

Make sure you space out your dosage carefully not to develop tolerance against its effects within this time frame. Some patients prefer taking a single dose per day, while others divide it into smaller doses which are taken thrice daily.

Conclusion: Is Oxiracetam Any Good?

When you need a safe and effective way to boost your focus, memory, and general mental health, Oxiracetam is a potent and safe nootropic to try.

Even better, its side-effects are negligible, which makes its use generally safe.