Alpha GPC Review: Benefits, Dosage & Side Effects

Alpha GPC is a nootropic used for cognitive function and physical performance. We look at how it works and explore the many health benefits and uses before recommending a safe dosage and listing potential side effects.

Alpha GPC is a very powerful nootropic that has been used for cognitive function, to improve working memory and improve overall mental and physical performance. It is also a chemical made inside the body, yet is used as a medicine and can be manually made in a laboratory.

As it is so effective, it has been used to help with symptoms of Alzheimer’s disease and can even significantly improve the power output of an athlete. This article looks at just how powerful this nootropic is by exploring the health benefits and uses, as well as looking at recommended dosage and side effects.

Let’s jump right in…

What is Alpha GPC?

Alpha GPC Review

In parts of Europe, Alpha GPC can be prescribed as medication for Alzheimer’s disease, yet in the United States, it’s only available to buy as a dietary supplement for memory enhancement and mental or physical performance. It can provide positive benefits to the brain and body and also has the potential to enhance an athlete’s endurance and power when training.

The cholinergic compound can supply choline to protect nerves and is a phospholipid that is essential for brain health. Choline is supplied to the nervous system as Alpha CPG provides the choline directly for cell membranes and myelin production.

Choline from Alpha GPC also builds up acetylcholine and this is a neurotransmitter that maintains cognitive and muscle function.

Alpha GPC is ingested orally and has shown promising results in its ability to enhance the production of growth hormones. This is what makes it so beneficial to athletes who are searching to improve their power output and performance.

It comes from sunflower or soy lecithin and when naturally found in the body, it is produced when fatty acids found in soy and other food break down and the metabolites release Alpha Glycerylphosphorylcholine.

Natural sources which contain Alpha GCP include eggs, chicken, whole grains, soybean, and beef liver.

Overall, Alpha GPC has shown positive results in slowing cognitive decline and enhancing physical performance, however, these effects require additional research.

How Does Alpha GPC Work?

Alpha GPC supports the nervous system as a result of its ability to boost acetylcholine and cholinergic activity. It might also be able to increase other neurotransmitters such as GABA, dopamine, serotonin, and inositol phosphate.

Choline is an essential nutrient and is a necessary precursor to produce the acetylcholine neurotransmitter. Choline is also a precursor required for the formation of phosphatidylcholine (PC), which is used to construct cell membranes, and although it can be found in food, it’s difficult to take in more than your nervous system uses from a regular diet.

The impact on the neurotransmitter aids the brain’s neuron’s ability to communicate with each other. This influences memory, learning, and mental clarity. It might also combat cognitive decline.

Alpha GPC impacts the production and development of cell membranes in the section of the brain that handles intelligence, motor function, and functions that relate to personality and who you are as a person. The benefit of the cell membranes inside the cerebral cortex might influence cognitive function too.

Although acetylcholine can’t penetrate lipid membranes, it also can’t pass the blood-brain barrier. Alpha GPC crosses it to affect choline levels and this is what makes it such a popular choline supplement to help with mental abilities.

What are the Benefits and Effects of Alpha GPC?

Though Alpha GPC is still under research, there are still many benefits and effects of the nootropic which are backed by science and can boost mental and physical performance. Let’s take a look:

Enhances Working Memory and Cognitive Function

When aging, forgetfulness can become a common part of living. However, working memory is essential to everyday life, and when age-related cognitive decline sets in, Alpha GPC is able to help.

Alpha GPC is known for memory enhancements and can significantly improve working memory. This is down to the amount of choline is supplies that convert to the neurotransmitter acetylcholine, and this supports the body’s ability to form and recall memories.

The improvement of cognition with Alpha GPC can help with brain fog and fatigue and can give you a boost of motivation to last through the day. It can also help you focus on tasks for prolonged periods.

Alpha GPC can help with this as it is known for improving overall mental performance and increasing attention span. It can also help with mental clarity and help you think clearly to remain focused on one task. Though research is limited, it’s also been proven to help boost mental energy too.

Acetylcholine and choline are what help cognitive improvements and the boost in these mean many people use the supplement with a stack containing racetams and caffeine for a mixture of nootropic benefits.

Helps with Dementia and Alzheimer’s Disease

As Alpha GPC can help with memory enhancement and improve age-related cognitive decline, in patients with memory loss due to degenerative brain diseases like Alzheimer’s disease and other forms of dementia, the effect is profound.

Alpha GPC has the potential to shield the brain and prevent cognitive decline, no matter what the cause. In Alzheimer’s disease, mutated proteins kill neurons and deplete acetylcholine which causes certain cognitive issues.

Alpha GPC has proven to directly help with symptoms of Alzheimer’s disease and cognitive decline associated with this. Research shows that taking Alpha GPC can improve thinking skills in Alzheimer’s patients after 3-6 months of treatment.

It also has the potential to reverse the symptoms of acute cerebrovascular disease and experts believe this has to do with improved blood flow. Alpha GPC can improve blood vessels to supply more blood to the brain and this means it might also enhance vascular dementia.

Increases Dopamine Levels

Alpha GPC can increase dopamine levels, however, research shows this usually only affects people who already suffer from dopamine deficiencies

Dopamine helps improve overall well-being and a variety of other brain and body functions. It regulates pleasure and reward, increases blood flow, and helps with motivation. This means, if Alpha GPC can increase this chemical in the brain, it can be used to help with mental health issues such as anxiety and depression.

Enhance Physical Performance

It is common for athletes and bodybuilders to use Alpha GPC as it can improve physical performance and help with recovery after extreme physical workouts. It might also help with quickness and strength and increase overall power output.

The effects the supplement has on cognitive function can also improve the mental-physical connection, which can improve athletic performance.

The effect it has on athletes relates to how it can increase growth hormone levels. Growth hormones help build muscles and strength, which can increase power output and decrease the risk of injury. Growth hormones are also able to improve muscle recovery, food intake, and metabolism.

The effect can also link with the supply of choline as evidence suggests this can affect the strength and mass of muscles.

Moreover, Alpha GPC might be able to help with burning fat. This means athletes are now using the supplement to not only increase their strength but also decrease their BMI.

Can Support Stroke Recovery

Early research shows that stroke patients who take Alpha GPC within a 10-day window after the stroke, seem to recover better. Alpha GPC can also help patients recover their mental functions after a stroke and improve overall cognitive function.

Stronger clinical evidence needs to be found to fully understand this benefit.

Alpha GPC Dosage

The recommended dosage for Alpha-GPC will depend on the user’s goal. If this goal is the basic benefits, the recommended dosage is between 300-600 mg daily.

You might also want to start with a lower dose of the supplement to analyze the behavior of the effects on your body. Alpha GPC can be effective for some users at a dose of 200 to 250 mg.

As Alpha-GPC is one of the most potent sources of choline available in a supplement (approximately 40% potency), you don’t need a big of a dose as you might do with other nootropics.

If you have a cognitive disorder and are using the supplement to help improve the deterioration associated with this disease, a higher dose is recommended. The dosage recommendation, in this case, would be no more than 1200 mg daily, divided into two 600mg doses or three 400mg doses taken in the morning, at lunch, and in the evening.

What are the Side Effects of Alpha GPC?

As with all supplements, there are potential side effects that users should be aware of. These include:

  • Headaches
  • Digestive issues
  • Irritability
  • Nausea
  • Diarrhea
  • Heartburn

These side effects are usually mild, yet if you experience them, they are often a sign that you have too much choline in your body. If this is the case, you should decrease the dosage.

Users who suffer from hypertension should also consult their doctor before taking Alpha GPC and if you are taking scopolamine to help with motion sickness, nausea after surgery, or managing IBS symptoms, you should consult your doctor too.

It’s not safe for children or pregnant women to consume and this is because of the lack of safety data surrounding the supplement.

Alpha GPC Reviews Shared on Reddit

Here are some reviews of Alpha GPC from users and contributors on Reddit.

According to ‘cfjones3’: (he notes how powerful the supplement is but warns users not to take it too late in the day because of this)

‘WOW! OMG! This stuff is amazing! I thought it was simply a "Go-along" to support the benefits of the racetam I'm already taking (phenylpiracetam). But this stuff has got me fully awake at 2 am and looking forward to my workout.

As this is my first dose ever, and first experience, the error I made here was to take it too late in the evening. I was so eager to try my new product when I arrived in the mail, I quickly took 300 mg (2 capsules - Nootropics Depot) around 6 pm. Now I can't get back to sleep! lol. It's all good though… now I know to never take a dose so late in the day.

Seems like this supplement has been way underrated and I totally underestimated its effectiveness. My overall take on this supplement: so far, the best nootropic I've experienced. I think this will be "The One"’

According to ‘Sibonda’:

‘Just thought I'd give a shout-out to Alpha GPC as I can't find many reports to match with my experience. This stuff has completely blown me away and been the most unexpected success of the many nootropics and supplements I have tried […]

I could feel a surge of confidence and controlled stimulation gradually building since I woke up and even before my first dose of the day (250mg). Not long after that, I was absolutely flying - increased sociability, positive thoughts, and just motivation to get shit done. I took my second dose (another 250mg) after six hours and it is currently 16 hours since this feeling started, 14 hours since my first dose and I still feel amazing…hence this long post.

I have taken various drugs in my life and this is honestly a similar feeling to amphetamine. I even got some pretty intense music appreciation when listening to some tunes on my way home from work!

I know this sounds crazy and I can't quite believe I'm saying all this but I really am buzzing right now. I can't find much more reports similar to mine so was wondering why it has affected me so much. All else I took was my usual vitamin d (I work nightshift) and one cup of coffee. I guess the obvious answer would be a Choline deficiency but I do consume a decent amount of eggs in my diet.’

Where to Buy Alpha GPC?

Alpha CPG, like other supplements, is not regulated by the FDA but can be sold throughout the country online and in drugstores. It can be sold over the counter without any restrictions, but we recommend you order online so you can do thorough research on the brand and get the best price. We suggest checking out this website below:

Frequently Asked Questions (FAQ)

Your questions answered:

Does Alpha GPC Make You Drowsy?

Alpha GPC can make some people feel tired. This is usually caused by how the brain processes more information throughout the day.

How Much Choline Does Alpha GPC Give You?

Alpha GPC is around 40% choline by weight. This means that 1000 mg of Alpha GPC provides about 400 mg of choline.

Can You Take Alpha GPC Every Day?

Alpha GPC can be effective and safe for daily use. However, if you develop side effects, lower your dose or take a break. If side effects don’t go away, consult a doctor.

How Long Does It Take for Alpha GPC to Take Effect?

Alpha GPC acts fast when taken orally. It crosses the blood-brain barrier quickly after ingestion, and most users notice effects within the hour.


Alpha GPC is a great supplement to help with maintaining brain health, boosting memory, preventing cognitive function, and improving overall mental and physical performance. It provides your brain and body with a concentrated dose of choline which people can struggle to get through diet alone and this is what makes it a great dietary supplement.

Your body, with Alpha GPC, has access to the nutrition it needs to produce the neurotransmitter which is responsible for memory, and the impact it has on growth hormone production also helps the mental clarity and power output in athletes.

We, therefore, recommend it as a great powerful nootropic with a wide range of health benefits and uses, but research is still being carried out to understand its relation to the treatment of advanced benefits such as the prevention of Alzheimer’s disease and helping with stroke recovery.