Sulbutiamine Review: Benefits, Dosage, Side Effects & Buy Online

If you want an improved focus, enhanced long-term memory, and reduced fatigue in multiple sclerosis, then you must read this Sulbutiamine review.

Sulbutiamine improves memory by increasing the amount of energy that the brain uses. It turns out that this nootropic known as Arcalion not only boosts your cognitive ability but also helps you gain the physical energy that you've lost.

Sulbutiamine is a lipid-soluble thiamine disulfide derivative; hence, it differs from thiamine tetrahydrofurfuryl disulfide or other thiamine derivatives. It has an extended structure that increases its bioavailability and absorption. The ingredients in sulbutiamine tablets are all-natural, like vegetarian capsules, and do not contain any harmful side effects.

The benefits of this supplement include increased energy, mood stabilization, improved mental performance, and a more regulated appetite. This compound also helps to combat high cholesterol as well as liver dysfunction. Sulbutiamine contains the following formula: thiamin vertase enzyme, beta-hydroxybutyric acid, dibencozide, and benzoic acid.

Sounds good?

Read on to find out more.

What is Sulbutiamine?

sulbutiamin structure

Sulbutiamine is a nootropic compound that can be obtained in tablet form. It is synthetically derived from the amino acid thiamine and is legal to purchase over the counter in most countries such as Japan and China. Sulbutiamine use was developed in Japan to treat conditions such as asthenia and fatigue.

Japanese scientists developed Sulbutiamine [R] (vitamin B analog) to treat thiamine deficiency. Binding two vitamin b1 molecules synthetically produce thiamine. Its brand names are Arcalion, Enerion, Bisibuthiamine, and Youvitan.

According to a data study, Sulbutiamine shows promising results in increasing the thiamine levels in the brain. The lack of thiamine poses health risks such as Beriberi.

Thiamine is essential in producing energy because it is important for the conversion of carbohydrates into blood glucose, which in turn produces ATP (Adenosine Triphosphate), which supplies cells with energy. Sulbutiamine also has neurotrophic effects on brain cells, meaning that it encourages the production of brain cell neurons.

Compared to thiamine, Sulbutiamine dissolves in fats. It can pass to the brain easier hence providing a mild stimulant effect.

Sulbutiamine capsules protect the brain and alleviate depression. Studies have shown that it can also significantly reduce fatigue and stimulate digestion versus placebo.

Imagebuy sulbutiamine
EffectsIncreases thiamine levels, improves focus, helps fight stress
Potential Side EffectsHeadache, diarrhea, nausea, tremor,  drowsiness
Half-Life5 hours
Common Dosage400 - 1,000 mg daily
Content10 g
Money Back GuaranteeCase-by-case
Rating⭐⭐⭐⭐⭐ 4.6/5
Best VendorClick Here ›

What is Sulbutiamine Used for?

Sulbutiamine's uses or mechanisms of action works around thiamine. Thiamine deficiency leads to serious health risks. It can cause a central nervous system disorder called Beriberi.

sulbutiamine review

Insufficient vitamin B1 in the brain cannot be supplemented with thiamine supplements alone.

Sulbutiamine was created to help supply the brain with enough thiamine. Its bioavailability makes it a better replacement for thiamine supplements.

In the medical field, patients in the early stage of moderate Alzheimer's disease benefit from the effects of the association of acetylcholinesterase inhibitor and Sulbutiamine.

Research showed that athletes could use the vitamin as it helps improve their athletic performance. It also deals with chronic fatigue based on experimentally induced pain. It likewise improves focus and alertness.

Sulbutiamine also improves peripheral nerve function in diabetic polyneuropathy. But further references such as studies are required to claim possible treatment with the supplement.

Several research article citations also showed that vitamin B analog is helpful in the anti-infective treatment of certain diseases.

Sulbutiamine Research

Many research references point to the clinical efficacy of sulbutiamine when used on mice or rats. The evidence of the studies can be seen here, but I will summarize them for you below.

1) Results of the study showed that sulbutiamine was effective in restoring memory deficits caused by benzodiazepines in the rat brain.

2) In different data, researchers found that sulbutiamine can restore memory with a chronic administration of scopolamine. An injection of sulbutiamine induces the increase of thiamine triphosphate.

3) Another study has shown sulbutiamine's ability to affect glutamatergic and dopaminergic cortical transmissions in the mice's brain.

4) A fourth study also concluded sulbutiamine's effectiveness at increasing dopamine in the prefrontal cortex and hippocampus in mice.

5) The final study concluded with success when used on Alzheimer's patients. "Sulbutiamine produced a significant improvement in the scales measuring conceptual disorganization and also improved performance on a test of mental flexibility. Thus, sulbutiamine may have beneficial effects on cognitive deficits which occur as a result of moderate Alzheimer's disease."

Scientific studies have concluded that sulbutiamine is an effective drug for treating cognitive deficits. There has been no research article done, however, on Sulbutiamine's memory-enhancing capabilities when used alone without scopolamine or other products.

Benefits & Effects

If you feel weak because of fatigue, this may be the right supplement for you. Apart from that, it has more benefits than what it is created for.

Here are the things you can get from taking it.

Helps improve mood

One of the benefits of Sulbutiamine is that it makes you feel energetic. Your mood improves, you are more composed, and you have a clearer head.

Better than coffee

If you need a stimulant to fight chronic fatigue, Sulbutiamine is a better option than coffee. A research article shows patients who were given a daily 600 mg of the pill had less fatigue.

Memory enhancer

Choline aids in the memory function. The lack of it will result in poor long-term memory. Scientists studied if it can help increase the level of choline. The clinical study showed Sulbutiamine's role in increasing choline activity in the brain, providing better memory retention [R].

Replenishes physical energy

It was found out that the anabolic steroids taken by some athletes contain Sulbutiamine. The intention was to boost their physical energy and improve their performance in the game with its mild stimulating properties.

Treats erectile dysfunction

Men who are suffering from psychogenic erectile dysfunction can benefit from taking this. Those who cannot maintain an erection because of psychological factors may try Sulbutiamine treatment for ED.

Protects the brain

The high level of thiamine helps increase focus and energy. It protects the brain from inflammation and helps optimize cognitive function for better memory. In addition, it can also increase the dopamine levels in the brain for better decision-making. It has also been shown to help improve the auditory brainstem response threshold.

Defend against anxiety

Most Sulbutiamine reviews say that it helps fight stress. A lot of information states that sufficient thiamine supplementation can direct the body to withstand stress. An improved mood is a defense to prevent anxiety and major depressive episodes.

Prevent nerve damage

A study was conducted among patients who have diabetes. They were treated daily with 400 mg of Sulbutiamine, and on the 6th week, their nerve and muscle function significantly improved.

How Does Sulbutiamine Work in the Brain?

Sulbutiamine improves memory and reduces feelings of weakness.

How does it happen?

Sulbutiamine cautiously helps essential chemicals cross the blood-brain barrier to increase the levels of thiamine pyrophosphate (TTP).

TTP forms part of the citric acid cycle that breaks fatty acids, amino acids, and monosaccharides into smaller molecules.

The cycle provides the building blocks necessary to produce brain cells that affect memory formation.

Low levels of TTP may show symptoms of Wernicke-Korsakoff syndrome that include memory loss or amnesic effects, vision changes, confusion, and loss of muscle coordination that can lead to coma and death.

The production of the neurotransmitter acetylcholine and the synthesis of myelin is another benefit of sufficient vitamin b1. These chemicals ensure that neurons can carry information that conducts signals for receptive brain functions.


According to some information, consider taking Sulbutiamine in the morning and small amounts first.

People who want to experience the benefits of this drug should take 100-200 milligrams or one tablet per day. If you have been taking sulbutiamine for a more extended period, no more than 300mg should be taken each day since it may cause side effects.

However, if taken properly, it can help fight age-related cognitive decline. A study recommended taking 400 mg to 1,000 mg daily for the best results.

Specialists provide medical advice to patients and caution them that an optimal dosage may intercept sleep at night because of its mild stimulant effect.

You might try starting with a low dose first and see how your body reacts to it.

You may also cycle the drug administration to prevent the usual tolerance problem as one of the side effects. You can take it straight for five days then have two days off.

Side Effects

The effects of Sulbutiamine on cognitive function are remarkable but are there any side effects when you use the compound?

There have been claims that insufficient evidence of sulbutiamine's side effects exists. And so, medical experts vouch for its safety. The food and drug administration may still look into the ingredients to ensure that research results are safe and effective.

However, Sulbutiamine danger may include side effects that are rare because it is non-toxic. The patient may experience skin rashes and eczema-like outbreaks if taken in a higher dosage without medical advice.

Those who have drug addiction tendencies and may abuse Sulbutiamine must be cautious because it can be addictive and cause euphoria in high doses.

Other side effects may also include headache, nausea, diarrhea, tremor, and drowsiness.

It is best to seek professional medical advice from your health care professional or your doctor and read a lot of information before trying this out.

Experiences Shared on Reddit

Here are some reviews from Sulbutiamine Reddit users and contributors.

According to QwertyCrusader:

"It's one of the nootropics that I can actually feel working. It's stimulating and appears to help me focus my thoughts, and gives me an edge in social situations.

I use it on an as needed basis, never really dosing past 150-200mg."

According to feltsandwich:

"I take it only occasionally. The only clear effect seems to be a reduction in the normal expected fatigue when exerting myself. For example, if I'm walking up a steep hill or stairs following administration of sulbutiamine, the resistance and fatigue I feel in my leg muscles is diminished. While it doesn't provide energy like a stimulant, this effect promotes and supports vigorous exercise.

I have found it ineffective at increasing sociability, and it doesn't seem to have an effect on mood."

Sulbutiamine Stacks

Sulbutiamine improves adult cognition. Research showed that the pill could boost thiamine production for better mental processes.

Sulbutiamine supplements are often used in stacks with choline sources to provide possible cholinergic mediation. Choline supplementation can also increase the bioavailability of sulbutiamine in the brain when taken together.

It stacks very well with Piracetam and Aniracetam. Others experience profound results while taking it with B-complex.

Alpha GPC is another nootropic that you can use with arcalion as it contributes to acetylcholine synthesis.

Where to Buy Sulbutiamine Powder & Capsules?

Sulbutiamine is a prescription drug in some countries. To countries that can sell this over-the-counter, you can find it on reliable online vendors.

For those who want to try it, you can buy Sulbutiamine online. The best website to buy the supplement is this one.

Frequently Asked Questions (FAQ)

Here are the answers to your questions.

How to Take It?

It is advised to take 400 mg to 1,000 mg Sulbutiamine every day, preferably in the morning, for the best results.

If you intend to take it for extended periods, you can do it in a cycle of 5 days straight then two days off.

How Long Does It Last?

After ingestion, Sulbutiamine only takes about an hour or two to experience the effect of the pill. Once in the body, it has an elimination half-life of 5 hours.

Is Sulbutiamine a Stimulant?

It helps increase the levels of thiamine and dopamine in the brain. It helps fight fatigue and improves mood. So, it is a stimulant.

What Does It Feel Like?

After taking Sulbutiamine, you feel energized as it recovers the physical energy that you lost. You get the effect of coffee without caffeine.

However, side effects may be experienced, such as headaches, nausea, and diarrhea. A higher dosage may result in skin rashes and mild agitation.

Is It Safe?

Sulbutiamine has non-toxic content, so it is safe and effective for the chronic treatment of thiamine deficiency among people.

How Long Does It Take to Kick in?

Once absorbed, it usually takes 1 to 2 hours before you feel the effects. Its half-life is 4 to 5 hours.

Sulbutiamine and Noopept: Are They Similar?

Sulbutiamine and noopept are similar in that they both contain two modified B vitamin molecules, but this is where the similarities end. Noopept has a molar mass of around 169 g/mol, while sulbutiamine's molar mass is 354 g/mol. This means that noopept contains 36% more of the molecules that cause the desired effects on a per weight basis.

Noopept and sulbutiamine also differ in their respective half-life times. Noopept has a half-life time of 40 minutes, while Sulbutiamine has a half-life time of only 15 minutes.

So what does this mean for you? On a per weight basis, it takes 5mgs of Noopept to equal the effects found in 10mgs of Sulbutiamine.

Sulbutiamine also has a lower threshold dosage than noopept (100mg/day is enough, while 400mg/day is needed for an equivalent amount of nootropics per weight).


Overall, Sulbutiamine provides many benefits like long-term memory formation, reduced fatigue, and improved mood. It also treats human conditions associated with thiamine deficiency.

While Sulbutiamine does have many benefits, it is essential to take precautions before supplementing with this vitamin. In some cases, the side effects may outweigh the benefits and lead you to feel worse instead of better.

Make sure that you research what supplements will work best for you and consult your doctor before taking any new medications or vitamins.

One crucial factor to consider is, even if it is synthetically made, it is safe.