Coluracetam: Review of Nootropic Benefits, Dosage, & Side Effects

Updated on February 10, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Overview of Coluracetam's nootropic benefits, dosage guidelines, and potential side effects.

Coluracetam, a synthetic nootropic belonging to the racetam family, has garnered attention in recent years for its potential cognitive-enhancing properties. This coluracetam review aims to explore the synthetic nootropic’s benefits, uses, recommended dosage, and possible side effects, shedding light on its mechanism of action.

The interest in coluracetam has grown as researchers and nootropic enthusiasts have explored its potential use in various cognitive domains, from boosting cognitive function and promoting memory enhancement to managing mood disorders like depression and anxiety

Could this be the nootropic supplement you’ve been looking for? Let’s find out!

What is Coluracetam?

Coluracetam (2-(2-oxypyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro(2,3-b)quinolin-4-yl)acetoamide), also known by its chemical name MKC-231 or BCI-540, is a fat-soluble nootropic drug that was patented in 2005 by a company in Japan called Mitsubishi Tanabe Pharma.

Coluracetam stands out within the racetam drug family due to its unique mechanism of action, primarily targeting high-affinity choline uptake (HACU).

It is a relatively new entrant in the world of cognitive-enhancing substances. Like other racetams, Coluracetam is primarily known for its cognitive and memory-enhancing effects. However, racetams like this nootropic drug are not yet approved by the FDA (U.S. Food and Drug Administration) for human consumption.

Taking Coluracetam boosts your neurotransmitter levels, leading to better decision-making and increased cognitive performance, learning capacity, and memory.(1) Additionally, this brain activity leads to reduced brain fog and a better mood, with fewer symptoms of anxiety and depression for people with major depressive disorder.

There is limited research and therefore limited evidence of Coluracetam’s effects, making it tricky for consumers to find available data. This novel high-affinity choline uptake enhancer has fewer human and animal studies compared to well-established racetam compounds like piracetam, aniracetam, or oxiracetam.

However, anecdotal reports support Coluracetam’s effects, with satisfied users worldwide stating they are pleased with its cognitive-enhancing effects. 


  • Improves mental performance by enhancing memory, focus, and learning capacity
  • Neuroprotective effects that aid in the prevention of cognitive decline
  • Improves mood and alleviates symptoms of anxiety and depression


  • More clinical trials and human studies needed to further understand the long-term safety profile
  • Not approved by the FDA

Mechanism of Action

Coluracetam’s mechanism of action primarily revolves around its influence on acetylcholine (ACH) synthesis and related neural processes that lead to positive effects.(2)

Here’s an in-depth look into how it interacts with various neurochemical systems:

  • High-Affinity Choline Uptake (HACU) Enhancement: Coluracetam works primarily by enhancing the high-affinity choline uptake (HACU) process. HACU is the rate-limiting step in acetylcholine synthesis. By boosting the efficiency of this process, Coluracetam improves choline uptake into neurons.
  • Impact on Cholinergic Neurons: The enhanced HACU directly affects cholinergic neurons, which are neurons that primarily use acetylcholine as a neurotransmitter. By ensuring a more efficient supply of choline, Coluracetam supports the therapeutic health and function of these neurons.
  • Influence on AMPA Receptors: Coluracetam interacts with AMPA receptors, which are involved in fast synaptic transmission in the central nervous system. AMPA receptors play a critical role in synaptic plasticity and are central to processes like learning and memory. By modulating these receptors, Coluracetam is effective at enhancing cognitive processes.
  • Interaction with Glutamate and GABA Systems: Although less emphasized, coluracetam might also have some interplay with the glutamate and GABA (gamma-aminobutyric acid) systems. Glutamate is the main excitatory neurotransmitter in the brain, while GABA is the main inhibitory neurotransmitter. The balance between these two is crucial for healthy brain function. Coluracetam treatment may also indirectly affect this balance through its primary action on acetylcholine synthesis, thereby influencing overall neural production, excitability, and mood.
  • Boosting Acetylcholine Levels: The effects of Coluracetam and its mechanism is the boosting of acetylcholine levels in the brain through choline transporters. This increase leads to improved cognitive function, memory enhancement, and better mood regulation.

Nootropic Benefits of Coluracetam

While more research is needed to fully understand the full spectrum of Coluracetam’s benefits, preliminary studies, and user reports suggest several potential benefits of this smart drug. Let’s cover some of the Coluracetam benefits for nootropic enthusiasts.

1. Improves Memory Function

Coluracetam nootropic powder significantly increases memory function, aiding in both the formation of new memories and the retrieval of existing ones. This is particularly relevant in the context of learning.

2. Enhancement of Learning Function

Associated with improved choline uptake in neurons, Coluracetam supplementation supports and enhances learning function, allowing for faster information processing.(3)

3. Positive Effects on Mood

Some evidence from clinical studies suggests this choline-targeting supplement is useful in treating major depressive disorder, acting as a mood enhancer or stabilizer.(4)

4. Neuroprotection

Some studies have shown that nootropic agents like Coluracetam prevent cognitive decline by protecting neurons from oxidative stress.(5)

Additionally, although still in the realm of theory and preliminary research, Coluracetam’s impact on memory and cognitive function suggests potential as a treatment or a supplementary therapy in conditions like Alzheimer’s disease.

5. Stimulant-Free Cognitive Boost

Unlike traditional stimulants, Coluracetam enhances cognition without the typical stimulant effects, making it a preferable option for those sensitive to stimulants.

Clinical research on Coluracetam using mice highlights its therapeutic effects that ease anxiety whilst also boosting cognitive performance.(6)

Uses of Coluracetam

There are several potential ways to benefit from the use of Coluracetam, mainly revolving around cognitive enhancement and mood regulation, such as:

  1. Cognitive Enhancement: Used to improve overall cognitive abilities, including memory, focus, and mental clarity.
  2. Improving Memory: Coluracetam is able to significantly increase your ability to form new memories whilst simultaneously increasing recall abilities.
  3. Learning Enhancement: Beneficial nootropic effects that enhance learning efficiency and the ability to process and retain new information through increased neuron activity.
  4. Mood Regulation: Some evidence suggests it could help in managing mood disorders, potentially beneficial for those with mild depression or anxiety.
  5. Vision Improvement: Anecdotal reports indicate that it might enhance visual perception, though this has not been extensively studied.
  6. Neuroprotection: Like other racetams, Coluracetam may offer neuroprotective benefits, potentially useful in age-related cognitive decline or neurodegenerative diseases.
  7. Treatment of Major Depressive Disorder: Investigated for its ability to treat major depressive disorder, especially in cases where conventional treatments are ineffective.

Where to Buy Coluracetam

Finding quality material online can be tricky in general, let alone when it comes to finding effective nootropics. 

However, through our in-depth research and testing, we have found a go-to for all nootropic enthusiasts looking for the best racetam products.

Simply place your order on, go to the secure online payment portal, and enjoy worldwide shipping to your door!

These nootropic compounds are third-party tested to ensure efficiency and safety, and there is a return-or-exchange policy available for 30 days after receiving your purchase.

Coluracetam Dosage

When it comes to the dosage of Coluracetam as a choline-targeting supplement, there isn’t a one-size-fits-all recommendation per day, as it largely depends on individual tolerance and the desired effects

However, a common starting point observed in clinical research done on animals and anecdotal reports is a dose ranging from 20 mg to 80 mg daily.

This dosage is usually divided into two or three administrations throughout the day.

Coluracetam Side Effects & Safety

As with many nootropics, the side effects of Coluracetam are not thoroughly documented, primarily due to the lack of extensive human studies.

Some users report mild side effects, such as:

  • Headache
  • Fatigue
  • Nausea

These symptoms are usually short-lived and disappear once your body adjusts to the daily dosage of Coluracetam (similar to most racetams). However, given its synthetic nature and potent effect on choline uptake, caution is advised, especially for those with pre-existing health conditions who haven’t tried Coluracetam before. 

Speak with a healthcare professional if you’re looking to benefit from extended usage.


Coluracetam, a synthetic nootropic from the racetam family, shows promise in enhancing cognitive functions through its unique mechanism of action on choline uptake.

While it is available as a supplement, its use should be approached with an understanding of its dosage, potential effects, and the limited nature of current research. 

As always, consulting healthcare professionals before starting any new supplement regimen is advisable.


How long does Coluracetam take to work?

The onset of effects for Coluracetam can vary from person to person. Some users report feeling its effects relatively quickly, within 15-30 minutes after ingestion, while others may take longer, up to an hour or more.

What is the elimination half-life of Coluracetam?

The elimination half-life of Coluracetam is estimated to be relatively short, around 2-3 hours. This means that the compound is metabolized and excreted from the body relatively quickly.

Should you cycle Coluracetam?

For Coluracetam, if you choose to use it, you might consider cycling it to avoid diminishing effects over time. A popular cycle is 2 months on, and 2 weeks off. However, the specific cycling schedule can vary from person to person, and it’s essential to monitor your response and consult with a healthcare professional if needed.

Can I stack Coluracetam with other nootropics?

Some individuals do stack Coluracetam with other nootropics to potentially enhance its effects or achieve a particular cognitive outcome. Some suitable options are piracetam, oxiracetam and aniracetam. Stacking should be done with caution, as interactions between different compounds can be complex. 

How should I store Coluracetam?

To maintain the stability of Coluracetam, it should be stored in a cool, dry place, away from direct sunlight and moisture. Many nootropic compounds are sensitive to environmental conditions, so using an airtight container and keeping it in a dark, dry cabinet is typically recommended.

Sources, Studies, and Scientific Research
  1. Murai, S et al. “MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.” Journal of neural transmission. General section vol. 98,1 (1994): 1-13. doi:10.1007/BF01277590 ↩
  2. Takashina, Ken et al. “MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.” Journal of neural transmission (Vienna, Austria : 1996) vol. 115,7 (2008): 1037-46. doi:10.1007/s00702-008-0049-0 ↩
  3. Bessho, T et al. “Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats.” Arzneimittel-Forschung vol. 46,4 (1996): 369-73. ↩
  4. Machado-Vieira, Rodrigo et al. “New targets for rapid antidepressant action.” Progress in neurobiology vol. 152 (2017): 21-37. doi:10.1016/j.pneurobio.2015.12.001 ↩
  5. Taupin, Philippe. “Nootropic agents stimulate neurogenesis. Brain Cells, Inc.: WO2007104035.” Expert opinion on therapeutic patents vol. 19,5 (2009): 727-30. doi:10.1517/13543770902721303 ↩
  6. Bessho, Tomoko et al. “MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.” Journal of neural transmission (Vienna, Austria : 1996) vol. 115,7 (2008): 1019-25. doi:10.1007/s00702-008-0053-4 ↩