Coluracetam Review: Benefits, Side Effects, Dosage & Where to Buy

Supplements have positive effects and benefits on people. Although there other several other reasons for its use and purposes, most users aim to have a combination of a healthy body and better cognition.

Racetams are the most commonly known memory enhancer. And this is the purpose of Coluracetam.

But does it have enough evidence for its claim that it is a novel high-affinity choline uptake enhancer?

Our Coluracetam review will answer this question by digging into the nootropic’s effectiveness, uses, safety, and more.

What Is Coluracetam?

coluracetam or bc 540 structure

Coluracetam (MKC 231 or n 2,3 dimethyl 5,6,7,8 tetrahydrofuro 2,3 b quinolin 4 yl )-2-(2-oxopyrrolidin-1-yl)acetamide [R] might be less popular than Piracetam, Phenylpiracetam and Aniracetam. But it's nonetheless a potent nootropic for boosting memory and cognitive functions.

The substance is part of the Racetam family, whose mechanism includes the reduction of cognitive decline such as Alzheimer's disease, depression, and anxiety disorder.

MKC 231 or 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide, a choline uptake enhancer, is used as a supplementation for people who suffer memory deficits, brain fog, and memory loss.

The high-affinity choline uptake HACU is the rate-limiting step of acetylcholine synthesis. MKC 231, a choline uptake enhancer ameliorates working memory deficits and decreases hippocampal acetylcholine induced by ethylcholine aziridinium ion in af64a treated rats.

Coluracetam's process in the body may result in long-lasting cognitive improvement.

In a study conducted by Mitsubishi Tanabe Pharma Corporation in 2005, the drug didn't yield the desired results in clinical trials, but it did show great potential for boosting brain function.

Later, the companyBrainCells Inc. began testing Coluracetam for Major Depressive Disorder (MDD) treatment. It conducted further human trials and discovered that the compound might be similar to other antidepressants, as stated in research articles.

In the journal of neural transmission, subsequent clinical trials showed enormous potential for using Coluracetam as a medication for the said conditions.

Imageproduct
NameColuracetam
ClassNootropic
EffectsImproves memory, increase the activity of acetylcholine in the brain
Potential Side EffectsHeadache
Half-Life3 - 6 hours
Common Dosage5 - 20 mg daily
Content1 g
Price$14.99
Money Back Guarantee30 days
Rating⭐⭐⭐⭐⭐ 4.8/5
Best VendorClick Here ›

Sadly, BrainCells Inc. discontinued trials. Nonetheless, you can buy Coluracetam powder or capsule in the US as an over-the-counter dietary supplement to improve mood, motivation and enhance vision.

coluracetam review

Effects & Benefits

The effects of Coluracetam are very similar to the structure of Noopept. Like Piracetam and Aniracetam, the drug increases cholinergic effects, triggering the neurotransmitter acetylcholine (ACh).

But unlike other Racetam substances that trigger ACh production by stimulating specific receptors, the synthesis of ingredients found in the Coluracetam works by increasing HACU (high-affinity choline uptake). The Japanese journal of pharmacology researchers explained that the HACU system determines the speed at which neurons convert choline into acetylcholine.

Here are the benefits.

Boosted Memory and Learning

Several studies indicate that it improves memory and cognitive function in rats or mice. Anecdotal evidence suggests that the drug boosts choline uptake, enhancing memory and learning.

Heightening Vision

Here's something that not many foods, supplements, and other nootropics can do. Users claim that Coluracetam boosts their vision, including shape recognition, color identification, and visual vividness.‍

May Help with Mental Disabilities

Coluracetam boosts the learning ability of people with Alzheimer's disease and other mental disabilities. Since schizophrenia impedes the production of ACh, it will help balance the production of this essential brain chemical.

Alleviating Depression and Anxiety

The BrainCells Inc. human clinical trials involving using Coluracetam to treat depression and anxiety were promising.

References describe the Coluracetam supplement as a mood booster that alleviates depression and anxiety. But some say it actually triggers depression and anxiety.‍

Dosage

Because the Food and Drugs Administration (FDA) doesn't regulate this product, there are no official guidelines regarding the amounts of supplementation.

Nonetheless, based on users' experiences, the solubility of Coluracetam's active quantity range seems to be between 5-20 mg dose. People who have MDD and depressive symptoms may require larger doses of up to 100 mg 3 times per day.

Side Effects

No mice, other animals, or human studies on Coluracetam indicate any adverse side effects from using the drug. But like every other substance, an increased dose may hinder improvement in the treatment of Alzheimer's disease and pose some risks.

People who abuse it in high doses are likely to experience headaches, which isn't unusual with Racetams. Changes in sleep patterns resulting in insomnia may also be experienced.

Patients who are into Coluracetam medications may also have their social interactions affected despite having increased concentration level.

Some users also report experiencing intermittent nausea and grogginess during the day. Please consult your doctor to know more about its dose, treatment, and side effects.

Experiences Shared on Reddit

Here's feedback from real people on Reddit after trying Coluracetam:

According to SunFlesh:

"The anxiolytic effects are great, also a very nice mood enhancer. And I noticed it significantly improved my vision, my short and long term memory, and even improved my verbal fluency…."

According to proxwell:

"I haven't noticed a tolerance building, and the effects are pretty consistent. I find it's most noticeable in visual and spatial memory and creativity... I'm usually using it alongside various other racetams…."

Coluracetam Stacks

Get better results from Coluracetam (MKC 231) by stacking it with other supplements.

Like other brain-boosting supplements, it becomes more potent when you stack it with other compounds that increase choline levels.

It stacks well with choline supplements like Alpha GPC. Stacking it with choline will minimize the risk of experiencing side effects and also boost the memory and cognitive enhancement benefits of the Coluracetam.

Where to Buy Coluracetam?

You can buy the best Coluracetam (MKC 231) powder online from several vendors. The product may come from California or resellers. To know more information, you can chat the customer service section. But if you want a safe product for the treatment of major depressive disorders or memory enhancement, buy Coluracetam from a reputable vendor with a track record for selling genuine nootropics like Science.bio.

Conclusion

Coluracetam's clinical trials on rats and humans may not be enough treatment for memory loss and anxiety disorder. But with proper dosing, improved concentration, focus, and alertness are effects that you and your family will surely benefit from.

But remember that people experience nootropics differently. So, while others may use Coluracetam to help with anxiety and depression, it may not do the same for you. But at the very least, it should improve your memory and learning.