Emoxypine: Review of Nootropic Benefits, Dosage, & Side Effects

Updated on May 28, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

In this Emoxypine review, we'll take an in-depth look at what this popular nootropic is. We'll also go over how Emoxypine works in the brain and provide information about its benefits, side effects, and where to buy it online.

Emoxypine is used as a cognitive enhancer to improve focus and reduce anxiety. But it is generally a go-to supplement to enhance and stabilize mood.

If you are experiencing these problems, should you give it a try? Let's find out.

Emoxypine Review Summary

Emoxypine, also known as Mexidol or Mexifin, is a nootropic drug with antioxidant and actoprotective properties. It has been studied for its potential cognitive benefits, such as improving sleep-wake cycles and enhancing cognitive function.

Emoxypine is generally well-tolerated and rarely causes serious side effects, though common side effects may include nausea, dry mouth, and allergic reactions.


  • It has anxiolytic effects
  • Reduces stress
  • Anticonvulsant
  • It has neuroprotective qualities and anti-inflammatory action


  • Hard to find high-quality Emoxypine online

What Is Emoxypine?

Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine), also known as Mexidol or Mexifin when used as the succinate salt, is a synthetic antioxidant actoprotector. It is derived from pyridoxine (Vitamin B6) and has a similar chemical structure.

emoxyprine information

Emoxypine is used for its cognitive enhancing effects and ability to protect against oxidative stress (OS). It has been shown to have anti-anxiety, neuroprotective, and anti-inflammatory properties and is available in capsule form and as a powder.

It was first synthesized by L.D. Smirnov and K.M. Dumayevy in the 1970s, and it is widely used in Russia as a prescription drug for neurological disorders. Emoxypine has been studied extensively in Russia, particularly as an antidepressant and anti-anxiolytic.(1)

How Does Emoxypine Work In The Brain?

Emoxypine possesses remarkable protective qualities, intercepting peroxide and hydroxyl radicals before they can cause harm to cell membranes. In effect, it guards against the free radical oxidation of biomembrane lipids - a process that could otherwise spell disaster for healthy cells.

By stimulating the activity of antioxidant enzymes like superoxide dismutase, Emoxypine has been found to profoundly impact lipid peroxidation and oxygen forms, which can cause cellular damage.

Emoxypine also modulates the activity of membrane-bound enzymes like phosphodiesterase, cyclic nucleotides, adenylate cyclase, aldose reductase, and acetylcholinesterase (AChE). It even modulates receptor complexes of brain membranes, such as benzodiazepine, GABA, and acetylcholine receptors (ACh), by increasing their binding ability.

Moreover, Emoxypine stabilizes biomembranes such as membrane structures of blood cells - erythrocytes and thrombocytes during stress conditions. It increases the content of the polar fraction of lipids (phosphatidyl serine and phosphatidyl inositol) while reducing the cholesterol/phospholipids ratio, which proves its lipid-regulatory properties.

It shifts structure transition into low-temperature zones that provoke the reduction of membrane viscosity and increase its fluidity while increasing the lipid-protein ratio.

Emoxypine plays a vital role in maintaining healthy biochemical pathways by inhibiting free radicals, modulating the production of prostacyclin and thromboxane A2, and blocking leukotriene formation. In effect, it helps keep our systems running smoothly.(2)

This mechanism of action makes Emoxypine a promising drug in treating cognitive diseases such as Alzheimer’s and brain injuries.(3)

What Is Emoxypine Used For?

Emoxypine is primarily used as an anxiolytic and anti-stress medication, mostly in the form of oral tablets. It reduces anxiety and improves cognitive performance in patients suffering from stress and neurosis.

emoxyprine benefits

Clinical studies have been conducted to assess the efficacy and safety of Emoxypine for treating anxiety disorders and found it to have remarkable effects in treating anxiety disorders-(4)

According to Larentsova, L I et al., Emoxypine produced emotional stabilization among 30 patients with a 2-year-old history of chronic trauma – 21 cases to be precise– whose initial level of anxiety was significantly reduced after only several weeks' worth of application.

Emoxypine is also believed to have neuroprotective and anti-inflammatory properties, which makes it an effective treatment for various neurodegenerative diseases such as Alzheimer's disease.

Studies suggest that long-term use of Emoxypine can help improve cognitive functions in Alzheimer’s patients. However, further research is still needed to back these claims up.(5)

In addition, Emoxypine has been used off-label for treating chronic pain conditions such as fibromyalgia and reducing fatigue associated with chronic fatigue syndrome. However, these uses of Emoxypine lack sufficient evidence from clinical trials to determine its effectiveness in treating these conditions.

Lastly, Emoxypine has also been studied for its potential application in treating cardiovascular diseases such as cardiosclerosis.(6)

In the study, Emoxypine showed remarkable antianginal and antiischemic effects, significantly reducing clinical symptomatology. The study's results further emphasize how regular use of Emoxypine can improve cardiological status in patients.

What Are The Benefits Of Emoxypine For Cognition?

Emoxypine is used as a cognitive enhancer to improve focus and mental clarity, reduce fatigue and protect neurons in the brain from damage caused by free radicals.

The primary benefit of taking emoxypine is its nootropic effects, which can help promote greater concentration levels and improved learning and memory. Other potential benefits include:

  • Neuroprotective effects
  • Antiamnestic effects
  • Antioxidant effects
  • Antihypoxic effects
  • Antiischemic activity
  • Increased energy levels
  • Improved brain blood circulation
  • Anxiety relief and enhanced mental clarity

Where To Buy Emoxypine Online?

If you're looking for a reputable vendor of Emoxypine, Cosmic Nootropic is the best place to buy. Cosmic Nootropic offers high-quality Emoxypine capsules (Mexidol brand) in 125 mg doses.

You can purchase 30 125 mg pills for just $19.50 USD.

They ship worldwide and offer excellent customer service, so you can be sure that your order will arrive safely and on time. The shipping is 2-5 days to the US and costs $6.90 USD.

If you want to get your hands on Emoxypine, you can find it right here:

What Do People Say About Emoxypine On Reddit?

Let's take a closer look at what people are saying about Emoxypine on Reddit.

According to one user:

“I started taking this a few months ago for general brain fog and not being able to keep my attention span long enough to get anything done…it has been amazing. I can focus and I'm more productive throughout my day.”

Another user wrote:

“I've been taking emoxypine for about two months now and I feel like it's really helping with my anxiety, depression, and overall mood. I'm much calmer than before and also more motivated to get things done.”

A user called Curious_cat11 added:

“I've been taking emoxypine for a few months now and I'm really impressed! It has helped reduce my stress at work, given me more clarity of thought, enabled me to stay focused on tasks for longer periods of time and it's also helping me with my sleeping issues. Highly recommend it.”

It's clear from the Reddit comments that Emoxypine can be a powerful tool for improving focus, reducing fatigue and anxiety, and boosting mood.

How Do You Take Emoxypine For Cognitive Enhancement?

Emoxypine is typically taken orally, with or without food, as a pill or tablet. The recommended dosage for cognitive enhancement is taken once or twice daily in the morning and at noon.

It is not necessary to cycle Emoxypine. However, taking breaks from use every few months can be beneficial to avoid tolerance buildup. Taking Emoxypine with food can help reduce gastrointestinal side effects such as nausea and upset stomach.

Emoxypine is typically administered orally in a therapeutic dose of 125-250 mg (1-2 pills) 1-2 times a day, with the maximum daily dose being 800 mg (6 pills). The duration of the standard treatment may vary from 2 to 4 weeks. Some studies have monitored the safety and efficacy levels of Mexidol at a dosage of 500 mg intravenously for 14 days.(7)

It is important to note that while some people on Reddit have reported taking doses of up to 800 mg, this amount is considered excessive and should be avoided.

Overall, it is recommended that individuals consult with their healthcare provider before taking emoxypine to determine what dosage is best for them based on their individual needs and health history.

What Are The Side Effects Of Emoxypine?

Common side effects of Emoxypine include nausea, dry mouth, and allergic reactions. In rare cases, it can cause drowsiness if taken in high doses or combined with other drugs.

Additionally, some studies have suggested that long-term use may lead to suppression of neurological and cognitive functioning due to its central nervous system depressant effects.

It is important to note that these side effects are generally mild and well tolerated when taken as directed.

What Nootropics Are Similar To Emoxypine?

As an anxiolytic, Emoxypine is similar to other nootropics such as Phenibut, L-Theanine, and Kava Kava.

Phenibut is a GABA analog with similar effects to Emoxypine. It's used for cognitive enhancement and reduces stress, anxiety, and insomnia. It also has a higher potential for abuse and addiction than Emoxypine.

L-Theanine, an amino acid found in green tea, has been studied for its cognitive-enhancing effects and ability to reduce stress and anxiety. Unlike Phenibut, it does not have sedative effects or the potential for abuse.

Kava Kava is a plant native to the Pacific Islands which has been used for centuries as an anxiolytic, sedative, and muscle relaxant. It has similar effects on cognition and stress reduction as Emoxypine but carries a higher risk of liver damage if taken in large doses.

What Brain Supplements Can Emoxypine Be Stacked With?

When Emoxypine is used as an anxiolytic, it can be stacked with other nootropics such as Piracetam, Aniracetam, and a choline source such as CDP-Choline.

  • Piracetam is the original nootropic studied for its effects on memory and cognition. It increases the brain's acetylcholine levels (ACh), improving focus and concentration.
  • Aniracetam is another nootropic with anxiolytic properties, which can help reduce stress and anxiety. It also increases acetylcholine levels in the brain, leading to improved cognitive performance.(8)
  • CDP-Choline is a choline source that helps increase acetylcholine levels in the brain, leading to improved cognitive performance.(9)

When taken together, these nootropics can provide a powerful stack that can improve focus and concentration while reducing stress and anxiety.

If you don't want to buy different nootropic ingredients to create your own stack, we highly recommend looking into nootropic blends like NooCube.

NooCube contains a mix of ingredients like Alpha GPC, Huperzine A, and Bacopa Monnieri that work together to support focus, mental clarity, and concentration.

It also contains L-Theanine, which can provide calming effects and help reduce stress, making it the perfect supplement to stack with Emoxypine.

Frequently Asked Questions (FAQ)

Let's look at the most commonly asked questions about Emoxypine.

How Long Does It Take For Emoxypine To Work?

The effects of Emoxypine can be felt within an hour after taking it. However, the full effects may take up to two weeks to become apparent.

How Does Emoxypine Make You Feel?

Emoxypine has anti-stress and anxiolytic effects, which can help improve mood, reduce nervousness, and focus and concentration. It makes you feel relaxed and calm.

Does Emoxypine Interact With Other Medications?

Yes, Emoxypine can interact with other medications like benzodiazepines, neuroleptics, antidepressants, and anti-epileptic drugs. It's important to consult with a healthcare professional before taking Emoxypine if you are already taking any of these medications.

What's The Half-Life Of Emoxypine?

The half-life of Emoxypine is approximately 2-2.5 hours, meaning it will take around 2.5 hours for half of the dose taken to be eliminated from the body.

Is It Safe To Use Emoxypine?

Yes, when taken as directed, Emoxypine is generally considered safe for use. However, it can cause side effects such as dizziness, headache, and sleepiness.


So what do we know about Emoxypine?

Emoxypine is a nootropic used for its anxiolytic and anti-stress effects. It can help reduce stress, improve mood, and increase focus and concentration.

When stacked with other nootropics like Piracetam, Aniracetam, NooCube, or CDP-Choline, it can provide powerful cognitive benefits while still providing calming effects.

The best Emoxypine dose is 125-250 mg, taken twice daily.