Citicoline (Cognizin): Benefits, Dosage & Side Effects

Citicoline is a naturally-occurring brain chemical that can be supplemented to help with cognitive function and brainpower. We take a look at the branded form of citicoline, Cognizin. We look at what benefits it can provide as well as dosage and potential side effects.

Citicoline is a brain-energizer and is linked to multiple cognition-enhancing and neurodegenerative effects in human research. This includes improving focus, information retention, and recall, increasing attention span, and improving overall brain health.

Cognizin is a branded form of the supplement which is tested and can provide your brain with enough nutrition to stay on top of your game. This article explores the naturally occurring nutrient, citicoline, as well as the Cognizin supplement and looks at the benefits, recommended dosage, and potential side effects.

What is Citicoline?

Citicoline (Cognizin)

Citicoline is a naturally occurring nutrient that is found in the brain and helps us stay alert and on top of our game. It also helps us focus and can improve our athletic performance. It’s known as nature’s way of keeping the brain’s energy-producing centers working on all cylinders.

It is a compound that is made up of two substances, cytidine and choline, and these both help with cognitive function and brain health.

As a medicine, it is taken as a supplement by mouth or injection. In Japan and Europe, it was originally prescribed as a memory-enhancing drug to improve thinking skills and brain function in patients recovering from a stroke.

As a drug, it has also been known to improve vision in people with glaucoma, used for Alzheimer’s disease, bipolar disorder, Parkinson’s disease, lazy eye, and a range of other conditions related to the brain.

Citicoline increases a brain chemical called phosphatidylcholine. This brain chemical is important for brain and cognitive function. Citicoline may also be able to increase the amounts of other chemicals that send messages in the brain and this is why it’s so vital in improving overall brain health.

What is Cognizin?

Cognizin is a nootropic that is pure, vegetarian, and allergen-free and will help you keep your mental edge sustainably and safely. It is a superior-quality brand and made with a patented fermentation process which yields a stable water-soluble nootropic.

It is also a stabilized nootropic and as it is pre-hydrated, it avoids the water-absorbing challenges that are associated with conventional citicoline. This enhances its stability and a wider range of delivery methods. It also means a longer shelf life.

Cognizin is a highly crystalline form of citicoline which ranges from 10% to 12% water by weight. Conventional citicoline is no more than 5% water by weight and is therefore highly susceptible to humidity, unlike Cognizin.

Cognizin was designed to help you stay focused and engaged and boost brain power all in one easy dietary supplement. Tested for efficiency, Cognizin is a brand of citicoline which enhances communication between neurons, protects neural structures, and supports overall brain health and energy.

It provided vital nutrients to help the brain generate electrical impulses and care for healthy brain cells. It also helps to maintain normal levels of acetylcholine which regulates cognitive function and it also supports the healthy mitochondria activity which is required for mental alertness.

The development of the branded supplement has improved how athletes can optimize their focus levels and athletes at all levels can keep endurance levels up and increase their concentration on difficult training programs and competitions.

Cognizin can increase membrane turnover and increase energy utilization which restores brain energy and allows athletes to perform to the best of their ability.

What are the Benefits and Effects of Citicoline (Cognizin)?

Citicoline (Cognizin) promises maximum mental sharpness and can open up a whole range of brain-boosting benefits.

Boosts Brain Power

As a form of Citicoline, Cognizin promotes the production of phospholipids. This is important for brain function as phospholipids makeup around 30% of brain tissue, aid neural communication, and protect neurons in the brain. It can also improve the brain’s physiological activity.

Research also shows it can increase brain energy and activity by increasing the formation of brain membranes and restoring brain energy by up to 13.6%. Cognizin energizes brain cells for peak performance without the crash of stimulants. Research also shows it can accelerate cell membrane formation by 26%.

Therefore, Cognizin optimizes brainpower at a cellular level and nourishes the brain with neuro-nutrients. This helps with brain metabolism, repair, maintenance, and regeneration to keep your cognitive abilities active.

Cognizin is a citicoline that can optimize brain cells’ mitochondria and this is what provides a healthy energy metabolism.

Keeps You Sharp and Focused

Cognizin can help you feel mentally alert and sharp as the brain is such a vital part of any task or workout. To feel focused and stay sharp, your brain needs a constant supply of energy and healthy communication between neurons. Cognizin can support brain metabolisms and protect neural structures from toxic radical damage.

Like many other nootropics, Cognizin supplies antioxidant activity which helps neutralize brain-cell damaging effects, whilst also adding a level of neuroprotective activity.

As it also stimulates the synthesis of phosphatidylcholine, this also helps to strengthen the brain cell membranes and enhance neural repairs.

Helps with Cognitive Decline

Citicoline helps form acetylcholine which is an executive neurotransmitter in the brain. This neurotransmitter can help with the function of working memory, information processing, learning, muscle contraction, and speech.

Acetylcholine levels decrease with age and when these levels are low, brain degeneration kicks in. Research suggests that citicoline supplements such as Cognizin and therapy might help with cognitive decline related to age.

Citicoline might also support the production of dopamine and norepinephrine and these are associated with more immediate effects for mood and performance-driven cognition.

Improves Motor Speed

Cognizin can enhance mind-muscle connection and improve motor speed. In one study, researchers found that attention and psychomotor speed increased and impulsivity decreased significantly after taking 250mg or 500mg of Cognizin over 28 days.

Improves Vision and Eye Health

Cognizin has been used in eye health applications and vision supplements. Based on research, its enhancement of phospholipid synthesis might have a neuroprotective effect used to support retinal cells. It can also promote dopamine, which is a neurotransmitter that helps with the signaling in the retina and optical pathways.

Stimulant-Free and 100% Pure

Cognizin helps to improve focus and increase attention span without the added jitters that sometimes come as a side effect of other stimulants. Cognizin doesn’t contain any caffeine or other stimulants which can lead to added and unwanted physical side effects.

Cognizin is caffeine-free yet still provides enough energy to give you that mental and physical boost which adds to mental clarity and improves overall focus.

Cognizin is also made by fermentation which is a natural process and therefore is vegetarian, allergen-free, and does not contain any additives or preservatives.


Cognizin is found in the form of a capsule as well as in complex and single-ingredient supplements.

Typically, 250-500mg of Cognizin has been studied in clinical trials and a dosage between these two numbers is said to be effective at boosting brain power whilst also being safe and well-tolerated by most users. However, research also suggests that as little as 50mg to 100mg of the supplement can improve memory, boost cognitive function and improve information-processing speeds.

For serious cases of cognitive decline, however, a higher dosage of around 500-2000 mg of citicoline is recommended.

You should take Cognizin daily to experience the full range of benefits and to permanently increase brain energy levels. It is not only safe to take daily but highly recommended.

What are the Side Effects of Citicoline (Cognizin)?

Cognizin has been clinically tested and few side effects have been reported. However, as with all supplements, these few side effects should be noted and you should monitor them to know when to adjust the dosage or stop taking the supplement. The side effects include:

  • Headache
  • Insomnia
  • Hypotension (Also known as low blood pressure)
  • Restlessness
  • Tachycardia (A heart rhythm disorder with heartbeats faster than normal, usually this means greater than 100 beats per minute)
  • Bradycardia (When your heartbeat drops to below 60 beats per minute)
  • Gastrointestinal Ailments

Citicoline Reviews Shared on Reddit

Here are some reviews of Citicoline supplements from users and contributors on Reddit.

According to ‘okatjapanese’:

‘Have used it for several months and I definitely notice improved cognition. I remember things easier and can put together concepts to make quick decisions. It's all quite great.’

According to ‘Got4ofem’:

‘I took a 2.4 Gram dosage [of citicoline], along with 2.85Grams of Piracetam and 2.8 Grams of Sulbutiamine, and I have to say… I WAS ON FIRE ALL DAY LONG. I mean, wow, how do I explain it… I was really REALLY REALLY REALLY sharp all day long.’

According to ‘aeramor’:

‘I've been taking the Jarrow Formulas Citicoline. 120tabs are reasonably priced and come in 250mg. So far it's my fav choline source (above Alpha GPC which I felt like I still needed to take more of to get the same effect)’

Where to Buy Citicoline?

If you're looking for the best possible quality and price, you should buy Cognizin/Citicoline from Pure Nootropics:

Frequently Asked Questions

Your questions answered.

Is Cognizin Safe?

The safety of Citicoline in supplement form such as Cognizin has been used in studies where participants ingested more than 250–500 mg per day, which is the recommended dosage. Cognizin is also vegetarian and allergen-free and doesn’t produce too many side effects.

How Old Do You Have to Be to Take Cognizin?

The benefits of Cognizin can be felt by people of all ages, helping to improve focus, increase attention span and improve cognitive abilities.

Can I Take Cognizin If I Have a Pre-Existing Health Condition?

There are no known health conditions that preclude taking Cognizin. However, you should double-check with your doctor before you begin taking this supplement as they have full access to your medical records.


Citicoline is a naturally-occurring brain-energizer that is linked to improved cognitive abilities and neurodegenerative effects. It helps to improve focus, retain and recall information, increase attention span and improve overall brain health. Although citicoline is a brain chemical that occurs in the brain, it can be supplemented and Cognizin is a branded form of this supplement.

We recommend Cognizin as a brand as not only is it vegetarian, allergen-free, and does not let your energy levels crash like other stimulants whilst also giving you the jitters, but taking Cognizin will provide your brain with adequate nutrition needed to stay alert and on top of your mental game.

It’s safe, clinically tested, and available to buy online, so why not give it a go, to help clear that brain fog, get that mental clarity back and stay on top of your game!