Panax Ginseng: Review of Nootropic Benefits, Uses, Dosage, & Side Effects

Updated on March 1, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
An article discussing the nootropic benefits, uses, dosage, and side effects of Panax Ginseng.

Welcome to the comprehensive world of Panax Ginseng, a remarkable herb with a storied history in traditional Chinese medicine, now embraced globally for its wide-ranging health benefits.

This article offers a deep dive into the numerous benefits of Ginseng, particularly focusing on its nootropic effects – enhancing cognitive function and mental health.

We’ll explore how ginseng use can lead to improvements in various health conditions, such as lowering blood sugar levels and enhancing mental and physical performance. It also offers treatments for a variety of conditions like erectile dysfunction.

Whether you’re a long-time Ginseng enthusiast or a curious newcomer to the nootropic community, this review promises to enlighten and guide you in harnessing the full potential of this extraordinary herbal remedy today!

What is Panax Ginseng?

Panax ginseng (Panax quinquefolius), often referred to as American ginseng, Korean ginseng, Chinese red ginseng, or Asian Ginseng, is a perennial plant that grows in the mountains of East Asia (namely Korea, China, and Siberia). It should not be confused with other variations of Ginseng that grow in other regions.

Its root extract has been a cornerstone of traditional Chinese medicine (TCM) for centuries, and it’s widely used to promote well-being.

It is renowned not just for its ability to boost the immune system but also for its positive impact on blood sugar levels.

The name “Panax” is derived from the Greek word “panacea,” meaning “all-healing,” which reflects the herb’s long-held reputation as a remedy for a wide range of ailments.

The key active ingredients of Panax ginseng are called ginsenosides, a group of saponins believed to be responsible for most of its medicinal properties.

Panax ginseng has been used for thousands of years to help improve overall health. It is often considered an adaptogen, a natural substance thought to help the body resist different types of stress, whether physical, chemical, or biological.

It’s traditionally used to enhance stamina and endurance to reduce fatigue. Ginseng also improves mental performance, including memory and concentration.

Panax Ginseng is thought to strengthen the immune system and help reduce the frequency of cold and other infections.

Additionally, it has positive effects on blood pressure and circulation, and some research indicates it might improve sexual function in men.


  • Enhances cognitive function to improve memory, concentration, and mental stamina
  • Adaptogenic qualities that reduce high blood pressure and stress levels
  • Improves immune function to promote overall well-being
  • Promotes hormonal balance and libido


  • Not approved by regulatory bodies such as the FDA (Food and Drug Administration)
  • Lack of clinical studies to determine long-term safety profile

Mechanism of Action

The mechanism of action and pharmacology of Panax Ginseng is complex and involves multiple pathways and systems within the body.(1)

The primary active compounds in ginseng are ginsenosides, a diverse group of steroidal saponins that are thought to be responsible for most of its pharmacological effects.(2)

Here’s an overview of how these ginsenosides and other components of Panax Ginseng interact with the body:

  1. Effect on the Central Nervous System: Ginseng is believed to influence the central nervous system by modulating neurotransmitters, which are chemicals that transmit messages between nerve cells. It may enhance brain functions like memory, concentration, and mood by affecting neurotransmitters such as dopamine, serotonin, and norepinephrine.
  2. Immune System Modulation: Ginseng can modulate the immune system. It enhances the activity of immune cells, like natural killer cells and macrophages, and influences the production of cytokines, which are substances secreted by immune cells that help mediate and regulate immunity and inflammation.
  3. Antioxidant Properties: Ginsenosides have been shown to have antioxidant properties, meaning they neutralize harmful free radicals in the body. This means Ginseng supplementation helps reduce oxidative stress, which is linked to various chronic diseases and aging.
  4. Effects on Blood Sugar Regulation: Ginseng can influence insulin production and improve insulin sensitivity. It helps in the regulation of blood sugar levels, which is particularly beneficial for people with diabetes or those at risk of developing diabetes.
  5. Cardiovascular Effects: Ginseng benefits heart health by improving circulation and blood vessel health. It can help regulate blood pressure and has been shown to have a cholesterol-lowering effect.
  6. Hormonal Effects: Ginseng has an impact on the body’s hormonal balance. It might have adaptogenic properties, helping the body adapt to stress, and can influence the hypothalamic-pituitary-adrenal axis, which is the central stress response system.
  7. Anti-inflammatory Effects: Some ginsenosides have been found to have anti-inflammatory properties, which are beneficial in reducing inflammation-related symptoms in various conditions.
  8. Effect on Sexual Function: In the context of sexual health, particularly erectile dysfunction, ginseng’s mechanisms involve nitric oxide synthesis in the endothelium of blood vessels, leading to improved blood flow.

In terms of specific brain regions and neurotransmitters that Panax Ginseng has been found to affect:

  • The prefrontal cortex: Panax Ginseng has been shown to increase activity in the prefrontal cortex, which is involved in executive function, working memory, and decision-making.
  • The hippocampus: Panax Ginseng has been found to increase neurogenesis in the hippocampus, which is important for learning and memory. The hippocampus is also involved in memory formation and retrieval.(3)
  • Acetylcholine: Panax ginseng has been shown to increase the activity of the cholinergic system, which is involved in learning and memory.(4)

Nootropic Benefits of Panax Ginseng

Panax Ginseng is increasingly recognized for its nootropic benefits, which refer to its potential to improve various aspects of cognitive function and brain health.

Here’s a closer look at the primary nootropic benefits of Ginseng.

1. Enhanced Memory and Cognitive Performance

Ginseng is known to improve aspects of cognitive function, such as memory, concentration, and learning. This is particularly beneficial for both healthy individuals and those experiencing cognitive decline.(5)

2. Increased Mental Energy and Alertness

Due to its adaptogenic properties, Panax Ginseng combats fatigue and enhances mental energy, leading to increased alertness and improved ability to handle mental tasks.

3. Stress Reduction

Ginseng may help reduce stress levels by modulating the body’s stress response. This can lead to improved mental clarity and a more balanced mood.(6)

4. Improved Mood

Regular consumption of ginseng can have a positive effect on mood, helping to alleviate symptoms of depression and anxiety.

5. Neuroprotective Effects

Ginsenosides in Panax Ginseng exhibit neuroprotective properties, potentially safeguarding the brain from various types of neuronal damage and reducing the risk of degenerative brain diseases.(7)

6. Enhanced Brain Function in the Elderly

Research suggests that Ginseng is particularly beneficial for the elderly, improving cognitive functions and potentially slowing the progression of diseases like Alzheimer’s.(8)

7. Improved Reaction Time

Some studies indicate that Ginseng improves reaction time and psychomotor performance, making it a valuable supplement for situations requiring quick reflexes and decision-making.(9)

8. Reduction in Mental Fatigue

Ginseng helps reduce mental fatigue, particularly in individuals performing demanding cognitive tasks over extended periods.(10)

Uses of Panax Ginseng

Panax ginseng is renowned for its numerous health benefits. It’s a plant whose root is highly valued in traditional medicine.

You might find it intriguing how diverse the uses of this single herb can be!

Here are some key ways you may benefit from incorporating Panax ginseng into your routine:

  1. Boosting Energy Levels: Ginseng may help fight fatigue and promote energy.
  2. Enhancing Cognitive Function: Some individuals use ginseng to enhance brain functions like memory, behavior, and mood.
  3. Immune System Support: Regular consumption could strengthen your immune system.
  4. Managing Erectile Dysfunction: Ginseng has shown promise in helping manage erectile dysfunction (ED).
  5. Antioxidant Effects: The herb offers antioxidant properties that protect cells from damage.

Where to Buy Panax Ginseng

The next step is figuring out where to purchase this potent herb. You want a source that’s both reliable and provides high-quality products.

One trusted supplier that stands out is LiftMode. They offer a range of supplements, including Panax ginseng in various forms such as powders and extracts. Their commitment to purity means you get a product that’s free from unnecessary additives.

  • LiftMode ensures their Panax ginseng products are lab-tested.
  • They provide certificates of analysis for consumers seeking transparency.
  • Their website facilitates easy shopping with detailed product descriptions.

Choosing LiftMode not only gives you access to quality Panax Ginseng but also customer service that can guide your selection process and provide more information.

If you’re ready to enhance your wellness routine, consider visiting their website and exploring the options available, today!

Panax Ginseng Dosage

When you decide to integrate Panax ginseng into your wellness routine, understanding the right dosage is crucial. The effectiveness of this traditional herb hinges on consuming it in proper amounts.

Here’s what you need to know about dosing Panax ginseng!

Start with a low dose and monitor your body’s response. For most adults, the recommended starting point is between 200 mg to 400 mg daily. This can be taken in capsule or tablet form, or as a liquid extract. Some choose to consume ginseng tea, where one cup typically contains around 1-2 grams of the root.

The standard dose for improving cognitive function and combating fatigue often ranges from 200 mg up to 600 mg daily.

However, these numbers are not set in stone; they vary based on individual factors such as age, health status, and tolerance levels.

For more specific needs like enhancing physical endurance or managing erectile dysfunction (ED), doses may differ:

  • Physical Endurance: Upwards of 2 grams per day, usually taken in divided doses.
  • Erectile Dysfunction: Around 3 grams per day, often split into multiple servings.

Remember that higher doses do not always equate to better results; sometimes less is more.

Give yourself a couple of weeks to get used to Ginseng before increasing your dose to avoid unwanted adverse effects.

Panax Ginseng Side Effects & Safety

While Korean red ginseng treatment is renowned for its health benefits, it’s crucial to be aware of potential side effects. Your body may react differently to this herb, just like any natural supplement.

Most people tolerate Panax Ginseng extract well when taken short-term. However, some users may experience adverse reactions.

Common side effects include:

  • Headaches
  • Sleep problems
  • Digestive issues

These symptoms are typically mild and often resolve without intervention. But if they persist or worsen, consult a healthcare provider.

In rare cases, more serious side effects can occur. These include:

  • Allergic reactions
  • Severe skin rashes
  • Liver damage

If you notice symptoms such as jaundice or severe itching, seek medical attention promptly.

It’s also important to note that Panax ginseng is an effective herbal medicine that can interact with other medications. This could alter the effectiveness of your medication drugs or increase the risk of negative reactions.

Always discuss with your doctor before adding Panax ginseng to your regimen.


As we conclude our exploration of the multifaceted world of Panax Ginseng, it’s clear that this ancient herb is more than just a staple of traditional Chinese medicine. Its remarkable nootropic benefits, ranging from enhanced cognitive function to stress reduction, position it as a valuable ally in our modern, fast-paced lives.

While the allure of its adaptogenic qualities and potential for boosting immune function is undeniable, it’s crucial to approach Ginseng with a balanced perspective. Remember, the journey to wellness is as much about understanding the nuances of herbal supplements as it is about experiencing their benefits.

Now, consider how this could interact with your lifestyle choices and daily routines.

If you lead a busy life or face stressful situations often, incorporating Panax ginseng into your regimen will help mitigate stress effects on your body and mind.

Remember to consult healthcare professionals before starting any new supplement routine, especially if you’re already managing other conditions or medications due to potential interactions.


How long does Panax Ginseng take to work?

Panax Ginseng starts working within 24 hours of ingestion, although it may take up to 48 hours for the full effects to be felt. It is important to note that the effects of Panax Ginseng can vary depending on your condition and the dosage taken.

What is the elimination half-life of Panax Ginseng?

There is no one-size-The half-life of Panax Ginseng varies depending on the type of ginsenoside but generally ranges from 0.2 to 18 hours. Ginsenosides Re and Rg1 have elimination half-lives between 0.7 and 4 hours, while the most abundant and stable ginsenoside, Rb1, has a half-life of 58.47 hours.

Should you cycle Panax Ginseng?

Yes. One reason to cycle Panax Ginseng is to prevent tolerance buildup. When consumed continuously without breaks, your body may become less responsive to the herb’s effects. By cycling—taking it for several weeks then pausing—you give your body time to reset.

Can I stack Panax Ginseng with other nootropics?

Yes. When stacking Panax Ginseng, look for synergistic effects where the combined impact of the substances exceeds their benefits. For instance, some users find that combining panax ginseng with a choline source like Alpha GPC enhances memory recall.

How should I store Panax Ginseng?

To maintain Panax Ginseng’s potency, storage is key. Your ginseng should be kept in a cool, dry place. Direct sunlight and moisture can degrade its quality. Think of your pantry or a cupboard away from heat sources.

Sources, Studies, and Scientific Research
  1. Bell, Lynne et al. “A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action.” European journal of nutrition vol. 61,1 (2022): 413-428. doi:10.1007/s00394-021-02654-5 ↩
  2. Mancuso, Cesare, and Rosaria Santangelo. “Panax ginseng and Panax quinquefolius: From pharmacology to toxicology.” Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol. 107,Pt A (2017): 362-372. doi:10.1016/j.fct.2017.07.019 ↩
  3. Lee, Chang Hwan et al. “Effects of Sun ginseng on memory enhancement and hippocampal neurogenesis.” Phytotherapy research : PTR vol. 27,9 (2013): 1293-9. doi:10.1002/ptr.4873 ↩
  4. Lee, Mi Ra et al. “Chronic dietary ginseng extract administration ameliorates antioxidant and cholinergic systems in the brains of aged mice.” Journal of ginseng research vol. 41,4 (2017): 615-619. doi:10.1016/j.jgr.2017.06.002 ↩
  5. Scholey, Andrew et al. “Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study.” Psychopharmacology vol. 212,3 (2010): 345-56. doi:10.1007/s00213-010-1964-y ↩
  6. Lee, Seungyeop, and Dong-Kwon Rhee. “Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis.” Journal of ginseng research vol. 41,4 (2017): 589-594. doi:10.1016/j.jgr.2017.01.010 ↩
  7. Huang, Xing et al. “Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives.” Molecules (Basel, Switzerland) vol. 24,16 2939. 14 Aug. 2019, doi:10.3390/molecules24162939 ↩
  8. Kim, Hyeon-Joong et al. “Panax ginseng as an adjuvant treatment for Alzheimer’s disease.” Journal of ginseng research vol. 42,4 (2018): 401-411. doi:10.1016/j.jgr.2017.12.008 ↩
  9. Bach, Hoang Viet et al. “Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis.” Journal of Korean medical science vol. 31,12 (2016): 1879-1886. doi:10.3346/jkms.2016.31.12.1879 ↩
  10. Arring, Noël M et al. “Ginseng as a Treatment for Fatigue: A Systematic Review.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 24,7 (2018): 624-633. doi:10.1089/acm.2017.0361 ↩