Most Effective Nootropic Stacks: The Top 8 Stacks in 2024

Updated on February 3, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Discover the most effective nootropic stacks for enhanced cognitive function.

Stacking nootropics is a great way to maximize their benefits for your brain. Many of the ingredients complement each other and work in synergy. Whether you want to focus better, learn faster, or improve memory, there are a number of nootropics to choose from.

Each stack, very-well formulated, serves as a unique conduit for your cognitive elevation. For instance, certain blends focus on invigorating neural connections, fostering an environment conducive to synaptic plasticity and mental agility. Others concentrate on sharpening your memory and accelerating thought processes, thereby augmenting your problem-solving skills and processing speed. Additionally, some stacks are designed as sanctuaries for mental tranquility, effectively countering stress and anxiety, thus paving the way for clear, focused cognition.

Individually stacking nootropics can be difficult, which is why we included 8 of the most effective pre-made nootropic stacks for you, also known as nootropic blends. Using pre-made nootropic stacks saves you weeks or months of trial and error you’d have to go through when designing individual stacks as a beginner. However, there are also several options for making your own custom stacks. We’ve highlighted 9 of those.

8 Top Nootropic Stacks on the Market

According to customer reviews and our own research, the 8 most effective nootropics stacks are:

1. Mind Lab Pro

Mind Lab Pro is the top nootropic stack that boosts cognitive functions such as mindset, performance, and memory.

This stack is the top nootropic used to improve memory, focus, recall, mood, motivation, and energy.

Mind Lab Pro promotes blood flow, energy, neuroregeneration, and neuroprotection.

The following are 11 ingredients found in Mind Lab Pro that improve cognitive function:

  • Bacopa Monnieri (Brahmi)
  • Citicoline
  • L Theanine
  • Maritime Pine Bark Extract
  • N-Acetyl L-Tyrosine
  • Organic Lion’s Mane Mushroom
  • Phosphatidylserine
  • Rhodiola Rosea
  • Vitamin B6, B9, B12

Mind Lab Pro’s amino acid benefits dopamine production that affects working memory and mood regulation. Its users claim that they experience minimal to no adverse reactions. It is also not prone to brain fog effects.

Mind Lab Pro is 100% vegan, allergen-free, and caffeine-free. This supplement has facilities that are GMP certified, proving adherence to regulatory procedures and standards.

Many users trust Mind Lab Pro as it is FDA-approved and is safe to use.

2. Vyvamind

Vyvamind is a top nootropic stack that contains L-tyrosine, a precursor to dopamine, a neurotransmitter that controls mood and motivation. It also contains citicoline, a nootropic ingredient that increases levels of acteylcholine in the brain and can lead to faster processing speeds, improved memory, and enhanced cognition. It also contains Vitamins B6 and B12. Vyvamind increases the production of dopamine, a neurotransmitter that increases motivation and improves overall cognitive function. Vyvamind also helps reduce the effects of stress and anxiety.

The ingredients stacked in Vyvamind are not complex and are of high quality. These substances are clinically tested and are effective at improving concentration and focus. The ingredients in this nootropic supplement counteract the negative effects of caffeine and reduce blood pressure. Furthermore, the combination of L-tyrosine and vitamin B12 is also known to lower the risk of heart attacks. Additionally, Vyvamind contains L-theanine, an amino acid that counteracts the adverse effects of caffeine when stacked.

The Vyvamind stack is easy to follow, and the ingredients are all natural and do not contain any synthetic ingredients. It works fast and stays effective even after extended use. The capsules contain less caffeine than one cup of coffee, which is helpful for those who are sensitive to caffeine. Moreover, this stack is safe to consume in low dosages.

3. NooCube

NooCube is the type of nootropic stack that lands first in the list of students and professionals who require sharp memory, focus, and critical thinking.

This popular brain supplement is safe to use as your daily most effective nootropic stack and is sure to fit your budget.

NooCube is one of the memory supplements that take effect after 30 to 45 minutes of intake. Its effects last up to 8 to 10 hours, allowing the user to multitask and experience a state of mental clarity.

NooCube’s seven powerful stacked ingredients are:

  • Alpha GPC
  • Bacopa Monnieri (Brahmi)
  • Cat’s Claw
  • Huperzine A
  • L Theanine
  • L-Tyrosine
  • Oat Straw

Stacking these ingredients plus DHA, a type of omega 3 fatty acids, also promotes better learning, nerve growth, and anti-aging effects.

4. Performance Lab Mind

This supplement is not like most nootropic stacks. Performance Lab not only enhances cognition but also offers other brain benefits.

The unique benefit of Performance Lab is its ability to help one recover from intense mental exertion. Users are less likely to feel burnout from using too much brainpower.

This stack also optimizes the brain’s energy up to 13.6% and promotes speed, memory, motivation, and alertness.

The nootropic ingredients available in this stack are:

  • Phosphatidylserine
  • Maritime Pine Bark Extract
  • L-Tyrosine
  • Cognizin (Citicoline)

These ingredients promote brain health through blood circulation support, brain cell formulation, and prevention against age-related brain issues.

5. Qualia Mind

Qualia Mind is a fast-acting nootropic supplement stack that improves a person’s willpower and ability to focus.

Qualia Mind has 28 ingredients with known benefits: energy enhancement, creativity, concentration, clarity, and memory improvement.

Qualia Mind stacks the most number of amino acids, minerals, and antioxidants than other nootropic stacks.

Most of its ingredients are:

  • Acetyl-L-Carnitine HCL
  • Alpha-GPC
  • Artichoke leaf extract
  • Bacopa monnieri extract
  • Celastrus paniculatus seed extract
  • Citicoline
  • Coffeeberry WCFE
  • Coleus forskohlii root extract
  • DHA
  • DL-Phenylalanine
  • Ginkgo biloba leaf extract
  • Huperzina serrata leaf extract
  • L-Theanine
  • Mucuna pruriens
  • N-Acetyl-L-Tyrosine
  • Phosphatidylserine
  • Pyrroloquinoline quinone
  • Rhodiola Rosea extract
  • Taurine
  • Theobromine
  • Uridine-5-Monophosphate heptahydrate disodium
  • Vitamin C

This composition also enhances brain nutrition and fights procrastination.

6. Brain Pill

Brain Pill nootropics stack is known for its long term benefit of clarity and productivity. This smart drug specifically improves attention, short-term memory, and mental energy.

BrainPill is burnout-resistant through its capacity to lower anxiety, making it well-loved by students and professionals with stressful jobs.

This nootropic stack has 13 ingredients, including various B vitamins and others, namely:

  • Vitamin B5
  • Vitamin B6
  • Vitamin B9
  • Vitamin B12
  • Bacopa Monnieri
  • Citicoline
  • DHA Complex
  • Ginkgo Biloba
  • Huperzine A
  • L Theanine
  • Phosphatidylserine
  • Tyrosine
  • Vinpocetine

These components, when combined with caffeine, can give an extra energy boost.

7. Onnit Alpha Brain

If you are caffeine sensitive, Alpha Brain is the most effective nootropics stack for you. It is caffeine-free, dairy, and gluten-free and is consisted of B vitamins and other ingredients:

  • Alpha GPC
  • Bacopa Monnieri Extract
  • Cat’s Claw Extract
  • Huperzia Serrata Extract
  • L-Leucine
  • L-Theanine
  • L-Tyrosine
  • Oat Straw Extract
  • Phosphatidylserine
  • Pterostilbene
  • Vinpocetine
  • Vitamin B6

The Alpha Brain nootropic stack supports memory, recall, and attention. It combats the mental-deteriorating effects of anxiety and stress by improving cognitive processing speed.

It makes a person experience the feeling of being “in the zone.”

8. Hunter Focus

Hunter Focus is one of the premium natural nootropics. This potent nootropic stack promotes concentration, memory, creativity, optimized learning, energy, sharpness, and elevated mood.

Hunter Focus is the best nootropic for those who need to be sharper and more alert. This supplement can improve your problem-solving skills and may help you increase motivation.

This stack is a blend of:

  • Ashwagandha Extract
  • Bacopa monnieri
  • Citicoline
  • Lion’s Mane Mushroom
  • L-Theanine
  • Maritime Pine Bark Extract
  • N-Acetyl-L-Tyrosine
  • Passion Flower
  • Phosphatidylserine

Another advantage Hunter Focus claims to have over the other supplements is that its users can stay calm under pressure. It also has a long-term effect on concentration.

How We Picked these Top-Performing Nootropic Stacks

To find the best nootropic stacks, we employed a comprehensive evaluation process that accounted for effectiveness, ingredient synergy, brand reputation, transparency, manufacturing quality, user experiences, price, and value. We thoroughly examined each of these factors to deliver a credible and well-rounded list of the top stacks.


We studied clinical trials and user reports to gauge the degree of cognitive enhancement, focusing on memory, focus, mental clarity, and mood.

Ingredient Synergy

We scrutinized each stack, prioritizing stacks that combine evidence-backed, natural, and high-quality ingredients that work together for optimal cognitive performance.

Scientific Evidence

We consulted peer-reviewed studies and meta-analyses to validate the effectiveness of key ingredients and their synergistic interactions in nootropic stacks.


We evaluated appropriate dosages and ingredient ratios, ensuring they were consistent with established research for maximum potency.


We confirmed the safety of each ingredient, considering potential side effects, interactions, and compliance with regulatory standards. FDA-approved ingredients are prioritized.

Brand Reputation

We assessed brands’ reliability and trustworthiness using customer reviews, expert recommendations, and company background.

Product Transparency

We emphasized thorough ingredient disclosure, including sources, concentrations, and proprietary blends, to facilitate informed consumer choices.

Manufacturing Process

We investigated manufacturing standards, favoring products produced in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, prioritizing testimonials that highlight cognitive enhancements and improved mental performance.


We weighed product prices, ensuring they were competitive and proportional to the quality and potency of the nootropic stack.


We determined overall value by weighing price, quality, and effectiveness, to ensure the best return on investment for consumers.

Custom Nootropic Stacks..

If you’re an advanced nootropics user and want to create your own custom stacks, this section is for you. We’ve collected the top 9 nootropic stacks that advanced smart drug users love.

1. Most Effective Nootropic Stack for Energy, Focus & Motivation

When it comes to stacking nootropics for increased energy, focus, and motivation, you have several options. Typically, the top stacks include:

  • Caffeine (80-150mg)
  • L-Theanine (150-300mg)
  • L-Tyrosine (300-600mg)
  • Alpha GPC (300-600mg)
  • Uridine (200mg)
  • Sulbutiamine (400-600mg)
  • Phenylpiracetam (100-200mg)

Because phenylpiracetam, caffeine, and sulbutiamine all build tolerance, taking this stack more than once or twice a week will not produce the same results. As a result, rather than making this your “everyday stack,” it makes sense to use it only when absolutely necessary.

2. Most Effective Nootropic Stack for ADHD

A good stack for ADHD resembles a stack for energy and focus. However, we designed the ADHD stack to be more appropriate for daily use. A stack for ADHD might include:

  • L-Tyrosine (500-1,000mg)
  • L-Theanine (100-200mg)
  • Mucuna Pruriens (100-150mg)
  • Citicoline / CDP Choline (200-300mg)
  • Centrophenoxine (250-500mg)
  • Omega 3 Fish Oil (4-6g)
  • Noopept (5-15mg)
  • Theacrine (150mg)

Dynamine, which has a shorter half life than Theacrine, can be used instead. If you think this stack is too weak, try Modafinil or Armodafinil instead of Theacrine. Just remember to take no more than half your usual dose because the Mucuna Pruriens and L-Tyrosine will already significantly increase your dopamine levels.

3. Most Effective Nootropic Stack for Mood, Anxiety & Depression

If you’re looking for the most effective stack to help you reduce anxiety and depression and improve your mood, consider stacking the following nootropics:

  • L-Tyrosine (150mg)
  • L-Theanine (400-600mg)
  • L-Tryptophane (400-800mg)
  • Centrophenoxine (250-400mg)
  • Aniracetam (400-700mg)
  • Picamilon (50-100mg)
  • Selank (400-800mcg)
  • Ashwagandha Extract (500-1,000mg)

4. Most Effective Nootropic Stack for Memory, Learning & Exams

The nootropics listed below can be stacked to improve memory retention and recall, which is useful for taking exams or learning languages:

  • Piracetam (500-800mg)
  • Noopept (10mg)
  • Citicoline / CDP Choline (250-500mg)
  • Lion’s Mane Mushroom Extract (500-1,000mg)
  • Bacopa Monnieri (350-500mg)
  • Ashwagandha Extract (400-800mg)
  • L-Theanine (200-400mg)

5. Most Effective Nootropic Stack for Creativity

There are several effective nootropic stacks for increasing creativity. This is an example of a basic stack that can be used as a starting point:

  • Noopept (10mg)
  • Aniracetam (700mg)
  • Citicoline / CDP Choline (250-400mg)
  • Uridine (300mg)
  • L-Theanine (600mg)

6. Most Effective Nootropic Stack for Cognitive Enhancement

A stack for cognitive enhancement should contain nootropics that increase BDNF and synaptic plasticity. The following compounds can be stacked to enhance cognition and slow down cognitive decline:

  • Alpha GPC (300mg)
  • Uridine (150mg)
  • Lion’s Mane Mushroom Extract (800-1,500mg)
  • Bacopa Monnieri (300-500mg)
  • Phosphatidylserine (100mg)
  • Omega-3 DHA (6g)
  • Semax (400-900mcg)

7. Most Effective Nootropic Stack with Noopept

If you’re looking for something to stack Noopept with, you may try the following stack:

  • Noopept (10-20mg)
  • Centrophenoxine (300-500mg)
  • Huperzine A (5mg)
  • Sulbutiamine (400mg)

8. Most Effective Nootropic Stack with Adderall & Vyvanse

L-Tyrosine, which provides the foundation for dopamine production, should always be included in a good stack to take with Adderall or Vyvanse. While we recommend Vyvamind as a nootropics stack for Adderall and Vyvanse, you could also try the following custom stack:

  • Caffeine (100mg)
  • L-Tyrosine (500-800mg)
  • L-Theanine (200mg)
  • Omega-3 / DHA (4g)
  • Uridine (200mg)
  • CDP Choline (250mg)

9. Most Effective Nootropic Stack with Phenibut

Although Phenibut is quite potent on its own, there are several nootropics that complement it well. A good Phenibut stack might look like this:

  • Phenibut (500-1,000 mg)
  • Picamilon (50mg)
  • L-Theanine (200mg)
  • Dynamine (100mg)

Why do we like to stack nootropics?

Nootropics are often stacked in order to increase the effects of each ingredient. Some of them are known to improve memory, while others are known to boost concentration and focus. Others promote neuron growth and reduce stress and anxiety.

When stacking nootropics, start at the lowest dose and gradually increase the doses until you reach the desired effect.

What are the Benefits of Stacking Nootropics?

Stacking nootropics can be a very beneficial approach to increasing your brain’s power. Some nootropics can even act as an anti-oxidant, while others are thought to help with mood, energy, and focus. You should experiment with different combinations of nootropics to see what works best for you.

Preformulated stacks are a convenient way to start stacking nootropics and can save you time and effort. You can get a mix that includes each ingredient, and they are usually sold in capsule form. While this method is convenient, you should still be careful when selecting the nootropics you want to stack.

Stacking nootropics is a common practice for nootropic enthusiasts. Stacking nootropics allows you to maximize the effects of each individual nootropic supplement. Because nootropics affect different parts of the brain, you can mix different types to get the best effects. For instance, you can combine nootropics that increase memory and attention with ones that lower anxiety.

What are the Drawbacks of Stacking Nootropics?

Stacking nootropics is a great way to improve cognitive performance quickly. However, you may have to experiment with several different combinations in order to find one that works best for you. Moreover, if you’re looking for long-term cognitive benefits, it’s best to try self-experimenting with individual nootropic substances. While stacking is not always wrong, the process is risky and requires trial and error.


Nootropic stacks work by enhancing cognitive performance and memory. These nootropic supplements are specially formulated to provide specific effects. They boost cognition and enhance mood. For this reason, the use of stacks is becoming more popular. In addition, the use of these supplements will improve your concentration.

Mind Lab Pro is the best overall stack out of all those listed. Mind Lab Pro is made with high-quality ingredients and is FDA-approved. It is a “all-around” brain supplement that users rely on for brainpower benefits such as improved memory, recall, energy levels, and other enhanced brain functions.