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Picamilon Review: Effects, Dosage & Where to Buy Powder

Picamilon is a brain-boosting supplement that helps with anxiety attacks, insomnia, and any mood and cognitive dysfunctions.

But if you think it isn’t enough to get you in the positive mood and right mindset, then you might want to try this supplement.

To know more if this brain-boosting supplement is beneficial for you, continue reading this Picamilon review.

What is Picamilon?

Picamilon [R], also known as N-Nicotinoyl-GABA or nicotinoyl-gamma-aminobutyric acid.

It is a synthetic drug combination of GABA (Gamma-aminobutyric acid) and niacin (vitamin B3).

It is a nootropic drug used in alternative medicine to improve brain function.

what is picamilon

Gamma-aminobutyric acid is one of the major inhibitory neurotransmitters in the brain that has complex functions, one of which is its relaxing effects.

Niacin, on the other hand, is a vitamin involved in DNA repair, vasodilation or widening of blood vessels, and fat and cholesterol synthesis.

Some people take a separate niacin dosage for depression.

Picamilon was discovered in Russia in the 1960s and has been sold in the country as a prescription drug for mood disorders, memory improvement, and cognitive degeneration prevention.

Others might wonder if it’s banned in the US. It’s not FDA-approved as a prescription drug in the United States.

It was even ruled out as a dietary supplement in 2015 as the product’s effects and safety do not fit the dietary ingredient categories in the Dietary Supplements Health and Education Act of 1994.

What is Picamilon (Pikatropin) Used for?

Picamilon, which is one of the known GABA-boosting supplements, aids in increasing the acid GABA levels.

The latter is an inhibitory neurotransmitter that slows down excitatory communication between neurons by blocking the activity of Glutamate, the brain’s most abundant primary excitatory neurotransmitter.

Too much Glutamate can cause feelings of anxiety and insomnia; the same happens with having too little Gamma-Aminobutyric Acid in the brain.

To counteract these stimulating health effects, an increase in the acid GABA levels is needed for the calming effects.

The two must be in balance to ensure relaxation and peace of mind. With Picamilon, sleep and good rest are guaranteed.

The inclusion of nicotinic acid in the formula helps improve the cognitive function.

Studies show that niacin enhances cell metabolism and cerebral oxygen supply, resulting in short-term and long-term memory enhancement.

Effects & Benefits

The combination of niacin and gamma-aminobutyric acid in Pikamilon is believed to treat health conditions such as anxiety, depression, migraine, epilepsy, and high blood pressure.

picamilon effects benefits

Some of its notable benefits are:

  1. Cognitive Boost. Studies have shown that the combination of GABA and Niacin affects the neurotransmitter regulation in the brain. This is thought to sharpen memory and protect against Alzheimer’s disease.
  2. Improves cerebral blood flow. Pikamilon has health benefits in regulating blood flow in the brain. The niacin acts as a vasodilator that relaxes blood vessels for freer flow. This protects the neurons against hypoxia, thus improving cognition.
  3. Provides “calm focus”. In a study conducted on patients with Parkinson’s disease, the supplement provides focus without inducing drowsiness. This helps normalize dopamine uptake and serotonin content for a better mood.
  4. Can treat migraines. There is a study published in the Nutrition Journal that reviewed 1990-2004 clinical trials focused on the use of niacin for anxiety, migraines, and other tension-type headaches.
  5. Helps in withdrawal symptoms. In Russia, the use of it is not just for relieving stress and anxiety, but also for helping addicts reduce cravings for substances. The supplement increases the niacin GABA receptors that are essential for recovering alcoholics.

How Does it Work?

A lot of research has been conducted by Russian scientists about cognitive health in the 60s and 70s. Soon after, they continued the research on GABA-derived compounds like Phenibut and Picamilon.

With GABA in its formula, glutamate is kept from overwhelming your brain. Boosting the gamma-aminobutyric acid with dietary supplements will relieve anxiety, restlessness, and stress, which also boosts alpha brain wave production to help you feel focused and relaxed.

When using Picamilon, you don’t just help enhance your cerebral circulation and lower blood pressure, but you also allow GABA to stimulate the pituitary gland to secrete the growth hormone and produce endorphins for a better mood.

However, it does not act as tranquilizer drugs as it does not induce muscle relaxation and lethargy.

How to Make GABA Cross the Blood-Brain Barrier?

Among its claimed benefits, the niacin in the formula helps in vasodilation, while the GABA stimulates brain receptors.

However, the acid GABA is unable to cross the blood-brain barrier which prevents solutes in the circulating blood crossing into the CNS. With these two combinations, Pikamilon is reported to effectively transport GABA into the brain, allowing the formulation to directly affect the cerebral function.

Its ability to readily cross the BBB is due to the niacin promoting vasodilation. Once in the brain, the combined formulation is then broken down into niacin and GABA.

Dosage & How to Take Powder and Capsules

The dosage reported by some clinical trials typically ranges from as little as 2.7 mg to 700 mg daily. Its elimination half-life is 30 minutes.

According to reviews from consumers, dosages can vary from product to product.

Others have said that there is greater efficacy when taken with food for maximum absorption.

However, the validity of these subjective reviews is still not clinically proven. There is no adequate data about its potency and safety.

Side Effects

Since this compound is not yet well-studied, there is no sufficient data to back up the claims of its safety to human users, nor is the frequency of the possible negative side-effects.

Some of the adverse side effects shown are the ff:

  • Headache
  • Dizziness
  • Skin flushing
  • Nausea

Higher doses are said to lower blood pressure, which is health detrimental for those who have hypotension or those on blood-lowering medication.

Experiences Shared on Reddit

To help you decide whether Picamillion is worth the risk and money, you should read the reviews online.

Here are some of the experiences shared by the consumers on Reddit:

From TrippinDannyTanner:

“For me, picamilon is a blessing. I find that it is somewhere between theanine and phenibut in terms of anxiety relief. If theanine is a 1, and phenibut a 10, picamilon is like a 3 or 4, probably 3. I find a sublingual picamilon and coffee combo to blow the theanine/coffee combo out of the water. What I will tend to do is split the dose. I’ll use half of the picamilon orally and the other half sublingual. I have to be honest though, if you are expecting anxiety to melt away, you’ll be disappointed.”

From Postkrunk:

“For me, it helped to keep my mind clear in a pretty stressful situation. The effect is mild and cumulative. So, it’s like you don’t feel its action all the time, but behave more effectively under pressure.”

Where Can I Buy Picamilon Powder and Capsules?

If you want to know where to buy Picamilon locally, there are a lot of companies in Russia who sell this product as prescription drugs. It is also still circulating the market in the United States despite being banned.

If you want to try Picamilon, only purchase from trusted vendors. Several websites offer Picamilon for sale. If you wish to order it online, you should check out the Science.bio website.

You can get the Sodium powder for $49.99.They have independent testing to meet quality standards. They also offer same-day and free shipping for a purchase of $300 on international orders.

Frequently Asked Questions (FAQ)

Find common questions and answers below.

Is Picamilon Legal?

Picamilion is known for its use as a prescription drug on treating depression, anxiety, and stress in Russia. However, this product is not approved as either a prescription drug, over-the-counter drug, or a dietary supplement by the Food Drug administration in the United States.

Its current legal status is questionable, however, there is no doubt that if you search on where to order Picamilon, USA still has vendors selling the supplement even online.

Is Niacin Good for Depression?

Niacin benefits for depression and anxiety prevention as there’s proof that people with this condition may be deficient in B vitamins. So if you are clinically diagnosed with depression, you should discuss taking niacin supplements with your physician.

However, there is currently no evidence that points out niacin to be used as a treatment for depression.

Picamilon vs. Phenibut: Which is Better?

Since the legality of Picamilon in the US is still dubious, there is an alternative product called Phenibut, which is designed to treat depression, anxiety, and sleep disorders.

If you are looking for a supplement to treat your anxiety, you may also want to use Phenibut. But since it is known as a recreational drug, it is subject to abuse.

Please do note that both Phenibut and Picamilon are not FDA-approved in the U.S, though they are easily purchased online. In April 2019, the Food and Drug Administration issued a warning to three companies that are marketing products with Phenibut.

How to Make Your Own Capsules?

Do you want to create your own capsule blends?

As a starter, you have to prepare a capsule machine and a milligram scale.

There are two DIY capsule machines available for personal use. One can cap 50 at a time while the other can cap 24 at a time.

If you are using nootropic powder supplements, it is best to use a milligram scale with 1mg accuracy.

You also need empty gel capsules, powder filler, and your nootropic powder.

Make sure to have these materials on hand if you are considering making your Picamilon.

Conclusion

If you are suffering from anxiety and depression, you might want to consider this supplement to help increase your GABA levels.

However, with the current issue on its legal status as a dietary supplement in the U.S, its safety and effectiveness are still in question with only limited evidence to back the claims up.

For health purposes, seek your trusted doctor to determine which treatment option is effective for you.

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