Picamilon is a brain-boosting supplement that helps with anxiety attacks, insomnia, and any mood and cognitive dysfunctions.
But if you think this smart drug isn't enough to get you in a positive mood, better health, and the right mindset, then you might want to try this product.
To know more if this brain-boosting supplement is beneficial for you, continue reading this Picamilon review.
What is Picamilon?
Picamilon [R] is also known as N-Nicotinoyl-GABA or nicotinoyl-gamma-aminobutyric acid.
It is a synthetic drug combination of GABA (Gamma-aminobutyric acid) and Niacin (vitamin B3).
It is a nootropic drug used in alternative medicine to improve brain function.
GABA is an amino acid and one of the major inhibitory neurotransmitters in the brain with complex functions, one of which is its relaxing effects.
On the other hand, Niacin is a vitamin involved in DNA repair, vasodilation or widening of blood vessels, and fat and cholesterol synthesis.
Some people take a different niacin dosage for depression.
Picamilon was discovered in Russia in the 1960s and sold in the country as a prescription drug for mood disorders, memory improvement, and cognitive degeneration prevention.
|Effects||Improves cerebral blood flow, provides focus, cognitive boost, can treat migraines|
|Potential Side Effects||Headache, dizziness, nausea, skin flushing|
|Common Dosage||2.7 - 700 mg daily|
|Money Back Guarantee||30 days|
|Best Vendor||Click Here ›|
Others might wonder if it's banned in the US. It's not approved by the Food and Drug Administration (FDA) as a prescription drug in the United States.
It was even ruled out as one of the dietary supplements in 2015 as the product's effects and safety do not fit the dietary ingredient categories in the Dietary Supplements Health and Education Act of 1994.
What is Picamilon (Pikatropin) Used for?
Picamilon, which is one of the known GABA-boosting supplements, aids in increasing acid GABA levels.
The latter is an inhibitory neurotransmitter that slows down excitatory communication between neurons by blocking the activity of glutamate, the brain's most abundant primary excitatory neurotransmitter.
Too much glutamate can cause anxiety and insomnia. The same happens with having too little Gamma-Aminobutyric Acid in the brain.
To counteract these stimulating health effects, an increase in the acid GABA levels is needed for the calming effects.
The two must be in balance to ensure relaxation and peace of mind. With Picamilon, sleep and good rest are guaranteed.
The inclusion of nicotinic acid in the formula helps improve cognitive function.
Studies show that Niacin enhances cell metabolism and cerebral oxygen supply, resulting in short-term and long-term memory enhancement.
Effects & Benefits
The combination of Niacin and gamma-aminobutyric acid in Pikamilon treat health conditions such as anxiety, depression, migraine, epilepsy, and high blood pressure.
Some of its notable benefits are:
- Cognitive Boost. Studies have shown that the combination of GABA and Niacin affects neurotransmitter regulation in the brain. This is thought to sharpen memory and protect against Alzheimer's disease.
- Improves cerebral blood flow. Pikamilon has health benefits in regulating blood flow in the brain. The Niacin acts as a vasodilator that relaxes blood vessels for more unrestricted flow. This protects the neurons against hypoxia, thus improving cognition.
- Provides "calm focus." In a study conducted on patients with Parkinson's disease, the supplement includes focus without inducing drowsiness. This helps normalize dopamine uptake and serotonin content for a better mood.
- Can treat migraines. A study published in the Nutrition Journal that reviewed 1990-2004 clinical trials focused on the use of Niacin for depression, migraines, and other tension-type headaches.
- Helps in withdrawal symptoms. In Russia, its use is not just for relieving stress and anxiety but also for helping addicts reduce cravings for substances. The product increases the Niacin GABA receptors that are essential for recovering alcoholics.
How Does it Work?
A lot of research has been conducted by Russian scientists about cognitive health in the 60s and 70s. Soon after, they continued the research on GABA-derived compounds and drugs like Phenibut and Picamilon.
With GABA in its formula, glutamate is kept from overwhelming your brain. Boosting the gamma-aminobutyric acid with dietary supplements will relieve anxiety, restlessness, and stress, increasing alpha brain wave production to help you feel focused and relaxed.
When using Picamilon, you don't just help enhance your cerebral circulation and lower blood pressure. Still, you also allow GABA to stimulate the pituitary gland to secrete the growth hormone and produce endorphins for a better mood.
However, it does not act as a tranquilizer drug as it does not induce muscle relaxation and lethargy.
The FDA does not approve the product, so it is best to be cautious when taking it.
How to Make GABA Cross the Blood-Brain Barrier?
Among its claimed benefits, the Niacin in the formula helps in vasodilation, while the GABA stimulates brain receptors.
However, the acid GABA cannot cross the blood-brain barrier, which prevents solutes in the circulating blood from crossing into the CNS. With these two combinations, Pikamilon effectively transports GABA into the brain, allowing the formulation to affect cerebral function directly.
Its ability to readily cross the BBB is due to the Niacin promoting vasodilation. Once in the brain, the combined formulation is then broken down into Niacin and GABA.
Dosage & How to Take Powder and Capsules
The dosage reported by some clinical trials typically ranges from as little as 2.7 mg to 700 mg daily. Its elimination half-life is 30 minutes.
According to reviews from consumers, dosages can vary from product to product.
Others have said that there is greater efficacy when taken with food for maximum absorption.
However, the validity of these subjective reviews is still not clinically proven. There is no adequate data about its potency and safety, and neither is it FDA approved.
Since this compound is not yet well-studied, there is no sufficient data to back up the claims of its safety to human users, nor is the frequency of the possible negative side-effects.
Some of the adverse side effects shown are the ff:
- Skin flushing
Higher doses are said to lower blood pressure, which is detrimental to those who have hypotension or those on blood-lowering medication.
The said product is not FDA-approved. Strict precaution is required when taking this product.
To help you decide whether this is worth the risk and money, you should read the reviews online.
Here are some of the experiences shared by the consumers on Reddit:
"For me, picamilon is a blessing. I find that it is somewhere between theanine and phenibut in terms of anxiety relief. If theanine is a 1, and phenibut a 10, picamilon is like a 3 or 4, probably 3. I find a sublingual picamilon and coffee combo to blow the theanine/coffee combo out of the water. What I will tend to do is split the dose. I'll use half of the picamilon orally and the other half sublingual. I have to be honest though, if you are expecting anxiety to melt away, you'll be disappointed."
"For me, it helped to keep my mind clear in a pretty stressful situation. The effect is mild and cumulative. So, it's like you don't feel its action all the time, but behave more effectively under pressure."
Where Can I Buy Picamilon Powder and Capsules?
If you want to know where to buy Picamilon locally, many companies in Russia sell this product as prescription drugs. It is also still circulating the market in the United States despite being banned by the FDA.
If you want to try Picamilon, only purchase from trusted vendors. Several websites offer Picamilon for sale. If you wish to order it online, you should check out the Science.bio website.
Price of Picamilon
The price of Picamilon varies depending on the place where it is purchased. For example, it can be between $5 for 30 capsules in Russia to $30 for 90 capsules.
You can get the Sodium powder for $49.99.They have independent testing to meet quality standards. They also offer same-day and free shipping for a purchase of $300 on international orders.
In the US, that $5 ranges up to $50. Various types of Picamilon will affect the price ranging from 50 milligrams up to 200 milligrams for a serving size.
Frequently Asked Questions (FAQ)
Find common questions and answers below.
Is Picamilon Legal?
It's known for its use as a prescription drug in treating depression, agitation, and stress in Russia. However, this product is not approved as either a prescription drug, over-the-counter drug or a dietary supplement by the Food Drug Administration (FDA) in the United States.
Its current legal status is questionable. However, there is no doubt that if you search on where to order Picamilon, the USA still has vendors selling the product even online.
Is Niacin Good for Depression?
Niacin benefits depression and anxiety prevention as there's proof that people with this condition may be deficient in B vitamins. So if you are clinically diagnosed with depression and want to improve your health, you should discuss taking Niacin dietary supplements with your physician.
Professional medical advice is still the best option in deciding which supplement is good for you.
However, there is currently no evidence pointing out Niacin to be used as a treatment for depression and better one's health.
How Often Should I Take Picamilon?
Picamilon should be taken every day. This will prevent it from having too short or too long of an effect.
The drug should be taken at a maximum of 250 mg per day to avoid overdosing. Most people take between 50 mg and 150 mg every day.
There are no known ways that one can help improve this medication's effects. It seems like you have to wait for it to start working.
Additionally, in combination with other supplements or drugs, its effects may be weaker, so if you're taking any medications, check the list of ingredients with your doctor before adding Picamilon. It is best to seek professional medical advice whenever you want to add something to your existing medications.
Picamilon vs. Phenibut: Which is Better?
Since the legality of Picamilon in the US is still dubious, there is an alternative product called Phenibut, which is designed to treat depression, anxiety, and sleep disorders.
If you are looking for a supplement to treat your anxiety, you may also use Phenibut. But since it is known as a recreational drug, it is subject to abuse.
Both Phenibut and Picamilon are not FDA-approved in the US, though they are easily purchased online. In April 2019, the Food and Drug Administration (FDA) issued a warning to three companies marketing products with Phenibut.
How to Make Your Capsules?
Do you want to create your capsule blends?
As a starter, you have to prepare a capsule machine and a milligram scale.
There are two DIY capsule machines available for personal use. One can cap 50 at a time, while the other can cap 24 at a time.
If you use nootropic powder supplements, it is best to use a milligram scale with 1mg accuracy.
It would help if you also had empty gel capsules, powder filler, and nootropic powder.
Make sure to have these materials on hand if you are considering making your Picamilon.
If you are suffering from anxiety and depression, you might want to consider this supplement to help increase your GABA levels.
However, with the current issue with the FDA of its legal status as a dietary supplement in the US, its safety and effectiveness are still in question, with only limited evidence to back the claims up.
For health purposes, seek your trusted doctor to provide medical advice which might be effective for you.