In this Picamilon review, we'll take an in-depth look at this popular nootropic. We'll go over how Picamilon works in the brain, its benefits, side effects, and where to buy it online.
Are you looking for a nootropic that can boost your energy levels, improve your cognitive function, and help you manage anxiety? If so, you may have come across Picamilon.
Picamilon is a nootropic compound that has recently gained popularity for its ability to improve cognitive function, reduce anxiety and increase energy levels.
So, how does Picamilon work exactly? Let's take a closer look below.
Picamilon Review Summary
Picamilon is a prodrug of GABA that was developed in the Soviet Union in 1969. It is a synthetic combination of niacin and GABA and is used as a drug to treat various neurological disorders. Picamilon is believed to work by increasing the availability of GABA in the brain, which can help to reduce anxiety and improve cognitive function.
While Picamilon does have some potential benefits, it is important to note that it is not FDA-approved, and there is limited research on its safety and efficacy.
- Has tranquilizing and psychostimulating effects
- Has antiaggregant, and antioxidant effects
- Acts as a vasodilator (dilates blood vessels in the brain)
- Not FDA-approved
- Limited research on safety and efficacy available
What Is Picamilon?
Picamilon (also known as N-nicotinoyl-GABA, pycamilon, and pikamilon) is a synthetic combination of niacin (Vitamin B3) and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 as a prodrug of GABA. In Russia, picamilon is sold as a prescription drug, and the rights to the drug belong to the Russian pharmaceutical company NPK ECHO ("НПК ЭХО").
Picamilon is a prodrug of GABA, meaning that it is converted into GABA within the body. GABA's role is to keep glutamate (another neurotransmitter) from being too active. This is important because too much glutamate can lead to excitotoxicity, linked to conditions like Alzheimer's and Parkinson's disease.
Thus, GABA acts as a 'brake' on the nervous system, and by increasing GABA levels, Picamilon can help to reduce anxiety.
Picamilon is a great choice for people who want to improve their cognitive function while also reducing anxiety and stress levels. It is unique because it can not only boost cerebral circulation but also helps to normalize GABA levels Mirzoyan R.S., Gan’shina T.S., Kosoi M.Y., Aleksandrin V.V., Aleksandrov P.N. “Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriolar … Learn more.
|Effects||Improves cerebral blood flow, provides focus, cognitive boost, can treat migraines|
|Potential Side Effects||Headache, dizziness, nausea, skin flushing|
|Common Dosage||2.7 - 700 mg daily|
|Money Back Guarantee||Case-by-case|
|Best Vendor||Click Here ›|
How Does Picamilon Work In The Brain?
There are 2 main ways that Picamilon is believed to work in the brain:
- By increasing cerebral blood flow and oxygenation
- By crossing the blood-brain barrier and increasing GABA levels
Cerebral blood flow is the amount of blood flowing to the brain, and adequate cerebral blood flow is necessary for healthy cognitive function. Since Picamilon is a derivative of GABA and niacin, it can cross the blood-brain barrier and increase GABA levels in the brain Kuriyama K., Sze P.Y. “Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals”Neuropharmacology Volume 10, Issue 1, January 1971, Pages 103–108.
Once Picamilon crosses the blood-brain barrier, it is converted into GABA and niacin. Niacin is a precursor of nicotinamide adenine dinucleotide (NAD+). As a precursor of NAD+, which is a coenzyme in the production of adenosine triphosphate (ATP), it plays an important role in energy metabolism Rennie, George et al. “Nicotinamide and neurocognitive function.” Nutritional neuroscience vol. 18,5 (2015): 193-200. doi:10.1179/1476830514Y.0000000112. It also acts as a vasodilator, meaning that it dilates blood vessels and increases blood flow Hamilton, Sandra J et al. “Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients.” Diabetes & vascular disease research vol. 7,4 (2010): … Learn more.
GABA is a neurotransmitter that acts as an inhibitory neurotransmitter, meaning that it reduces the activity of neurons. A study from 2001 done on rats showed how this niacin and GABA combination regulate neurotransmitters in the brain Kuchmerovs'ka, T M et al. “Korektsiia nikotynamidom ta nikotynoïl-HAMK obminu dofaminu v holovnomu mozku shchuriv za eksperymental'noho parkinsonizmu” [Correction by nicotinamide and … Learn more.
What Is Picamilon Used For?
Picamilon is used as a tranquilizer. It has a calming effect on the nervous system and can help to reduce anxiety, stress, and insomnia. It is also used to improve cognitive function and memory.
One animal study found Picamilon to increase cerebral blood flow in cats, inhibit neurogenic spasms of cerebral vessels, and restore the initial condition of cerebral hemodynamics disturbed by serotonin Mirzoian, R S, and T S Gan'shina. “Novyĭ tserebrovaskuliarnyĭ preparat pikamilon” [The new cerebrovascular preparation pikamilon]. Farmakologiia i toksikologiia vol. 52,1 (1989): 23-6.
In one study published in the journal Psychopharmacology, researchers found that taking nicotinic acid improved both short-term memory and sensory registration by 10-40% in young and middle-aged adults Loriaux, S M et al. “The effects of nicotinic acid and xanthinol nicotinate on human memory in different categories of age. A double blind study.” Psychopharmacology vol. 87,4 (1985): 390-5. … Learn more.
Loriaux et al. showed that niacin improves neuronal transmission, enhances cell metabolism and oxygen supply to the brain.
What Are The Benefits Of Picamilon For Cognition?
Niacin and GABA work synergistically to relieve stress and offer a sense of calmness so that your mind can rest easily. You’ll also have more deep sleep, which helps maintain overall brain health.
Picamilon's most notable benefits are:
- Cognitive Boost. Studies have shown that the combination of GABA and Niacin affects neurotransmitter regulation in the brain. This is thought to sharpen memory and protect the brain against inflammation and damage Tykhonenko, Tetiana et al. “Modulatory effects of vitamin B3 and its derivative on the levels of apoptotic and vascular regulators and cytoskeletal proteins in diabetic rat brain as signs of … Learn more.
- Improves cerebral blood flow. Picamilon has health benefits in regulating blood flow in the brain. Niacin acts as a vasodilator that relaxes blood vessels for more unrestricted flow. This protects the neurons against hypoxia, thus improving cognition.
- Can treat migraines. A study published in the Nutrition Journal that reviewed 1990-2004 clinical trials focused on using Niacin for depression, migraines, and other tension-type headaches Prousky, Jonathan, and Dugald Seely. “The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature.” Nutrition … Learn more.
Where To Buy Picamilon Online?
Picamilon can be bought online from a variety of different retailers. Some of the more reputable and reliable sellers include PureRawz, which offers 5g of Picamilon for $20.06. It's sold as Picamilon Sodium NICOTINOYL-GABA.
All of the products offered by PureRawz are tested in-house and third-party tested for purity and quality. There is a 30-day return policy in place, and they ship all of their products from the US.
What Do People Say About Picamilon On Reddit?
We took a look at some of the top posts about Picamilon on Reddit and here's what we found:
Reddit user u/The_Bio_Hacker said:
"I've been using Picamilon for 3 weeks now, and I have to say that I'm really liking it. I take it every day, either in the morning or early afternoon, and it definitely helps me feel calmer and more relaxed. I'm not sure if it's improving my cognitive function or memory, but it definitely doesn't seem to be hurting."
Another Reddit user said:
"I have experimented with Picamilon for a few months and can say it absolutely works for me to reduce my anxiety. I am prescribed Adderall but find that it gives me anxiety and makes it difficult to fall asleep at night."
A third Reddit user said:
"Picamilon has given me the ability to focus on things outside of work and has helped my anxiety immensely. I would highly recommend it to anyone looking for a way to reduce their anxiety."
Picamilon seems a popular nootropic supplement among Reddit users, with many reporting benefits such as reduced anxiety and improved focus and concentration.
There are also a few reports of side effects, such as headaches and stomach upset, but these appear to be relatively rare.
How Do You Take Picamilon For Cognitive Enhancement?
Picamilon is typically taken in powder form for cognitive function, which can be mixed with water or another beverage. It can also be taken in capsule form.
Picamilon can be taken with or without food, depending on your personal preference. It is best to start with a lower dose and increase gradually as needed. Picamilon can be taken daily or on an as-needed basis, and there is no need to cycle Picamilon.
If you are pregnant, breastfeeding, or have any medical conditions, please consult your doctor before taking Picamilon for cognitive enhancement.
What Is The Recommended Dosage For Picamilon?
The recommended daily dosage of Picamilon is 50 mg 2 or 3 times daily. Anecdotal reports from Reddit suggest that 100 mg 2 or 3 times daily may be more effective for some people.
What Are The Side Effects Of Picamilon?
The most common side effects of Picamilon are headaches and stomach upset. These side effects are typically mild and disappear with continued use.
Other potential side effects of Picamilon include dizziness, drowsiness, dry mouth, and nausea. Picamilon is generally well-tolerated, with few reports of serious side effects.
Higher doses are said to lower blood pressure, which can be detrimental to those with hypotension or those on blood-lowering medication.
What Nootropics Are Similar To Picamilon?
Nootropic drugs that are similar to Picamilon include: L-dopa, Vinpocetine, L-theanine, and Phenibut.
- Vinpocetine: is a derivative of the alkaloid vincamine, which has been clinically used in many countries to treat cerebrovascular disorders such as stroke and dementia. It has the same anxiolytic effects as Picamilon.
- L-dopa: is a nootropic drug used to treat anxiety and depression. It works by increasing dopamine levels in the brain, which helps to improve mood and reduce anxiety.
- Phenibut: is a synthetic compound similar to gamma-aminobutyric acid (GABA), a neurotransmitter that helps regulate mood and behavior. Phenibut (or fenibut) has been shown to effectively reduce anxiety and improve sleep in adults. It works by binding to GABA receptors in the brain, which increases the inhibitory effects of GABA.
- L-theanine: is an amino acid found in green tea. It is known for its ability to reduce stress and improve sleep quality. L-theanine also has some cognitive benefits, such as improved attention and focus.
Picamilon, Vinpocetine, L-dopa, and Phenibut effectively reduce anxiety and improve mood. L-theanine also has some cognitive benefits, but it is not as effective as Picamilon or Phenibut at reducing anxiety.
What Brain Supplements Can Picamilon Be Stacked With?
Picamilon can be stacked with other nootropics, such as racetams, to enhance its effects. Racetams, like Piracetam and Aniracetam, are a class of cognitive enhancers that work by increasing levels of neurotransmitters in the brain.
Adding a choline source to a Picamilon stack can also help to improve its efficacy. Choline is a nutrient that is involved in the production of acetylcholine (ACh), a neurotransmitter that plays a key role in cognitive function. CDP-choline and Alpha-GPC are two popular choline supplements that can be stacked with Picamilon.
If you don't want to buy each nootropic ingredient separately, you can also find NooCube, a pre-formulated nootropic blend. NooCube contains 13 powerful nootropic ingredients that work together to support cognitive function and reduce anxiety. It also includes choline, which enhances the effects of Picamilon.
NooCube is the perfect foundation on which to build a powerful nootropic stack. It can be used on its own or stacked with other nootropics, such as Picamilon, to enhance its effects.
You can find NooCube here:
Frequently Asked Questions (FAQ)
Find the most common Picamilon questions here.
How Long Does It Take For Picamilon To Work?
Picamilon is known to work relatively quickly, with most of the compound being found in the brain within 30 minutes of ingestion. This speedy penetration is likely because Picamilon is a combination of niacin and GABA, both of which can cross the blood-brain barrier. This fast uptake may be why Picamilon is often seen as a more efficient alternative to GABA supplements, as it doesn't require as much time for the compound to take effect.
How Does Picamilon Make You Feel?
Picamilon makes you feel relaxed and calm. It is a unique nootropic that crosses the blood-brain barrier and increases GABA levels while stimulating nitric oxide production. This combination of effects results in a host of benefits for the neurohacker, including relief from anxiety, stress, and social inhibition. Picamilon also provides a clearheaded focus without sedation, making it an excellent choice for those seeking to improve their productivity.
What's The Half-Life Of Picamilon?
Picamilon's half-life is 1-2 hours, meaning that the plasma concentrations of the drug drop significantly after a few hours. This is due to the fact that picamilon is hydrolyzed into GABA and nicotinic acid, both of which have shorter half-lives.
Is It Safe To Use Picamilon?
Picamilon is considered safe at the recommended dosages. There have been no reports of serious side effects associated with picamilon supplementation.
Is Picamilon Legal?
In the United States, the Food and Drug Administration (FDA) has deemed Picamilon an adulterated dietary ingredient because it is not a legal one. However, in Russia, Picamilon is a prescription medication that is used to treat neurological conditions.
So what do we know about Picamilon?
Picamilon is a unique nootropic with a wide range of benefits for the brain. It is an effective anxiety reliever and mood enhancer and can also improve cognitive function and productivity.
If you are looking for a nootropic that can help you focus and be productive without causing serious side effects, Picamilon may be a good choice.
Though Picamilon looks promising for cognitive enhancement, more research is still needed to confirm its efficacy in humans. If you decide to take Picamilon, be sure to start with a low dose and increase gradually as needed.
|↑1||Mirzoyan R.S., Gan’shina T.S., Kosoi M.Y., Aleksandrin V.V., Aleksandrov P.N. “Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriolar system” Bulletin of Experimental Biology and Medicine May 1989, Volume 107, Issue 5, pp 668-670|
|↑2||Kuriyama K., Sze P.Y. “Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals”Neuropharmacology Volume 10, Issue 1, January 1971, Pages 103–108|
|↑3||Rennie, George et al. “Nicotinamide and neurocognitive function.” Nutritional neuroscience vol. 18,5 (2015): 193-200. doi:10.1179/1476830514Y.0000000112|
|↑4||Hamilton, Sandra J et al. “Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients.” Diabetes & vascular disease research vol. 7,4 (2010): 296-9. doi:10.1177/1479164110376206|
|↑5||Kuchmerovs'ka, T M et al. “Korektsiia nikotynamidom ta nikotynoïl-HAMK obminu dofaminu v holovnomu mozku shchuriv za eksperymental'noho parkinsonizmu” [Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease]. Ukrains'kyi biokhimichnyi zhurnal (1999 ) vol. 73,6 (2001): 108-12.|
|↑6||Mirzoian, R S, and T S Gan'shina. “Novyĭ tserebrovaskuliarnyĭ preparat pikamilon” [The new cerebrovascular preparation pikamilon]. Farmakologiia i toksikologiia vol. 52,1 (1989): 23-6.|
|↑7||Loriaux, S M et al. “The effects of nicotinic acid and xanthinol nicotinate on human memory in different categories of age. A double blind study.” Psychopharmacology vol. 87,4 (1985): 390-5. doi:10.1007/BF00432500|
|↑8||Tykhonenko, Tetiana et al. “Modulatory effects of vitamin B3 and its derivative on the levels of apoptotic and vascular regulators and cytoskeletal proteins in diabetic rat brain as signs of neuroprotection.” Biochimica et biophysica acta. General subjects vol. 1866,11 (2022): 130207. doi:10.1016/j.bbagen.2022.130207|
|↑9||Prousky, Jonathan, and Dugald Seely. “The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature.” Nutrition journal vol. 4 3. 26 Jan. 2005, doi:10.1186/1475-2891-4-3|