Phenylpiracetam: Review of Nootropic Benefits, Uses, & Effects

Updated on January 31, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Review of phenylpiracetam's benefits, uses, and effects on cognitive enhancement.

Phenylpiracetam, also known as Phenotropil, is an active agent that may enhance memory, enhance cognitive function, and increase physical performance. In addition, some people report that Phenylpiracetam has a positive effect on concentration, attention, and overall cognitive performance.

Whether you are a seasoned nootropic enthusiast or new to the world of cognitive enhancement, this article will equip you with valuable data on Phenylpiracetam’s efficacy 

This information will help you make effective decisions about the use of the Phenylpiracetam supplement (a potent derivative of Piracetam) in your cognitive journey.

What is Phenylpiracetam?

Phenylpiracetam, a member of the racetam family and also known as carphedon, is a synthetic nootropic drug developed in Russia during the 1980s. It is known for its stimulant properties and potential to enhance cognitive function. Phenylpiracetam’s structure is derived from piracetam, with the addition of a phenyl group, which imparts unique properties to this nootropic agent that may increase its potency on brain function.

This nootropic exerts its effects primarily on the central nervous system, where it may stimulate various neurotransmitter systems. Phenylpiracetam’s bioavailability is noteworthy, allowing for efficient absorption and utilization within the body and past the blood-brain barrier. As a result, phenylpiracetam has gained recognition for its ability to improve memory, cognitive performance, and attention span.

One of the remarkable aspects of Phenylpiracetam is its impact on circulation and blood flow. It enhances cerebral blood flow, contributing to increased oxygen and nutrient delivery to the brain. This property may play a crucial role in the reported effects of Phenylpiracetam on cognitive function and mental alertness.

Phenylpiracetam’s stimulation properties make it akin to a mild stimulant, which can lead to heightened focus and wakefulness. This stimulation, combined with its potent effects on cognition, has led to its use in various settings where increased mental acuity, energy, and attention are desired.

In terms of administration, Phenylpiracetam is available in multiple forms, including capsule and powder form, making it accessible to those seeking its potential benefits.


  • Improved memory, increased focus, and enhanced mental clarity
  • Increased alertness and wakefulness
  • Cognitive boost without experiencing prolonged stimulation or sleep disturbances
  • Improved cerebral blood flow, potentially benefiting brain health


  • Tolerance can develop with regular use of Phenylpiracetam
  • Not approved by the FDA (Food and Drug Administration) for medical use

Mechanism of Action

The mechanism of action of Phenylpiracetam is multifaceted and involves interactions with various neurotransmitter systems and receptors within the central nervous system (CNS). 

Phenylpiracetam is primarily composed of the r-isomer, as opposed to the racemic mixture found in a number of other racetams and nootropic products.

Here is an overview of Phenypiracetam’s mechanism of action:

  1. Receptor Interaction: Phenylpiracetam modulates neurotransmitter receptors in the brain. It enhances the sensitivity of these receptors, leading to increased neurotransmitter activity. This receptor interaction contributes to its cognitive-enhancing effects. This is supported by a single study noting Piracetam’s effect on rat brain neurotransmitter receptors during testing of the conditioned passive avoidance task.(1)
  2. Noradrenaline Modulation: Phenylpiracetam influences noradrenaline levels in the brain, which can impact alertness and wakefulness. The modulation of noradrenaline is considered a part of its mechanism of action and may contribute to its pharmacologically and stimulating properties.
  3. Dopamine and Serotonin: Phenylpiracetam has been shown to have a significant impact on dopamine and serotonin levels in the brain. This neurotransmitter modulation can lead to improved mood, focus, and motivation.
  4. Vascular Effects: Phenylpiracetam is known to influence vascular function. It may enhance blood flow and circulation, potentially benefiting cardiovascular and cerebral blood flow. This property can contribute to increased oxygen and nutrient delivery to brain cells.
  5. Blood-Brain Barrier: Phenylpiracetam has a relatively low molecular weight, which facilitates its ability to cross the blood-brain barrier. This allows it to reach its site of action within the CNS more effectively.

Nootropic Benefits of Phenylpiracetam

Phenylpiracetam is associated with a range of cognitive benefits and has garnered attention for its unique properties.

Here is an overview of some of the nootropic benefits of Phenylpiracetam.

1. Enhanced Cognitive Function

Phenylpiracetam is recognized for its potential to enhance cognitive performance. Users often report improvements in memory, concentration, and overall mental clarity.

2. Stimulation and Alertness

Phenylpiracetam’s stimulant-like effects can boost wakefulness and alertness, making it a valuable tool for those looking to combat fatigue and maintain focus during demanding tasks.

3. Antidepressant Potential

Some studies and anecdotal reports suggest that Phenylpiracetam may have antidepressant properties.(2) It is believed to modulate neurotransmitter systems, including dopamine and serotonin, which can influence mood and alleviate symptoms of depression.

4. Anxiety Reduction

Some users of Phenylpiracetam report reduced anxiety, which could potentially involve interactions with GABA receptors. This is because anxiolytic effects often relate to the balance of excitatory (glutamate) and inhibitory (GABA) neurotransmission in the brain.

5. Improved Memory

Phenylpiracetam has been linked to improvements in memory function, making it a popular choice among students and professionals seeking cognitive enhancement.

Additionally, studies have shown that Phenylpiracetam may decrease the effects of scopolamine induced memory impairment.(3) This suggests its potential in counteracting memory deficits caused by certain factors.

6. Enhanced Physical Stamina

Phenylpiracetam is known for its ability to increase physical stamina and endurance. Athletes and fitness enthusiasts have reported benefits in terms of improved performance and reduced perceived effort during workouts.(4)

7. Potential Neuroprotection 

Some research suggests that Phenylpiracetam may have neuroprotective properties and could potentially be beneficial in slowing cognitive decline associated with aging or neurodegenerative conditions.(5)

Uses of Phenylpiracetam

Phenylpiracetam, a nootropic compound with diverse pharmacological properties, has found utility in various clinical applications and cognitive enhancement scenarios. Below is an overview of some of the uses and potential clinical applications of Phenylpiracetam:

  1. Stimulating Cognitive Enhancement: Phenylpiracetam is widely known for its cognitive-enhancing effects, which include improved memory, enhanced focus, and increased mental clarity. It may help individuals seeking to optimize their cognitive performance in academic, professional, or daily tasks.
  2. Increasing Physical Stamina and Performance: Athletes and fitness enthusiasts have turned to Phenylpiracetam for its potential to increase physical stamina and endurance during workouts and physical activities. Some users report reduced perceived effort during exercise, which may contribute to enhanced performance.
  3. Supporting Neuroprotective Effects: Research suggests that Phenylpiracetam has neuroprotective properties, potentially protecting the brain from damage due to various factors, including ischemic conditions and oxidative stress.(6) Its use in clinical applications related to the consequences of brain organic lesions is of interest.
  4. Providing Cerebrovascular Benefits: Phenylpiracetam is believed to enhance cerebral blood flow and circulation. This may have implications for cerebrovascular health and the delivery of oxygen and nutrients to the brain. Its potential role in supporting cerebral circulation and treating CNS disorders is a subject of study and clinical exploration.
  5. Improving Respiratory Function: In some clinical applications, Phenylpiracetam has been investigated for its effects on respiratory function and oxygen utilization, particularly in conditions where oxygen supply may be limited.
  6. Epilepsy Management: While more research is needed, there is interest in exploring Phenylpiracetam’s potential in the management of epilepsy and its effects on seizures. However, there is not enough scientific evidence or human studies to support this claim, yet. 
  7. Increasing Locomotor Activity: Research studies have examined the effects of Phenylpiracetam on locomotor activity, particularly in animal models.(7) It may influence motor function and activity levels.

Where to Buy Phenylpiracetam

Phenylpiracetam is not a prescription drug and is available over the counter and from online vendors. However, you need to ensure you’re purchasing Phenylpiracetam from a reliable source in order to avoid adverse effects and scams. 

We have searched for the best place to buy Phenylpiracetam online and have chosen the following as our top picks. 

Each of these options has third-party tested nootropics to verify their clinical pharmacology, a reliable reputation, great prices, and to-your-door shipping. 

Phenylpiracetam Dosage

The recommended dosage of Phenylpiracetam can vary depending on individual factors, including body weight, tolerance, and the specific effects you’re aiming to achieve.

That said, here are some general guidelines for Phenylpiracetam dosage:

  • Standard Dosage: A common starting dose for Phenylpiracetam is around 100 mg per day, typically taken in one or two divided doses. As always, lower doses are more appropriate for first-time users, as it’s better to monitor your response before trying higher doses.
  • Enhanced Cognitive Function: If you’re primarily using Phenylpiracetam for cognitive enhancement, a dosage in the range of 100-200 mg per day is often sufficient. Some users may find that they achieve their desired cognitive effects at the lower end of this range.
  • Physical Performance: For those seeking to improve physical stamina and endurance, doses of 200 mg or 300 mg per day, taken about 30-60 minutes before exercise, may be more appropriate.

Tolerance can develop with Phenylpiracetam over time, so it’s advisable to use it intermittently and not on a daily basis.

Phenylpiracetam Side Effects & Safety

Phenylpiracetam, a popular member of the racetam family of nootropics, is generally considered safe when used responsibly and at recommended dosages. However, like any supplement or medication, it may come with potential side effects and considerations.

Here are some common side effects:

  • Restlessness
  • Increased heart rate
  • Headaches
  • Insomnia

Additionally, here are some safety notes to consider: 

  • Tolerance: Tolerance to Phenylpiracetam can develop with prolonged and frequent use. To avoid this, it’s recommended to cycle its usage during the weeks of use, taking breaks between periods of supplementation.
  • Interactions: Phenylpiracetam may interact with other drugs or supplements you’re taking. Consult with a healthcare professional if you have concerns about potential interactions.
  • Individual Variability: Responses to Phenylpiracetam can vary widely among individuals. Some may experience significant benefits, while others may not notice a substantial effect.

In summary, Phenylpiracetam benefits offer potential cognitive and physical enhancement, but users should be aware of potential side effects and the importance of responsible use.


In a comprehensive review of Phenylpiracetam, this nootropic from the racetam family exhibits promising cognitive and physical benefits. Phenylpiracetam, often administered at doses of 100-200 milligrams per day, is known for its potential to enhance memory, focus, and mental clarity.

Its stimulant-like properties make it valuable for increasing alertness and wakefulness, benefiting cognitive performance and potentially aiding in conditions like depression and anxiety. Phenylpiracetam may also enhance physical stamina, making it appealing to athletes and fitness enthusiasts. 

While its potential cognitive and neuroprotective effects are significant, it’s essential to monitor individual responses and use it intermittently to avoid tolerance. Consultation with a healthcare professional is advisable before incorporating Phenylpiracetam into a regimen due to variations in individual reactions and potential interactions with other substances.


How long does Phenylpiracetam take to work?

The onset of Phenylpiracetam’s effects can vary from person to person, but many users report feeling its cognitive-enhancing effects within 30 minutes to 1 hour after taking it. The speed of onset may depend on factors like individual metabolism and whether it’s taken with food.

What is the elimination half-life of Phenylpiracetam?

The elimination half-life of Phenylpiracetam is relatively short, estimated to be around 3-5 hours in most individuals. This means that it takes this amount of time for half of the Phenylpiracetam to be metabolized and eliminated from the body. Due to its short half-life, some people may take multiple doses throughout the day.

Should you cycle Phenylpiracetam?

While Phenylpiracetam is considered safe when used as directed, it’s generally a good idea to cycle the use of most nootropics, including Phenylpiracetam. A common approach is to use Phenylpiracetam for 2-3 days on, and then take a break of 2-3 days off. Overall, we do not recommend using Phenylpiracetam for a duration of 30 days (one month) without taking a break. This could lead to dependence issues and intoxication.

Can I stack Phenylpiracetam with other nootropics?

The practice of stacking nootropics, or combining them with other substances, should be done cautiously and with careful consideration of potential interactions and effects. It’s essential to consult with a healthcare professional or a knowledgeable expert in nootropic use before creating a stack.

How should I store Phenylpiracetam?

Phenylpiracetam should be stored in a cool, dry place, away from direct sunlight and moisture. It’s essential to follow the specific storage instructions provided by the manufacturer or retailer, as they may vary depending on the product’s formulation and packaging.

Sources, Studies, and Scientific Research
  1. Bhattacharya, S K et al. “Effect of piracetam, a nootropic agent, on rat brain monoamines and prostaglandins.” Indian journal of experimental biology vol. 27,3 (1989): 261-4. ↩
  2. AIu, Savchenko, N. S. Zakharova, and I. N. Stepanov. “The phenotropil treatment of the consequences of brain organic lesions.” Zhurnal Nevrologii i Psikhiatrii Imeni SS Korsakova 105.12 (2005): 22-26. ↩
  3. Piercey, M F et al. “Reversal of scopolamine-induced amnesia and alterations in energy metabolism by the nootropic piracetam: implications regarding identification of brain structures involved in consolidation of memory traces.” Brain research vol. 424,1 (1987): 1-9. doi:10.1016/0006-8993(87)91186-3 ↩
  4. Docherty, J R. “Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA).” British journal of pharmacology vol. 154,3 (2008): 606-22. doi:10.1038/bjp.2008.124 ↩
  5. Scheuer, K et al. “Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.” Pharmacopsychiatry vol. 32 Suppl 1 (1999): 10-6. doi:10.1055/s-2007-979231 ↩
  6. Zvejniece, Liga et al. “Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice.” Inflammopharmacology vol. 28,5 (2020): 1283-1292. doi:10.1007/s10787-020-00705-7 ↩
  7. Samotrueva, M A et al. “Psychoimmunomodulatory effect of phenotropil in animals with immune stress.” Bulletin of experimental biology and medicine vol. 151,1 (2011): 51-4. doi:10.1007/s10517-011-1257-4 ↩