8 Best Nootropics for Depression & Anxiety in 2024 (Tested & Reviewed)

An article discussing the use of nootropics for improving depression and anxiety.

Are you looking for ways to manage your depression and anxiety naturally?

If so, nootropics may help easy symptoms of depression.

In this guide, we’ll explore the best nootropics for depression and anxiety and how they can help you manage your symptoms.

Good Nootropics for Depression Relief

1. Nooceptin

Nooceptin is a natural nootropic supplement that can help with the symptoms of depression. It works by increasing the activity of neurotransmitters such as serotonin, dopamine, and norepinephrine. It also helps to reduce stress and anxiety.

Nooceptin supplement bottle

Nooceptin is non-habit forming and has been clinically proven to be safe and effective in treating depression.

2. Ginkgo Biloba

Ginkgo Biloba is one of the most popular and widely used nootropics for treating depression. This plant extract has been used for hundreds of years in traditional Chinese medicine for its calming and antidepressant effects.

Studies have shown that it can increase serotonin levels in the brain, which is linked to improved mood and a reduction in depressive symptoms.

Ginkgo Biloba also has antioxidant properties and can help protect the brain from damage caused by free radicals. Additionally, it can help improve cognitive function, focus, and memory.

3. Lion’s Mane Mushroom

Lion’s Mane Mushroom is a powerful nootropic that has been used for centuries to promote cognitive health and improve mood. Recent research has also suggested that Lion’s Mane Mushroom may be beneficial in treating symptoms of depression.

Studies have shown that consuming Lion’s Mane Mushroom can increase the production of Nerve Growth Factor (NGF), a natural growth factor that aids in the development and regeneration of neurons in the brain. This increased production of NGF can help to improve mood and reduce symptoms of depression.

Furthermore, Lion’s Mane Mushroom is also known for its anti-inflammatory properties, which can help to reduce stress and anxiety, both of which can contribute to feelings of depression. Lion’s Mane Mushroom is available in capsules, powders, and tinctures, making it easy to incorporate into your daily routine.

4. N-Acetyl L-Cysteine

N-Acetyl L-Cysteine (NAC) is a powerful antioxidant that has been shown to reduce symptoms of depression. It works by increasing the levels of glutathione, a powerful antioxidant in the brain that can help protect against oxidative damage and stress.

NAC also helps to increase the production of neurotransmitters such as dopamine, serotonin and norepinephrine, which can improve mood and reduce symptoms of depression. In addition, NAC may also help to reduce inflammation and improve cognitive function.

It is generally recommended to take NAC in supplement form, although it can also be found in foods such as broccoli, garlic and onions.

5. Rhodiola Rosea

Rhodiola Rosea is an adaptogenic herb that has been used for centuries in traditional medicines. It has been shown to reduce symptoms of depression and improve cognitive function.

It is believed to act on serotonin and dopamine receptors in the brain, resulting in increased alertness and improved mood.

Rhodiola Rosea also has anti-inflammatory and antioxidant properties, which can help protect the brain from damage caused by stress and depression.

6. Bacopa Monnieri

Bacopa monnieri is a natural nootropic that has mental health benefits and is used to treat depression. It is a traditional Ayurvedic herb and has been used for centuries to improve memory and cognitive performance.

Bacopa monnieri works by increasing serotonin levels in the brain, which helps to regulate mood and reduce anxiety. It also increases the activity of brain-derived neurotrophic factor (BDNF), a protein that helps to protect neurons from damage and strengthens synaptic connections.

Studies have shown that Bacopa monnieri may help to improve cognitive function and reduce symptoms of depression. It can be taken as a supplement or as a tea, and is generally safe for most people when taken in recommended doses.

7. Ginseng

Ginseng is a well-known nootropic that is commonly taken to help improve mental performance and reduce stress. It is also used to treat depression because it is thought to help regulate mood, increase energy levels, and reduce fatigue.

Ginseng can be taken in the form of a powder, capsules, or tea. It can also be found in Chinese and Korean herbal medicines. Ginseng has been studied extensively and has been found to help improve mood, reduce anxiety, and provide antidepressant effects. However, it is important to note that there is not enough scientific evidence to prove its efficacy in treating depression.

Additionally, there are some potential side effects associated with taking ginseng, including dizziness, insomnia, headaches, and stomach upset. Therefore, it is best to talk to your doctor before taking ginseng for depression.

8. Aniracetam

Aniracetam is a fat-soluble molecule that is known for its cognitive-enhancing and mood-boosting properties. It’s believed to be more potent than Piracetam, and it’s also thought to have anti-anxiety effects.

It’s thought to work by increasing levels of serotonin, dopamine, and acetylcholine, which are all neurotransmitters associated with mood.

Aniracetam may also help protect against oxidative damage and improve blood flow to the brain, which can help with cognition and overall mental health.

How We Picked Nootropics that Help with Depression

We employed a multi-factor approach to identify the top nootropics for depression management. We took into consideration effectiveness, ingredients, scientific evidence, brand reputation, product transparency, manufacturing process, user feedback, pricing, and overall value. By assessing all these factors, we aimed to provide readers with a reliable and comprehensive list of the most effective nootropics for alleviating depression.


We examined clinical studies and user experiences to determine improvements in mood, reduction in depressive symptoms, and enhancement of overall mental well-being.


We carefully evaluated each formula, prioritizing natural, high-quality, and evidence-supported ingredients that specifically target depression.

Scientific Evidence

We consulted peer-reviewed research and meta-analyses to confirm the effectiveness of key ingredients in alleviating depressive symptoms.


We evaluated optimal dosages and ingredient ratios, ensuring they are in line with established research for maximum mood-enhancing benefits.


We confirmed the safety of each ingredient, considering potential side effects, interactions, and adherence to regulatory guidelines. We prioritized FDA-approved ingredients.

Brand Reputation

We assessed brands’ credibility and trustworthiness through customer reviews, expert recommendations, and company history.

Product Transparency

We appreciated full disclosure of ingredients, encompassing sources and concentrations, to facilitate informed consumer choices.

Manufacturing Process

We investigated manufacturing standards, prioritizing products made in certified facilities that adhere to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, giving weight to testimonials that report mood improvements and enhanced mental well-being.


We compared product prices, ensuring they were competitive and reflective of the quality and efficacy of the nootropic.


We evaluated overall value, taking into account the balance of price, quality, and efficacy to guarantee an optimal return on investment.

How Can Nootropics Help with Depression?

Nootropics, also known as “smart drugs,” are substances that can help improve cognitive performance and promote healthy brain function. They can be natural or synthetic and are used to improve memory, concentration, focus, and mood. While nootropics are not a cure-all for depression, they may help to alleviate some of the symptoms associated with the disorder.

They work by increasing the availability of neurotransmitters in the brain, such as serotonin and dopamine, which can help to regulate mood and improve overall mental health. Nootropics can also help to reduce stress and anxiety, two common symptoms associated with depression.

Additionally, some nootropics have been found to increase energy levels and reduce fatigue, which can be beneficial for those suffering from depression.

The Benefits of Nootropics for Depression Reduction

Nootropics are natural substances that can aid in the treatment of depression. They are known to help improve cognitive function, mood, and overall well-being. By stimulating the production of certain neurotransmitters in the brain, nootropics can help to balance the levels of serotonin, dopamine, and other hormones associated with depression.

For example, Rhodiola Rosea is known to reduce stress and improve mood, while Lion’s Mane mushroom has been found to be effective in treating depressive symptoms. Nootropics can also boost energy levels, improve concentration, and reduce anxiety.

They can also help to regulate emotional responses and improve social skills. In short, nootropics can be an effective treatment for those suffering from depression.

The Safety and Side Effects of Taking Nootropics for Depression

When considering taking nootropics for depression, it is important to be aware of the potential side effects and safety concerns associated with them. It is important to always research any supplement you are considering taking and to speak to your doctor if you have any concerns.

Generally, nootropics are considered safe and have very few side effects when taken at the recommended dosage. However, some nootropics can interact with other medications you may be taking, so it is important to consult your doctor before taking any supplement.

Additionally, as with any supplement, it is important to monitor your symptoms closely in order to determine if the nootropic is helping or if it is causing any negative side effects.

Tips on Choosing the Right Nootropic for Depression

When it comes to choosing the right nootropic for depression, it’s important to remember that everyone’s body is different and the effects of any supplement can vary from person to person. It’s also important to consider the individual ingredients and how they may interact with any medications you are taking. Additionally, it is wise to consult with your doctor before beginning a new supplement regimen.

When choosing a nootropic, it is important to consider the level of evidence available for the supplement, its safety profile and the type of depression you are experiencing. For instance, some nootropics may be more effective for those with major depressive disorder and not for those with bipolar disorder. Additionally, it may be wise to select a nootropic that has been studied extensively in clinical trials in order to ensure its efficacy and safety.

It is also important to consider the amount of time it will take for the nootropic to work. Some nootropics may take several weeks before they become effective, while others may work more quickly. Additionally, it is important to consider any potential side effects of taking the supplement, especially if you are already taking other medications.

Finally, it is important to remember that nootropics are not a replacement for professional treatment or medication. If you or someone you love is suffering from depression, it is essential that they seek help from a qualified mental health professional. Nootropics may help to reduce symptoms of depression, but they are not a substitute for therapy

Conclusion: The Pros and Cons of Taking Nootropics to Help Depressions

Nootropics offer a natural, safe, and effective way to treat depression. For many people, these nootropic supplements can help to reduce the symptoms of depression and improve overall mood.

However, it is important to remember that not all nootropics are created equal and some may have side effects associated with them. It is important to research the different nootropics available and consult with a medical professional before starting any nootropic regimen.

Additionally, it is important to remember that nootropics should not be used as a replacement for proper medical care or psychotherapy. With the right nootropic supplement and proper care, however, many people can find relief from the symptoms of depression.

Nooceptin supplement bottle

Jacob Kovacs is a cognitive neuroscientist and author at WholisticResearch, specializing in nootropics and neuroactive peptides. His expertise in neuroscience and psychopharmacology bridges cognitive science with drug development. Kovacs’ work focuses on enhancing cognitive functions and brain health through innovative, efficient neuroactive compounds that overcome traditional pharmacokinetic challenges. His contributions are pivotal in advancing the understanding and treatment of neurological diseases.