Dynamine: Review of Nootropic Benefits, Uses, Dosage, & Side Effects

Updated on February 8, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
A review of Dynamine's nootropic benefits, uses, and side effects on neural health.

Dynamine® (Methylliberine) is a notable natural compound in the world of caffeine alternatives and nootropics, known for its ability to provide increased and sustained energy.  

This compound is gaining attention in the nootropic community and nutraceutical industry for its ability to boost energy levels, enhance mood and focus, and improve overall cognitive function.

This article will delve into Dynamine benefits, optimal dosage, and potential side effects, as well as its unique position in the world of nootropics and energy supplements.

Read on to learn more if you want to increase your energy levels with Dynamine!

What is Dynamine?

Dynamine, scientifically known as Methylliberine, is a purine alkaloid found in coffee beans, kucha tea, green tea, and yerba mate, emerging as a compelling ingredient in the realm of nootropics and sports nutrition. 

It’s a xanthine derivative, with a molecular structure similar to caffeine, which is why it’s popular in pre-workout supplements and as a standalone energy booster to provide increased motivation and physical energy.

As for its effects on the brain, Dynamine is known to enhance cognitive functions such as alertness, focus, and energy levels for demanding tasks.

When used in combination with caffeine pills it creates an effective pre-workout stack. Dynamine amplifies the energy-boosting effects and cognitive benefits without the risk of jitteriness or a crash often associated with high caffeine intake. Additionally, its synergy with Teacrine, another compound known for enhancing physical performance, offers a balanced and prolonged energy lift. 

Overall, Dynamine is a preferred choice for those seeking similar effects to caffeine and energy drinks, but with more stable and longer-lasting increased energy levels, without restlessness.


  • Enhanced energy and alertness
  • Improved cognitive performance, focus, and concentration
  • Acutely increased energy without the crash
  • Improved mood and increased motivation


  • A relatively new compound with limited research available
  • Cardiovascular effects that increase heart rate and blood pressure

Mechanism of Action

Dynamine’s mechanism of action in the body, particularly its effects on brain function and energy levels, is intriguing. Like caffeine,(1) Dynamine works in similar ways to provide an energy boost, primarily by interacting with certain neurotransmitters and receptors in the brain to stimulate your central nervous system.

One of the key neurotransmitters affected by Dynamine is dopamine, which plays a crucial role in mood, motivation, and attention.(2) By working as a modulator for dopamine levels, Dynamine enhances mental alertness and cognitive performance. It also works as a dopamine reuptake inhibitor, allowing for sustained, long-lasting effects. 

Furthermore, Dynamine acts on the adenosine receptors in the brain. Normally, adenosine promotes relaxation and sleepiness; when Dynamine blocks adenosine receptors, it prevents adenosine from exerting its usual effects, thus maintaining a state of alertness and reducing feelings of fatigue.

Notably, Dynamine achieves these effects without significantly increasing oxygen uptake. This makes Dynamine beneficial for those seeking an energy boost without the cardiovascular effects and strain that are associated with a higher amount of oxygen consumption. As previously mentioned, Dynamine’s effect is similar to the effects of caffeine but without the crash or jitteriness that accompanies high doses of caffeine or energy drinks.

Overall, Dynamine, as a component of compound solutions aimed at enhancing energy and cognitive function, operates by modulating neurotransmitter activity and blocking certain receptors in the brain.

There is limited information from clinical studies about the long-term safety and efficiency of this product.  Its mechanism of action is also still undergoing tests to help us fully understand the full spectrum of the benefits of Dynamine.

Nootropic Benefits of Dynamine

As a nutraceutical, Dynamine is often used as an ingredient in dietary supplements, particularly those aimed at improving mental performance, energy, and focus.

Here are some key nootropic benefits of Dynamine for people considering its use in their daily supplementation routine, or as a pre-workout.

1. Enhancement of Cognitive Functions

Dynamine enhances alertness and focus, making it easier to concentrate on tasks and process information more efficiently for longer periods. Additionally, Dynamine works as a dopamine reuptake inhibitor, which increases creativity, memory, and overall cognitive function.(3)

2. Enhanced Mood and Motivation

Some users report that Dynamine improves their mood, allowing them to feel happier. This indirectly boosts cognitive performance. A better mood from increased dopamine activity is often associated with increased motivation and a more positive outlook, which enhances cognitive performance and productivity.

3. Synergistic Effects with Caffeine and Other Stimulants

Dynamine works to prolong and enhance the effects of caffeine and other stimulants, like pre-workouts. This synergistic effect has been shown to lead to a more sustained cognitive boost without the crash associated with most stimulant formulations.(4) Overall, Dynamine is able to help you see results in a shorter time, without increasing your toxicology or acid levels.

4. Quick Onset of Action

Unlike some nootropics that take time to show effects, Dynamine is known for its quick onset. This rapid action is particularly beneficial for tasks requiring immediate cognitive enhancement. It is also very effective to use Dynamine a couple of minutes before your workout routine for an instant boost.

5. Neuroprotective Effects

Preliminary research suggests that compounds like Dynamine might offer neuroprotective benefits, although much more research is needed in this area.(5) Protecting the brain cells contributes to improved cognitive function over time, and prevents cognitive decline.

6. Unimpacted Sleep Quality

For some users, Dynamine provides a cognitive boost without significantly affecting sleep, especially when compared to caffeine. This is important as good quality sleep is crucial for cognitive function, motivation, and sustained energy levels.

Uses of Dynamine

Dynamine (Methylliberine) as a natural compound has gained attention for its potential uses and benefits in various fields, particularly in the areas of energy-boosting, cognitive enhancement, and fitness. 

Here are some of the primary uses of Dynamine:

  1. Cognitive Enhancement: One of the most notable uses of Dynamine is in cognitive enhancement. It is believed to improve mental alertness, focus, and overall cognitive function, making it a popular ingredient in nootropic supplements.
  2. Energy Boosting: Dynamine acts as a stimulant, providing a quick and effective energy boost. This makes it a common ingredient in energy drinks and supplements, offering an alternative to traditional stimulants like caffeine.
  3. Pre-Workout Supplementation: In the fitness and sports nutrition industry, Dynamine is often used in pre-workout supplements. It enhances physical performance, increases endurance, and reduces the perception of effort during exercise.
  4. Mood Enhancement: Some users report mood-enhancing effects after taking Dynamine. It contributes to a feeling of elevated mood and increased motivation, which is beneficial in both physical activities and daily tasks.
  5. Weight Management: While not a primary use, Dynamine may contribute to weight management efforts. Its energy-boosting properties enhance physical activity levels, and its role in appetite regulation is being explored.
  6. Stacking With Other Stimulants: Dynamine is known for its synergistic effects, especially when combined with caffeine, theacrine, teacrine, or other energy-boosting supplements. It enhances and prolongs the effects of caffeine, leading to more sustained energy and focus without the typical caffeine crash.

Where to Buy Dynamine

Finding a reliable source to purchase your nootropics from is difficult. There are many scammers out there selling impure, untested products. 

Luckily, we have you covered, so you don’t need to go through the grueling process of finding a trustworthy website.

According to our in-depth research and testing, the best online vendor for Dynamine is PureNootropics.net.

This company provides third-party tested nootropics, with a 30-day money-back guarantee. 

Here, you will find Dynamine in capsule form, with 90 servings per bottle.

Dynamine Dosage

Determining the appropriate dose of Dynamine (Methylliberine) is important for achieving desired effects while minimizing potential side effects.

Dynamine is typically dosed in the range of 100 mg – 200 mg per serving.

Starting at the lower end of the dosage spectrum (such as 100 mg or even less) will help you understand how your body reacts to Dynamine.

When combined with other stimulants like caffeine, the dosage of Dynamine must be adjusted. Since Dynamine enhances the effects of other stimulants, the combined dosage should be considered to avoid overstimulation.

Remember, the optimal dosage of Dynamine varies based on individual factors like body weight, tolerance, and desired effects.

Dynamine Side Effects & Safety

While more research is needed, Dynamine has a self-affirmed GRAS, meaning it’s generally recognized as safe for consumption for short-term use.(6)

Unlike some other nootropics and stimulants, Dynamine as an energy supplement is reported to have minimal side effects. It’s a different choice for those who are sensitive to the more intense effects of substances like caffeine.

However, with this in mind, there are some reported side effects users may experience, including:

  • Gastrointestinal discomfort
  • Nausea
  • Upset stomach
  • Headaches
  • Dizziness

Note: These side effects are usually only experienced when Dyanmine is taken on an empty stomach, or in high doses. Additionally,  people with certain health conditions, such as anxiety disorders, heart problems, or hypertension, should consult a healthcare provider before using Dynamine.


Remember to think twice before you use that morning cup of coffee to get the increased energy you need to make your day productive. Dynamine is the best caffeine alternative when compared to most other stimulant compound solutions, allowing you to experience similar results.

The best part? You are free from jitteriness and have the added benefit of prolonged effects.

Dynamine is a nootropic stimulant with a variety of uses for both mental and physical enhancement, providing a way for students, athletes, and professionals to increase productivity and focus.

With increased energy levels and dopamine neurotransmitter activity, using Dynamine will give you the boost you need to get through your tasks and activities. It has a self-affirmed GRAS, making it safe to use for healthy adults, and it also provides instant effects.


How long does Dynamine take to work?

Dynamine is known for its fast-acting effects. Users typically report feeling its stimulating effects within 15 to 30 minutes after ingestion. However, like many supplements, the exact onset time can vary based on individual factors like metabolism, body weight, and tolerance.

What is the elimination half-life of Dynamine?

The elimination half-life of Dynamine is not extensively documented in scientific literature. However, it is understood to be a fast-acting compound with a relatively short half-life of 1-1.4 hours.

Should you cycle Dynamine?

Cycling stimulants like Dynamine can be beneficial to prevent tolerance and dependency and to preserve the acute effects. Although cycling isn’t crucial for a nootropic like Dynamine, users sometimes follow a similar approach to caffeine, taking breaks or reducing dosage periodically.

Can I stack Dynamine with other nootropics?

Dynamine can be stacked with other nootropics, especially those that don’t have stimulating effects, to potentially enhance cognitive benefits. It’s often combined with caffeine for a more pronounced effect.

Sources, Studies, and Scientific Research
  1. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655 ↩
  2. Cools, Roshan et al. “Dopamine and the motivation of cognitive control.” Handbook of clinical neurology vol. 163 (2019): 123-143. doi:10.1016/B978-0-12-804281-6.00007-0 ↩
  3. Salvi, Carola et al. “The Effect of Dopaminergic Replacement Therapy on Creative Thinking and Insight Problem-Solving in Parkinson’s Disease Patients.” Frontiers in psychology vol. 12 646448. 5 Mar. 2021, doi:10.3389/fpsyg.2021.646448 ↩
  4. Tartar, Jaime L et al. “A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers.” Cureus vol. 13,12 e20534. 20 Dec. 2021, doi:10.7759/cureus.20534 ↩
  5. Kolahdouzan, Mahshad, and Mazen J Hamadeh. “The neuroprotective effects of caffeine in neurodegenerative diseases.” CNS neuroscience & therapeutics vol. 23,4 (2017): 272-290. doi:10.1111/cns.12684 ↩
  6. VanDusseldorp, Trisha A et al. “Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults.” Nutrients vol. 12,3 654. 28 Feb. 2020, doi:10.3390/nu12030654 ↩