J147: Review of Nootropic Benefits, Uses, Dosage & Side Effects

J147, a novel neurotrophic drug for cognitive enhancement, stands at the forefront of disease drug discovery, particularly in the treatment of neurodegenerative diseases and memory deficits associated with the aging brain.

The neuroprotective effects of J147 as a neurotrophic compound are particularly intriguing. The drug administration of J147 could offer new avenues for addressing memory impairment (such as Alzheimer’s disease) in the elderly population.⁽¹⁾

Is this the nootropic solution you’ve been looking for?

Read on to learn more about the effects of treatment with J147, its mechanism of action, side effects, and optimal dosage recommendations.

What Is J-147?

Developed initially as a novel curcumin derivative for research use, this potent compound has demonstrated potential therapeutic effects in various mouse models.⁽²⁾ Its primary focus is on treating cognitive deficits and enhancing memory, especially when it comes to aging in the brain.

As J147 treatment progresses through clinical trials, it holds the promise of not just treating symptoms, but also potentially reversing cognitive impairment in aged individuals.

Its development and subsequent studies have been a collaborative effort among researchers like Schubert, Goldberg, Dargusch, Currais, Maher, and others, who have explored various aspects of its molecular action to show that J147 is safe and has valid therapeutic potential for the central nervous system.

In summary, J147 is a promising experimental drug with potential neuroprotective and neurotrophic effects. It has shown efficacy in animal models for treating age-related cognitive impairments and diseases, with ongoing Phase 1 clinical trials to determine the effect of J147 in human patients.

Pros:

• Neuroprotective and neurotrophic effects
• Reduction in amyloid-β production
• Potential to reverse cognitive impairments and increase the production of brain cells

Cons: 

• Limited human studies and clinical data
• Not approved by the FDA for human consumption

Mechanism of Action

The mechanism of action of J147 in the brain works by manipulating the body’s natural requirements for energy and focus. The primary focus of J147 treatment is on aging and neurodegenerative diseases, particularly Alzheimer’s disease, rather than a broad range of conditions like Crohn’s disease, Celiac disease, and Lupus.⁽³⁾

In animal studies, notably in mice, J147 has shown promising results in reversing memory impairments and improving brain health. It targets the biological processes at the cellular level, influencing mitochondrial ATP synthase levels and mitochondrial protein function. This action is crucial in maintaining energy metabolism within brain cells, which is an essential action of a drug for treating cognitive memory deficits.

In studies, particularly involving the plasma of samp8 mice treated with J147, researchers observed significant changes in the plasma and liver biochemistry.⁽⁴⁾ These changes include modulation of acetyl-CoA levels, which play a vital role in metabolic processes within the liver and the brain. Acetyl-CoA is a critical molecule in energy metabolism, and its regulation by J147 suggests a broader impact on the body’s overall metabolic health. This means J147 treatment could reduce cognitive impairments caused by low Acetyl-CoA levels, such as TBI.

The relationship between aging and dementia, a key focus of the therapeutic effects of J147, underscores the importance of such innovative drug candidates in addressing the challenges posed by neurodegenerative diseases associated with aging.

The activity of J147 is multifaceted, targeting several key pathways and processes within the body, particularly in the brain and liver. Studies reported that J147 exerts both neurotrophic and neuroprotective effects.⁽⁵⁾

One of the primary actions of J147 is its ability to stimulate the production of new brain cells and neurons. This effect is crucial for maintaining and enhancing cognitive functions, especially in aging individuals. By promoting neurogenesis, J147 significantly contributes to the overall health and resilience of the aging brain.

J147’s impact extends to its ability to signal pathways in the liver.⁽⁶⁾ Using J147 has been shown to exert an inhibitory effect on certain pathways, potentially reducing the adverse effects of conditions like fatty liver disease by treating high liver FFA levels. 

This action, coupled with the fact that J147 reduces free fatty acid levels in the plasma and brain, suggests that J147 may assist in managing metabolic dysfunctions associated with brain aging. It’s been found that J147 could protect the brain against neurotoxicity and prevent neurodegenerative diseases.⁽⁷⁾

Nootropic Benefits of J147

The beneficial effects of J147, particularly as a neurotrophic compound, have been increasingly recognized in research, especially in the context of cognitive impairment and neurodegenerative diseases like Alzheimer’s.

1. Reversal of Cognitive Impairment

In studies, it was found that the neurotrophic compound j147 reverses cognitive impairment effectively in various mouse models by managing ATP levels, BDNF (Brain-Derived Neurotrophic Factor) levels, and NGF (Nerve Growth Factor) levels. This is particularly significant in the context of cognitive disease and forms of dementia, offering a potential therapeutic avenue for these conditions.⁽⁸⁾

Additionally, research has suggested that J147 may help reduce the formation or accumulation of amyloid plaques in the brain. This effect can be crucial in slowing the progression of Alzheimer’s disease or potentially reversing some of its symptoms.⁽⁹⁾

2. Targets Molecular Mechanisms

The molecular target of J147 is crucial in its role as a nootropic agent. Studies suggest that J147 may influence specific molecular pathways associated with cognitive function and degeneration. Therefore, J147 provides a targeted approach to treating cognitive deficits.⁽¹⁰⁾

In addition to its effects on brain cells and memory enhancement, J147 also shows promise in treating conditions like fatty liver disease and mitigating effects associated with acute ischemic stroke. The protective effects of J147, observed as early as 4 hours after stroke onset, suggest its potential in acute therapeutic scenarios.⁽¹¹⁾

3. Enhances Neurotrophic Factors to Improve Memory

J147 functions as a neurotrophic compound, which means it supports the growth and survival of neurons. This action is essential for maintaining healthy brain function and has implications for improving memory and preventing the loss of cognitive abilities, especially in aging populations.

4. Neurogenic Potential

Studies have tested J147 selecting for neurogenic potential as an alternative approach in cognitive therapy. This research implies that J147 not only protects existing neurons but also promotes the formation of new neural connections, enhancing the brain’s capacity to adapt and learn.

5. Potential Treatment for Depression

Inflammation plays a role in the pathophysiology of depression. J147’s anti-inflammatory effects might contribute to alleviating depressive symptoms by reducing inflammation in the brain.

Additionally, while the direct effects of J147 on neurotransmitters associated with depression (like serotonin, dopamine, and norepinephrine) need more exploration, its overall neuroprotective action might indirectly influence these neurochemical pathways, potentially offering effective relief from depressive symptoms.⁽³⁾

Lastly, depression is often exacerbated by chronic stress. If J147 can modulate the body’s response to stress at a cellular level, it might provide additional benefits in managing depression.

Uses of J147

Here are some of the key uses of J147 for cognitive improvement: 

• Cognitive Impairment Treatment: J147 has been shown to reverse cognitive impairments, particularly in aging and neurodegenerative conditions.
• Neuroprotective Agent: J147 prevented the neurodegeneration of neurons within the aging brain of mice. This makes J147 a potent neurotrophic.
• Memory Enhancement: J147 enhances memory, especially in contexts where memory loss is inhibited by j147, along with other neurodegenerative diseases associated with aging.
• Neurotrophic Effects: The compound promotes the growth and survival of neurons, contributing to overall brain health.
• In Vitro Studies: J147 has been extensively studied in vitro, providing insights into its mechanism of action and potential therapeutic uses.
• Mitochondrial Function: It supports mitochondrial function, crucial for energy metabolism in brain cells.
• Protein Kinase Regulation: J147 interacts with protein kinase pathways, which are vital for numerous cellular processes.
• Alzheimer’s Disease Research: It has shown promise in Alzheimer’s disease research, particularly in its potential to prevent or slow down the progression of the disease.
• Inhibition of Neurodegeneration: J147 has inhibited certain pathways that lead to neurodegeneration, suggesting its use in various neurodegenerative diseases.
• Exploring Broader Applications: Research is ongoing to determine whether J147 could be beneficial in other conditions beyond neurodegeneration, such as metabolic diseases or psychiatric disorders.
• Understanding Its Structure: Studies on the structure of J147 contribute to understanding how it interacts with different molecular targets.
• Protective Against Cellular Stress: J147 was also found to protect cells from various forms of stress, which is critical in neurodegenerative diseases where cellular stress is a common feature.

J147 Dosage

A single oral dose of J147 is recommended to be taken twice daily, once in the morning and again at night. A typical daily dosage of J-147 powder lies between 5 mg and 30 mg, with 10mg being an optimal amount.

In addition, we recommend eating something before taking J147, as it can cause nausea if taken on an empty stomach. You should not exceed two doses a day or six capsules of J147 per week.

Note: The optimal dosage of J147 for human use is yet to be established through clinical trials, and it is advised to consult with a healthcare professional for any use. Individual factors such as age, body weight, the severity of the condition, and co-existing health issues can influence the optimal dosage for each patient.

Where To Buy J147

You can buy J147 from our top pick for the best online vendor, Science.Bio. 

Science.Bio offers third-party tested research chemical products and nootropics, with worldwide shipping. 

J147 Side Effects and Safety

J147 has been clinically tested by independent labs and shown safe for long-term use.

In addition, it does not contain any GMOs (genetically modified organisms) or gluten.

However, as with all research chemicals, potential side effects still exist. Users have reported a range of side effects, including: 

• Increased heart rate
• High blood pressure
• Insomnia
• Gastrointestinal discomfort

These side effects do not last long, and are usually gone once your body has adjusted to the new compound in your central nervous system. However, if they persist, see a medical professional immediately. 

Summary

In summary, J147, an experimental drug candidate, shows promise as a potential therapeutic for neurodegenerative diseases, particularly in aging brains. Developed from a curcumin derivative, it’s been studied in mouse models, revealing its ability to improve memory, reverse cognitive impairments, and exert neuroprotective effects.

J147 targets mitochondrial ATP synthase, crucial for cellular energy metabolism, and has been effective in models of Alzheimer’s disease. Its protective effects extend to acute conditions like ischemic stroke, observable as early as 4 hours post-onset.

Currently, in clinical trials, J147’s potential as a disease-modifying drug offers hope for treating age-associated cognitive decline and neurodegenerative disorders.

If you’re considering J147 treatment, then remember to consult with a healthcare professional. A doctor will help you understand the best terms of J147 use for your particular condition or intended use.

1. Emmanuel, Iwuchukwu A et al. “Deciphering the ‘Elixir of Life’: Dynamic Perspectives into the Allosteric Modulation of Mitochondrial ATP Synthase by J147, a Novel Drug in the Treatment of Alzheimer’s Disease.” Chemistry & biodiversity vol. 16,6 (2019): e1900085. doi:10.1002/cbdv.201900085 ↩
2. Daugherty, Daniel J et al. “A novel curcumin derivative for the treatment of diabetic neuropathy.” Neuropharmacology vol. 129 (2018): 26-35. doi:10.1016/j.neuropharm.2017.11.007 ↩
3. Qiu, Fang et al. “Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review.” BMC neurology vol. 23,1 317. 6 Sep. 2023, doi:10.1186/s12883-023-03358-5 ↩ ↩
4. Currais, Antonio et al. “Elevating acetyl-CoA levels reduces aspects of brain aging.” eLife vol. 8 e47866. 19 Nov. 2019, doi:10.7554/eLife.47866 ↩
5. Kepchia, Devin et al. “The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 147 (2022): 112648. doi:10.1016/j.biopha.2022.112648 ↩
6. Kepchia, Devin et al. “The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver.” Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 147 (2022): 112648. doi:10.1016/j.biopha.2022.112648 ↩
7. Goldberg, Joshua et al. “The mitochondrial ATP synthase is a shared drug target for aging and dementia.” Aging cell vol. 17,2 (2018): e12715. doi:10.1111/acel.12715 ↩
8. Prior, Marguerite et al. “The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice.” Alzheimer’s research & therapy vol. 5,3 25. 14 May. 2013, doi:10.1186/alzrt179 ↩
9. Ma, Chen et al. “Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions.” Molecules (Basel, Switzerland) vol. 27,4 1210. 11 Feb. 2022, doi:10.3390/molecules27041210 ↩
10. Goldberg, Joshua et al. “Targeting of intracellular Ca²⁺ stores as a therapeutic strategy against age-related neurotoxicities.” NPJ aging and mechanisms of disease vol. 6 10. 24 Aug. 2020, doi:10.1038/s41514-020-00048-1 ↩
11. Cai, Junying et al. “Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases.” BioMed research international vol. 2014 (2014): 601084. doi:10.1155/2014/601084 ↩