Pramiracetam: Review of Nootropic Benefits, Uses, & Side Effects

Updated on May 17, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Pramiracetam is a cognitive-enhancing power pill with wonderful effects on the brain. You may have problems recalling things, or you may have been under brain trauma treatment. If so, you too can dive into this review and learn how this powerful drug works.

Continue reading to learn more about Pramiracetam's brain-boosting properties.

What is Pramiracetam?

pramiracetam structure

Parke-Davis Pharmaceutical Company developed and sold Pramiracetam(1) as Primastar in 1979. It is recognized for its cognitive-enhancing effects, similar to Piracetam, but it acts up to 30 times stronger. Initially, the supplement was created for people suffering from neurodegenerative illnesses, brain traumas, and other central nervous system disorders.

Pramiracetam is an AMPA receptor positive allosteric modulator. It has been examined for its ability to improve cognition, neuroprotection, and mood. This nootropic is gaining popularity in the United States and certain European countries. It is used as a supplement to boost mental capacities, such as information generation, processing, and retrieval.

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Despite the fact that it was designed for the elderly and individuals with brain injuries, healthy people are now flocking to get their hands on the pills.

Mechanism of Action

Pramiracetam is a 2-oxo-pyrrolidine racetam with a piperidine group. This distinguishes the compound from its close relatives, such as Piracetam and aniracetam. Unlike Piracetam, Pramiracetam has a strong affinity for both synaptic and extrasynaptic AMPA receptors in rat forebrain membranes, but no affinity for NMDA or kainate receptors. Pramiracetam has a K I = 9-17 M affinity for the PSB site in rat brain membranes.

What is the Use of Pramiracetam?

Pramiracetam was created from Piracetam as a drug to improve mental capacity via the high-affinity choline uptake (HACU) process.

pramiracetam review

Affects memory

Pramiracetam helps treat individuals suffering from neurodegenerative disorders and to prevent memory loss in the elderly.

After several years, its potential as a neuroenhancer was tested in humans, both young and healthy, regardless of whether they had brain-related health concerns.

As a result, it was identified as a nootropic that dramatically improved retention while also easing symptoms of moderate amnesia.


Pramiracetam is a medication that protects the brain against many sorts of injury. It stimulates cerebral activity and improves memory. Seizure patients can be prescribed this drug by their doctors.

Pramiracetam has also been widely researched for its use in the treatment of Alzheimer's disease, Parkinson's disease, stroke recovery, depression, and other conditions.

Pramiracetam improves memory and mental function while also acting as a neuroprotectant. It is thought to have a high potency because of its greater lipid solubility, which allows it to pass the blood-brain barrier.

Recovery from Brain Injury

This supplement is commonly used in many European nations to assist treat neurological problems. This is not confined to the elderly; it is also used in individuals with ADHD, dyslexia, and dementia.(2)

Pramiracetam is a nootropic medication used to help prevent and treat neurological illnesses and disorders. It also improves cognitive performance and reduces brain damage caused by head injuries.

Effects & Benefits of Pramiracetam

Pramiracetam is well-known not only as a treatment in the medical field. Pramiracetam reviews show that it is also used as a supplement by healthy young people.

The following are some advantages of taking the pill:

Improves recall. According to research, it plays a critical role in dramatically improving memory. It works in the hippocampus region of the brain to improve memory and learning ability.

It protects the brain. This is one advantage that addresses the potential harm caused by toxins and other drugs such as scopolamine, which causes memory loss. A partial case reduction was recorded, slowing a person's cognitive decline.

effects of pramiracetam

Improves brain injury recovery time. When the brain is injured or traumatized, large doses of drugs are frequently administered to speed recovery. Because Pramiracetam is 30 times more powerful than other nootropics, a lower dose is all that is required to help reduce the side effects of mild neurological injuries.

Reduces memory loss. A sufficient blood supply to the brain ensures better memory; however, when the arteries supplying the blood are blocked, negative cognitive symptoms occur. Patients who have taken Pramiracetam have reported improved memory after several weeks of treatment.

Is there any scientific evidence that Pramiracetam has any positive effects?

Yes. Pramiracetam has been shown in studies significantly to enhance cognition and mood in older adults with memory impairment. A separate study found that taking 300 milligrams of Pramiracetam improved visual information processing, spatial planning ability, and associative learning.

It has also been used to prevent neurodegeneration and improve cognitive function in healthy people due to its neuroprotective properties.

Although it has some minor side effects, such as headaches and nausea, these can most likely be avoided by adjusting the dosage or taking pills instead of powder for the supplement.

How Does It Work in the Brain?

Pramiracetam maintains and increases blood flow and oxygen delivery to the brain while keeping glucose metabolism stable.

It improves brain activity by stimulating the chemicals through increased choline levels or high-affinity choline uptake. Choline is essential for the activation of the acetylcholine receptor, which functions as a neurotransmitter in the hippocampus. With enough choline, mental energy can be used to store and recall long and short-term memories.

Clinical trials have shown that providing the brain with an adequate supply of blood and oxygen improves its overall cognitive abilities.

Dosage of Pramiracetam

The best dose is between 500 and 1600 mg, divided into several doses.

Begin with a 500 mg dose spread throughout the day when taking Pramiracetam. You can escalate your dosage as your body becomes accustomed to the drug. It is also recommended that you take it during the day after a meal.

Pramiracetam should be taken in two doses of 600 mg per day. Some users take up to 1 g per day. However, many experts believe this is dangerous because of potential side effects, such as increased agitation and irritability. An overdose could cause poisoning.

Pramiracetam has been shown to increase cognition and improve mood at a safe dosage of 600 milligrams per day.

How to Take Pramiracetam?

Pramiracetam can be taken in powder, capsule, or tablet form. To get the most out of the nootropic, spread the dose out throughout the day and after each meal.

how to take pramiracetam

Side Effects

Pramiracetam is a low-risk nootropic with a lower dose requirement than other nootropics. Increasing the dose would only result in intolerance.

Even if you only take a small dose, you may experience very few side effects that are common with nootropics.

Pramiracetam is well tolerated, but at higher doses, some people experience mild side effects such as headache, insomnia, nausea, and irritability.

Pramiracetam raises dopamine levels in the brain, which causes agitation and anxiety in some users. It's unclear why this happens for some people but not others, so be wary of any negative side effects when taking pramiracetam supplements.

If you continue to experience anxiety or irritability after discontinuing the use of the pramiracetam supplement, consult your doctor immediately.

How to Reduce Side Effects

Pramiracetam is a beautiful nootropic that should be included in any drug stack, but it can cause some side effects in users. Headaches are the most common side effect. Some users have also reported insomnia, dry mouth, vertigo, nervousness, stomach discomfort, nausea, and constipation.

side effects of pramiracetam

Fortunately, there are ways to reduce the side effects of Pramiracetam for people who experience these symptoms.

Taking this smart drug with meals rather than on an empty stomach will help reduce nausea and discomfort in many people. Along with Pramiracetam, drinking plenty of water can help relieve dry mouth and constipation.

Because insomnia is a potential side effect of pramiracetam, it should be taken in the morning or early afternoon rather than late at night.

Each side effect is different for each person, but if none of the suggestions above help, it's best to stop taking this smart drug or consult with your doctor about other options.

Experiences Shared on Reddit

Here's what the users have to say about this smart drug.

According to MisterYouAreSoDumb:

"Pramiracetam is one of the most effective nootropics for me personally. I actually love it.

I have a feeling it has something to do with pramiracetam's ability to increase nitric oxide via nitric oxide synthase."

According to DigitallyAborted:

"Pram gave me one of the best racetam experiences and helped "get me out of my head". I might not want it for taking exams but it's suited more for reading/working/studying IMO."

According to baronjpetor:

"Pramiracetam is my favorite racetam when it comes to clean focus and memory boost.

The only downside is that for some people (me included) it seems to have a weird depersonalization effects at medium-high doses. A redditor coined it as the "Spock effect" in another prami post.

I personally call it the "Rain Man effect" :)"

Pramiracetam Stacks

Choline deficiency is a common side effect of racetam use.

pramiracetam stack

Let us not forget that choline is essential for signaling to the brain. It is the precursor to acetylcholine, a neurotransmitter that handles all signal transmission. The pramiracetam stack is popular for improving well-being and cognitive function.

You can combine it with other nutritional supplements or drugs to create a synergy that will give you the best results.

These are some of the best stacks for getting the most out of the Pramiracetam nootropic, according to research.


When you take the supplement, you get the benefits and some side effects. One example is low choline levels in the brain. This should be at the top of your stack list because adequate choline supply is critical.

Alpha GPC and Citicoline are two of the best choline supplements. You can take either of these two drugs, and you will undoubtedly benefit from Pramiracetam without changing your diet. It also aids in the reduction of side effects such as headaches while taking nootropics.


Aniracetam reduces stress, allowing you to focus and concentrate more effectively, resulting in increased productivity.

When combined with Pramiracetam, your mental ability is enhanced and your mood improves.

This drug combination reduces stress and anxiety, allowing you to socialize and learn at the same time.

Other Nootropics

If you have never used nootropics before, you can start with Pramiracetam and see how it affects your body. After a few weeks, you can try stacking it with other nootropics that are relevant to the outcome you seek.

Armodafinil, Modafinil, and Adrafinil are a few nootropics to consider. These smart drugs increase mental energy, allowing for greater focus and concentration. People frequently stack it with any of these when they need to study for long periods of time.

Where to Buy Pramiracetam Capsules & Powder?

Pramiracetam is available as a powder, capsule, or tablet. The FDA has not yet approved this drug in the United States, but there are no restrictions on purchasing it online.

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The best place to buy it is from a reputable site with a track record of supplying legitimate nootropics, such as this one. One advantage of this website is that you can contact them via email for more information on the nootropics.

It has an independent testing laboratory and has been selling nootropics that have been subjected to extensive testing and research. It offers a variety of nootropics, and you can be certain that it sells Pramiracetam on its website.

How Much Does it Cost?

Pramiracetam powder typically costs $1.50 to $2.00 per gram, depending on quantity ordered and other factors, such as raw material quality and company selling it.

Pramiracetam capsules cost about $0.30 to $0.60 each, but that does not include shipping costs or individual state taxes, which may be added to each purchase and raise the price even more depending on location.

The best way to estimate the price of Pramiracetam is to contact several suppliers and compare their prices per gram.

Also, while the price of Pramiracetam is relatively low when compared to other racetams like Aniracetam or Oxiracetam, the quality of the raw material used does matter when determining how effective it will be.

Frequently Asked Questions (FAQ)

If you have questions that are bothering you, you may find the answers here.

How Long Does It Take Pramiracetam to Work?

It usually takes 30-60 minutes after taking Pramiracetam to feel the effects. You become more alert, have more energy, and can absorb information more easily.

Is Pramiracetam Safe?

Compared to other racetams and research chemicals, pramiracetam is relatively safe. However, keep in mind that it is neither completely safe nor a natural nootropic supplement.

Although the FDA has not yet approved it in the United States, it is not prohibited to purchase Pramiracetam online. The drug is used to treat neurological diseases that cause memory loss in Russia and some European countries.


Pramiracetam is a racetam-family nootropic that promises improved mental capabilities and prevents memory loss caused by aging or neurodegenerative diseases or injuries.

Many people use it to help them concentrate on their studies or to reduce the risk of cognitive decline.

This product has undergone human clinical trials to determine its effectiveness. With all of the distractions, this nootropic is worth a shot if you want to improve your cognitive function and overall well-being.

Pramiracetam: Review of Nootropic Benefits, Uses, & Side Effects 1

Are you starting to become forgetful and unable to focus on your tasks? Pramiracetam is the solution to get the mental focus and competence that you need.

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