Bromantane: Review of Nootropic Benefits, Uses, & Side Effects

Updated on February 6, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Exploring the nootropic benefits, uses, and side effects of Bromantane.

Bromantane, also known as Ladasten, is a unique nootropic and stimulant that has gained attention for its potential to enhance both mental and physical performance.

Initially developed in the 1980s, Bromantane stands out due to its dual action as both a stimulant and anxiolytic, aiming to improve physical endurance and cognitive performance without the adverse effects commonly associated with traditional stimulants.

But, are these claims true? Let’s find out if this is the right nootropic for you.

What is Bromantane?

Bromantane (also known by the name Ladasten, Adamantylbromphenylamine, and ADK-709) is a derivative of Adamantane. It is a unique synthetic compound known for its dual role as both a stimulant and an anxiolytic drug.

Developed in the late 1980s by the Russian Academy of Medical Sciences, Bromantane is popular because it purportedly improves mental and physical performance.

Bromantane is notable for its dopaminergic and serotoninergic activity. This means it is effective at increasing dopamine and serotonin to promote improved brain activity. Increasing dopamine leads to improved motivation, reward, and motor control, while serotonin is linked to mood regulation, among other functions.

Therefore, Bromantane improves cognitive functions such as memory, attention, and learning. Simultaneously, it is said to boost physical performance, enhancing energy levels, stamina, and strength.

Unlike typical stimulants that can increase anxiety, Bromantane has anxiolytic properties. This means it works to help relieve fatigue and anxiety, which is beneficial for those who need both mental alertness and emotional calmness.

One of the key appeals of Bromantane is its ability to work as an actoprotector (a pharmacology term from Russia) to enhance physical activity, particularly under extreme or stressful conditions. 

Bromantane treatment has been explored for various applications, including enhancing recovery from physical exertion and treating neurasthenia, a condition characterized by chronic fatigue and weakness.

The effects of Bromantane include improved mood, increased energy, enhanced concentration, and reduced feelings of fatigue.

Unlike many stimulants, Bromantane is not associated with a significant risk of dependence and withdrawal symptoms, making it a safer option for those concerned about these issues.


  • Improves mental and physical performance simultaneously
  • Reduces anxiety and stress with anxiolytic effects 
  • Enhances mood, motivation, and drive
  • Reduces fatigue and lethargy without drastically increasing blood pressure


  • Not approved by the FDA (Food and Drug Administration) or WADA (World Anti-Doping Agency)
  • Limited research on the safety of high doses or long-term use

Mechanism of Action

Bromantane (Ladasten) is chemically modified from the Adamantane base structure, primarily by the addition of a bromine atom and an amine group. This modification gives Bromantane its unique pharmacological properties and biological activity as a nootropic drug. 

The action of Bromantane and how it works on the human brain is multifaceted and involves several pathways.

Bromantane produces psychostimulant effects because it influences the release and metabolism of dopamine, a key neurotransmitter associated with motivation, pleasure, motor control, and focus. By stimulating an increase in dopamine activity, Bromantane helps improve mental alertness and enhances physical activity under extreme environmental conditions.(1)

As an actoprotector, the effects of Bromantane have stress-protective properties, helping the body adapt to physical and mental stress.

Unlike many stimulants, Bromantane exhibits low peripheral sympathomimetic effects. This means it doesn’t excessively stimulate the peripheral nervous system, which can lead to side effects like increased heart rate and hypertension.

The unique action of Bromantane works to relieve fatigue and reduce anxiety. Its anxiolytic properties distinguish it from typical stimulants that often exacerbate anxiety and stress.

By modulating neurotransmitter levels and reducing fatigue and anxiety, Bromantane administration purportedly improves both mental and physical performance. This makes it a popular choice for situations requiring enhanced cognitive function and physical endurance.

One of the ways Bromantane improves dopamine levels is by enhancing the conversion of tyrosine hydroxylase and amino acid decarboxylase into dopamine. This dopamine formation from tyrosine and decarboxylase contributes to the drug’s stimulant effects, making Bromantane treatment an effective option for people suffering from neurasthenia.

Additionally,  Bromantane enhances the efficiency of your body’s energy use. It does this by optimizing biochemical processes that contribute to physical and mental performance without increasing oxygen consumption or causing an increase in heart rate or blood pressure. 

The Zakusov State Institute of Pharmacology has been involved in the development and initial research of Bromantane. It played a significant role in understanding the pharmacological properties and potential therapeutic applications of the drug.

Some available animal research found that Bromantane may also affect the body at a genetic level. According to a macroarray analysis of gene expression changes in a rat brain, Bromantane use has the potential for this activity and impact on unique gene expression.(2) However, robust clinical trials are needed to confirm these preliminary findings. 

However, the exact mechanism of action of Ladasten (Bromantane) is still unknown, and more clinical trials are needed to understand information about its long-term safety profile and its benefits for human health.

Nootropic Benefits of Bromantane

Bromantane is considered a nootropic (also known as a smart drug) due to its potential to improve cognitive functions like memory, attention, and problem-solving skills. 

Let’s have a look at the effects of the Bromantane drug and how it can benefit people in the nootropic community.

1. Improvement in Cognitive Functions

Bromantane has been found to enhance various cognitive functions, beneficial for managing ADHD symptoms. This includes increased attention, better focus, and improved mental clarity.

2. Modulation of Neurotransmitters

Studies Bromantane administration increased the levels of neurotransmitters like dopamine and serotonin in rat brains.(3) These changes lead to improved mood, enhanced learning ability, and increased motivation. This allows for higher drive, concentration, focus and productivity both mentally and physically. 

3. Gene Expression Changes

Research involving rats has shown that Bromantane induces gene expression changes. While the exact implications of these changes are still being explored, they may contribute to its cognitive-enhancing effects.(4)

4. Anxiolytic Effects

Unlike many stimulants, Bromantane has anxiolytic effects, which helps reduce anxiety, thereby potentially improving cognitive functions impaired by stress and anxiety. This makes it useful for tasks requiring sustained mental effort.

5. Enhanced Physical Performance

Beyond cognitive improvement, Bromantane also enhances physical performance. This dual effect can be particularly beneficial in activities requiring both mental sharpness and physical endurance.(5)

Additionally, in studies, growth development differences were insignificant in experimental animals, suggesting it does not adversely affect these aspects.(6) Bromantane was given to female rats before pregnancy, and there was no increase in death rate or weight in the pups. However, bromantane increased the speed of their development. The female rat’s infant rats developed reflexes faster than other rats in this study.

This makes Bromantane an ideal product for fitness enthusiasts who want to take their daily workout routines to the next level!

6. Enhancement of Learning and Memory

The impact on dopamine and serotonin also suggests potential benefits in memory formation and learning processes, essential components of cognitive functioning.

Uses of Bromantane

Bromantane is known for its unique combination of stimulating and anxiolytic properties. Here are its primary uses:

  • Enhancement of Physical Performance: Increases endurance and strength, and reduces fatigue, especially useful in athletes and physically demanding professions.
  • Cognitive Enhancement: Improves mental alertness, focus, and cognitive functions, beneficial in tasks requiring mental acuity.
  • Treatment of Asthenia Disorders: Used to treat neurasthenia, a condition characterized by physical and mental weakness, often post-illness.(7) Additionally, it is also used to 
  • Reduction of Anxiety: Exhibits anxiolytic properties, helping to reduce anxiety without sedative effects.
  • Improvement in Mood: Bromantane positively affects mood, contributing to overall well-being and performance. Bromantane is useful in the treatment of depression and for people who want to experience a better quality of life.(8)
  • Stress Resistance: Enhances the body’s ability to withstand physical and mental stress.
  • Neuroprotective Effects: Has potential neuroprotective properties, although more research is needed in this area.
  • Management of ADHD Symptoms: May be beneficial in managing attention deficit and hyperactivity disorder (ADHD) symptoms due to its effects on focus and concentration.
  • Synergistic Effects with Other Nootropics: Often used in combination with other nootropics for enhanced cognitive benefits.
  • Increase of Reproductive Health: Research on Bromantane has included investigations into its effects on various physiological aspects, including reproductive health. This drug may help increase sperm count and sperm movement.
  • Potential Use in Neurodegenerative Diseases: Some research suggests potential utility in the context of neurodegenerative diseases, but this requires further investigation.

Remember, while Bromantane is known for these uses, its availability and legal status might vary by region, and it should be used under appropriate medical guidance.

Where to Buy Bromantane

Finding high-quality chemicals and nootropics is tough, with so many low-quality products being sold, it’s hard to know which vendors to trust.

That’s why we did a lot of digging and in-depth testing.

According to our research, the top pick for where to purchase Bromantane is Science.Bio.

Science.Bio offers third-party tested nootropics and research chemicals, along with free worldwide shipping for orders over $100. Their products are the highest quality on the market, with a global community of happy customers.

Bromantane Dosage

A single dose of Bromantane is commonly dosed in the range of 50 mg – 100 mg per day.

This range is considered effective for a single treatment. Most patients experienced the desired cognitive and physical performance enhancements with this dosage.

However, it’s important to rememember that the effective dosage of Bromantane can vary significantly among individuals due to differences in metabolism, body weight, and tolerance to stimulants.

Bromantane is usually taken once daily. In some cases, the daily dose may be divided into two administrations (morning and early afternoon) to maintain its effects throughout the day.

Bromantane Side Effects & Safety

Bromantane is typically considered to be safe.

However, like most nootropics, users do experience some of side effects.

The most commonly reported adverse effects of Bromantane include: 

  • Dizziness and headaches
  • Nausea
  • Stomach discomfort
  • Changes in appetite
  • Sleep disturbances

If any severe adverse effects are experienced, discontinue use and consult a healthcare professional. 

Key considerations when it comes to Bromantane’s safety profile include: 

  • Allergic Reactions: As with any substance, there is a potential for allergic reactions, which may manifest as skin rashes, itching, or other allergic symptoms.
  • Long-Term Safety: The long-term safety profile of Bromantane is not fully established, as most studies have focused on short-term use.
  • Risk of Abuse and Dependence: Withdrawal symptoms upon discontinuation of Bromantane are uncommon, giving it a low addictive potential. However, as it is still a stimulant, this potential still exsists.
  • Interactions with Other Medications: Bromantane could interact with other medications, particularly those affecting the central nervous system. It’s important to consult with a healthcare provider about potential drug interactions.
  • Contraindications: Bromantane may be contraindicated for individuals with certain medical conditions, such as severe liver or kidney disease, cardiovascular disorders, or psychiatric conditions.


In conclusion, Bromantane stands out in the world of pharmacology for its unique combination of stimulant and anxiolytic properties. Developed in Russia, it enhances both physical and cognitive performance, making it valuable for a variety of applications, from athletic endeavors to cognitive demands.

Its mechanism, influencing dopamine and serotonin levels, offers improvements in mood, focus, and resilience against stress, while maintaining a lower risk profile for dependence and major side effects.

Could this be the right nootropic for you? Try it and find out, today.


How long does Bromantane take to work?

The time it takes for Bromantane to start working can vary depending on individual physiology and dosage. Typically, users may begin to feel the effects within hours of administration

What is the elimination half-life of Bromantane?

The elimination half-life of Bromantane is not precisely established in the scientific literature. It is metabolized in the liver, but the exact duration of its presence in the body can vary among individuals.

Should you cycle Bromantane?

Cycling nootropics, including Bromantane, is often recommended to prevent tolerance and potential side effects. While there’s no universally accepted cycling protocol for Bromantane, some users choose to take it for a period followed by a break.

Can I stack Bromantane with other nootropics?

Stacking Bromantane with other nootropics can be done, but it’s important to be cautious. The interactions between Bromantane and other substances are not thoroughly studied. It’s recommended to start with lower dosages and monitor your body’s response.

How should I store Bromantane?

Bromantane should be stored in a cool, dry place away from direct sunlight and moisture. Keeping it in its original packaging and ensuring the cap is tightly closed can help maintain its efficacy.

Sources, Studies, and Scientific Research
  1. Grekhova, T V et al. “Effekt novogo immunostimuliatora s psikhostimuliruiushchim deĭstviem–bromantana na vysvobozhdenie i metabolizm dofamina v dorsal’nom striatume svobodnopodvizhnykh krys: mikrodializnoe issledovanie” [The effect of bromantane, a new immunostimulant with psychostimulating action, on release and metabolism of dopamine in the dorsal striatum of freely moving rats: a microdialysis study]. Biulleten’ eksperimental’noi biologii i meditsiny vol. 119,3 (1995): 302-4. ↩
  2. Vakhitova, Iu V et al. “Ladasten indutsiruet ékspressiiu genov, reguliruiushchikh biosintez dofamina v razlichnykh strukturakh mozga krys” [Ladasten induces the expression of genes regulating dopamine biosynthesis in various structures of rat brain]. Eksperimental’naia i klinicheskaia farmakologiia vol. 67,4 (2004): 7-11. ↩
  3. Kudrin, V S et al. “Vliianie bromantana na dofamin- i serotoninergicheskie sistemy mozga krys” [The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain]. Eksperimental’naia i klinicheskaia farmakologiia vol. 58,4 (1995): 8-11. ↩
  4. Salimgareeva, M Kh et al. “Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases.” Bulletin of experimental biology and medicine vol. 152,3 (2012): 313-7. doi:10.1007/s10517-012-1516-z ↩
  5. Oliynyk, Sergiy, and Seikwan Oh. “The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.” Biomolecules & therapeutics vol. 20,5 (2012): 446-56. doi:10.4062/biomolther.2012.20.5.446 ↩
  6. Iezhitsa, I N et al. “Effects of bromantan on offspring maturation and development of reflexes.” Neurotoxicology and teratology vol. 23,2 (2001): 213-22. doi:10.1016/s0892-0362(01)00119-2 ↩
  7. Neznamov, G G et al. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova vol. 109,5 (2009): 20-6. ↩
  8. Tallerova, A V et al. Eksperimental’naia i klinicheskaia farmakologiia vol. 74,11 (2011): 3-5. ↩