13 Best Nootropics for Mood Enhancement in 2024 (Mood-Boosting Nootropic Supplements)

Updated on February 25, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
An article discussing the benefits of mood-boosting nootropic supplements for emotional well-being.

Nootropics are brain supplements that improve cognitive function such as memory, focus, and attention.

More than the typical boost in cognitive performance, nootropics also enhance the mood while reducing stress, anxiety, and depression.

Suppose you need other serotonin sources. In that case, and dopamine aside from engaging in fun activities, you can also opt to supplement yourself with nootropics that focus on giving the motivation and energy you need.

Since numerous nootropic supplements claim to improve mood and energy levels, finding the best one would be like looking for a needle on a haystack.

To help you know the best supplements for anxiety and depression, we have listed the scientifically-proven nootropics that can lift your mood or even bring you to a euphoric state.

In many cases, mood changes can be attributed to different medical diagnoses. You may be experiencing mental health conditions like depression and anxiety, hormonal changes, or just a case of being unmotivated.

Despite focusing on emotional health, our mood is still a significant aspect of our brain function. If you have problems maintaining a positive mood due to cognitive impairments or hormonal changes, it would likely cause a dent in your productivity and performance. You may also have difficulty concentrating on your tasks, retaining information, or retrieving long-term memory.

By taking a nootropic supplement, it may modulate the neurotransmitters’ production and release. Whether natural or synthetic smart drugs like Noopept, nootropic promotes brain health and function to target depression.

Although nootropic supplements such as Noopept may not be enough to cause significant improvement for mood disorders, these can be effective for people who have temporary changes in mood to restore their motivation.

Besides seeking medical help and engaging in fun activities, you may also try smart drugs like Noopept to help deal with your mood. We have listed below the best nootropics that will boost your mood and cause significant changes in your cognitive performance. These are available as a nootropic powder, supplement, or part of nootropic ingredients.

Best Nootropics for Mood Enhancement

  • NooCube — The best supplement for overall brain health
  • L-Theanine — Best to promote relaxation and calmness
  • Phenibut — Great to reduce stress, anxiety and insomnia
  • Uridine — Great for supporting brain health and function
  • Fasoracetam — Best to modulate acetylcholine and glutamate
  • L-Tyrosine — Great for increasing dopamine and adrenaline levels
  • Rhodiola Rosea — Best adaptogenic herb against mental stress
  • Ashwagandha — Best for balancing neurotransmitters
  • Ginkgo Biloba — Best for improving oxygen delivery to brain
  • Vinpocetine — Great for enhancing cerebral metabolism
  • Lion’s Mane Mushroom — Great for stimulating nerve growth factor
  • Picamilon — Best for increasing GABA levels in brain
  • SAMe (S-Adenosyl-L-Methionine) — Great for supporting cellular energy production

How to Choose the Best Nootropics for Mood?

Selecting the most suitable nootropics for mood enhancement involves understanding several critical factors that can influence their effectiveness.

FactorDescriptionWhy It’s Important
Ingredient QualityThe purity and source of the nootropic ingredients.High-quality ingredients ensure safety and efficacy.
Scientific BackingEvidence from clinical studies supporting the nootropic’s mood-boosting claims.Scientifically-backed nootropics are more likely to be effective.
Dosage & SynergyThe amount of each ingredient and how they work together.Correct dosages and synergistic effects can maximize benefits.
Side Effect ProfilePotential adverse reactions or interactions with other substances.Knowing side effects helps in assessing risks and avoiding harm.
User FeedbackExperiences and reviews from individuals who have used the nootropics.Real-world experiences can provide insight into the nootropic’s performance.
  • Ingredient Quality: Ensuring that nootropics contain high-grade ingredients is crucial for their safety and effectiveness. High-quality ingredients are less likely to contain contaminants that could negatively affect your mood or health.
  • Scientific Backing: Nootropics supported by clinical research offer more assurance that they will positively affect mood. These studies often reveal the mechanisms by which nootropics influence mood and cognitive function.
  • Dosage & Synergy: Proper dosing is key to achieving the desired mood-enhancing effects without overstimulation or side effects. Additionally, some ingredients work better together, enhancing each other’s effects.
  • Side Effect Profile: Being aware of potential side effects is important for avoiding adverse reactions. Some nootropics may not be suitable for everyone, especially those with pre-existing health conditions or who are taking other medications.
  • User Feedback: Reviews and testimonials from users can provide practical information on the nootropic’s efficacy and safety from a consumer perspective, supplementing clinical evidence.

The Best Nootropics for Mood of 2024

According to scientific research and customer reviews, the 13 best nootropics for mood are:

1. NooCube: Best Nootropic for Mood and Motivation

The nootropic NooCube is a natural mood enhancer that works by increasing levels of dopamine, serotonin, and norepinephrine.

Dopamine is a neurotransmitter that regulates the pleasure center of the brain. When you feel happy, it increases. When you feel sad, it decreases. Serotonin is a neurotransmitter that regulates mood. When you are calm, it increases. When you are anxious, it decreases. Norepinephrine is a neurotransmitter that regulates your stress response. When you feel calm, it increases. When you feel stressed, it decreases.

The nootropic NooCube has been scientifically proven to increase levels of dopamine, serotonin, and norepinephrine. It is also an all-natural supplement that is free from any harmful side effects.

2. L-Theanine

L-Theanine is widely used to help with cognitive enhancement and alleviating anxiety and tension. Theanine is a naturally-occurring amino acid found on tea leaves and is popular in countries in East Asia. This substance improves mood as it produces alpha waves in the brain associated with wakeful relaxation.

A study shows that after 4 weeks of L-Theanine administration, symptoms of depression decreased, while the mental functions increased (Hidese et al., 2019). L-Theanine raises GABA levels, dopamine, and serotonin, which are directly associated with mood enhancement.

Studies suggest that L-Theanine can also decrease sleep-related problems compared to placebo.

3. Phenibut

Phenibut was originally developed in Russia as an anxiolytic supplement and treatment for insomnia. Studies show its effective anxiety relief and tension headaches reduction.

Phenibut stimulates neurotransmitters like dopamine and serotonin in the prefrontal cortex, which improves your mood that leads to a feeling of happiness. It is also shown that Phenibut has a calming effect, which alleviates stress and tension.

The recommended Phenibut dosage for anxiety is 250-500 mg, which you can take thrice per day. This smart drug is also available as a prescription drug in Russia, Ukraine, and Latvia for insomnia and anxiety but is unregulated in the US and not used for medical use.

4. Uridine: Best Nootropic for Mood and Energy

Uridine is a nootropic commonly known as a natural energy-promoting substance. Uridine Monophosphate is a precursor of RNA for protein synthesis. This naturally-occurring nucleotide also helps optimize brain cognition and improve memory.

Moreover, Urdine can stabilize mood and help people with anxiety as it modulates the release of neurotransmitters.

5. Fasoracetam

Fasoracetam is a new member of the racetams family. Studies indicate that Fasoracetam specifically modulates the metabotropic glutamate receptor (MGluR), which functions in brain protection from neurodegenerative diseases. It also stimulates acetylcholine release and uptake.

Research showed improvement for adolescents with ADHD and glutamatergic gene network variants upon supplementing with Fasoracetam.

6. L-Tyrosine

L-Tyrosine is an amino acid that is a precursor of different neurotransmitters like dopamine, norepinephrine, and adrenaline. N-Acetyl L-Tyrosine (NALT) is its more bioavailable form.

Research shows that L-Tyrosine is responsible for enhancing brain cognition, improving mental energy levels, and promoting focus, especially for people under extreme amounts of stress.

7. Rhodiola Rosea

Rhodiola Rosea, also known as golden root, is an adaptogen that combats the adverse effects of stress and helps achieve normal balance after experiencing a stressful event. This is beneficial for people who are constantly feeling burnt out. Moreover, it also helps boost mental energy and brain cognition.

One study involving students under distress due to examinations has shown that the supplementation of Rhodiola had significantly enhanced the students’ general well-being and physical fitness.

8. Ashwagandha

Ashwagandha is a potent adaptogen that combats stress and helps your body get back to its normal functions.

Studies confirm that Ashwagandha provides anxiolytic effects, especially for people diagnosed with psychological disorders. It also has the potential as a treatment for panic disorder and depression.

Moreover, Ashwagandha also has promising effects that promote overall well-being by reducing cortisol levels in the body. A high level of this hormone can be associated with unhealthy body implications like high blood pressure and impaired immune system, to name a few.

9. Ginkgo Biloba

Ginkgo Biloba offers various exciting benefits for your memory, cognition, and mood. Gingko Biloba is a popular nootropic ingredient known for its antioxidant properties that protect your brain from toxic radicals’ negative effects.

This nootropic interacts well with other ingredients, which may also act as a reagent for other supplements. Ginkgo Biloba is available as a dietary supplement in the US but not as a prescription drug.

10. Vinpocetine

Vinpocetine is a synthetic derivative of the Periwinkle plant used as a prescription drug for age-related cognitive impairments in Eastern Europe.

Aside from its effects on memory and cognition, research also suggests that Vinpocetine may improve mood and emotional state. This nootropic helps increase blood flow and modulates glucose metabolism.

11. Lion’s Mane Mushroom

Lion’s Mane is one of the most promising natural nootropics in the market due to its wide range of benefits.

The research discovered that Lion’s Mane stimulates nerve growth factor (NGF), a brain protein that helps enhance memory, mood, and learning. NGF protects existing brain cells and even promotes brain cell formation. It also has a role in reducing symptoms of depression.

12. Picamilon

Picamilon is a Russian nootropic that is good for your mood, as well as sleep quality. It has a half-life of 30 minutes.

This nootropic is more known for its anti-anxiety and depression effects as it stimulates GABA production in the brain. Increasing GABA levels will lead to relaxing effects.

However, it is vital to note that the FDA banned Picamilon in the US and Canada in 2015.

13. SAMe (S-Adenosyl-L-Methionine)

SAMEe is a potent compound that can improve your mood, relieve depression, and promote long-term memory. It helps in the generation of neurotransmitters like dopamine, serotonin, and melatonin.

A study of healthy adults who received SAM-e infusions shows that this natural compound can serve as an antidepressant.

What to Consider Before Buying Nootropics for Mood?

When on the market for mood-enhancing nootropics, there are several key considerations to ensure you make the right choice for your mental health and cognitive needs.

1. Personal Health and Sensitivities

It’s essential to take into account any personal health issues or sensitivities, including allergies to certain ingredients. Nootropics can have different effects depending on your individual health profile.

  • Review the ingredient list for potential allergens or compounds known to cause you discomfort.
  • Consider any underlying health conditions that may be affected by the nootropics you’re considering.

2. Long-Term Sustainability

Reflect on the long-term sustainability of taking a nootropic supplement, both in terms of physical health and financial commitment.

  • Investigate whether the nootropic is intended for short-term relief or if it’s suitable for long-term use.
  • Assess whether the cost of the nootropic is manageable over an extended period.

3. Compatibility with Lifestyle

Your lifestyle can significantly influence the effectiveness of nootropic supplements. A nootropic should complement, not complicate, your daily routine.

  • Consider if the suggested dosage schedule aligns with your lifestyle and if it’s convenient to maintain.
  • Think about how the nootropic might interact with your diet, exercise routine, and sleep patterns.

4. Expectations and Goals

It’s important to have realistic expectations and clear goals when selecting a nootropic for mood enhancement.

  • Set defined objectives for what you want to achieve with the nootropic, such as stress reduction or improved mood stability.
  • Understand that nootropics are not magic pills, and results may vary depending on a variety of factors including diet, sleep, and overall health.

How We Picked the Top Nootropics for Mood Lifting

We employed a comprehensive evaluation process to identify the best nootropics for mood enhancement. Our selection criteria included efficacy, ingredient quality, brand credibility, transparency, manufacturing methods, user feedback, pricing, and overall value. By examining each of these factors, we provided readers with a reliable and well-rounded list of the top mood-boosting nootropics.


We analyzed clinical studies and user experiences to measure mood improvement, focusing on stress reduction, emotional stability, and mental well-being.


We thoroughly examined each formula, prioritizing natural, high-quality, and scientifically proven ingredients that support healthy mood regulation.

Scientific Evidence

We consulted peer-reviewed research and meta-analyses to confirm the effectiveness of key ingredients in promoting a balanced mood.


We evaluated dosages and ingredient ratios, ensuring they correspond with established research for optimal efficacy.


We confirmed the safety of each ingredient, considering potential side effects and interactions, and adhering to regulatory guidelines. FDA-approved ingredients were given preference.

Brand Reputation

We assessed brand’s reliability and trustworthiness through customer reviews, expert recommendations, and company background.

Product Transparency

We appreciated complete ingredient disclosure, encompassing sources and concentrations, to facilitate informed consumer choices.

Manufacturing Process

We scrutinized manufacturing standards, prioritizing products created in certified facilities and abiding by Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, giving importance to testimonials that report mood enhancement and emotional wellbeing.


We compared product prices and ensured they were competitive, aligning with the quality and effectiveness of the nootropic.


We assessed overall value by considering the balance of price, quality, and effectiveness in order to guarantee the best return on investment.

Nootropics for Mood Enhancement in Summary

Nootropics are an excellent headstart for people who want to improve mental functions and target depression. The smart drugs and nootropics mentioned above are some of the best nootropics for your mood and brain health. However, you must remember that nootropics are not intended to diagnose, treat, cure, or prevent any disease.

Moreover, this review does not serve as medical advice, diagnosis, or treatment. This review’s content is for informational purposes only and does not provide a comprehensive explanation of the different compounds. If you want to have more subjective views, you may visit Reddit and look for user reports regarding their experiences with the mentioned nootropics.

You must also consult your doctor first, especially when experiencing major mood disorders like depression, stress, and anxiety that affect your occupational participation.

FAQs About Nootropics for Mood

What are nootropics, and how can they help with mood enhancement?

Nootropics are cognitive-enhancing supplements that improve brain function, focus, memory, and mood. They work by modulating neurotransmitters and optimizing brain health, which can lead to an overall positive outlook and well-being.

Which nootropics are known for their mood-enhancing effects?

Some popular mood-enhancing nootropics include L-Theanine, Ashwagandha, Rhodiola Rosea, Bacopa Monnieri, Phenylalanine, and Aniracetam. These substances can help alleviate stress or anxiety and promote happiness or relaxation.

How do these nootropics improve mood specifically?

These nootropics work on different pathways in the brain, such as regulating stress hormones, modulating the release of neurotransmitters like dopamine and serotonin, or enhancing communication between brain cells, ultimately promoting a sense of well-being.

What are the recommended dosages for these mood-enhancing nootropics?

Recommended dosages vary between individuals and substances. It’s essential to follow the manufacturer’s label or consult a healthcare professional to determine the optimal dosage for optimal results and safety.

Can these mood-enhancing nootropics be used in combination?

Yes, many individuals find that stacking (combining) certain nootropics can lead to synergistic benefits. It’s crucial to research each specific combination and consult a healthcare professional before trying a personalized stack.

How long does it take for mood-enhancing nootropics to show effects?

The onset of effects varies by substance and individual. Some nootropics, like L-Theanine, may have immediate effects, while others, like Bacopa Monnieri, may take several weeks for the full benefits to manifest.

Are there side effects associated with using these mood-enhancing nootropics?

Side effects of nootropics generally tend to be mild and rare, but they can occur. It’s important to start with the lowest recommended dose and monitor your response to minimize any potential adverse reactions.

Can individuals with mood disorders use these nootropics safely?

While these nootropics may help alleviate some mood-related concerns, it’s important to consult a healthcare professional, especially if you have a diagnosed mood disorder or take medications, as interactions may occur.