Nicergoline Review: Nootropic Benefits, Dosage, & Side Effects

Updated on April 1, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

In this Nicergoline guide, we'll look at this popular nootropic in-depth. We'll also review how Nicergoline works in the brain and provide information about its benefits, side effects, and where to buy it online.

Nicergoline (also known as Sermion) is a highly effective vasodilator that improves cerebral blood flow. It reduces vascular resistance and augments arterial flow, stimulating the utilization of oxygen and glucose in the brain.

Today, Nicergoline is widely used as a nootropic supplement to help improve mental performance and boost cognitive abilities. It enhances alertness, recall, focus, and other executive functions.

To comprehend how this nootropic operates and why it can be a helpful aid to bolster your cognitive abilities, let us take an in-depth look below.

Nicergoline Review Summary

Nicergoline is a vasodilator supplement that helps improve cognitive abilities. It increases oxygen and glucose utilization in the brain to enhance mental performance, alertness, recall, focus, and other executive functions.

So far, no serious side effects have been reported from taking Nicergoline.


  • Enhances cognitive abilities
  • Increases mental performance
  • Promotes alertness and focus
  • No serious side effects reported


  • It's difficult to find high-quality Nicergoline

What Is Nicergoline?

Nicergoline, sold under the brand name Sermion, is a medication from the ergot alkaloid class of drugs derived from the ergot fungus. It has been studied extensively for its potential to treat multiple age-related conditions, senile dementia, and vascular disorders.

nicergoline structure

Nicergoline has been used for frontotemporal dementia and early cases of Lewy body dementia and Parkinson's Dementia. Its vasoactive properties allow it to reduce vascular resistance while increasing arterial blood flow in the brain, ultimately improving oxygenation and glucose utilization by neurons.(1)

This occurs not only in the brain but also in other areas, such as the lungs. Moreover, unlike ergotamine or similar ergolines, Nicergoline does not lead to cardiac fibrosis – making it an ideal choice for many patients.(2)

It is currently approved by the European Medicines Agency (EMA) for treating dementia associated with cerebrovascular disease and age-related cognitive decline.

However, its ability to prevent memory loss, increase alertness and enhance overall cognitive function is what has made Nicergoline popular as a nootropic supplement, with anecdotal evidence of it being used to treat ADHD in some cases as well.

Let's take a closer look at how Nicergoline asserts its nootropic effects on the brain and what benefits it provides.

How Does Nicergoline Work In The Brain?

Nicergoline has been proven to have a broad spectrum of effects on the brain. In laboratory trials, it was observed to protect neurons from β-amyloid toxicity.(3)

Furthermore, research demonstrated that this compound could protect nerve cells and promote cholinergic and catecholaminergic neurotransmission in rats when subjected to experimentally induced growth factor deprivation.(4)

It has been demonstrated that Nicergoline not only acts as an antagonist of α1-adrenoceptors(5), improving arterial blood circulation and inhibiting platelet aggregation. It also supports metabolic activity, thus increasing oxygen and glucose utilization.

Moreover, Nicergoline shows neurotrophic properties in rats in vivo while having antioxidant effects.(6) Additionally, evidence suggests positive improvements in cognitive function among mouse models with Alzheimer’s disease.

Using EEG/ERP mapping technology, a double-blind, placebo-controlled clinical study was conducted to analyze the effects of Nicergoline on multi-infarct dementia and Alzheimer’s disease patients.(7) The results were remarkable, as enhanced alertness and information processing at a neurological level triggered substantial behavioral improvements for both vascular and degenerative dementia patients.

The protective consequences of these effects safeguard the neurological pathways, enhancing cognitive and behavioral proficiency, making Nicergoline one of the most exciting nootropic supplements available.

What Is Nicergoline Used For?

nicergoline benefits

Nicergoline is used in various medical applications, including but not limited to the following:

  • Treatment of acute and chronic cerebral metabolic-vascular disorders such as cerebral arteriosclerosis, thrombosis, cerebral embolism, and transitory cerebral ischemia.
  • Treatment of acute and chronic peripheral metabolic-vascular disorders, including organic and functional arteriopathies of the limbs, Raynaud's disease, and other syndromes caused by altered peripheral irrigation.
  • Management of migraines of vascular origin.
  • Adjunctive therapy for clinical situations accompanied by platelet hyper-aggregability and arterial tension.
  • Treatment of corio-retinal vascular disorders, such as diabetic retinopathy, macular degeneration, and retinal angiosclerosis.
  • Management of oto-vestibular problems of vascular origin, such as dizziness, auditory hallucinations, and hypoacusis.

In a nootropic context, Nicergoline is used as a cognitive enhancer to improve cerebral blood flow, enhance oxygen utilization, and increase neurotransmitter activity, thus improving overall cognitive function and mental clarity.

As a vasoactive nootropic, Nicergoline also helps to prevent oxidative damage caused by free radicals and other sources, allowing the brain to operate at peak efficiency.

What Are The Benefits Of Nicergoline For Cognition?

Nicergoline has been proven beneficial in improving cerebral blood flow and is now commonly administered for managing cognitive, emotive, and behavioral disorders.

Furthermore, experiments on animals have suggested that Nicergoline promotes corneal regeneration by increasing Nerve Growth Factor (NGF) concentrations in the area.

In a single, interventional study with 24 participants suffering from NK (Neurotrophic Keratopathy) that had been resistant to other treatments, the effects of 2 weeks' oral Nicergoline were studied. Astonishingly, 23 out of the 24 corneal epithelial defects healed between 7 days and 30 days after treatment began - an impressive result.(8)

The benefits for cognition brought by Nicergoline include improved neuroplasticity, increased oxygen utilization in brain tissue, enhanced cerebral blood flow, and greater efficiency of neurotransmitters.

The benefits of Nicergoline for cognition include:

  • Enhanced alertness and information processing.
  • Improved neural connectivity and communication.
  • Heightened concentration, focus, and memory.
  • Increased motivation and mental clarity.
  • Reduced anxiety and depression symptoms.
  • Balanced moods and improved cognitive performance.

Where To Buy Nicergoline Online?

We recommend purchasing Nicergoline (Sermion®) from CosmicNootropic. Their products are shipped from the United States and contain pure Nicergoline at a low price, starting from $43 USD. The shipping takes 2-5 days domestically and 7-14 days internationally.

Nicergoline is currently available from CosmicNootropic in 50 pills of 10 mg. You can find more information about Nicergoline on CosmicNootropic right here:

What Do People Say About Nicergoline On Reddit?

Let's take a look at what people on Reddit have to say about Nicergoline:

nicergoline dosage

According to u/shtuf:

"Nicergoline takes the prize in terms of noticeable effects on brain function, hands down. The mornings that I include 30mg of Nicergoline, I feel remarkably clearheaded as if thoughts are flowing naturally. Probably the best way to explain it is what the exact opposite of an alcohol hangover feels like, from a mental perspective. Or perhaps what it feels like after some vigorous cardio exercise when the brain feels invigorated."

According to u/rxdick:

"I have been using nicergoline on and off many times over the years (originally brought from Europe since us is stingy with things like that), and it is the only noot from the 100 I have tried, including your favorites, ashwagandha lions manes theanine, etc. anyway, it all works great..."

According to ThrowawayTaDay:

"I did push the limit on the max suggested daily dosage the other day. Took 60mg (2 x 30mg doses within 3 hours of each other). I had a little dizziness when standing up too quickly, but the effects were actually quite pleasant once I sat down and got settled in."

How Do You Take Nicergoline For Cognitive Enhancement?

The administration of Nicergoline is oral. For chronic cerebral circulatory disorders, vascular cognitive impairment, or post-stroke states, taking Nicergoline 3 times a day is recommended.

Nicergoline's therapeutic effect develops gradually; the course duration should be at least 3 months. To treat vascular dementia, the drug should be taken twice a day. It is recommended to consult a doctor every 6 months regarding the continuation of therapy.

For peripheral blood flow disorders, the drug should be taken 3 times a day for an extended period of time (several months).

Here's an overview of how the Nicergoline dosing works:

  1. Peripheral Vascular Disease: For this condition, the recommended dosage of Nicergoline is typically 10 mg to 20 mg, taken orally two to three times a day. The duration of treatment may vary depending on the individual's response to the medication.
  2. Raynaud's Syndrome: For Raynaud's syndrome, the recommended dosage of Nicergoline is 30 mg to 40 mg per day, taken orally in divided doses.
  3. Nootropic Use: When used as a nootropic, the recommended dosage range of Nicergoline is 5 mg to 10 mg, taken orally one to two times a day.

It is important to remember that these are general guidelines, and the dosages recommended for each condition may vary depending on the individual's age, weight, medical history, and other factors.

Stacking Nicergoline with other nootropic supplements can also affect the dosage and potency of the drug. It is always best to consult a medical professional before taking Nicergoline or any other nootropic supplement.

What Are The Side Effects Of Nicergoline?

Some of the most common side effects associated with Nicergoline include:

  • Gastrointestinal symptoms, such as nausea, vomiting, and diarrhea.
  • Headaches, dizziness, or lightheadedness.
  • Flushing or hot flashes.
  • Skin rash or itching.
  • Insomnia or other sleep disturbances.
  • Increased or decreased heart rate.
  • Low blood pressure.
  • Visual disturbances or changes in color perception.

In rare cases, Nicergoline can cause more serious side effects, such as heart palpitations, chest pain, or signs of an allergic reaction, such as swelling or difficulty breathing. If you experience any of these symptoms, seek medical attention immediately.

It is important to remember that not everyone will experience side effects from nicergoline, and many people tolerate the medication well. However, if you have any concerns or questions about the potential side effects of nicergoline, be sure to discuss them with your healthcare provider.

What Nootropics Are Similar To Nicergoline?

Because Nicergoline increases cerebral blood flow, it is often compared to nootropics such as Vinpocetine, Piracetam, and Ginkgo Biloba.

  • Vinpocetine - This nootropic compound is derived from the periwinkle plant and has been shown to increase blood flow to the brain. Like Nicergoline, it also has neuroprotective effects and can improve cognitive function.
  • Piracetam - Piracetam is a popular nootropic compound that enhances cognitive function by increasing blood flow to the brain. It has been used to improve memory, learning, and focus.
  • Ginkgo Biloba - This herbal supplement has been used for centuries to improve cognitive function and memory. It has been shown to increase blood flow to the brain and has neuroprotective effects.

The biggest difference between the 3 and Nicergoline is that Vinpocetine, Piracetam, and Ginkgo Biloba are used mainly for cognitive enhancement purposes, while Nicergoline is used primarily as a vasoactive agent.

As such, the dosage of each nootropic may vary depending on what results you are looking to achieve.

What Brain Supplements Can Nicergoline Be Stacked With?

Although Nicerogline can produce beneficial results on its own, it can also be stacked with other nootropic supplements to increase its benefits. When we stack one nootropic with another, we create a synergistic effect – meaning the potential benefits can be greater than if each nootropic was taken individually.

Common brain supplements that can be stacked with Nicergoline include:

  • Alpha-GPC - This supplement is a natural choline compound that can increase acetylcholine (ACh) production, an essential neurotransmitter for memory and learning. Combining Nicergoline with Alpha-GPC improves cognitive function and memory.
  • Citicoline - This is another choline compound that can increase acetylcholine production. It also has neuroprotective properties and may help improve focus and attention. Combining Nicergoline with Citicoline improves cognitive function and reduces the risk of age-related cognitive decline.
  • Bacopa Monnieri - This herbal supplement has been shown to have cognitive-enhancing effects and helps improve memory and focus. Combining Nicergoline with Bacopa Monnieri further enhances these cognitive benefits.
  • Omega-3 fatty acids - These healthy fats are essential for brain health and can help improve cognitive function. Combining Nicergoline with Omega-3 supplements enhances its cognitive-enhancing effects.

Pre-formulated stacks are also available if you don't want to buy each nootropic individually. We highly recommend using NooCube as your foundational nootropic supplement stack, whether you're taking Nicergoline.

NooCube is a blend that combines 13 all-natural and potent nootropic ingredients designed to improve focus, concentration, and memory. It is a great supplement for anyone looking to enhance their cognitive performance.

You can find more information about NooCube right here:

Frequently Asked Questions (FAQ)

Let's look at some frequently asked questions about Nicergoline.

Is Nicergoline safe?

Yes, Nicergoline is generally considered safe when taken as prescribed. It is an ergot derivative used to treat senile dementia and other disorders with vascular origins with a robust safety profile.

How Long Does It Take For Nicergoline To Work?

After a Nicergoline treatment period lasting between 4 and 8 weeks, evidence suggests that changes to the neurological indicators in the brain lead to enhanced cognitive functioning and improved alertness.

How Does Nicergoline Make You Feel?

Nicergoline makes you feel more alert and focused, allowing you to think clearly, remember things better and concentrate for longer periods of time. It can also improve your mood by reducing anxiety and stress levels.

What's The Half-Life Of Nicergoline?

Nicergoline takes up to 13-20 hours for its effects to reduce by half, meaning that the elimination half-life of Nicergoline is 13–20 hours.


So what do we know about Nicergoline?

We know that Nicergoline is a nootropic drug that is primarily used to enhance cognitive function and memory. It is a vasoactive agent and is usually prescribed for treating senile dementia and other disorders with vascular origins.

The usual dosage for Nicergoline ranges from 5-30 mg once or twice daily, depending on what results you are looking to achieve. It can be taken independently or stacked with other nootropics such as Alpha-GPC, Citicoline, Bacopa Monnieri, and Omega-3 fatty acids.

Nicergoline is a safe and effective supplement that can help improve cognition, alertness, and focus while reducing stress and anxiety.