Sunifiram: Review of Nootropic Benefits, Uses, & Side Effects

Updated on May 12, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Sunifiram is a nootropic drug that has been making waves in the world of cognitive enhancement. This compound, also known as DM-235, is a type of ampakine that works by stimulating the AMPA receptors in the brain.

This stimulation leads to enhanced memory formation, increased attention span, and improved mental clarity. Sunifiram is believed to have potent effects on cognitive function, and some even compare it to other popular nootropics like piracetam and oxiracetam.

In this article, we will explore what sunifiram is, how it works, and what its benefits and drawbacks are. We will also take a look at some of the existing research on sunifiram and give you an idea of how safe and effective this supplement really is.

So if you are looking for ways to boost your cognitive abilities or are simply curious about the latest advances in brain science, keep reading!

sunifiram review

What is Sunifiram?

sunifiram structure

Sunifiram, also known as DM-235, is an experimental drug that has been developed with the aim of treating cognitive decline in elderly individuals. It is a piperazine derived ampakine-like drug, which means it works by acting on AMPA receptors in the brain to enhance cognitive function. (1) Sunifiram has anti-amnesiac properties and has been found to be significantly more potent than piracetam, a well-known nootropic drug.

While Sunifiram is still in the experimental stages and has not yet been approved for medical use, it has shown promising results in animal studies and is being researched for its potential to treat cognitive impairment and neurodegenerative diseases.

Sunifiram's Mechanism of Action

Sunifiram's mechanism of action is not entirely understood, but it is believed to primarily act as an ampakine, which enhances the activity of AMPA receptors in the brain. It is structurally similar to piracetam, and some researchers have hypothesized that it may work similarly through modulating cholinergic and glutamatergic receptors.(2) Additionally, Sunifiram has been found to have similar properties to nefiracetam in the hippocampus, further supporting its potential as a cognitive enhancer.(3)

Despite the uncertainty surrounding its precise mechanism of action, animal studies have consistently shown Sunifiram's ability to improve memory and learning, making it a promising nootropic for those looking to enhance their cognitive abilities.

Nootropic Benefits of Sunifiram

Sunifiram is hailed for its impressive nootropic benefits. It increases focus, attention spans, and mental energy levels by amplifying acetylcholine activities in the brain. In animal studies, it has been shown to improve memory retention, learning speed, and recall. Sunifiram also has potential for treating neurodegenerative diseases and cognitive impairment. It is the perfect nootropic for individuals who want to elevate their performance bar, increase productivity, and fight depression. Although it is an experimental drug, its mechanisms of action make it a promising alternative to traditional nootropics.

Before taking Sunifiram, however, it is essential to be aware of the potential side effects and ensure that it is bought from a reliable source. With proper use and adherence to the recommended dosage, Sunifiram can be the secret weapon to achieving higher cognitive function.

Uses of Sunifiram

Based on the current scientific evidence available, Sunifiram shows promise in improving memory, learning ability, and overall mood. Additionally, it may increase energy levels and alertness, which makes it valuable for people who need to concentrate for longer periods of time. Another potential use for Sunifiram is assisting in the treatment of cognitive impairment, such as those seen in degenerative diseases like Alzheimer's and Parkinson's.

However, it should be noted that Sunifiram is still a research chemical and is not approved for human use. Therefore, further research is needed to determine its safety and effectiveness.

Improvement in Memory and Cognitive Function

Sunifiram has shown promising results in improving memory and cognitive function. Many studies have indicated that this nootropic drug enhances learning abilities and memory retention in impaired or unimpaired individuals. Sunifiram has been found to antagonize memory disruption induced by various drugs, including scopolamine. Additionally, it is believed to affect cellular energy use in the brain, resulting in an increase in alertness and energy levels.

Moreover, it is used to treat brain dysfunction, psychiatric syndromes, and mental disorders. With its potential for assisting in treating cognitive impairment and neurodegenerative diseases, Sunifiram is a promising drug for improving cognitive function.

Increase in Alertness and Energy Levels

One of the benefits of taking Sunifiram includes an increase in alertness and energy levels. As an ampakine, Sunifiram may enhance mental focus and energy, making it an ideal supplement for those who require increased attention and productivity throughout the day. Moreover, this nootropic drug's potential for increasing energy levels makes it an exciting development in the world of nootropics, and it may prove beneficial for individuals who experience fatigue and lethargy.

Assistance in Treating Cognitive Impairment

Sunifiram has shown promising results in assisting with treating cognitive impairment. It is believed to work by activating CaM kinase II and protein kinase C in the brain, which can help improve cognitive function. Studies have shown that sunifiram can help with memory retention, increase alertness and energy levels, and potentially treat neurodegenerative diseases. Sunifiram may also be helpful for those suffering from cognitive decline or impairment, such as individuals with Alzheimer's disease or dementia.

Potential for Treating Neurodegenerative Diseases

Sunifiram has shown promising potential in the treatment of neurodegenerative diseases. Due to its ability to enhance cognitive function by binding to the glycine site of NMDARs, sunifiram has been studied in relation to Alzheimer's, Parkinson's, multiple sclerosis, schizophrenia, and other cognitive impairments. Additionally, sunifiram has been shown to prevent amnesia induced by certain drugs, indicating its potential in the treatment of dementia.

Further, studies involving mice have suggested that sunifiram may also have potential in treating neuropsychiatric diseases, such as mild cognitive impairment. However, more research is needed to fully understand the extent of sunifiram's potential in the treatment of these diseases.

Side Effects of Sunifiram

Sunifiram has been reported to have some potential side effects, especially when used in high doses.(4) Some of the commonly reported side effects include headache, hot flashes, difficulty sleeping, and manic feelings. These side effects are not often experienced when used within the recommended 5-10mg dosage range. Additionally, users have reported minor and temporary side effects such as increased body temperature, perspiration, salivation, and nasal congestion.

It is important to note that Sunifiram has not been extensively studied in humans, and long-term effects remain unknown. If you experience any adverse reactions while using Sunifiram, it is advisable to discontinue use and seek medical attention immediately. As with any nootropic, it is essential to stick to the recommended dosage and consult a physician before use.

Where to Buy Sunifiram

When it comes to buying Sunifiram, there are various options available. For those who prefer online shopping, there are trusted vendors like that offer high-quality Sunifiram powder. Some local and online supplement stores might also carry Sunifiram capsules.

It is essential to ensure the legitimacy and quality of the product by checking for third-party lab testing and reviews from other customers.

It is important to note that Sunifiram is an experimental research chemical that is not approved for human consumption, and its purchase and use should be done with caution and at one's own risk.

Is Sunifiram safe to take?

According to the available studies, Sunifiram is generally considered safe to take as a nootropic. However, its long-term effects are unknown and therefore more research is needed to determine its safety.

How should I take Sunifiram?

While there is no standard dosage for Sunifiram, it is recommended to start with a small amount and gradually increase over time. Sunifiram is typically taken orally and can be administered either sublingually or mixed in with a beverage.

How long does Sunifiram take to work?

The effects of Sunifiram can usually be felt within 30 minutes to an hour of consumption, with peak effects lasting for 2-3 hours. It is not recommended to exceed the recommended dosage or use Sunifiram for extended periods of time.

Can I stack Sunifiram with other nootropics?

Sunifiram can be stacked with other nootropics, but it is important to research and understand the potential interactions and their individual effects before doing so.

Sunifiram Summary

In summary, Sunifiram is a piperazine-derived ampakine-like drug that has shown significant potency in animal studies as a nootropic agent. Structurally similar to racetams, Sunifiram has been found to improve cognitive deficits in olfactory bulbectomized mice through activation of CaM kinase II and protein kinase C.

Its nootropic benefits include improved memory and cognitive function, increased alertness and energy levels, and potential assistance in treating cognitive impairment and neurodegenerative diseases.

Although Sunifiram has shown remarkable promise, it is important to note that potential side effects of this drug include headaches and nervousness. Purchasing Sunifiram from reputable sources is also important, as purity levels must be ensured.

Sunifiram: Review of Nootropic Benefits, Uses, & Side Effects 1

Is Sunifiram a good brain and mood booster? Our Sunifiram review answers these questions and also lets you know if this nootropic is safe to use.

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