Adrafinil: Reviews, Dosage, Side Effects & Where To Buy

In this review, we looked at what Adrafinil is, how it works, and what it's used for. We went over the benefits, best dosage, where to buy Adrafinil online, and what side effects you may run into when using it.

Are you looking for a cognitive enhancer that doesn't make you feel like a jittery mess?

Adrafinil is a unique compound that has caught the attention of many people looking for an effective way to stay focused and alert. It's one of the few eugeroics on the market, and it comes with a lot of promise.

But what is Adrafinil, is it safe, and how well does it work? We will answer all those questions and more in our in-depth review.

What Is Adrafinil?

structure C15H15NO3S

Lafon Laboratories is the company that created Adrafinil (also known under its trade name Olmifon) [R] in 1974. Even though there is little research and its use is unregulated in the US, UK, and Canada, many people still use it to increase their endurance levels, prevent fatigue, and stay alert. The drug can deliver these health benefits because it operates as a stimulant.

But unlike traditional stimulants, such as caffeine or amphetamines, the use of Adrafinil (or CRL-40028) is focused on keeping you energized and focused without inducing restlessness. Some individuals even use it as a nootropic to help with cognitive tasks that require sustained attention and alertness, such as studying for exams.

adrafinil review

Adrafinil is a prodrug, and as such, it stays biologically inactive until it enters your body and becomes available. Inside your body, it becomes metabolized into a pharmacologically active drug called Modafinil.

Imagebuy adrafinil
EffectsImproves mood and focus
Potential Side EffectsHeadache, dizziness, nausea, anxiety
Half-Life12 hours
Common Dosage300 - 1,200 mg daily
Content10 g
Money Back GuaranteeCase-by-case
Rating⭐⭐⭐⭐⭐ 4.5/5
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Lafon Laboratories was able to synthesize Modafinil and sell it separately. Since both drugs have the same effect, you can use either. But since only parts of it become metabolized into Modafinil by your liver, you'll need it in a larger dosage to get the same effect as using Modafinil.

Adrafinil's formal name, as used in research, is:

  • 2-Benzhydrylsulfinylethanehydroxamic acid
  • 2-[(diphenylmethyl) sulfinyl]acetohydroxamic acid
  • Adrafinil's CAS number is 63547-13-7.

Adrafinil Benefits & Effects

Unlike Modafinil, there isn't a lot of research done on humans when it comes to the long-term use or safety of Adrafinil. On the other hand, there has been evidence from several peer-reviewed Modafinil studies with positive results. Both Adrafinil and Modafinil were created as medications for the treatment of narcolepsy [R] and Idiopathic hypersomnia to boost the mental health of elderly people.

In its metabolized form, and as backed up by Science, Adrafinil primarily influences the operation of the hypothalamus and amygdala [R]. That's unlike other psychostimulants that promote alertness and keep you awake through general neuronal activation. The ability of Adrafinil to keep you awake and alert without leaving you wired is possibly due to its specific neuronal activation.

Metabolized Adrafinil also keeps you awake by stimulating the orexin system. The brain's orexin system regulates appetite, wakefulness, and arousal. Low orexin levels are known to cause narcolepsy. Research shows that Modafinil rectifies this by triggering orexin neurons and histamine production, resulting in treatment [R].

The cognitive effects of Adrafinil also indirectly influence your brain's production of dopamine - the chemical responsible for pleasure responses. Its effectiveness and mechanisms of action are relatively well-studied.

How do all these effects of the smart drug benefit your health?

Let's take a look:

Keeps You Awake and Alert

While there are not enough human tests and research to back the treatment wonders, anecdotal reports and animal testing indicate that taking Adrafinil can improve health, boost alertness and wakefulness.

Even better, unlike other stimulants like Modafinil, this one gives you endurance without leaving you feeling wired or jittery.

Improves Mood

Modafinil has been shown to have antidepressant effects [R] and since Adrafinil is broken down into Modafinil in the body, it is likely that Adrafinil has similar effects.

Anecdotal reports also support this claim with many people reporting that Adrafinil improved their mood and well-being [R].

For example, 70 depressed patients received Adrafinil doses, reducing depressive symptoms during a two-month research study [R]. Its effect was similar to the treatment of depression with Clomipramine but without the adverse effects.

Healthy individuals using this Adrafinil compound will be happier and have a brighter disposition, while people with depression will experience alleviated symptoms.

Decreases Appetite

According to some Adrafinil users, it may reduce your appetite. While there's no clinical evidence to prove this, the fact that metabolized Adrafinil stimulates the orexin system, which regulates appetite, makes the claim feasible.

Considering the positive effects Adrafinil has on energy levels, this could be an excellent dietary supplement for working out and losing weight. However, consult your doctor or healthcare provider before using Adrafinil for weight-loss purposes.

Enhances Cognitive Function

Like Modafinil, many nootropics, and other compounds and substances, this powder shows great promise as a stimulant in improving learning speed, overall cognition, and brain health.

In a study involving aged canines receiving Adrafinil, the dogs learned faster, completed more tasks, and made fewer errors [R].

The human studies, clinical trials, and other references available are limited. A lot of the data and research on Adrafinil has been conducted on animals. 

Adrafinil Dosage

Lack of regulation and minimal testing in humans means there are no general guidelines regarding proper dosing. But based on feedback from users, the drug seems to be most effective in doses of 200 to 1,200 milligrams (mg).

Because of some stimulatory side effects, you should not exceed this dosage range. Play it safe by starting with the lowest effective dose and gradually working your way up until you get the desired effect. But never exceed 1,200 mg.

You can take Adrafinil orally or sublingually. If taken sublingually on an empty stomach, it delivers faster action and the best results while experiencing its efficacy the soonest.

Also, because you can develop a tolerance, it's best to take Adrafinil cyclically - ex. 3 days on, 4 days off. That being said, how many times you want to take it is completely up to you.

Adrafinil Side Effects

Generally, Adrafinil has a low potential for dependence or addiction. But it does have some health risks, which can escalate if you abuse it. These threats are the result of some factors while using the product.

Adrafinil can negatively impact the liver, which is why it's essential to use it cyclically instead of continuously and with necessary precautions.

Some users have reported experiencing headaches, high blood pressure, stomach pain, irritability, anxiety, aggression, dizziness, and insomnia even in moderate dosage. Quit it immediately if you experience any overwhelming adverse effects while using Adrafinil.

To be safe, always consult a doctor or a health care professional for medical advice about drug interactions and more information before using this nootropic, especially if you are using it in addition to Modafinil, other stimulant medications, or have a pre-existing liver or heart condition.

Adrafinil Experiences Shared On Reddit

Here are reports from Redditors about the real-life experience of using this legal nootropic.

According to Honorio:

"Not tried Adrafinil, but I regularly use Modafinil – 100mg on waking, 100 at mid-day, and possibly another 100 early evenings. Effects similar to what you describe – increased productivity, much more interest in trying things out; things get done. Among those to whom I have introduced it, the consensus is just as you said: a wonder drug."

According to 1_player:

"This is a wonder drug for me…I take 300mg of Adrafinil powder as soon as I get up, and usually, in 90 minutes, I can feel its effects. I don't get any high, no peak, no plateau, and no crash. I just discovered I've been more productive at work in the last 6 weeks than in the last 6 months…"

Adrafinil Stacks

You can stack Adrafinil powder with other cognitive enhancers, especially Racetams, to get even better results. For example:

  • Adrafinil + Noopept Stack: This combination will keep daytime sleepiness at bay, letting you focus on tasks and remain productive. The effective stack dose is 300 mg Adrafinil and 20 mg Noopept once daily.
  • Adrafinil + Pramiracetam: The memory-boosting effects of Pramiracetam combined with Adrafinil's focus and energy boost makes this the ideal study aid task [R]. It will boost concentration, learning speed, memory retention, and recall. Even without a prescription, you can take the ideal dose of 100 mg of Pramiracetam and 300 mg of Adrafinil.
  • Adrafinil + L-Theanine: Adrafinil keeps you energized, while L-Theanine promotes relaxation and fights fatigue. The combination works longer with less fatigue. The ideal dose is 50 mg of L-Theanine with 300 mg Adrafinil.

Where to Buy Adrafinil Powder?

You can legally buy Adrafinil products in countries like the US, UK, France, and Canada, as it is not a prescription drug. But because the drug is unregulated and Food and Drug Administration (FDA) approved, you need to buy it from a vendor with a track record for selling safe and effective nootropics.

Based on our experience and positive feedback from several nootropic substances enthusiasts, PureRawz is a reputable supplier that sells top-quality Adrafinil and Modafinil online at competitive prices.

You can find Adrafinil in powder form, capsules, pill and tablets.

Adrafinil vs. Modafinil

The main difference between adrafinil and modafinil is that adrafinil is a prodrug of modafinil, meaning that adrafinil gets turned into modafinil in the liver (it's a metabolite).

Both adrafinil and modafinil are usually used to treat excessive daytime sleepiness associated with narcolepsy. They're also being used off-label as nootropics to improve focus and cognitive function.

Frequently Asked Questions (FAQ)

Want more information about Adrafinil? All your questions are answered here:

How Long Does Adrafinil Last?

After ingestion, it takes your body and liver enzymes about an hour to metabolize Adrafinil into Modafinil. After conversion, Modafinil has a half-life of about 12 hours in the human body.

How Much Adrafinil Should I Take?

It is safest and most effective in doses of 200-1200 mg.

Is Adrafinil as Good as Modafinil?

Because your body converts Adrafinil into Modafinil, you'll experience similar effects when it comes to alertness and focus. That being said, Modafinil is usually stronger than Adrafinil when you take each of them separately. Since your body needs time to turn Adrafinil into Modafinil - and a fair amount of it is lost during the metabolizing process - Modafinil is faster acting and more potent. At the same time, Adrafinil requires a higher dosage, especially for the treatment of certain diseases like narcolepsy.

Is Adrafinil Good?

It's useful for keeping sleep at bay and boosting energy, focus, attention, learning, and physical performance. Be aware that Adrafinil is banned by the World Anti-Doping Agency, so don't use it in competitive sports.


The benefits of Adrafinil cannot be overstated even if compared to Modafinil.

It is an incredibly powerful nootropic with a wide range of benefits for cognitive function, memory, focus, and energy.

Adrafinil is also non-addictive with few side effects when used at the recommended dosage.

To ensure the negatives of the supplement do not outweigh its benefits, you should use it cyclically and in the proper dosage, as backed up by some research.

Since Adrafinil isn't approved by the FDA and is only made for research purposes in most countries, it's important to do your research when buying it online.