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Adrafinil Reviews: Benefits, Side Effects, Dosage & Where to Buy

When it comes to nootropics that keep you awake, alert, and focused, the eugeroic Adrafinil gets a lot of recognition.

But is this cognitive enhancing compound safe and how effective is it?

Our in-depth review answers these questions and more, starting with an explanation of what Adrafinil is.

What Is Adrafinil?

adrafinil structure C15H15NO3S

Lafon Laboratories created Adrafinil (also known under its trade name Olmifon) [R] in 1974. Even though its use is unregulated in the US, UK, and Canada, many people still use it to increase their energy levels, prevent fatigue, and stay alert. The drug can deliver these benefits because it operates as a stimulant.

But unlike other stimulants, such as caffeine or amphetamines, Adrafinil (or CRL-40028) can keep you energized and focused without inducing restlessness or anxiety. Some people also use Adrafinil as a mood booster and to improve overall mental health.

As a prodrug, it stays biologically inactive until it enters your body and becomes available. Inside your body, it becomes metabolized into a pharmacologically active drug that’s called Modafinil.

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Lafon Laboratories was able to synthesize Modafinil and sell it separately. Since both drugs have the same effect, you can use either. But since only parts of Adrafinil become Modafinil in the liver, you’ll need it in larger doses to get the same effect as using Modafinil.

Its formal name is 2-Benzhydrylsulfinylethanehydroxamic acid or 2-[(Diphenylmethyl)sulfinyl]acetohydroxamic acid and its CAS number is 63547-13-7.

Effects & Benefits of Adrafinil

There isn’t a lot of research into the long term use or safety of Adrafinil. On the other hand, there have been several Modafinil human studies with positive results. Both drugs were originally created for the treatment of idiopathic hypersomnia, narcolepsy, and to boost the mental health of older people.

In its metabolized form, it primarily influences the operation of the hypothalamus and amygdala. That’s unlike other psychostimulants that promote alertness and keep you awake through general neuronal activation. Adrafinil’s ability to keep you awake and alert without leaving you wired is possibly due to its specific neuronal activation.

Metabolized Adrafinil also keeps you awake by stimulating the orexin system. The brain’s orexin system regulates appetite, wakefulness, and arousal. Low orexin levels are known to cause narcolepsy. Adrafinil’s Modafinil rectifies this by triggering orexin neurons and histamine production.

The effects of Adrafinil also indirectly influences your brain’s production of dopamine – the chemical responsible for pleasure responses. How do all these effects benefit you?

Let’s take a look:

Keep You Awake and Alert

While there are no human tests to back it up, anecdotal reports and animal testing indicate that using Adrafinil can boost alertness and keep you awake. Even better, unlike other stimulants, it gives you energy without leaving you feeling wired or jittery.

Improve Mood

As an anti-depressant, it can improve your mood. Animal studies and limited human studies back up this claim.

For example, 70 depressed patients received Adrafinil doses, leading to reduced depressive symptoms during a two-month study. Its effect was similar to treating depression with Clomipramine but without the adverse side effects.

Healthy people using this will be happier and have a brighter disposition, while people with depression will experience alleviated symptoms.

Decrease Appetite

According to some users, Adrafinil may reduce your appetite. While there’s no clinical evidence to prove this, the fact that metabolized Adrafinil stimulates the orexin system, which regulates appetite, makes the claim feasible. Taking into consideration the drug’s positive effects on energy levels, this could be an excellent supplement for working out and losing weight.

Cognitive Enhancement

Like many nootropics, it shows great promise in improving learning speed and overall cognition. In a study involving aged canines receiving Adrafinil, the dogs learned faster, completed more tasks, and made fewer errors.

Some human studies also indicate it has significant nootropic potential. For example, a double-blind study of patients over 65 years old showed that participants who took Adrafinil had better moods, concentration, and power of recall.‍ The patients who received placebos showed no improvements.

Adrafinil Dosage

Lack of regulation and minimal human testing means there are no general guidelines regarding proper doses. But based on feedback from users, the drug seems to be most effective in doses of 300 to 1,200 milligrams (mg).

Because some side effects of Adrafinil, you should not exceed this dosage range. Play it safe by starting with the lowest effective dose and gradually working your way up until you get the desired effect. But never exceed 1,200 mg.

Since the drug is water-soluble, you can take it orally or sublingually. Sublingually on an empty stomach delivers faster action and the best results.

Also, because you can develop a tolerance, it’s best to take it cyclically. The more tolerant you become, the higher the dose you’ll need to feel the desired effect, which can get dangerous if you exceed 1,200 mg.

Side Effects

Generally, Adrafinil has a low potential for dependence or addiction. But it does have some health risks, which can escalate if you abuse it. For instance, it negatively impacts the liver, which is why it’s essential to use it cyclically, instead of continuously.

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Even in moderate doses, some users have reported experiencing headaches, irritability, aggression, dizziness, nausea, and insomnia. At high doses, there are reports of elevated blood pressure and heart problems. If you experience any overwhelming side-effects while using Adrafinil, quit it immediately.

To be safe, consult a doctor for medical advice before using this, especially if you are using other medication or have a pre-existing liver or heart condition.

Adrafinil Experiences Shared on Reddit

Here are Adrafinil reviews from Redditors about the real-life experience of using this legal nootropic.

According to honorio:

“Not tried Adrafinil, but I regularly use Modafinil – 100mg on waking, 100 at mid-day and possibly another 100 early evening. Effects similar to what you describe – increased productivity, much more interest in trying things out; things get done. Among those to whom I have introduced it, the consensus is just as you said: a wonder drug.”

According to 1_player:

“Adrafinil is a wonder drug for me…I take 300mg Adrafinil as soon as I get up, and usually in 90 minutes I can feel its effects. I don’t get any high, no peak, no plateau and no crash. I just discovered I’ve been more productive at work in the last 6 weeks than in the last 6 months…”


To get even better results, you can stack Adrafinil with other cognitive enhancers, especially Racetams. For example:

  • Adrafinil + Noopept Stack: This combination will keep sleep at bay, letting you focus on tasks and remain productive. The effective stack dose is 300 mg Adrafinil and 20 mg Noopept once a day.
  • Adrafinil + Pramiracetam: The memory-boosting effects of Pramiracetam combined with Adrafinil’s focus and energy boost makes this the ideal study aid task [R]. It will boost your concentration, learning speed, memory retention, and recall. An ideal dose is 100 mg of Pramiracetam and 300 mg Adrafinil.
  • Adrafinil + L-Theanine: Adrafinil keeps you energized while L-Theanine promotes relaxation and fights fatigue. The combination works longer with less fatigue. The ideal dose is 50 mg of L-Theanine with 300 mg Adrafinil.

Where to Buy Adrafinil?

You can legally buy Adrafinil in the US, UK, and Canada. But because the drug is unregulated, you need to buy it from a vendor with a track record for selling safe and effective nootropics. If not, you could end up with a product that does more harm than good.

Based on our experience and positive reviews from several nootropic enthusiasts, is a reputable supplier that sells top-quality Adrafinil at competitive prices.

Frequently Asked Questions (FAQ)

Your questions about Adrafinil answered.

How Long Does Adrafinil Last?

After ingestion, it takes your body about an hour to convert Adrafinil into Modafinil. After conversion, Modafinil has a half-life of about 12 hours in the human body.

How Much Should I Take?

It is safest and most effective in doses of 300-1200 mg.

Is It as Good as Modafinil?

Because your body converts Adrafinil into Modafinil, they are basically the same substance. But since your body needs time to turn Adrafinil into Modafinil – and a fair amount of it is lost during the metabolizing process – Modafinil is faster acting and more potent.

Is Adrafinil Good?

Adrafinil is useful for keeping sleep at bay, as well as boosting energy, focus, learning, and physical performance. Be aware that it’s banned by the World Anti Doping Agency, so don’t use it in competitive sports.


The benefits of Adrafinil cannot be overstated.

To ensure the side effects of the supplement do not outweigh its benefits, you should use it cyclically and in the proper doses.