4 Best Caffeine Pills 2024 Reviewed (+ Better Alternatives)

Updated on February 10, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
A comparison of caffeine pill alternatives focusing on health impacts.

Looking for a powerful nootropic in pill-form to help you focus and get more done?

Caffeine is one of the most popular nootropics in the world for a good reason. It’s effective, affordable, and easy to find. It’s a great choice if you’re looking for an immediate boost in energy and focus!

Whilst most simply consume caffeine content via hot beverages or energy drinks to give them the boost they need, there has been a rise in the demand for caffeine supplements and pills, which often contain additional ingredients that are synergistic and enhance the effects of caffeine while lowering the side-effects.

Let’s take a closer look at what seem to be the best ones on the market, their effects, dosage, and potential side-effects down below.

Best Caffeine and Caffeine-Containing Pills

  • Vyvamind
  • Dynamine
  • Caffeine + L-Theanine
  • Optimal Energy Complex

1. Vyvamind

When it comes to caffeine-based cognitive enhancers, few products compare to Vyvamind. This unique blend contains only natural ingredients, which makes it a safe and effective way to improve memory, learning, and focus.

Josh Marroquin, a first-time nootropics buyer, recently wrote us an email letting us know how much Vyvamind has changed his life for the better. This hardly ever happens so it’s just another confirmation of the efficacy of this pill! If you have any success stories yourself, please email us at support@wholisticresearch.com and we will forward your message to the editor of this article.

Now for starters, Caffeine Anhydrous that it contains is different from regular Caffeine because it is more concentrated. This means that it takes less of it to get the same effects as regular Caffeine.

The Vyvamind formula contains 6 powerful nootropic ingredients:

  1. Vitamin B6
  2. Vitamin B12
  3. L-Tyrosine
  4. CDP-Choline
  5. L-Theanine
  6. Caffeine Anhydrous

These ingredients work together to promote optimal cognitive function. For example, vitamins B6 and B12 are essential for healthy brain function. L-Tyrosine is a precursor to dopamine, which is responsible for motivation and pleasure.

CDP-Choline enhances memory and learning ability. L-Theanine is an amino acid that helps reduce stress and anxiety. And Caffeine Anhydrous improves focus and concentration.

Together, these ingredients create a synergistic effect that improves cognitive performance. Vyvamind is also one of the more affordable nootropic blends on the market, making it a great value for your money.

It’s worth noting that Vyvamind uses Caffeine Anhydrous. Caffeine Anhydrous is a powdered form of Caffeine made from coffee plants’ seeds and leaves. The word “anhydrous” means “without water.” After harvesting, Caffeine is extracted from the plant matter and dehydrated. This produces a highly concentrated Caffeine powder.


  • It contains only natural ingredients
  • Safe and effective
  • Improves memory, learning, and focus
  • Reduces stress and anxiety
  • Improves focus and concentration
  • Affordable


  • The shipping time may take up to 2 weeks
  • Not ideal for people who are hypersensitive to Caffeine content

2. Pure Nootropics Dynamine Capsules

Pure Nootropics Dynamine capsules contain methylliberine as Dynamine. Methylliberine is characterized as a pure alkaloid that comes from coffee and other natural stimulants. Dynamine is made up of Methylliberine and 1,7,9-tetramethyluric acid. This molecular makeup increases the substance’s absorbability, ensuring that it delivers the required effect.


Dynamine is a leading supplement for its energy-boosting benefits. The capsules contain Methylliberine, which derives from coffee and is a natural stimulant. It has been shown to boost energy and reduce fatigue (1).

The product’s ingredients contain properties that regulate adenosine from binding to receptors. The effect of this results in a boost of energy without feeling drowsy. Though a derivative of caffeine, Dynmine can produce long-lasting energy without the effects of crashing and feeling lethargy associated with caffeine.

This caffeine nootropic, therefore, surpasses expectations by providing a solution to the effects of caffeine content and makes it an ideal solution for those who want a powerful nootropic without experiencing any crashes.

The properties contained in Dynamine work to increase fat-burning potential as well. This effect makes Dynamine a popular choice as a pre-workout supplement. As a derivative of coffee, it also provides metabolism-boosting benefits. Its ability to boost metabolism makes it a popular weight loss supplement as it aids in burning more calories to create a leaner physique.

If you’re looking to lose weight and burn fat, Dynamine is the supplement for it. Established as an energy-boosting supplement, its effect helps to increase fat-burning potential. Increased energy increases the body’s physical capabilities (2).

It provides long-lasting energy, which contributes to burning more calories and burning fat. The supplements work by increasing the body’s oxygen intake, which increases the level of fat burning throughout the day.

Dynamine offers more than energy-boosting benefits, it also provides cognitive boosting benefits. The supplement provides nootropic effects that enable mental clarity and focus, increasing attention for enhanced physical and mental performance.

Clinical trials show that this product produces exceptional results when it is combined with Teacrine. With it being combined with Teacrine, the Dynamine capsules can boost energy without having a stimulatory effect on the heart rate or blood pressure, according to VanDusseldorp et al.

Similarly, research shows that taking Dynamine alone is believed to not affect blood pressure and the heart rate in the way that caffeine in a coffee can, according to a study published in the Journal of Toxicology (3).

Other benefits include an increased energy level that improves mood as prolonged exercise increases the release of endorphins. The result of which is a brighter and more positive mood and a feeling of euphoria.

Additionally, the lethargic effects of caffeine are absent as Dynamine offers a steady dose of energy without feeling depleted or interrupting sleep.

Overall Benefits:

  • Fat-burning potential
  • Enhanced physical capability
  • Increased energy
  • Improved cognitive performance
  • Improved mood


Dynamine capsules contain 100 mg of Methylliberine per 1 capsule. There are 30 and 90 capsules in a bottle, depending on your size. The recommended dosage of Dynamine capsules is 1 to 2 capsules daily, or as otherwise directed by a healthcare practitioner. It’s advised that you begin with a lower dose and build it up so that you can see how the body reacts.

Side Effects

Experiencing side effects from Dynamine is rare. However, any medication or supplement is a risk of experiencing side effects. Side effects that could be experienced include nausea and dizziness. Toxicology research shows that Dynamine is believed to not affect blood or heart rate.


Pure Nootropics offers Dynamine, a formula that boosts energy and improves focus. The capsules contain ingredients that derive from a species of coffee.

Their Dynamine capsules offer a subtle but noticeable energy shift similar to the effects caused by caffeine content. However, the effects are considerably smoother and offer a clean transition without a jittery buzz.

The effects of Dynamine last for about 3 hours. This makes it an ideal pre-workout supplement. The effects become prevalent 20 minutes after ingestion, and the effects will hit their peak after 45 minutes.

3. Pure Nootropics Caffeine + L-Theanine

Pure Nootropics Caffeine L-theanine contains caffeine from tea (Camellia Sinensis) and L-theanine. Caffeine it contains is commonly known for its energy-boosting benefits.

However, it is also associated with creating feelings of energy depletion and jitteriness. Pure Nootropics’ combination of caffeine and L-theanine works to combat the jittery effects of caffeine.

L-theanine is most commonly found in tea leaves and is known for its ability to promote relaxation without causing drowsiness.

Ultimately, Pure Nootropics Caffeine and L-theanine provide the increased positive effects of alertness and cognitive focus created by caffeine with the balance of L-theanine, which reduces the negative effects of caffeine.

Benefits of our favorite friend: Caffeine

Caffeine works to improve alertness and attention by blocking adenosine receptors associated with making you feel tired. In doing so, caffeine boosts energy and alertness. It also boosts dopamine, a neurotransmitter responsible for our brain’s reward and pleasure response. This results in creating a feeling of pleasure and improved mood (4).

L-theanine is characterized as a natural amino acid. Studies have shown that L-theanine contains properties that create a state of relaxation and calm and a release of tension by reducing stress and lowering blood pressure and heart rate (5).

It does this by reducing the body’s physiological stress response by mimicking the actions of inhibitory transmitters known as gamma-aminobutyric acid.

This prevents excitatory responses in the brain that would usually increase activity and consequently reduce levels of stress and tension.

Another study found that the combination of caffeine and L-theanine had significant effects in improving cognitive performance by improving memory, attention, and suppressing distraction (6). Hence, combining caffeine and L-theanine is the best for improving long-term focus.

It has been proven that L-theanine and caffeine work together to improve attention by decreasing deviations of attention. The combination works as a dynamic duo that provides a feeling of energy and wakefulness created by the caffeine, which is calmed by the effects of L-theanine, creating a balance for focus.

Its ability to reduce the susceptibility to distractions and boost cognitive performance makes it a popular supplement choice for studying and working.

Other benefits include its ability to stimulate creativity. The presence of even a small amount of L-theanine is found to increase alpha waves in the brain. The result of this is a relaxed mind that is free of distraction and is able to focus and become creative.

Overall Benefits:

  • Reduced level of stress and tension
  • Increased energy and alertness
  • Improved memory and attention
  • Suppressed distraction


The Caffeine + L-theanine capsules contain 100 mg of caffeine contents from tea and 200 mg of L-theanine per serving. There are 120 capsules in a bottle. The recommended dosage for these supplements is 1 capsule to be taken daily or as recommended by a healthcare practitioner.

Side Effects

Both caffeine and L-theanine are considered to be safe. However, as with all medication and supplements, there is always a risk of side effects as substances react differently for different people.

For healthy adults, the FDA has cited 400 milligrams of caffeine a day—that’s about four or five cups of coffee—as an amount not generally associated with dangerous, negative effects

When starting any new medication or treatment, it’s important to exercise caution and follow the recommended dosage. Some side effects associated with caffeine and L-theanine include nausea and headache.

It’s advised that L-theanine should not be mixed with blood pressure medications as it has been proven to reduce blood pressure.


Pure Nootropics Caffeine + L-theanine capsules contain a balance of properties that improve cognitive performance and promote relaxation. The combination of the two effects results in an advanced state of focus. The effects of caffeine and L-theanine typically last up to 6 hours. This enables a long duration of steady and advanced focus.

4. Pure Nootropics Optimal Energy Complex

Pure Nootropics Optimal Energy Complex capsules contain Caffeine anhydrous, L-theanine, Teacrine, Dynamine (Methylliberine), and Theobromine.

The combination of these ingredients creates a powerful energy-boosting supplement. This product is a combination of the effects of Pure Nootropics’ Dynamine capsules and Caffeine and L-theanine capsules. The capsules contain ingredients that create optimum focus, stimulation, and energy.

Pure Nootropics Optimal Energy Complex is one of the most powerful legal nootropics on the market, providing a host of benefits from improving cognitive performance and promoting alertness to enhancing mood and creating focus.


Pure Nootropics Optimal Energy Complex provides energy-boosting benefits. The product also contains Caffeine Anhydrous and works by blocking adenosine receptors in the brain to boost energy without inducing drowsiness and is instead shown to boost energy.

Whilst Caffeine Anhydrous is highly effective in boosting energy, it is also associated with causing people’s energy to crash, causing a lethargic feeling. However, Pure Nootropics curbs this problem by creating a supplement that contains L-theanine, Theobromine and Dynamine.

Theobromine is another naturally occurring stimulant that provides a similar effect as caffeine. However, the core difference between the two is that Theobromine doesn’t stimulate the nervous system.

Therefore, Theobromines stimulate the body and provide long-lasting energy whilst also creating a feeling of being refreshed as it works to reduce the central systolic blood pressure (7). It does this by reducing the widening of blood vessels.

The combination of caffeine and Theobromine provides powerful energy-boosting benefits that provide long-lasting, stimulating energy that leaves you feeling refreshed and not drowsy.

The Optimal Energy Complex capsules also improve cognitive performance due to the presence of caffeine and L-theanine.

Studies have shown that caffeine was found to improve alertness and cognitive performance whilst L-theanine works to increase alpha waves in the brain that relax the mind (8). This combination results in maximum focus and mental alertness for hours of concentration.

The capsules also contain Theobromine which studies show positively influences physiological processes that consequently improve cognitive function (9). It enables the mind to focus during moments of sustained mental demand. This is beneficial when it comes to multitasking or moments where you require in-depth focus.

The same study also shows that Theobromine interacts with the endothelial function and works by increasing blood flow. The result is reduced mental fatigue and overall cognitive improvement.

Pure Nootropics Optimal Energy Complex capsules also interact with the serotonergic system by causing an increase in the production of dopamine which is related to pleasure. This results in causing pleasure and boosting mood.

Overall Benefits:

  • Energy-boosting
  • Enhanced cognitive performance
  • Sustained focus
  • Mood-boosting


The Optimal Energy Complex capsules contain 100 mg of Caffeine, 200 mg of L-Theanine, 125 of Dynamine (Methylliberine), and 150 mg of Theobromine per 1 capsule.

Side Effects

Pure Nootropics Optimal Energy Complex is one of the most powerful legal stimulants available on the market; that being so, it’s highly advised that no more than 1 capsule be taken a day with food. L-Theanine and Theacrine are generally recognized as safe by the U.S. FDA and Dynamine is considered to have similar effects to Theacrine.

The potential side effects of Optimal Energy Complex include;

  • Side effects of caffeine include insomnia, anxiety, nausea, restlessness, and irregular heartbeat. More severe side effects of caffeine may include ketosis, hyperglycemia, and metabolic acidosis. Chronic caffeine use in large amounts may cause tolerance, addiction, or psychological dependence.
  • Side effects associated with Theobromine are rare. It may cause sweating, headaches, and trembling when taken in high doses.
  • Side effects associated with L-Theanine are few. Taken in high doses, it may cause increased sleeplessness and headaches.
  • Those who are sensitive to caffeine or stimulants are advised not to use the product, as are pregnant and nursing women under the age of 18. Anyone with an existing medical condition or currently taking medication of any kind should exercise caution. It is advised that you consult with a professional practitioner before using the product.


Optimal Energy Complex is a powerful stimulant that provides a host of benefits. Used appropriately, it can promote all the energy-boosting benefits of caffeine without the unwanted effects.

It increases attention and focus for maximum concentration and enhances mental clarity and cognitive performance. This supplement is a well-rounded nootropic.

What you Need to Know Regarding the Top Caffeine Pills

A multi-factor review process is needed if you want to find the better caffeine-containing pills on the market. Consider effectiveness, ingredients, brand reputation, transparency, production method, user feedback, price, and value. Assess each of these aspects to get a better idea of complete and credible list of the front-runner caffeine supplements.


You need to analyze clinical trials and user experiences to gauge the energy-boosting and mental alertness effects of caffeine capsules and pills, focusing on the duration and strength of their impact.


You need to scrutinize each formula, prioritizing pure, natural, and high-quality caffeine sources that effectively improve mental alertness and energy level.

Scientific Evidence

You need to reference peer-reviewed studies and meta-analyses to verify the efficacy of caffeine as a stimulant and its benefits for cognitive function and performance.


You need to assess optimal dosages and caffeine forms, ensuring they align with established research standards for maximum benefits and safety.


You need to verify the safety of each formula, taking into account potential side effects, contraindications, and compliance with regulatory guidelines. FDA-approved ingredients are prioritized.

Brand Reputation

You need to evaluate the credibility and trustworthiness of brands through customer reviews, expert endorsements, and company history.

Ever seen those fancy “gas station” caffeine pills? Well.. in November 2023 the FDA has issued a warning against using or purchasing any products from the supplement brand Neptune’s Fix. This warning follows multiple reports of severe reactions to these supplements, including seizures and hospitalizations. Neptune’s Fix supplements are believed to contain tianeptine, an opioid alternative used as an antidepressant in some countries but not approved in the U.S. The FDA has previously highlighted the dangers of tianeptine, linking it to addiction and deadly overdoses.

Authorities are concerned that other harmful substances might be mixed into these illegally sold products, available online and in places like gas stations and vape shops. In New Jersey, a cluster of poisonings linked to tianeptine products, including Neptune’s Fix, was identified, with more than half of the patients suffering seizures and requiring hospitalization. Other symptoms reported include hallucinations and vomiting.

New Jersey’s poison control center has received 23 calls about tianeptine since June 17, with more than half related to Neptune’s Fix. The FDA is currently testing these products for illegal and harmful ingredients, but the duration of this investigation is unknown. Tianeptine, often referred to as “gas station heroin” due to its availability, has led several states to take steps to restrict its sale. The drug binds to the body’s mu opioid

Product Transparency

You need to value complete ingredient disclosure, including sources and amounts of caffeine, to help consumers make informed decisions.

Manufacturing Process

You need to examine manufacturing standards, prioritizing products made in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

You need to analyze real customer feedback, giving weight to testimonials describing increased energy, focus, and cognitive performance.


You need to compare product prices, ensuring they are competitive and aligned with the quality and efficacy of the caffeine supplements and pills.


You need to assess overall value, considering the balance of price, quality, and effectiveness to ensure optimal return on investment for our readers.

Factors to Consider When Choosing Which to Buy

  • Power – Caffeine capsules and pills alone are considered to be one of the most potent nootropics. However, if you’re looking for that extra step up and want something a little more powerful, look for a supplement containing a combination of caffeine and L-theanine. This will ensure that you get the energy-boosting benefits without the negative effects of caffeine and instead feel clear and refreshed.
  • Focus – Nootropics for enhanced focus, mental clarity, and concentration are increasing in popularity as there is an increasing demand for stimulants that help people navigate within a competitive society. If you’re looking for a supplement that provides uninterrupted focus, look for a supplement that contains L-theanine. It not only promotes alertness but also works to relax the body at the same time, creating an ideal environment for deep focus.
  • Energy – Caffeine is a key component of providing energy-boosting benefits. However, the benefits of caffeine can be accelerated in combination with Dynamine and L-Theanine. Both Dynamine and L-Theanine produce a stimulating effect without interacting with the central nervous system. The result is a long-term energy boost without caffeine’s negative effects. Instead, the negative effects are replaced with a calm feeling, enhancing physical and mental capabilities.

Caffeine Pill Reviews

According to Zacharia W:

Optimal energy complex – “Good, clean feeling energy, no jitters or crashes. I have a very irregular work schedule and one of these will help me wake up, no matter what time it is, and I won’t be feeling extra tired like I do when I drink coffee.”

According to Majed Alnakhli:

Caffeine + L-theanine – “No jitters, solid energy throughout the day. No high intensity just delivers good focus and drive.”

Where to Buy?

Caffeine pills can be brought from several independent online suppliers. However, with so many offering different potency and strengths, it’s important to ensure that you source from reliable suppliers.

To ensure you are sourcing from an authentic supplier, you’ll want to ensure that the products are of premium quality, that they are lab tested and lab-verified for safety, and that they are ideally third-party tested. A reliable brand that sells various brands and dosages of caffeine supplements is Pure Nootropics.

All of their products are lab tested and verified by third-party labs. They are a leading global supplier that has been producing supplements since 2013. Their range of products, especially the three presented, offer great benefits in improving cognitive performance, enhancing mental capacity, and reducing mental stress and fatigue.

It’s also advised that you take a look at the customer reviews and the feedback. This will help you get a clearer idea of how the product works and what to expect. You’ll be able to compare which products are best suited to you.

Other Brands and Products

Below are some other common caffeine-containing products that are frequently seen in retail shops. Although they surely contain caffeine and get the job done, we didn’t include them higher on this list because are either too strong, or don’t contain anything useful beyond the primary ingredient of caffeine

Here are ten of the most commonly recognized caffeine pills and supplements. Please note that the popularity and availability of these products can vary based on region and market trends.

  1. Vivarin: A well-known brand that provides 200 mg of caffeine per tablet, often used for mental alertness.
  2. NoDoz: Another popular choice, NoDoz also offers 200 mg of caffeine per pill and is used for wakefulness.
  3. Jet-Alert Double Strength: This brand provides a higher dose of caffeine (200 mg per tablet) and is known for its effectiveness in combating fatigue.
  4. ProLab Caffeine: Often used by athletes and fitness enthusiasts, ProLab Caffeine tablets typically contain 200 mg of caffeine.
  5. Caffeine Anhydrous Pills by Nutricost: These are popular for their high potency, with each pill containing around 200 mg of caffeine.
  6. Elite Caffeine with L-Theanine: This supplement combines caffeine with L-Theanine, often used for improved focus and energy without the jitters.
  7. Muscletech Platinum 100% Caffeine: Known for its use in the fitness community, each pill contains 220 mg of caffeine.
  8. Kaged Muscle Natural Caffeine: Sourced from green coffee beans, this is a choice for those seeking a more natural supplement.
  9. Vali Time Release Caffeine: Known for its time-release formula, providing a steady stream of energy.
  10. Zhou Energy + Focus: This supplement combines caffeine with L-Theanine, similar to Elite, for sustained energy and focus.


The list of energy-boosting, cognition-enhancing, and mood-boosting caffeine pills provides superior benefits. With nootropics growing in popularity, Pure Nootropics products provide products that contain active ingredients that provide stimulating effects.

Though the research on nootropics is still young, many studies and reviews show their potential for improving mental and physical performance. They are amongst the most powerful nootropics, it’s advised that they be taken with care.

If you’re looking to help you in areas of cognitive performance or increasing energy and focus, use this review as a guide to help you narrow down which supplement is best for you.

Sources, Studies, and Scientific Research
  1. VanDusseldorp, Trisha A et al. “Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults.” Nutrients vol. 12,3 654. 28 Feb. 2020, doi:10.3390/nu12030654 ↩
  2. Cesareo, Kyle R et al. “The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men.” Journal of the International Society of Sports Nutrition vol. 16,1 47. 28 Oct. 2019, doi:10.1186/s12970-019-0316-5 ↩
  3. A toxicological evaluation of methylliberine (Dynamine®) – researchgate. (n.d.). Retrieved July 13, 2022, from https://www.researchgate.net/publication/336850377_A_Toxicological_Evaluation_of_Methylliberine_DynamineR ↩
  4. Volkow, N D et al. “Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain.” Translational psychiatry vol. 5,4 e549. 14 Apr. 2015, doi:10.1038/tp.2015.46 ↩
  5. Hidese, Shinsuke et al. “Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.” Nutrients vol. 11,10 2362. 3 Oct. 2019, doi:10.3390/nu11102362 ↩
  6. Owen, Gail N et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience vol. 11,4 (2008): 193-8. doi:10.1179/147683008X301513 ↩
  7. van den Bogaard, B., Draijer, R., Westerhof, B. E., van den Meiracker, A. H., van Montfrans, G. A., & van den Born, B.-J. H. (2010). Effects on peripheral and central blood pressure of cocoa with natural or high-dose theobromine. Hypertension, 56(5), 839–846. https://doi.org/10.1161/hypertensionaha.110.158139 ↩
  8. Nobre, Anna C et al. “L-theanine, a natural constituent in tea, and its effect on mental state.” Asia Pacific journal of clinical nutrition vol. 17 Suppl 1 (2008): 167-8. ↩
  9. Baggott, Matthew J et al. “Psychopharmacology of theobromine in healthy volunteers.” Psychopharmacology vol. 228,1 (2013): 109-18. doi:10.1007/s00213-013-3021-0 ↩