Centrophenoxine Review: Nootropic Benefits, Side Effects, Dosage & Where to Buy

Updated on November 30, 2022
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

In this Centrophenoxine review, we'll take an in-depth look at what this popular nootropic is. We'll also go over how Centrophenoxine works in the brain, information about the benefits, side effects, and where you can buy it online.

Centrophenoxine, also known as Lucidril, Amipolen, and Meclofenoxate, is a cholinergic agent that supports cognitive function and overall brain health in elderly patients.

It's an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), increasing cellular membrane phospholipids' levels to improve memory recall ability other things like increased blood flow and nerve impulse transmission for better cognition.

Let's take a closer look at how this nootropic works and what Science has to say about it.

Centrophenoxine Review Summary

Centrophenoxine, or Meclofenoxate, combines DMAE with pCPA to improve brain function, memory recall ability, and overall cognitive performance. This combination allows Centrophenoxine to cross the blood-brain barrier (BBB) more easily, improving brain health and function.

Centrophenoxine also increases levels of phospholipids in the body's cells, which improves cognitive functioning and overall cognition.

Pros

  • Crosses the blood-brain barrier more easily
  • Improves cognitive functioning and overall cognition
  • Helps protect brain cells from damage caused by age or environmental factors
  • Generally considered safe with few side effects

Cons

  • Can be difficult to find high-quality Centrophenoxine online
  • Not sold in most supplement stores

What Is Centrophenoxine?

structure of centrophenoxine

Centrophenoxine, or Meclofenoxate, was one of the first cholinergic nootropics created. It is a combination of DMAE (dimethylethanolamine) and pCPA (parachlorophenoxyacetic acid), which originated in France all the way back in 1959.

Cholinergic compounds are structurally similar to acetylcholine (ACh) and/or butyrylcholine. Acetylcholine is abundant within the parasympathetic nervous system (PNS) and is responsible for several of its functions [1]. Cholinergic drugs can be broadly classified into two categories: direct-acting and indirect-acting.

Centrophenoxine is a direct-acting cholinergic nootropic that increases ACh levels within the brain. It can cross the blood-brain barrier (BBB) and increase acetylcholine concentrations by inhibiting its breakdown.

The increased choline accumulation in neurons stimulates neurotransmitter production and improves memory, learning, reasoning, attention span, cognition, and mental alertness [2].

DMAE is an amine found in small quantities naturally in the brain. Some researchers theorize that DMAE could raise levels of acetylcholine (ACh) by blocking choline metabolism elsewhere in the body. It also acts as a free radical scavenger, protecting neurons from oxidative stress [3].

pCPA is a synthetic version of auxins. Auxins are growth hormones naturally produced in plants that cause cell division, stem and root growth, and the plant's orientation toward sunlight.

DMAE is more bioavailable in the body when combined with pCPA, which then helps DMAe cross the blood-brain barrier more easily, thus, giving it the nootropic properties it's known for.

Imagebuy centrophenoxine
NameCentrophenoxine
ClassNootropic
EffectsBetter brain energy, longer lifespan, improve memory levels
Potential Side EffectsHeadache, body odor, increased blood pressure, insomnia, confusion
Half-Life30 min - 1 hour
Common Dosage400 mg daily
Content25 g
Price$14.98
Money Back GuaranteeCase-by-case
Rating⭐⭐⭐⭐⭐ 4.8/5
Best VendorClick Here ›

How Does Centrophenoxine Work In The Brain?

Centrophenoxine boosts cognitive function and brain health in two specific ways:

  1. It improves memory by boosting the enzyme Acetylcholinesterase (AChE), which breaks down acetylcholine (ACh). When AChE levels are increased, more ACh remains in the brain. This leads to a better recall of information and higher cognitive functioning overall.
  2. It acts as a free radical scavenger that protects the brain and neurons from oxidative damage as we age. Oxidative stress is a primary cause of the age-related cognitive decline.

A study published in the peer-reviewed journal; Neuropharmacology, looked at how Centrophenoxine increases choline levels in rat brains [4].

The study found that rats given Centrophenoxine had elevated levels of choline (CH) in their central nervous system (CNS), with a corresponding rise in acetylcholine in the hippocampus.

The researchers found that Centrophenoxine induced dramatic alterations in CNS choline metabolism, thus, making it a useful therapeutic tool for potentiating depressed cholinergic neurons in the brain.

Another study published in the world's leading multidisciplinary science journal; Nature, looked at the effects of Centrophenoxine on the lipofuscin pigments in the neurons of senile guinea pigs [5].

Lipofuscin pigments, or age pigments, are age-related deposits made of oxidized fats, proteins, and other molecules. They also contain cellular heavy metal waste like mercury and aluminum, which are known neurotoxins [6].

These lipofuscin pigments can accumulate in the neurons and brain, contributing to the cognitive decline that occurs with age.

Researchers found that administering Centrophenoxine helped remove lipofuscin from the brain cells and improved learning ability in senile guinea pigs.

What Is Centrophenoxine Used For?

Centrophenoxine is a nootropic supplement used to improve cognitive function and alleviate the symptoms of age-related cognitive decline - especially in people with dementia. It is typically used by older adults to improve memory, focus, and mood.

review of centrophenoxine

Many people also use it as a brain booster to enhance their focus and reasoning skills, improve their ability to process information quickly, and reduce the effects of stress on the brain.

Since Centrophenoxine effectively boosts acetylcholine levels, students and professional workers often use it to improve their memory and focus.

What Are The Benefits Of Centrophenoxine For Cognition?

The benefits of Centrophenoxine for cognition include:

  • Improved memory and recall: Centrophenoxine increases levels of acetylcholine (ACh) in the brain, which forms long-term memories. It also helps with different types of learning and mental processing, such as shifting attention to new information or tasks. This makes it a valuable tool for students and anyone who needs to retain large amounts of information.
  • Boosted mental energy: Centrophenoxine helps increase blood flow in the brain, which improves energy levels and helps you focus for longer periods.
  • Protects your neurons: Because Centrophenoxine acts as an antioxidant and removes toxic waste products from the brain, it helps protect your neurons from damage. This makes it useful for delaying or preventing age-related cognitive decline.
  • Improved mood: Centrophenoxine can help reduce stress and promote feelings of well-being, which contributes to improved cognitive function.

Centrophenoxine is water-soluble, quickly enters your brain after consumption, and temporarily boosts acetylcholinesterase. This benefits your memory, reasoning skills, and overall cognition.

It also synthesizes acetylcholine and clears cells of free radicals and lipofuscin, which is particularly beneficial for people who want to prevent age-related cognitive decline.

Where To Buy Centrophenoxine Online?

When it comes to purchasing Centrophenonxine online, you can find it on many online health and supplement websites. There are also many user reviews that can help you determine which product is best suited to your needs.

However, before buying Centrophenoxine from any source online, it's worth noting that the quality and purity of supplements can vary significantly. To get the best results, you should look for a reputable vendor that uses high-quality ingredients and offers third-party testing for quality assurance.

We at WholisticResearch highly recommend using the vendor; PureRawz to buy Centrophenoxine online. They offer high-quality supplements and competitive pricing, making them one of the most trusted vendors for nootropic users worldwide.

PureRawz sell Centrophenoxine in powder form starting at $14.98 (USD) for 25 grams. You can get your hands on it right here:

What Do People Say About Centrophenoxine On Reddit?

Let's take a look at what some of the users on Reddit have to say about Centrophenoxine:

centrophenoxine dosage

According to user karnage1:

"I've been using Centrophenoxine for a few months now and I absolutely love it. I find that it helps me stay focused, sharp, and energized throughout the day. It's been a great noot for improving my memory and cognitive skills."

According to user jayc303:

"I've used Centrophenox in the past to help improve my focus and mental clarity, and it really did work for me. I highly recommend this nootropic if you're looking for a boost in your brain power!!"

According to user Pukster:

"For me, centrophenoxine has been an absolute lifesaver. I used to struggle with memory issues and fatigue, but now that I'm taking this supplement regularly, I feel like my brain is sharper and more efficient than ever before.."

How Do You Take Centrophenoxine For Cognitive Enhancement?

Centrophenoxine is typically taken in powder or capsule form, depending on your preference. Most people choose to split the recommended daily dosage into two equal doses throughout the day, taken with or without food (doesn't really matter).

To get the best results from Centrophenoxine and to minimize any potential side effects, it's important to start with a low dose and work your way up gradually. This will help you avoid any unpleasant reactions as your body adjusts.

Although Centrophenoxine and DMAE are related to choline, it's important to note that they are not identical. That's why biohackers usually take Centrophenoxine with a pure and potent choline source, such as Alpha GPC or CDP Choline, for cognitive enhancement. This helps to boost acetylcholine production and maximize the benefits of Centrophenoxine.

Regarding cycling on and off Centrophenoxine, most users find it best to take this nootropic regularly for at least a few months without any breaks. This will allow you to get the most out of your Centrophenoxine dosage and continue reaping its cognitive benefits for the long term.

The daily recommended Centrophenoxine dosage is 500 mg to 1 gram. However, you may need to start with a smaller dose and increase your dosage gradually over time. This will help prevent adverse reactions while allowing your body to adjust properly to the supplement.

If you combine, or stack, Centrophenoxine with other nootropics, such as any of the racetams, we highly recommend starting at 250 mg and slowly increasing your dosage to 500 mg. This will help you avoid any unpleasant side effects or negative interactions between these different nootropics.

What Are The Side Effects Of Centrophenoxine?

Although Centrophenoxine has been used without many reported side effects for nearly 50 years, some people have experienced indigestion, sleepiness, confusion, slightly high blood pressure levels, moderate sadness, and irritability [7].

Because Centrophenoxine boosts acetylcholine levels in the brain, it's important to avoid taking this supplement if you struggle with Bipolar disorder, depression, or other mental health conditions. An excess of acetylcholine in the brain have shown to exacerbate these conditions [8].

If you experience any unpleasant side effects or symptoms while taking Centrophenoxine, we recommend stopping the supplement and speaking with your doctor immediately. You may need to adjust your dosage or try a different nootropic altogether.

Although Centrophenoxine is generally considered safe, it's always important to consult with a medical professional before starting any new supplements, especially if you have any underlying health conditions, such as the ones we described above, or are taking other medications regularly.

side effects of centrophenoxine

What Nootropics Are Similar To Centrophenoxine?

The 3 most popular nootropics similar to Centrophenoxine are DMAE, Alpha GPC, and CDP Choline. All of these nootropics work in a very similar way to Centrophenoxine.

Each one increases acetylcholine levels (ACh) in the brain and is known for boosting cognitive function, improving memory formation and retention, increasing focus and concentration, and boosting overall brain health.

The biggest difference between Alpha GPC and CDP Choline is that Alpha GPC has the highest bioavailability compared to CDP Choline. CDP Choline is only 18.5% choline by weight, while Alpha GPC is 40% choline by weight. This means that Alpha-GPC is the most direct precursor to acetylcholine.

What Brain Supplements Can Centrophenoxine Be Stacked With?

Centrophenoxine stacks with Aniracetam, Noopept, or Piracetam.

  • Aniracetam modulates some excitatory receptors, known as AMPA receptors [9], which decreases the rate of receptor desensitization. This typically results in a prolonged and controlled neurological stimulation effect. Aniracetam also increases the release of certain neurotransmitters in the brain, such as glutamate, acetylcholine, and dopamine.
  • Noopept is a derivative of Piracetam that is said to be 1,000 times more potent [10]. Its potential benefits based on preclinical studies include increased acetylcholine signaling, increased expression of BDNF and NGF (two protein growth factors), protection from glutamate toxicity, and enhanced inhibitory neurotransmission in the brain.
  • Piracetam inhibits erythrocyte adhesion [11] to the vascular endothelium, prevents vasospasm, and improves microcirculation. It was originally sold by UCB Pharma in 1971 and is known as the first nootropic drug because it can improve cognitive function without causing sedation or stimulation.

If finding the perfect Centrophenoxine stack seems daunting, we highly recommend looking into nootropic blends like NooCube. NooCube contains 13 different nootropic ingredients (including Alpha GPC) that all work synergistically to improve memory, focus, learning ability, mental speed, and overall brain health.

The ingredients are all backed by clinical research, and many of them also have neuroprotective properties as well. So if you're looking for the perfect foundation to stack with Centrophenoxine, we highly recommend looking into NooCube. You can learn more about NooCube here:

Frequently Asked Questions (FAQ)

Let's take a look at some of the most common questions and answers surrounding Centrophenoxine:

How Long Does It Take For Centrophenoxine To Work?

Centrophenoxine works right away. However, you may notice the full benefits more gradually over time as your brain becomes more accustomed to increased acetylcholine levels.

How Does Centrophenoxine Make You Feel?

Centrophenoxine provides a gentle increase in brain energy levels when taken first thing in the morning. It helps with memory recall and improves cognitive function overall. Some people report feeling more focused and alert throughout the day while taking Centrophenoxine.

What's The Half-Life Of Centrophenoxine?

The half-life of Centrophenoxine is short at only 30 to 45 minutes. This means that it takes 30 to 45 minutes for half of the dose to be cleared from the body.

Is It Safe To Use Centrophenoxine?

Centrophenoxine is considered to be safe and high in tolerability. However, some side effects may include headaches, digestive upset, and insomnia.

Is Centrophenoxine Legal?

Centrophenoxine is sold as a prescription drug in Japan and some European countries, such as Germany, Hungary, and Austria. However, it is not currently FDA-approved in the US. This means that it falls into a legal grey area and may be sold as a dietary supplement.

Conclusion

So what do we know about Centrophenoxine?

Centrophenoxine combines DMAE with a compound known as pCPA to create a powerful nootropic that can improve memory, boost brain energy levels, and protect the brain from age-related decline.

It increases acetylcholine signaling in the brain, an important neurotransmitter for learning and memory. Centrophenoxine is considered safe and well-tolerated, with very few reported side effects. It stacks well with racetams such as Piracetam and Aniracetam.

Centrophenoxine also works well when combined with a well-rounded nootropic blend such as NooCube. This unique nootropic formula contains powerful ingredients like Alpha GPC that work well with Centrophenoxine to enhance and improve focus, learning ability, and overall brain health.

References

References
1Lindh, B, and T Hökfelt. “Structural and functional aspects of acetylcholine peptide coexistence in the autonomic nervous system.” Progress in brain research vol. 84 (1990): 175-91. doi:10.1016/s0079-6123(08)60902-4
2Marcer, D, and S M Hopkins. “The differential effects of meclofenoxate on memory loss in the elderly.” Age and ageing vol. 6,2 (1977): 123-31. doi:10.1093/ageing/6.2.123
3Malanga, Gabriela et al. “New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger.” Drug metabolism letters vol. 6,1 (2012): 54-9. doi:10.2174/187231212800229282
4Wood, P L, and A Péloquin. “Increases in choline levels in rat brain elicited by meclofenoxate.” Neuropharmacology vol. 21,4 (1982): 349-54. doi:10.1016/0028-3908(82)90099-5
5Nandy, K, and G H Bourne. “Effect of centrophenoxine on the lipofuscin pigments in the neurones of senile guinea-pigs.” Nature vol. 210,5033 (1966): 313-4. doi:10.1038/210313a0
6Katz, Martin L, and W Gerald Robison Jr. “What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies.” Archives of gerontology and geriatrics vol. 34,3 (2002): 169-84. doi:10.1016/s0167-4943(02)00005-5
7Casey, D E. “Mood alterations during deanol therapy.” Psychopharmacology vol. 62,2 (1979): 187-91. doi:10.1007/BF00427135
8Higley, Michael J, and Marina R Picciotto. “Neuromodulation by acetylcholine: examples from schizophrenia and depression.” Current opinion in neurobiology vol. 29 (2014): 88-95. doi:10.1016/j.conb.2014.06.004
9Nakamura, K et al. “Impulsivity and AMPA receptors: aniracetam ameliorates impulsive behavior induced by a blockade of AMPA receptors in rats.” Brain research vol. 862,1-2 (2000): 266-9. doi:10.1016/s0006-8993(00)02160-0
10Ostrovskaia, R U et al. “Original'nyĭ nootropnyĭ i neĭroprotektivnyĭ preparat noopept” [The original novel nootropic and neuroprotective agent noopept]. Eksperimental'naia i klinicheskaia farmakologiia vol. 65,5 (2002): 66-72. 
11Nalbandian, R M et al. “Erythrocyte - endothelial cell adherence in sickle cell disease, diabetes mellitus, and falciparum malaria: adverse effects reversed with piracetam.” Medical hypotheses vol. 8,2 (1982): 155-62. doi:10.1016/0306-9877(82)90098-6
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