Fladrafinil (CRL-40,941) Review: Effects & Where to Buy

If you are tired of being tired then Fladrafinil might ease your burden.

You can restore your attention and focus with a little help from this nootropic that not only promises wakefulness but also better brain function.

Feeling active and sharp even having little sleep is often a common problem in the workplace or school.

Let’s give this smart drug a shot and dive into this Fladrafinil review.

What is Fladrafinil?

Fladrafinil (also called Fluorafinil or CRL 40,941) is a nootropic referred to as a “smart drug” and is classified as a eugeroic.

what is fladrafinil

Eugeroics promote wakefulness, helping you to stay alert and awake.

It is a bis (p-fluoro) ring-substituted derivative of adrafinil with a molar mass of 325.33 g/mol.

The drug was first founded in the 1970s and was patented in France in 1982 and the US the year after. It is used to improve brain function, memory, and focus.

Although it has similar effects as Modafinil and Adrafinil, it is considered a more intense eugeroic. Studies have shown that it poses an anti-aggressive effect on animals while the other eugeroics do not.

Nootropic users who have tried CRL 40,941 rave about its potency among the different afinils.

With a much lower dose of 2-[bis(4-fluorophenyl) methyl sulfinyl]-N-hydroxyacetamide, users experience wakefulness and focus without any serious side effects, making it a more favored nootropic.

What Does It Do & How Does It Work?

Fladrafinil (2-[bis(4-fluorophenyl)methyl sulfinyl]-N-hydroxyacetamide) mimics the effects of Adrafinil and Modafinil.

It is more closely compared to Adrafinil or CRL-40028 since they have similar neuropsychopharmacological properties. They only differ when it comes to the anti-aggressive effects which are observed in Fladrafinil.

This powder drug is often used for the treatment of insomnia or narcolepsy.

Once 2-[bis(4-fluorophenyl)methyl sulfinyl]-N-hydroxyacetamide is ingested, it is metabolized into modafinil and affects the central nervous system. The powder helps prevent dopamine reuptake resulting in improved brain functions and wakefulness.

Effects & Benefits

If you are a frequent nootropic user, taking the Fladrafinil or Fluorafinil powder (CRL 40,941) will give you similar cognitive effects as other smart drugs.

fladrafinil benefits effects

Anecdotal records show heightened attention among users that helps them focus and concentrate. Students refer to it as the “study pill” keeping them awake during review nights.

Here is a summary of the benefits of CRL 40,941:

  • Wakefulness
  • Alertness
  • Concentration
  • Focus
  • Memory formation and recall
  • Cognition
  • Lower aggression
  • Calmative properties

Although the drug has similar effects as other smart drugs, its greater potency makes it stand out. However, the powder must be used by those who have developed tolerance in other smart drugs over time.

Dosage & How to Take Fladrafinil Powder and Capsules

It’s noted as significantly more powerful than Adrafinil hence, a lower dose is recommended to achieve the desired result.

New users may get a bit overwhelmed when taking the drug and so a 30 to 80 mg dosage of the capsule or powder should be enough. The administration should be within 14 to 16 hours daily.

You can increase your dose once your body gets the hang of it but it should not exceed more than 200 mg daily.

It is not recommended to use the product for more than a week.

Please be advised that using the product if you have other medications or medical conditions might put you at risk.

Side Effects

Since its use, there are no reported serious medical issues in taking the powder as long as it is administered in the recommended dose and frequency.

One particular minor issue is that it leaves a smell on one’s urine. It may also cause vasoconstriction or narrowing of the blood vessels.

The product has not gone through extensive research to prove all these. If you are in doubt, it is best to consult medical experts before taking the drug.

Experiences Shared on Reddit

Hearing stories from users could give us more clarity on the effects of the powder.

Let us read what they have to say.

According to rmcfar11:

“I have to say, of all the finil-logs I’ve tried, Fladrafinil is the absolute best for me personally…I only needed about a 1/32 scoop in the AM per day and I was good. Yes, I measured it many times which came out to be ~50mg< Soon after a dose I would feel very aware of my surroundings, had good reaction time, and my brain just felt wide awake, but not uncomfortably so.”

According to attentionless:

“The reply below is from my source. FWIW, I have tried the fladrafinal a few times and I like it, FWIW. I have taken every ADHD med known and a bunch of different nootropic stacks (yawn). FROM MY SUPPLIER, I have tried this a few times and like it a lot.”

Where to Buy Fladrafinil Powder?

The powder drug has become popular among nootropics users unfortunately, it is not available for over-the-counter purchase.

There are reputable websites that sell the genuine powder form but it is sold only for research use. These online vendors also offer supplements or any chemical related to treatment drugs.

You may do your diligent research and check out trusted vendors who have the powder Fladrafinil for sale or you may simply go to the website of Science.bio and see their available products.

Frequently Asked Questions (FAQ)

Since the powder chemical has accrued attention, frequent nootropic users, and even potential users often have these questions in mind.

Is It Legal?

No. The chemical powder has not enough human research to prove that it is safe and effective. Although it is available online, the product is sold only for research use.

Fladrafinil vs Flmodafinil: What’s the Difference?

Fladrafinil (CRL 40941) and (CRL 40940) are both smart drugs or nootropics that are available in powder form. Both have been used and praised by many for their ability to prolong attention span, increase focus, and better brain function.

But some differences make one more favorable than the other.

Fladrafinil is a prodrug of the other. Meaning, the former is an inactive compound that when taken into the body metabolizes to produce a drug.

Prodrugs have a longer half-life and often more effective to use.


The reviews on the use of Fladrafinil (CRL 40-941) powder varies from positive to negative.

Some are convinced and some have not experienced the tiniest result of what they are supposed to feel.

Many people have vouched for its efficacy related to wakefulness and cognition, however, there is yet a need for more human studies to conclude on its claims.