Fladrafinil (CRL-40,941) Review: Effects & Where to Buy

If you are tired of being tired, then Fladrafinil might ease your burden.

For almost 5 years, I have tried countless energy drinks and supplements.

I couldn’t say any of those didn’t work.

Some of it did, but only for a few days. Some worked only a few hours, and after the product wore off, I felt exhausted, sleepy, and so down.

There’s a sudden crash on my energy levels, and in a snap, I just wanted to go to bed and rest.

I have never felt frustrated every single time. And it happens right when I should need energy and motivation the most. 

Well, everything turned right up when I started using Fladrafnil. It restored my attention and focus.

With little help from this nootropic, I enjoy my wakefulness and better brain function during work hours. I feel active and sharp in the workplace, even with little sleep.

What makes Fladrafinil different from other energy supplements?

fladrafinil featured image

Let’s dive into this Fladrafinil review and find out.

What is Fladrafinil?

Fladrafinil (also called Fluorafinil or CRL 40,941) is a nootropic referred to as a “smart drug” and is classified as a eugeroic.

what is fladrafinil

Eugeroics promote wakefulness, helping you to stay alert and awake. 

It is a bis (p-fluoro) ring-substituted derivative of adrafinil with a molar mass of 325.33 g/mol. 

The drug was first founded in the 1970s and was patented in France in 1982 and the US the year after. It is used to improve brain function, memory, and focus. 

Although it has similar effects as Modafinil and Adrafinil, it is considered a more intense eugeroic. Studies have shown that it poses an anti-aggressive effect on animals while the other eugeroics do not. 

Nootropic users who have tried CRL 40,941 rave about its potency among the different afinils. 

With a much lower dose of 2-[bis(4-fluorophenyl) methyl sulfinyl]-N-hydroxyacetamide, users experience wakefulness and focus without any serious side effects, making it a more favored nootropic.

What Does It Do & How Does It Work?

Fladrafinil (2-[bis(4-fluorophenyl)methyl sulfinyl]-N-hydroxyacetamide) mimics the effects of Adrafinil and Modafinil. 

It is more closely compared to Adrafinil or CRL-40028 since they have similar neuropsychopharmacological properties. They only differ when it comes to the anti-aggressive effects which are observed in Fladrafinil.

This powder drug is often used for the treatment of insomnia or narcolepsy. 

Once 2-[bis(4-fluorophenyl)methyl sulfinyl]-N-hydroxyacetamide is ingested, it is metabolized into modafinil and affects the central nervous system. The powder helps prevent dopamine reuptake resulting in improved brain functions and wakefulness.

Effects & Benefits

If you are a frequent nootropic user like me, taking the Fladrafinil or Fluorafinil powder (CRL 40,941) will give you similar cognitive effects as other smart drugs.

fladrafinil benefits effects

If you are a frequent nootropic user like me, taking the Fladrafinil or Fluorafinil powder (CRL 40,941) will give you similar cognitive effects as other smart drugs.

Anecdotal records show heightened attention among users that helps them focus and concentrate. Students refer to it as the “study pill,” keeping them awake during review nights. 

Here is a sum of the benefits of CRL 40,941.

  • Wakefulness
  • Alertness
  • Concentration
  • Focus
  • Memory formation and recall
  • Cognition
  • Lower aggression
  • Calmative properties

Although the drug has similar effects as other smart drugs, its greater potency makes it stand out. However, the powder must be used by those who have developed tolerance to other smart drugs over time. 

Dosage & How to Take Fladrafinil Powder and Capsules

Fladrafinil is noted as significantly more powerful than Adrafinil. Hence, a lower dose is recommended to achieve the desired result.

As a new user, I get a bit overwhelmed when taking the drug, so I took a 30 to 80 mg dosage of the capsule or powder. The administration should be within 14 to 16 hours daily. 

Once I felt like my body already got the hang of it, I increased my dose but not exceeding more than 200 mg daily. 

I recommend using the product for more than a week.

Please be advised that using the product if you have other medications or medical conditions might put you at risk. 

Side Effects

Since its use, there are no reported serious medical issues in taking the powder as long as it is administered in the recommended dose and frequency. 

One particular minor issue I had is that it leaves a smell on my urine. Some say it may also cause vasoconstriction or narrowing of the blood vessels, but I haven’t experienced any of these so far.

The product has not gone through extensive research to prove all these. So, if you are in doubt, it is best to consult medical experts before taking the drug.

Experiences Shared on Reddit

Before using the product, I actually read stories from users to clarify the powder’s effects. 

This is what they have to say.

According to rmcfar11:

“I have to say, of all the finil-logs I've tried, Fladrafinil is the absolute best for me personally…I only needed about a 1/32 scoop in the AM per day and I was good. Yes, I measured it many times which came out to be ~50mg< Soon after a dose I would feel very aware of my surroundings, had good reaction time, and my brain just felt wide awake, but not uncomfortably so.”

According to attentionless:

“The reply below is from my source. FWIW, I have tried the fladrafinal a few times and I like it, FWIW. I have taken every ADHD med known and a bunch of different nootropic stacks (yawn). FROM MY SUPPLIER, I have tried this a few times and like it a lot.”

Where to Buy Fladrafinil Powder?

The powder drug has become popular among nootropics users. Unfortunately, it is not available for over-the-counter purchase. 

There are reputable websites that sell the genuine powder form, but it is sold only for research use. These online vendors also offer supplements or any chemical related to treatment drugs.

You may do your diligent research and check out trusted vendors who have the powder Fladrafinil for sale.

I bought it from Science.bio as I don’t see any other more reputable website than this one.

Frequently Asked Questions (FAQ)

Since the powder chemical has accrued attention, frequent nootropic users and even potential users often have these questions in mind.

Is It Legal?

My answer is yes. Although the chemical powder has not enough human research to prove that it is safe and effective, it isn't illegal. Although it is available online, the product is sold only for research use.

Fladrafinil vs Flmodafinil: What's the Difference?

Fladrafinil (CRL 40941) and (CRL 40940) are both smart drugs or nootropics available in powder form. Both have been used and praised by many for their ability to prolong attention span, increase focus, and better brain function. 

But some differences make one more favorable than the other. 

I have researched that Fladrafinil is a prodrug of the other. Meaning, the former is an inactive compound that metabolizes to produce a drug when taken into the body. 

Prodrugs have a longer half-life and often more effective to use.


The reviews on Fladrafinil (CRL 40-941) powder vary from positive to negative. 

I am basically convinced of its effects, and for some time now, I can still feel the positive result. 

Some may not have experienced the tiniest result of what they are supposed to feel. Let’s just keep in mind that results may vary depending on how your body reacts to it.