How Long Does It Take for Lion’s Mane to Work?

Updated on February 12, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Abstract representation of Lion's Mane mushroom's gradual cognitive benefits and mental enhancement.

How long does it take for Lion’s Mane Mushroom to work?

Lion’s Mane, also known as Hericium erinaceus, is a medicinal mushroom that has gained popularity for its potential cognitive health and immune support benefits. This unique mushroom is rich in antioxidants and medicinal compounds that may promote brain health, improve memory, and enhance overall well-being. 

But how long does Lion’s Mane take to work and reduce brain fog? 

In this article, we will explore the mechanism of Lion’s Mane, the factors influencing its effectiveness, the expected timeline for effects, and tips to maximize its benefits.

You will learn the best time to use Lion’s Mane in order to get the maximum benefit for your lifestyle.

Understanding Lion’s Mane and Its Benefits

No, not like The Lion King. This mushroom doesn’t roar.

But, if you’re wondering why this mushroom has this name, it’s because of the way it flowers.

When this magnificent mushroom starts to grow, its outer appearance bears an unmistakable resemblance to a lion’s mane. It has multiple white, fluffy, shaggy spines that cover the mushroom for protection, giving it an incredibly unique appearance. 

Cool, right?  

Its appearance has also earned it many other names. Such as the monkey head mushroom, bearded tooth mushroom, or pom-pom mushroom. 

Lion’s Mane is a medicinal mushroom that has been used for centuries in traditional Chinese medicine. This mushroom contains various bioactive compounds, including erinacines and hericenones, which contribute to its powerful health benefits.(1)

You can find these marvels of the mycelium world growing in North America and Canada. They grow on dead logs (like most mushrooms) during the late summer and fall seasons. Unless you’re feeling like taking a trip this year to go mushroom hunting, then the likelihood of you finding these mushrooms is rare.

However, there are many Lion’s Mane supplements available on the market, manufactured in FDA-approved facilities with regulated dosages to ensure that you get the best out of this mushroom. 

But, what are the benefits of Lion’s Mane? how do these supplements really help?

Imagine you’re about to present an incredibly important project to your CEO – but suddenly, your thoughts start to race and you begin feeling stressed. This could lead to you messing up an important chance to showcase your abilities. What a disaster! We all know how debilitating that sensation can be.

Enter Lion’s Mane, your brain’s knight in shining armor.

This mushroom works to combat symptoms of anxiety and depression, allowing you to think clearly. Taking this supplement will boost your brain to give you the cognitive focus you need to produce your best work and stay focused.

Some benefits of Lion’s Mane supplements include:

  • Cognitive Health: Lion’s Mane has been shown to promote nerve cell growth factor (NGF) production in the brain, which can support the health and regeneration of brain cells. This may help improve cognitive function, memory, and focus, leading to significant improvements in brain health. 
  • Immune Support: Lion’s Mane contains beta-glucan, a type of complex carbohydrate that has immune-modulating effects. It can help regulate the immune response and support a healthy immune system.
  • Antioxidant Properties: The bioactive compounds in Lion’s Mane have antioxidant properties, which can help protect against oxidative stress and reduce inflammation in the body.
  • Energy boost: Lion’s Mane has energizing or anxiolytic effects that increase your vitality and alleviate symptoms of depression and anxiety to make users feel calmer. 

Understanding the potential effects of Lion’s Mane mushrooms sets the stage for exploring how it works in the body and how short-term and long-term effects are felt.

The Mechanism of Lion’s Mane

Lion’s Mane has a variety of fascinating mechanisms in the body that have been designed by none other than Mother Nature herself, the world’s best physician!

This remarkable mushroom is a great example of the connection between immune health and organic bioactive compounds.

Some notable mechanisms of the ”Pom-Pom” mushroom include:

  • Nerve Growth Factor Stimulation: Lion’s Mane has shown the potential to promote nerve cell production of NGF, a protein that plays a crucial role in the growth, maintenance, and repair of nerve cells. By increasing NGF levels, Lion’s Mane may support brain health, neurogenesis (the growth of new neurons), and overall cognitive ability.(2)
  • Anti-Inflammatory Effects: Chronic inflammation in the body can contribute to various health issues, including cognitive decline. Lion’s Mane contains bioactive compounds that have anti-inflammatory properties, helping to reduce inflammation and promote healthy brain function.(3)
  • Antioxidant Activity: Oxidative stress, caused by an imbalance between free radicals and antioxidants in the body, can damage cells and contribute to aging and disease with mycochemicals. Lion’s Mane’s antioxidant properties help neutralize free radicals and protect against oxidative damage.(4)
  • Beta-Glucan Content: Lion’s Mane contains beta-glucan, a type of complex carbohydrate that has immunomodulatory effects. Beta-glucan can help regulate immune function and support a healthy immune system.(5)

Isn’t that AMAZING?

For many who struggle with scattered focus, this is a shining light of hope.

Understanding these mechanisms provides insight into how Lion’s Mane works in the body. It also helps us to understand its ability to clear brain fog and promote brain health for overall well-being with regular use.

Factors Influencing the Effectiveness of Lion’s Mane

There are many things to consider about the effectiveness of this natural substance. Several factors influence how quickly and effectively Lion’s Mane works in individuals.

Here are some common influences on the efficacy of this nootropic:

  • Dosage: The dose of Lion’s Mane can vary depending on the form and brand. It is important to follow the recommended daily intake instructions provided by the manufacturer for optimal effects.
  • Individual Health Status: Each individual’s body may respond differently to Lion’s Mane depending on their overall health status. Factors such as age, underlying health conditions, and individual biochemistry can influence the effectiveness of Lion’s Mane.
  • Lifestyle Factors: Lifestyle plays a significant role in the overall effectiveness of Lion’s Mane. Factors such as diet, exercise, stress levels, and sleep quality can impact the body’s response to Lion’s Mane and its potential benefits.
  • Absorption and Bioavailability: The body’s ability to absorb and use the bioactive compounds in Lion’s Mane can vary from person to person. Factors such as gastrointestinal health and nutrient absorption capacity can affect the bioavailability of the Lion’s Mane mushroom and its effectiveness.

Consider these factors to set realistic expectations and get the best out of your Lion’s Mane. supplementation.

How Long It Takes for Lion’s Mane to Work 

Lion’s Mane Mushroom supplements may start to show effects immediately for some individuals. But, it typically takes around two to three weeks of consistent use to notice significant benefits. Ensuring regular intake of Hericium erinaceus supplements stimulates its positive effects and helps to maintain its potency.

It’s always best to take natural nootropics consistently to reap the best of their powerful benefits!

The best part?

This is one of the safest nootropics for long-term use, with no adverse health risks from continued use. 

 Here is a general timeline for Lion’s Mane effects:

  • Immediate Effects: Some individuals experience an immediate boost in mood, focus, and mental clarity after taking Lion’s Mane. This could be attributed to the bioactive compounds stimulating Nerve Growth Factor production in the brain, which promotes increased mental clarity. 
  • Short-Term Benefits: Within a few weeks of consistent use, individuals start to notice improvements in cognitive ability, memory, and overall brain health. These short-term benefits are often attributed to the cumulative impact of Lion’s Mane on neurogenesis and inflammation reduction.
  • Long-Term Benefits: Long-term use of Lion’s Mane lead to more pronounced and sustained improvements in cognitive function, memory recall, and overall well-being. The neuroprotective and regenerative properties of Lion’s Mane may contribute to these long-term benefits.

5 Tips to Maximize the Benefits of Lion’s Mane

As with all nootropics that increase cognitive function and well-being, there is a way to optimize the Lion’s Mane mushroom’s effects. This will allow you to get the best out of your supplementation regimen and boast your newly found, naturally induced sense of clarity. 

Here are some great tips to increase the effectiveness of your Lion’s Mane treatment: 

  1. Follow Recommended Dosage: Adhere to the recommended daily dose instructions provided by the manufacturer to ensure optimal effectiveness.
  2. Combine with a Healthy Lifestyle: Incorporate Lion’s Mane supplementation into a healthy lifestyle that includes a balanced diet, regular exercise, quality sleep, and stress management techniques. These lifestyle factors can enhance the benefits of Lion’s Mane for cognitive health.
  3. Consider Supplement Combination: Lion’s Mane can be combined with other supplements that support brain health and cognition, such as omega-3 fatty acids, vitamin D, and B vitamins. Consult with a healthcare professional to determine the appropriate supplement combination for your individual needs.
  4. Be Consistent: Consistency is key when using Lion’s Mane. Regular and continuous use is more likely to yield noticeable effects over time.
  5. Monitor Personal Response: Pay attention to your own body’s response to Lion’s Mane and adjust your daily intake or timing if needed. Everyone’s individual biochemistry is unique, so finding the optimal regimen may require some experimentation.

By keeping these useful tips in mind, you can enhance the effects of this mushroom to promote well-being.

Are you wondering what the best time of day would be to take Lion’s Mane?

Well, that answer varies, depending on your lifestyle and responsibilities. But, often the best time to take this mushroom is in the morning, before your day begins. You can also ingest Lion’s Mane before bed to promote cell regeneration in your sleep, or in the early evening if you need to maintain your cognitive focus throughout the night.


Lion’s Mane is a medicinal mushroom that offers a wide range of potential health benefits, particularly in the realms of cognitive health and immune support.

The timeline for experiencing the benefits of Lion’s Mane can vary depending on factors such as dose, individual health status, lifestyle factors, absorption, and bioavailability.

Overall, some users experience immediate results, and other’s experience results after 2-3 weeks of supplementation. 

By following supplementation guidelines, adopting a healthy lifestyle, and monitoring personal responses, individuals maximize the benefits of Lion’s Mane supplementation.

As always, it’s best for your mental health that you consult with a healthcare professional before starting any new supplement regimen to ensure it meets your individual needs. This will also allow you to avoid potential interactions with other medications you may be on.

Sources, Studies, and Scientific Research
  1. Chong, Pit Shan et al. “Therapeutic Potential of Hericium erinaceus for Depressive Disorder.” International journal of molecular sciences vol. 21,1 163. 25 Dec. 2019, doi:10.3390/ijms21010163 ↩
  2. Lai, Puei-Lene et al. “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International journal of medicinal mushrooms vol. 15,6 (2013): 539-54. doi:10.1615/intjmedmushr.v15.i6.30 ↩
  3. Mori, Koichiro et al. “The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages.” International journal of medicinal mushrooms vol. 17,7 (2015): 609-18. doi:10.1615/intjmedmushrooms.v17.i7.10 ↩
  4. Ghosh, Sandipta et al. “Mycochemical Profiling and Antioxidant Activity of Two Different Tea Preparations from Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).” International journal of medicinal mushrooms vol. 23,11 (2021): 59-70. doi:10.1615/IntJMedMushrooms.2021040368 ↩
  5. Ma, Bowen et al. “The Inhibitory Effects of Hericium erinaceus β-glucan on in vitro Starch Digestion.” Frontiers in nutrition vol. 7 621131. 21 Jan. 2021, doi:10.3389/fnut.2020.621131 ↩