IDRA-21 Review: Nootropic Benefits, Dosage, & Side Effects

Updated on September 14, 2022
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

This article reviews IDRA-21, a nootropic compound that is claimed to offer various benefits, including improved cognitive function and increased intelligence. We will discuss the evidence for these claims and the potential risks and side effects associated with IDRA-21 use.

If you've been looking for an edge to boost your productivity and help you focus, you may have come across IDRA-21.

This nootropic offers a range of benefits, from better cognitive function to improved mental clarity.

But what is IDRA-21 exactly? How much do you need to take for optimal results? And are there any potential side effects?

In this post, we'll take a closer look at IDRA-21 and everything you need to know about it. Let's get started!

IDRA-21 Review Summary

IDRA-21 (C8H9ClN2O2S) is a nootropic compound that has been shown to improve cognitive function, learning, and memory. It works through the positive allosteric modulation of the glutamate AMPA receptors in the brain.

IDRA-21 binds to and activates GluR1/2 receptors, facilitating the transmission of excitatory neurotransmitters. This makes IDRA-21 a potential target for research into aging-related cognitive disorders.

Pros:

  • Improves cognitive function
  • Enhances memory, concentration and learning
  • Boosts neurotransmission and mental clarity

Cons:

  • Difficult to find high-quality IDRA-21

What Is IDRA-21?

The active form of IDRA-21 is a positive allosteric modulator of the AMPA receptor. It's also a benzothiadiazole derivative. This means that it binds to the receptor and alters its conformation, increasing the efficacy of glutamate binding and enhancing AMPA receptor function. 

idra-21 featured image

IDRA-21 has been shown to increase long-term potentiation (LTP), a process that underlies learning and memory formation [1]. It's a chiral molecule, meaning it exists as two structurally different forms rotating around a central axis.

The (+)-form (the "active" form) is more potent than the (-)-form and is the one that produces the cognitive benefits seen in animal studies.

IDRA-21 is 10–30 times more potent than Aniracetam, another popular nootropic, in reducing cognitive impairment induced by scopolamine or alprazolam [2]. However, it is unknown whether this increased potency translates to greater cognitive benefits in humans.

How Does IDRA-21 Work In The Brain?

IDRA-21 improves cognitive function and increases excitatory synaptic strength by attenuating rapid desensitization of the AMPA receptors. These are a type of glutamate receptors, which are the most abundant excitatory neurotransmitters in the brain.

how does idra 21 work

Glutamate is important for learning, memory, and other cognitive processes. By increasing the efficacy of glutamate binding, IDRA-21 enhances AMPA receptor function and increases LTP. This leads to improved cognitive function, learning, and memory.

The activation of glutamate receptors leads to an influx of calcium ions into the cell. This triggers a series of events that eventually lead to channels opening in the cell membrane, allowing sodium and potassium ions to flow in and out of the cell [3].

This depolarizes the cell membrane and causes an action potential. Action potentials are the electrical signals that travel along neurons and allow them to communicate with each other.

What Is IDRA-21 Used For?

IDRA-21 improves learning and memory in elderly subjects with age-related cognitive decline. It has been shown to effectively reduce cognitive impairment induced by scopolamine or alprazolam.

According to Thompson, D M, et al., IDRA-21 improved performance on a task that measures visual recognition memory with no adverse effects in patas monkeys.

Off-label, IDRA-21 is sometimes used as a nootropic supplement to improve cognitive function, memory, and learning. While some evidence supports its use for these purposes, more research is needed to confirm its efficacy in humans.

What Are The Benefits Of IDRA-21?

The benefits of IDRA-21 for cognition include improved learning, memory, and visual recognition.

An overview of IDRA-21 benefits for cognition:

  • IDRA-21 significantly improves learning and memory
  • Increases focus and attention
  • Improves mood and energy levels
  • Increases excitatory synaptic strength
  • It is 10-30 times more potent than Aniracetam for cognition
  • Produces sustained nootropic effects lasting up to 48 hours

It's worth pointing out that most of these benefits are seen in animal studies, not human trials. So while there is promising evidence for IDRA-21's cognitive benefits, more research is needed to confirm its efficacy in humans.

Where To Buy IDRA-21 Online?

We recommend buying IDRA-21 from PureRawz. They are a reputable nootropic vendor that offers high-quality products at competitive prices.

  • The price of 500 mg IDRA-21 is $14.48
  • The price of 1000 mg IDRA-21 is $20.48
  • The price of 5000 mg IDRA-21 is $75.48

PureRawz offers 1st and 3rd party lab-tested products with a Certificate of Analysis (CoA). This ensures that their products are high quality and free of impurities.

What Do People Say About IDRA-21 On Reddit?

Reddit users seem to be pretty happy with IDRA-21. Here are some of the things people are saying about it:

“I'm really liking it so far. I'm taking 20mg twice a day... I noticed an effect within the first hour after dosing. It's hard to describe, but I just feel more focused and present. I'm also more talkative and outgoing on it, which is unusual for me!!”

“It's been working well for me so far. I've tried a lot of different nootropics, but this is the first one that has really made a noticeable difference for me when it comes to focus. Taking 10 mg once a day as we speak.”

“LOVE IDRA-21 so far! I'm taking 10 mg twice daily, and I've noticed a significant improvement in my energy levels. I'm also more focused and motivated to get things done. Overall, it's been a great experience 10/10 wud recommend.”

How Do You Take IDRA-21 For Cognitive Enhancement?

We recommend taking IDRA-21 with food to reduce the chances of gastrointestinal side effects. Take it at the same time each day to maintain consistent levels in your system.

how to take idra 21

Take it once or twice daily. Some people prefer to split their dose and take it twice a day for better results.

We recommend a low dose once daily if you're just starting out. You can increase the dose gradually over time if you need to.

Anecdotal reports suggest that cycling IDRA-21 is unnecessary; however if you decide to cycle it, we recommend a break of at least 2 weeks between cycles.

What Is The Recommended Dosage For IDRA-21?

IDRA-21 comes in powder form in different sizes - 500 mg, 1000 mg and 5000 mg. Studies done on animals have used the dose range of 0.15-10 mg/kg [4]. Jerry J et al. showed that oral administration of IDRA-21 significantly improved performance on a computer-automated delayed matching-to-sample task.

According to PureRawz, one of the most reputable nootropic vendors online, the daily recommended IDRA-21 dosage for humans is 10 mg to 20 mg.

What Are The Side Effects Of IDRA-21?

Common side effects of IDRA-21 include:

  • Headache
  • Dizziness
  • Nausea
  • Fatigue
  • Anxiety
  • Irritability

These side effects are usually mild and go away on their own. If they persist or if they're bothersome, you can try reducing the dose or taking it with food.

Although IDRA-21 doesn't seem to produce neurotoxicity under normal conditions, a study from 2004 published in Annals of Neurology showed that it might worsen neuronal damage following global ischemia after stroke or seizures [5].

What Nootropics Are Similar To IDRA-21?

Aniracetam is a similar nootropic to IDRA-21 that also has cognitive-enhancing effects. Both drugs modulate the AMPA receptor, but aniracetam is less potent than IDRA-21.

Since IDRA-21 is a drug in the ampakine class, other nootropics in this class, such as sunifiram and oxiracetam, are similar. Ampakines are a subgroup of AMPA receptor-positive allosteric modulators with a benzamide or closely related chemical structure.

The biggest difference between these nootropics is their potency and effects. IDRA-21 is the most potent of the bunch, while the racetams are the least potent.

What Brain Supplements Can IDRA-21 Be Stacked With?

Stacking is when you take two or more nootropics together to enhance the effects of each. The best way to stack IDRA-21 is with a choline source and an acetylcholinesterase inhibitor.

Choline is an essential nutrient that's involved in memory, learning, and muscle control. It's also the precursor to acetylcholine, the neurotransmitter that's responsible for communication between neurons.

A solid choline source will improve the effects of IDRA-21 by increasing levels of acetylcholine in the brain. Citicoline and alpha GPC are two great choline sources that can be stacked with IDRA-21.

Acetylcholinesterase inhibitors (AChEIs) prevent the breakdown of acetylcholine in the brain. This results in increased levels of acetylcholine, which has a variety of benefits for cognitive function.

Huperzine A is a popular AChEI that's often stacked with IDRA-21. It's a natural compound that's derived from the Chinese club moss plant and has been shown to work synergistically with IDRA-21 in several studies [6].

If all of these choices give you a headache, don't worry. Noocube has you covered. NooCube is a nootropic blend that contains all of these ingredients plus more. It's the perfect foundation to stack IDRA-21 with or any other nootropic for that matter.

NooCube is a natural supplement that's designed to support cognitive function. It contains 13 powerful ingredients that work together to help you think faster, focus better, and remember more.

Frequently Asked Questions (FAQ)

How Long Does It Take For IDRA-21 To Work?

IDRA-21 works within an hour, but it can take up to three hours to reach peak levels in the brain. Depending on the dose, the effects can last up to 48 hours.

How Does IDRA-21 Make You Feel?

IDRA-21 makes you feel alert and focused. It's a very clean-feeling nootropic with no crashes or jitters. It makes you feel motivated and driven to get things done.

What's The Half-Life Of IDRA-21?

The half-life of IDRA-21 is 48 hours. This means that it takes 48 hours for the levels of IDRA-21 in the body to decrease by 50%.

Is It Safe To Use IDRA-21?

IDRA-21 is considered to be safe if you use it as directed. The recommended dose is 10-20 mg per day. Higher doses may cause side effects such as headaches, anxiety, and insomnia.

Conclusion

So what do we know about IDRA-21?

IDRA-21 is a potent nootropic that's known for its cognitive-enhancing effects. It's often used to improve memory, focus, and learning. It has a very clean feeling with no crashes or jitters. IDRA-21 is considered to be safe if used as directed.

If you're looking for a nootropic to improve your cognitive function, IDRA-21 is a great choice. It's also a great compound to stack with other nootropics. Noocube is the perfect foundation to stack IDRA-21 with because it contains all of the necessary ingredients for a synergistic effect.

You can get your hands on IDRA-21 by visiting the PureRawz website here:

References

References
1Arai, Amy; Guidotti, Alessandro; Costa, Erminio; Lynch, Gary. Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices. NeuroReport: September 2, 1996 - Volume 7 - Issue 13 - p 2211-2215
2Thompson, D M, et al. “7-Chloro-3-Methyl-3,4-Dihydro-2h-1,2,4-Benzothiadiazine S,S-Dioxide (IDRA 21), a Congener of Aniracetam, Potently Abates Pharmacologically Induced Cognitive Impairments in Patas Monkeys.” Proceedings of the National Academy of Sciences, vol. 92, no. 17, 1995, pp. 7667–7671., https://doi.org/10.1073/pnas.92.17.7667.
3“AMPA Receptor.” AMPA Receptor - an Overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/neuroscience/ampa-receptor.
4Buccafusco, Jerry J et al. “The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.” Neuropharmacology vol. 46,1 (2004): 10-22. doi:10.1016/j.neuropharm.2003.07.002
5Yamada, Kelvin A., et al. “The Diazoxide Derivative IDRA 21 Enhances Ischemic Hippocampal Neuron Injury.” Annals of Neurology, vol. 43, no. 5, 1998, pp. 664–669., https://doi.org/10.1002/ana.410430517.
6Malkova, Ludise et al. “The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.” Neuropharmacology vol. 60,7-8 (2011): 1262-8. doi:10.1016/j.neuropharm.2010.12.018
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