Kanna: Nootropic Benefits, Uses, Dosage, & Side Effects

Kanna, a psychoactive plant native to South Africa, is a natural way to improve your mood, focus, and memory.

This unique succulent plant has been used for centuries for its medicinal properties. Now, professionals, athletes, and students are using it for its stress-reducing and antidepressant effects and memory-enhancing properties.

Its active compounds, primarily mesembrine alkaloids, modulate serotonin and other neurotransmitter systems.

While generally safe, proper dosing and awareness of potential interactions are crucial.

Kanna’s unique profile sets it apart from other nootropics, offering a balanced approach to cognitive enhancement and emotional well-being.

What is Kanna?

Kanna (Sceletium tortuosum), also known as kougoed or channa, is a psychoactive succulent plant native to the semi-arid Karoo region of South Africa. It grows naturally in the wild and is also cultivated for its medicinal properties.

It has been used traditionally by the Khoi San people for its sedative, anxiolytic, and euphoric effects.

Kanna contains mesembrine alkaloids, which act as serotonin (happiness inducer) reuptake inhibitors (SRI), modulating serotonin levels in the brain.

Emerging research suggests Kanna has nootropic benefits for improving mood, reducing anxiety, and enhancing cognitive function.

Besides its nootropic benefits, Kanna also offers physiological benefits like pain relief, treatment of cough and fever, and appetite control.

What Active Compounds are Present in Kanna?

The main active compounds in Kanna, such as mesembrine, mesembrenone, and mesembrenol, primarily exert their effects by modulating serotonin activity in the brain.

Here’s how these compounds play an active role in the functions of the body:

1. Serotonin Regulation: Mesembrine increases levels of serotonin in the synaptic region, enhances serotonin signaling
2. GABAergic Activity: Reduces neuronal excitability by slowing down neurotransmission
3. Endocannabinoid System Modulation: Activates cannabinoid receptors
4. cAMP (cyclic adenosine monophosphate) Activity: Mesembrenone inhibits phosphodiesterase 4 (PDE4), raising synaptic plasticity through rising cAMP levels
5. Other Neurotransmitter Systems: Regulates dopamine and melatonin levels

Kanna Extract: Benefits and Considerations

Kanna extract represents a concentrated form of the plant’s active compounds, offering more consistent potency and effects compared to raw plant material. Understanding the specific characteristics of extracts is essential for optimal use.

Extraction Methods and Potency:
Different extraction methods yield varying alkaloid profiles and potencies:

• Alcohol-based extracts: Typically contain 0.5-2% total alkaloids and provide balanced effects across all active compounds. These are the most common commercial extracts.
• CO2 extracts: Generally higher in mesembrine (up to 4%) with fewer other alkaloids, producing more pronounced mood enhancement with less sedation.
• Water-based extracts: Milder in effect but often preferred for anxiety relief with fewer side effects. These typically contain 0.3-1% total alkaloids.
• Traditional fermented extracts: Created through the “kougoed” method of crushing and fermenting the plant material, these contain a unique alkaloid profile with potentially stronger effects on mood.

Standardization of Extracts:
Commercial extracts are typically standardized to contain specific percentages of mesembrine alkaloids:

• Low potency: 0.5-1% total alkaloids, suitable for beginners
• Standard potency: 1-2% total alkaloids, most commonly available
• High potency: 2-4% total alkaloids, used for therapeutic purposes

Extract-Specific Side Effects:
Due to their concentrated nature, extracts may produce different side effect profiles:

• Higher likelihood of serotonergic effects like mild euphoria and emotional openness
• Reduced gastrointestinal discomfort compared to raw plant material
• More pronounced pupil dilation and potential for insomnia
• Faster onset of effects (15-30 minutes versus 30-60 minutes for raw plant)

Dosage Adjustments for Extracts:
Extracts require significantly lower dosages than raw plant material:

• A 2% standardized extract is approximately 8-10 times more potent than raw dried plant material
• When switching from raw Kanna to extract, begin with 1/8 to 1/10 of your usual dose
• Sublingual administration of extracts increases potency by approximately 30-40% compared to oral consumption

Extract Storage and Shelf Life:
Properly stored Kanna extracts maintain potency longer than raw plant material:

• Keep in airtight containers away from light, heat, and moisture
• Alcohol-based extracts typically remain potent for 2-3 years
• Powdered extracts generally maintain potency for 1-2 years
• Refrigeration can extend shelf life but is not necessary for short-term storage

What Are the Nootropic Effects of Kanna?

Kanna has several nootropic benefits:

• Reducing anxiety and stress
• Enhancing mood and well-being
• Improving memory and learning skills
• Enhancing mental clarity and focus
• Providing hallucinogenic therapeutic benefits

Could Kanna be Used to Treat Anxiety and Stress Disorders?

Kanna is well-known for its sedative and anti-anxiety effects. By acting as a serotonin reuptake inhibitor, Kanna significantly reduces anxiety, stress, and nervous tension.

Furthermore, Kanna’s effect on GABAergic activity leads to reduced neuronal excitability and a calming effect on the central nervous system. This reinforces Kanna’s ability to alleviate anxiety symptoms and mitigate stress responses.

In one study, a single 25mg dose of Zembrin, a standardized Kanna extract, reduced anxiety during an interactive public speaking test. Participants also had lower amygdala reactivity to fearful stimuli.⁽¹⁾

Another randomized controlled trial found that participants who consumed Kanna extract experienced significant reductions in anxiety levels.⁽²⁾

Some anxiety and stress conditions manageable by Kanna include:

• Social anxiety disorder
• Generalized anxiety disorder
• Panic disorder
• Stress management
• Sleep difficulties

Does Kanna Have Potential as an Antidepressant or Mood Stabilizer?

Yes, Kanna has shown potential antidepressant and mood-altering properties.

Kanna’s primary alkaloid, mesembrine, is directly involved with alleviating depressive states and providing emotional stability through maintaining serotonin levels in the brain.⁽³⁾

In a study investigating the relationship between depressive states and Kanna extracts, significant antidepressant-like effects were observed in the subjects.⁽⁴⁾

Kanna also influences dopamine levels, which helps stabilize mood swings and enhance emotional resilience.

Moreover, Kanna’s ability to elevate cAMP levels also contributes to its antidepressant effects.

Scientific research backs up these claims. A study demonstrates that Kanna extract had significant antidepressant-like effects comparable to fluoxetine (Prozac).⁽⁵⁾

Can Kanna Improve Memory and Learning?

Yes, Kanna can improve memory and learning by promoting synaptic growth.

Kanna optimizes brain conditions by enhancing synaptic plasticity by boosting cAMP levels. This optimization has a favorable effect on improving memory retention and learning focus.

A study shows the rise in anti-inflammatory activity in the brain, pushed by enhanced cAMP levels, leads to better learning habits and memory retention capacity.⁽⁶⁾

Kanna’s ability to control reuptake levels of serotonin raises the state of happiness and well-being, promoting a better learning mindset and memorizing conditions.

A study checking the acute effects of Kanna shows this tendency to keep serotonin at a certain level in the brain, which raises the brain’s capacity to grow memory and learning muscles.⁽⁷⁾

How Does Kanna Support Mental Clarity and Focus?

A good primer to heightened focus and conscious thinking is the ability to regulate mood swings and emotional outbursts.

Kanna slows down such anxiety symptoms while improving mood through its calming effects. This therapeutic pathway has a direct effect on improving attention and mental acuity.⁽⁸⁾

Moreover, the serotonin level increase caused by Kanna also facilitates clear thinking.

Kanna’s ability to recondition gamma-aminobutyric acid (GABA) slows excessive neuronal firing, calming the mind and reducing distractions.⁽⁹⁾

Does Kanna Have Hallucinogenic Effects?

At common doses, Kanna does not typically cause strong hallucinations. However, some users report enhanced colors, patterns, and closed-eye visuals, especially at higher doses.

Kanna’s (mild) hallucinogenic effects are usable for therapeutic purposes that help treat mental health issues like depression, anxiety, PTSD, and substance abuse disorders.

A study reports that participants experience increased sensory perception and subtle changes in visual and auditory experiences at higher doses of Kanna, in PTSD patients.⁽¹⁰⁾

What Are the Recommended Dosages of Kanna?

The optimal dosage of Kanna depends on several factors, including the specific extract or preparation, individual tolerance, and desired effects.

Here are some general dosage guidelines based on available research and anecdotal reports:

Kanna extract powders are typically standardized to contain a certain percentage of mesembrine alkaloids. Effects last 2-4 hours.

Some general standards for optimal consumption of Kanna include:

• Start with a low dose and gauge your response. Some people may be more sensitive to Kanna’s effects than others.
• It’s also a good idea to take Kanna on an empty stomach for maximum absorption.
• Wait at least 2-3 hours before taking more Kanna. Re-dosing quickly can lead to nausea or dizziness.
• For regular use, take Kanna 3-4 times per week to avoid building tolerance.
• Cycle off periodically to maintain sensitivity.

Dosage for Anxiety Management

When using Kanna specifically for anxiety relief, dosage requirements may differ based on the severity and type of anxiety:

• Acute/Situational Anxiety: For immediate relief of situational anxiety (such as before public speaking or stressful events), 25mg of standardized Kanna extract (like Zembrin) has shown clinical efficacy. This can be taken 1-2 hours before the anxiety-inducing situation.
• General Anxiety Disorder: For ongoing management of general anxiety, 10-20mg of standardized extract taken twice daily has been reported effective by many users. Start with the lower dose and adjust as needed.
• Social Anxiety: 15-25mg of standardized extract approximately 60 minutes before social interactions may help reduce social anxiety symptoms.
• Panic-Related Anxiety: For those prone to panic attacks, maintaining a regular dosing schedule of 15mg twice daily may help prevent episodes, rather than using only during acute attacks.

For anxiety management, the powdered form can be more effective when taken sublingually (under the tongue) for faster absorption. Tinctures also provide rapid relief and can be dosed more precisely for anxiety symptoms.

Remember that individual responses vary significantly. Some people with anxiety may be more sensitive to Kanna’s effects, so starting with the lowest effective dose is particularly important.

What are the Risks and Safety Concerns of Using Kanna?

While Kanna has a long history of traditional use and appears to be well-tolerated, there are some potential risks and safety concerns to be aware of, especially with chronic high-dose use.

What are the Potential Side Effects and Adverse Reactions to Kanna?

The most common side effects reported with Kanna use include:

• Headache: Occurs in approximately 15-20% of users, typically mild to moderate in intensity. Usually subsides after 1-2 hours or can be managed with adequate hydration.
• Nausea: Reported by about 10-15% of users, more common with higher doses or when taken on an empty stomach. Taking Kanna with a light meal can reduce this effect.
• Dizziness: Affects roughly 8-12% of users, particularly when standing quickly after consumption. More prevalent in first-time users and typically diminishes with regular use.
• Drowsiness: Experienced by 10-15% of users, more common with higher doses. Consider timing consumption for evening use if this effect is pronounced.
• Dry mouth: Very common (25-30% of users) but generally mild. Staying hydrated before and after taking Kanna can minimize this effect.
• Dilated pupils: Occurs in approximately 5-10% of users, more noticeable at higher doses. Not typically problematic but may cause light sensitivity.
• Diarrhea: Uncommon (3-5% of users) and typically mild. More likely with raw plant material than with extracts.
• Insomnia: Reported by 8-10% of users when taken within 6 hours of bedtime. Avoid late afternoon or evening dosing if this occurs.

Long-term vs. Short-term Side Effects:
Most side effects are acute and resolve within hours of consumption. Long-term users occasionally report mild psychological dependence and tolerance development, requiring periodic breaks from use.

Side Effects by Form:

• Standardized extracts (like Zembrin): Generally produce fewer gastrointestinal side effects but may cause more pronounced mood effects.
• Raw plant material: More likely to cause digestive discomfort but often produces milder psychoactive effects.
• Fermented Kanna: Traditional preparation may cause stronger effects overall, including both benefits and side effects.

Managing Side Effects:

• Start with the lowest effective dose
• Stay well-hydrated before and after consumption
• Take with a small amount of food to reduce gastrointestinal effects
• Avoid combining with alcohol or other serotonergic substances
• Use earlier in the day if insomnia occurs
• Take periodic breaks (1-2 weeks) after every 4-6 weeks of regular use

Are There Any Known Contraindications or Drug Interactions with Kanna?

Yes, there are some potential contraindications and drug interactions to consider before using Kanna:

• MAOI (monoamine oxidase inhibitors): Lead to serotonin syndrome, wait 2 weeks before using MAOIs and Kanna
• SSRI (serotonin reuptake inhibitors): Agitation, tremor, and hyperthermia, people on antidepressants should avoid
• Sedatives: Benzodiazepines, sleeping pills, depressants, and muscle relaxers
• Pregnancy/nursing: Avoid due to lack of safety data
• Psychiatric conditions: Bipolar disorder
• Surgery: Discontinue 2 weeks before a scheduled surgery

Does Kanna Pose a Risk of Dependence or Addiction?

The risk of Kanna dependence or addiction is low compared to other psychoactive drugs. However, frequent high-dose use can lead to tolerance.

While not physically addictive like opioids or stimulants, abrupt discontinuation of chronic Kanna use may cause a withdrawal syndrome, causing:

• Irritability
• Low mood
• Sleep disturbances
• Cravings
• Headaches

What are the Signs of Kanna Abuse or Overdose?

A Kanna overdose is rare but potentially dangerous. Excessive dosing can lead to serotonin toxicity, with symptoms like:

• Agitation
• Tremors
• Muscle rigidity
• Hyperthermia
• Rapid heartbeat
• High blood pressure
• Seizures
• Coma

If serotonin syndrome is suspected, seek emergency medical attention immediately.

Overdose risk is higher when combining Kanna with other serotonergic drugs.

How Does Kanna Compare to Other Nootropics?

While it shares some similarities with other natural nootropics, Kanna has a distinct effect profile. Also, its benefits can be enhanced by carefully choosing the right complementary supplement.

Here’s a quick comparison of how Kanna matches up with some other popular nootropics:

While Kanna may not be the strongest in any one domain, its well-rounded benefits and safety profile make it an attractive option for many.

Can Kanna Be Combined with Other Nootropics for Enhanced Effects?

Yes, Kanna can be combined with other nootropics to create a synergistic effect.

Here are some nootropics that may combine well with Kanna:

• Ashwagandha: Greater relaxation, emotional resilience, and neuroprotective benefits
• Bacopa monnieri: Balances mental sharpness and anxiety reduction
• L-theanine: Promotes alertness
• Gotu kola: Cognitive-enhancing and neuroprotective properties

Kanna’s Role in Nootropic Stacks

Kanna offers unique benefits that make it valuable in nootropic stacking strategies. Its dual action as a serotonin reuptake inhibitor and PDE4 inhibitor creates distinctive cognitive enhancement effects that complement many other nootropics.

Cognitive Functions Enhanced by Kanna:

• Working memory through cAMP modulation
• Emotional regulation supporting decision-making
• Stress resilience enhancing cognitive performance under pressure
• Social cognition through reduced social anxiety

Kanna in Common Nootropic Stacks:

• Focus and Mood Stack: Combining Kanna (15-25mg) with L-Theanine (200mg) and a low dose of caffeine (50-100mg) creates a balanced effect of improved focus without the anxiety sometimes triggered by stimulants. Kanna’s serotonergic effects complement L-Theanine’s GABAergic calming properties.
• Memory Enhancement Stack: Kanna (20mg) paired with Bacopa Monnieri (300mg) and Lion’s Mane (500-1000mg) creates synergy between Kanna’s immediate cognitive effects and the long-term neurogenesis benefits of the other compounds.
• Anxiety-Free Productivity Stack: Combining Kanna (25mg) with Ashwagandha (300mg) and Rhodiola Rosea (200mg) helps maintain cognitive performance during stressful periods by balancing multiple neurotransmitter systems simultaneously.

Unlike synthetic nootropics such as racetams or modafinil that may cause jitteriness or insomnia, Kanna provides cognitive enhancement without overstimulation. Its natural origin also means it typically has fewer side effects than synthetic alternatives when used appropriately.

The PDE4 inhibition mechanism of Kanna is particularly valuable in nootropic applications, as this pathway is involved in long-term potentiation and memory formation—effects not commonly found in other natural nootropics.

1. Brendler, Thomas, et al. “Sceletium for managing anxiety, depression, and cognitive impairment: a traditional herbal medicine in modern-day regulatory systems.” Current Neuropharmacology 19.9 (2021): 1384.↩
2. Chiu, S., et al. “Investigation of the anxiolytic effects of Sceletium tortuosum in healthy subjects: a randomized controlled trial.” Journal of Clinical Psychopharmacology, vol. 34, no. 2, 2014, pp. 185-191.↩
3. Meltzer, Herbert Y. “Role of serotonin in depression.” Annals of the New York Academy of Sciences (1990).↩
4. Schell, Rebecca. “Sceletium tortuosum and mesembrine: a potential alternative treatment for depression.” (2014).↩
5. Harvey, Alan L., et al. “Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids.” Journal of Ethnopharmacology 137.3 (2011): 1124-1129.↩
6. Lee, Daewoo. “Global and local missions of cAMP signaling in neural plasticity, learning, and memory.” Frontiers in pharmacology 6 (2015): 154210.↩
7. Terburg, David, et al. “Acute effects of Sceletium tortuosum (Zembrin®), a dual 5-HT reuptake inhibitor and PDE4 inhibitor, on the fear response in healthy volunteers: A double-blind placebo-controlled trial.” Neuropsychopharmacology, vol. 38, no. 13, 2013, pp. 2708-2716.↩
8. Smith, Angela M., et al. “Effects of Mindfulness-Based Stress Reduction on Mindfulness, Mental Well-being, and Perceived Stress: A Randomized Controlled Trial in Urban Schoolteachers.” Mindfulness, vol. 11, no. 5, 2020, pp. 1166-1178.↩
9. Gericke, Nigel, and Barbara van der Watt. “Sceletium—a review update.” Journal of Ethnopharmacology, vol. 159, 2015, pp. 83-91.↩
10. Lyndon, Stanley, and Philip R. Corlett. “Hallucinations in posttraumatic stress disorder: Insights from predictive coding.” Journal of Abnormal Psychology 129.6 (2020): 534.↩