Memantine Review: Benefits, Dosage, Side Effects & Where to Buy Memantale

Have you ever experienced forgetting what you need to do as you go to your living room?

Or have you felt so tired after getting complete 8 hours of sleep, and it is still the middle of the morning?

Well, you are not alone. Many people go through the same issues and problems as you. If you have ever felt like this, you should try Memantine.

What is Memantine (Memantale)?

Memantine is an oral N-methyl-D-aspartate glutamate receptor antagonist known to treat neurodegenerative diseases. It has a molecular formula of C12H21N and is an NMDA receptor antagonist used to treat the symptoms of Alzheimer's disease. It is an oral medication for treating patients with Alzheimer's disease.

what is memantine

Memantine's effects are independent of acetylcholine and acetylcholinesterase.

The NMDA receptor antagonists are a type of medication with blocking effects. It blocks the NMDA receptor on neurons which helps regulate how the brain processes information and is responsible for forming new memories.

The NMDA receptor is a type of glutamate receptor. Indeed, it's not the only glutamate receptor in the brain, but it is the most important. It is a primary regulator of synaptic plasticity and helps regulate the brain's memory, mood, and behavior.

You have probably heard of glutamate before. Glutamate is a neurotransmitter that is used to transmit signals between brain cells. It is also responsible for the formation of new memories.

Therefore, if the NMDA receptor is blocked, you will be unable to form new memories.

How Does Memantine Work as a Medication?

Memantine Hydrochloride works by blocking the NMDA receptor on neurons. It is a prescription drug used to treat moderate to severe confusion ( dementia ) related to Alzheimer's disease.

When the NMDA receptor is activated, glutamate can bind to it. This leads to an increase in glutamate release in the brain.

Memantine prevents glutamate from binding to the NMDA receptor and prevents glutamate release. This is how it helps to reduce the amount of glutamate that is released in the brain.

When the glutamate is reduced, the amount of GABA is also reduced. This is because the NMDA receptor helps to regulate the release of GABA.

If the NMDA receptor is blocked, the GABA is not released. When the GABA is not released, the amount of GABA is also reduced.

What are the Benefits of Memantine in Dementia?

According to the National Institute of Health, it is estimated that about 5.5 million Americans are currently living with dementia, specifically Alzheimer's disease. It is expected that the number will grow to more than 14 million by the year 2050.

memantine benefits

Apart from the many Memantine uses, it is the only medication approved by the FDA to treat the symptoms of Alzheimer's disease.

And then, it is only approved for use in the United States.

There are many reasons why Memantine is such a popular medication.

  • Enhances memory. Memantine has been proven to improve memory and cognition in patients with Alzheimer's disease.
  • Uplifts mood. It has been proven to improve mood and reduce the symptoms of agitation.
  • Gives calmness. The drug is also helpful in treating hallucinations and delusions.
  • Improves sleep. Memantine is also helpful in improving the quality of life of patients. It can help them sleep better.
  • For better concentration. It can help patients to focus and concentrate.
  • Prevents seizures. Memantine can also help reduce the risk of seizures and is considered a Prevents seizures.first-line treatment for preventing seizures in patients with Alzheimer's disease.

Many studies show the benefits of Memantine in Alzheimer's disease.

Memantine Use and Indications from FDA-approved Medicine Labels

The approved labels by the FDA have their share of effects and benefits from using the substance.

  • Treatment of moderate to severe Alzheimer's disease.
  • Treatment of moderate to severe dementia associated with Parkinson's disease.
  • Treatment of moderate to severe dementia associated with Huntington's disease.
  • Treatment of moderate to severe dementia associated with HIV infection.
  • Treatment of moderate to severe dementia associated with progressive supranuclear palsy.
  • Treatment of moderate to severe dementia associated with corticobasal degeneration.

Memantine Experiences and Reviews Shared on Reddit

Memantine is a medication used to treat Alzheimer's disease and other forms of dementia.

And here are some of the experiences of taking the product.

According to Ripumanity:

"I've done 3-4 cycles of Memantine 5 mg to 10mg per day for 1-2.5 weeks, and I can say that I've not noticed any bad permanent side effects at all. I would say it helps my ADD by slowing me down slightly."

According to Chairman_Mittens:

"I tried taking Memantine 3 separate times and couldn't handle the profound side effects. I felt drunk all the time, without the euphoria or lack of inhibition. I don't think I experienced any lasting negative effects that didn't go away after a week, but it's hard to say."

According to Anonymous:

"Everyone says it's mania clearly knows nothing about Memantine. Memantine is an incredibly effective mood stabilizer and anti-manic agent. I use it to treat bipolar disorder type 1 and have successfully pulled myself and a couple of friends out of manic/psychotic episodes with it in a matter of days."

Memantine Pharmacological Information

To know more about how Memantine positively affects the brain, read down about its pharmacology.

memantine pharmacology

Glutamate

The dysfunction of glutamate neurotransmission, which can be seen as neuronal excitotoxicity, is hypothesized to be involved in the etiology of Alzheimer's disease. Targeting the glutamatergic system, specifically NMDA receptors, offers a novel strategy for the treatment given the limited efficacy of existing drugs targeting the cholinergic system.

Memantine is a low-affinity NMDA receptor antagonist. On the one hand, Memantine binds to the NMDA receptor with a higher affinity than Mg2+ ions, inhibiting the prolonged influx of Ca2+ ions, particularly from extrasynaptic receptors, and leading to neuronal excitotoxicity.

The low affinity, uncompetitive nature, and rapid off-rate kinetics of Memantine at the level of the NMDA receptor channel allow it to remain activated following a depolarization event in the postsynaptic neuron.

Memantine has been studied in countless research projects investigating the uses of this drug to treat Alzheimer's. The function of this drug is due to its interaction with NMDA receptors, which provide symptom relief. There is no evidence that these effects can also modify other symptoms of disease, though this has been suggested for animal models.

Memantine has been the subject of new interest because it seems to work well in antagonizing the NMDA receptors that seem to be involved with the pathophysiology of mood disorders and possible treatments.

Serotonin

Memantine is a non-competitive antagonist with a potency similar to NMDA receptors. The clinical significance of this activity as an emetic in Alzheimer's treatment is unknown.

Cholinergic

Memantine acts as a non-competitive antagonist of different neuronal nicotinic acetylcholine receptors (nAChRs) at one possible effectiveness level. It isn't easy to ascertain accuracy because it desensitizes the nAChR response quickly.

It can be noted from research that Memantine acts as an antagonist at the Alpha-7 nAChR, which may contribute to the initial worsening of cognitive function during early memantine treatment. Long-term chronic administration of Memantine seems to directly affect the level of Alpha-7 nAChR upregulation, which could explain the cognitive-enhancing effects of long-term regular memantine treatment.

It has been shown that the number of nicotinic receptors in the brain is decreased in Alzheimer's disease, even in the absence of a general decrease in its number of neurons, and nicotinic receptor antagonists are seen as interesting targets for anti-Alzheimer drugs.

Dopamine

Memantine acts as an agonist at the dopamine D2 receptor, with equal or slightly higher affinity than the NMDA receptors.

Sigmaergic

Memantine acts as an agonist at the σ1 receptor with a low affinity (Ki 2.6 μM). The consequences of this activity are unclear (as the role of sigma receptors, in general, is not yet that well understood).

Memantine, though it does not appear to have any sigma suppressor or agonist effect because of low affinity for the elderly population, excessive doses do activate this receptor.

Where to Buy Memantine?

Memantine is a prescription drug and, therefore, not available over the counter in the United States. If you want to buy from your local pharmacy, you have to get a prescription from a licensed medical provider.

Otherwise, you can order from the website of Cosmic Nootropic. This website offers nootropics and does not simply research substances. You can also check their social media pages for more information about their products.

Memantine Oral Dose

Memantine is a safe nootropic. However, just like any other substance, excessive intake is dangerous to one's body health. That is why it is essential to stick to the recommended dosage.

As an illustration, here are the Memantine dosage guidelines for adults:

  • Mild to Moderate Alzheimer's disease: Memantine 5mg to 20 mg/day.
  • Moderate to Severe Alzheimer's disease: Memantine HCL 10 mg to 40 mg/day.
  • Moderate to Severe Dementia associated with Parkinson's disease: 10 to 20 mg/day.
  • Moderate to Severe Dementia associated with Huntington's disease: Memantine HCL 10mg to 20 mg/day.
  • Moderate to Severe Dementia associated with HIV infection: Memantine hydrochloride 10 mg to 20 mg/day.
  • Moderate to Severe Dementia associated with Progressive Supranuclear Palsy: 10 to 20 mg/day.
  • Moderate to Severe Dementia associated with Corticobasal Degeneration: 10 to 20 mg/day.

If you use Memantine 10mg for an extended period, you can also increase the dosage. However, it would help if you did so gradually. This will help to avoid the side effects.

Renal impairment or hepatic impairment does not affect the dose of Memantine.

Memantine can be taken with or without food, and do not mix Memantina with any other liquid.

Although many similar substances can be taken through a syringe, Memantine does not have available injectables.

Consume the entire capsule contents, do not divide the dose, and swallow the capsule whole or open and sprinkle on a spoonful of applesauce; do not chew or crush.

If missed for several days, dosing may need to be resumed at lower doses and re-titrated as described above.

If you have any other questions, you can always contact the customer support team of Cosmic Nootropic.

Patients should inform their doctor or dentist of any history of medical conditions, including those affecting the brain, that could make them more susceptible to these effects. They should first get clearance from their doctor to help them monitor the supplement's reaction to their bodies.

As advised, you should also avoid drinking alcohol while taking the drug because it can increase the risk for dizziness and drowsiness.

Neither it should be taken if you are pregnant or breastfeeding due to the potential for congenital disabilities in your baby if taken during pregnancy or breastfeeding.

Patients should also avoid taking Memantine if they are allergic to it, have a history of seizures, or are taking other medications or competition supplements that could interact with it.

Patients should seek medical attention if they experience any adverse effects while taking Memantine. Knowing more about the supplement's health information would help avoid any negative re action.

How to Take Memantine for Better Brain Condition?

Memantine comes in two forms: tablets and oral solutions. There are recommended dosages for each form.

The recommended dosage of Memantine is 10 to 20 mg/day. It would be best if you took the entire dose.

memantine dosage

If you are taking the drug with food, you can take it at any time. However, if you take the medication on an empty stomach, you should take it before breakfast.

Memantine comes with serious risks if you don't take it as prescribed or miss doses.

If you stop taking the drug or don't take it at all, your dementia symptoms may not be relieved, and they may get worse.

If you miss doses or don't take the drug on schedule, your medication may not work well or stop working altogether.

Taking too much Memantine can lead to side effects such as agitation, confusion, hallucinations, slowed heart rate, increased blood pressure, dizziness, unsteadiness, fainting, and fatigue.

Memantine comes with serious risks if you don't take it as prescribed or miss doses.

If you stop taking the drug or don't take it at all, your dementia symptoms may not be relieved, and they may get worse.

If you miss doses or don't take the drug on schedule, your medication may not work well or stop working altogether.

Taking too much Memantine can lead to side effects such as agitation, confusion, hallucinations, slowed heart rate, increased blood pressure, dizziness, unsteadiness, fainting, and fatigue.

Memantine Medications Side Effects and Safety

Memantine warnings include dizziness, confusion, headache, constipation, cough, high blood pressure (hypertension), backache, pain, sleepiness, fainting, vomiting, shortness of breath, fatigue, acute kidney failure, blockage in the brain (cerebral infarction), stroke (cerebrovascular accident), deep venous thrombosis, hepatitis, liver failure, and intracranial hemorrhage.

Memantine may also cause blood and lymphatic system disorders like the ones on this list:

  • reduced white blood cells ( leukopenia )
  • deficiency of red blood cells
  • white blood cells and platelet
  • low platelets
  • blood clots (thrombotic thrombocytopenic purpura [ TTP ])
  • seizure (including grand mal)

While it may actually work fine at the start, some users reported these postmarketing side effects:

  • blood and lymphatic system disorders
  • cardiac disorders
  • gastrointestinal disorders
  • hepatobiliary disorders
  • psychiatric disorders
  • renal and urinary disorders

Memantine may be associated with side effects that can be serious if not taken properly, including death.

It is important to tell your doctor about your medications, including vitamins and supplements.

Frequently Asked Questions (FAQ)

Anything bothering you? Let's answer them here.

What is the difference between Memantine and other nootropics?

Compared to other nootropics, Memantine is one of the safest and most effective nootropics. It is used to treat Alzheimer's disease and other neurodegenerative disorders. It is also used to treat moderate to severe dementia associated with Parkinson's disease, Huntington's disease, HIV infection, progressive supranuclear palsy, and corticobasal degeneration.

Is Memantine addictive?

Memantine HCL is not addictive. But just like any other substance, anything in excess will do you no good. However, if you take the drug for an extended period, you can experience addiction.

Some users experienced increasing the dose to have its effects felt longer. But in the end, they felt euphoria and do not seem to go back to lower doses anymore.

Does Memantine cause any withdrawal symptoms?

Withdrawal symptoms are not common. However, if you are withdrawing from the drug, you can experience headaches, nausea, and fatigue.

Does Memantine cause any overdose?

Overdose of Memantine is rare. However, if you experience an overdose, you should contact your doctor immediately.

Is Memantine a Prescription Drug?

Memantine is a prescription drug used to treat moderate to severe confusion (dementia) related to Alzheimer's disease.

Memantine oral tablet comes in three forms: immediate-release tablet, oral solution, and extended-release capsule.

Generic drugs usually cost less than the brand-name version of Memantine but may not be available in every strength or form as the brand-name drug.

Memantale is a brand name for memantine oral tablets that you can buy from Cosmic Nootropic. 

Memantine Drug Information Review: Conclusion

Memantine is an anti-Alzheimer's drug that has been shown to improve memory and cognitive function in mouse models of Alzheimer's disease.

Memantine was more effective than placebo in improving memory and cognitive function, with a more significant effect seen in those with lower levels of amyloid-beta plaques.

Memantine may also have anti-inflammatory properties that could help protect the brain against the damage caused by Alzheimer's disease.

Memantine should not be used as a substitute for regular medical care and should only be prescribed to patients who have failed to respond to other forms of treatment for Alzheimer's disease.

With further research and continuing education activity Memantine long-term effects on human memory and cognitive function will be established.

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