NACET Review: Benefits, Dosage, Side Effects & Where to Buy

Updated on January 14, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

NACET is a dietary supplement that has been proven to help increase energy levels, improve the immune system and fight off infections.

This article provides you with information about NACET and its benefits.

What is NACET?

NACET is an excellent product for those who want to improve their energy levels and performance.

nacet information

N-Acetylcysteine ethyl ester (NACET) is a new lipophilic cell-permeable cysteine derivative with a unique pharmacokinetic profile and unique antioxidant properties. It penetrates the cells quickly and is trapped there, converted into NAC and cysteine. In comparison to NAC, NACET increased the glutathione content of most tissues studied, including the brain, and protected rats from paracetamol intoxication after oral therapy.

NACET is also unique in that it accumulates in human erythrocytes, where it acts as a powerful antioxidant against oxidative damage caused by hydroperoxide. Because of its ability to enter cells and create NAC and cysteine, our research reveals that NACET enhances circulating hydrogen sulfide (H(2)S), making it a good candidate for oral usage as an H(2)S producer with evident advantages over NAC.

As a mucolytic agent, a paracetamol antidote, and a GSH-related antioxidant, NACET has the potential to replace NAC.

How Does NACET Supplement Work?

NAC's lipophilicity and pharmacokinetics are improved by esterifying the carboxyl group to form N-acetylcysteine ethyl ester. NACET has substantially better bioavailability than NAC (about 60%). It enters cells quickly, becomes stuck, and converts into NAC and cysteine.

Because it may pass the blood-brain barrier and provide a variety of beneficial antioxidant actions, NACET is present in the cells of various tissues, including the brain. It can be taken orally and aids in glutathione production, positively affecting the skin and face.

The supplement can build in human erythrocytes and may act as a powerful antioxidant against oxidative damage caused by hydroperoxide. NACA is a chemical that improves bioscaffolds and biomaterials' endurance and resident time by having a higher bioavailability than NAC. On NAC, over 800 reviews have been published.

Benefits of NACET (N-Acetyl L-Cysteine Ethyl-Ester)

NACET is known to be beneficial to the brain and the immune system.

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  • N-Acetyl-L-cysteine ethyl ester powder 59587-09-6 is a natural or manufactured drug that can increase mental performance by enhancing brain function. They're commonly referred to as nootropics or smart medicines, and they've grown in popularity in today's hyper-competitive world. They're most widely used to improve memory, focus, creativity, intelligence, and motivation (3).
  • One feature of NACET is that it raises circulating hydrogen sulfide (H(2)S), making it a suitable candidate for use as an H(2)S producer in the oral cavity, with clear advantages over NAC (4).
  • NACET (but not NAC) increased the GSH content of most tissues in the rat (including the brain) after oral therapy and protected them from paracetamol intoxication (5).
nacet brain benefit

Immune Health

  • A vast amount of primary research shows that dietary supplementation with the powerful antioxidant N-acetylcysteine (NAC) can lower the severity of related disorders by inhibiting RNA virus replication (1).
  • This modification of NAC provides unrivaled oxidative damage protection for your blood cells, allowing your immune system to effectively defend your body against COVID-19's ravages (This is not medical advice). Because NAC is quickly digested in your liver before reaching your tissues, it has a low oral bioavailability. This is especially true of the lung epithelium, which is most vulnerable to COVID-19-induced oxidative damage (2).

NACET is not intended to cure or treat specific diseases. It has been a subject of study and trials, and the results merely show its abilities in the brain.

NACET Experiences and Reviews Shared on Reddit

NACET seems to be a very promising nootropic. To back or refute this notion, we have to read the experiences shared by some of its users.

According to Bassomatic42:

"This is probably one of the most powerful compounds I've had the opportunity to try in the last few months minus drugs such as RAD140 (testolone) and Fasoracetam. For me, it has had a rapid antidepressant effect. It has improved many chronic problems that I've been having, such as insomnia, anxiety, depression, and low self-confidence. I sourced this from a relatively well-established RC/Noot vendor who supplied me with a couple of grams to run with."

According to Humancyclone7:

"Can highly recommend NACET. The effects are stronger, last longer, and are subjectively different from NAC. It doesn't have the latter's side effects, e.g., NACET allows me to fall (and stay) asleep instantly, and I don't experience headaches or nausea at high doses. Currently, the best nootropic I have for stopping OCD and rumination (next to phenibut and kratom, but those can't be used daily)."

According to Kindly-Implement1573:

"It was good for mood, helped me with anxiety, and just felt more at ease, but one of the side effects of NAC is itchiness and difficulty breathing. You can search this up. I'll tell you about it, and the second week in, I started having these side effects. The breathing part was mild, but the itchiness was getting worse, so I had to stop taking it."

Where to Buy NACET Powder and Tablets?

Buying nootropics and other supplements have become easy with several online vendors. Nootropics feature a brain stimulant capability making them marketable to students and older people. As for NACET, you can check the website of Liftmode for the price and shipment fee in your area. It is known to be a credible supplier of nootropics.

Although many vendors claim to sell only legit products, it is still worth the time to further check on such claims. Ensure that they have the necessary certification to sell supplements and substances for personal or research use.

N Acetyl Cysteine Ethyl Powder and Tablet Dosage

NACET is safe at a dose of up to 400mg in adults.

nacet dosage

If you are under treatment for a particular condition, you should consult a doctor on how much NACET to take. 

The recommended daily dosage of NACET is 200mg, taken twice a day. If you take NACET for more than two weeks, you may be able to increase the amount you take.

How to Take NACET?

In taking NACET, make sure you have the proper dosage for administration. It's essential to know your exact dosage because it can be harmful if you take too much.

Know your health history. The supplement is not intended for people with kidney problems or liver disease. If you have these conditions, consult your doctor before taking NACET, as some of its chemical concentrations may contradict your current medicines.

Take your tablet as directed. You must take the NACET tablet every day. Don't skip doses. It can be taken before or after a meal. If taking it before a meal, take it 30 minutes before eating. It is advisable to take it at the same time every day. Swallow it whole with a glass of water.

NACET Side Effects and Safety

NACET is a natural supplement that is used to prevent colds and flu. There are a few side effects to take note of. For starters, there is a chance that you may experience an upset stomach. This is because NACET contains a natural ingredient called ginger which can cause nausea and stomach upset.

nacet side effect

Another side effect is that NACET can cause you to feel dizzy or light-headed. This is because NACET contains caffeine and ephedra, which are stimulants. However, these side effects are rare.

NACET has been proven to be safe for most people, but it's always best to talk to your doctor if you are concerned about any side effects.

Frequently Asked Questions (FAQ)

Your questions answered.

What Does it Do?

NACET has been shown to help increase energy levels, improve the immune system and fight off infections.

Who Should Use NACET?

Anyone looking for ways to improve their health, increase energy levels and improve their immune system can benefit from NACET. It's especially beneficial for those looking for ways to boost their energy levels.

Final Thoughts About Taking NACET

In conclusion, I'd like to share some final thoughts about taking NACET. First, I want to say that I am not an expert on NACET. I'm just someone who wants to help other people live longer, healthier lives.

I've used NACET for more than a year, and it has helped me feel better, live longer, and look younger. I've also read a lot about NACET, and I know how it works and the risks. I'm sharing all of this information with you because I was hoping you could make an informed decision about whether or not you wish to try NACET.