NACET: Review of Nootropic Benefits, Dosage, & Side Effects

Updated on May 10, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

In this NACET review, we'll look at this popular nootropic in-depth. We'll also go over how NACET works in the brain and provide information about the benefits, side effects, and where to buy it online.

Are you looking for a powerful nootropic to enhance your cognitive function? Look no further than N-Acetylcysteine ethyl ester (NACET).

This novel lipophilic cell-permeable cysteine derivative has remarkable antioxidant properties and an unusual pharmacokinetic feature.

With enhanced cell permeability, NACET is a potent precursor to glutathione and can improve brain function, memory, and focus.

Today, we will explore the benefits of NACET as a nootropic and how it can help you achieve optimal cognitive performance.

NACET Review Summary

NACET, known as N-Acetylcysteine ethyl ester, is a powerful nootropic with remarkable antioxidant properties. It increases the intracellular concentration of GSH (Glutathione) and can help to improve cognitive function, immune function, memory, and focus.

If you're looking for a powerful nootropic that has better bioavailability than other similar nootropics like NAC (N-Acetyl Cysteine), then NACET is the perfect choice for you.

Pros

  • Increases concentration of GSH in cells
  • Improves cognitive function and memory retention
  • Enhances focus and concentration
  • Can improve brain health over time

Cons

  • Limited research is done on NACET in humans

What Is NACET?

NACET, or N-Acetylcysteine ethyl ester, is an innovative cysteine derivative with pharmacological properties that surpass those of its predecessor, N-acetyl-l-cysteine (NAC).

nacet information

Although both compounds are derived from the amino acid cysteine, NACET has several enhanced characteristics due to its higher lipophilicity. The carboxylic group of NAC is almost entirely negatively charged at physiological pH values, thus requiring active transmembrane transport for cellular uptake.

This limitation can be circumvented through the esterification of the carboxyl group, which increases lipophilicity and, consequently, bioavailability.

NACET displays not only mucolytic efficacy but also antioxidant activity as well as GSH replenishment, and paracetamol antidote functions. It is clear that NACET has many advantages over its parent compound and could replace it in numerous contexts.(1)

It penetrates the cells quickly and is trapped there, converted into NAC and cysteine. NACET is also unique in that it accumulates in human erythrocytes, acting as a powerful antioxidant against oxidative damage caused by hydroperoxide.(2)

Because of its ability to enter cells and create NAC and cysteine, our research reveals that NACET enhances circulating hydrogen sulfide (H(2)S), making it a good candidate for oral usage as an H(2)S producer with evident advantages over NAC.

NACET has taken the biohacking community by storm, as it is widely used to boost cognitive capabilities and energy levels. It also works wonders in enhancing memory retention, energy levels, and focus while reducing oxidative damage.

NACET is also known by several other names, including:

  • 59587-09-6
  • (R)-ethyl 2-acetamido-3-mercaptopropanoate
  • N-acetyl-, ethyl ester
  • N-ACETYL-L-CYSTEINE ETHYL ESTER
  • ethyl (2R)-2-acetamido-3-sulfanylpropanoate

How Does NACET Work In The Brain?

NACET increases glutathione levels (γ-glutamylcysteinylglycine, GSH), a powerful antioxidant, in the brain. GSH is essential in protecting the brain from oxidative stress and inflammation associated with various neurological disorders such as Alzheimer's disease, Parkinson's disease, and depression.

This helps to reduce inflammation and oxidative stress in the brain, leading to improved cognitive functioning and reduced risk of age-related cognitive decline.

NACET also protects against paracetamol intoxication, as well as aiding erythrocytes in protecting against hydroperoxide-induced damage.

Consequently, NACET has been demonstrated to be a powerful and effective antioxidant for preserving brain health and reducing age-related cellular dysfunctions.(3)

What Is NACET Used For?

NACET is a powerful antioxidant studied and used for its effects on the body, including its ability to improve intracellular glutathione levels.

nacet benefits

These higher glutathione levels have been linked to an enhanced capacity of the body to combat oxidative stress (OS) from free radicals. This can lead to decreased cellular damage and improved overall health.

NACET has higher bioavailability than unmodified NAC and is known to reduce inflammation, protect against paracetamol intoxication, increase circulation of H2S in the brain, and protect erythrocytes from hydroperoxide-induced damage.

This, in turn, leads to improved cognitive functioning, memory, and focus. Although the clinical data is limited, NACET has shown promising effects in animal models as a free radical scavenger and neuroprotector.

Off-label, people use NACET to improve cognitive performance, enhance mood, boost energy and motivation, and decrease fatigue. That said, more research is needed to understand the effects of NACET on humans fully.

What Are The Benefits Of NACET For Cognition?

The benefits of NACET for cognition are wide-reaching. Increased glutathione levels in the brain lead to improved cognitive functioning, memory retention, and focus while reducing oxidative damage and inflammation associated with various neurological disorders.

In addition, it has been shown to protect against paracetamol intoxication, increase the circulation of hydrogen sulfide (H2S) in the brain, and protect erythrocytes from hydroperoxide-induced damage.

N-acetyl-L-cysteine ethyl ester (NACET) also protects retinal pigment epithelium (RPE) cells from oxidative stress-induced toxicity, which could protect against age-related macular degeneration.

Overview of the benefits of NACET for cognition include:

  • Increased glutathione levels in the brain.
  • Reduction of oxidative stress and inflammation.
  • Protection against paracetamol intoxication.
  • Increase circulation of hydrogen sulfide (H2S) in the brain.
  • Protecting erythrocytes from hydroperoxide-induced damage.
  • Improved cognitive performance and mood overall.

Where To Buy NACET Online?

NACET is available for purchase online from liftmode, one of the leading vendors of nootropic supplements and cognitive enhancers. This vendor offers NACET in 5 g, 10 g, and 20 g powder forms.

Here's a quick price breakdown of NACET:

  • 5 g: $22.68 (USD)
  • 10 g: $39.68 (USD)
  • 20 g: $76.68 (USD)

Liftmode is based in the USA and ships worldwide. Their website is easy to navigate, offering detailed information about NACET and other cognitive-enhancing supplements.

For more information about buying NACET online, visit their website here.

Although many vendors claim to sell only legit products, it is still worth the time to further check on such claims. Ensure that they have the necessary certification to sell supplements and substances for personal or research use.

What Do People Say About NACET On Reddit?

NACET seems to be a very promising nootropic. To back or refute this notion, we have to read the experiences shared by some of its users on Reddit.

According to Bassomatic42:

"This is probably one of the most powerful compounds I've had the opportunity to try in the last few months minus drugs such as RAD140 (testolone) and Fasoracetam. For me, it has had a rapid antidepressant effect. It has improved many chronic problems that I've been having, such as insomnia, anxiety, depression, and low self-confidence. I sourced this from a relatively well-established RC/Noot vendor who supplied me with a couple of grams to run with."

According to Humancyclone7:

"Can highly recommend NACET. The effects are stronger, last longer, and are subjectively different from NAC. It doesn't have the latter's side effects, e.g., NACET allows me to fall (and stay) asleep instantly, and I don't experience headaches or nausea at high doses. Currently, the best nootropic I have for stopping OCD and rumination (next to phenibut and kratom, but those can't be used daily)."

According to Kindly-Implement1573:

"It was good for mood, helped me with anxiety, and just felt more at ease, but one of the side effects of NAC is itchiness and difficulty breathing. You can search this up. I'll tell you about it, and the second week in, I started having these side effects. The breathing part was mild, but the itchiness was getting worse, so I had to stop taking it."

How Do You Take NACET For Cognitive Enhancement?

N-Acetylcysteine ethyl ester (NACET) has gained popularity for its potential cognitive enhancement benefits. If you're interested in taking NACET for this purpose, here are some things to keep in mind:

  • Timing: No specific time of day is recommended for taking NACET. Some prefer to take it in the morning, while others take it at night. It's important to be consistent with the timing once you find what works best for you.
  • Frequency: NACET can be taken daily or intermittently, depending on your goals and needs.
  • Cycling: Cycling NACET may not be necessary as no evidence suggests it causes tolerance or dependence. However, if you decide to cycle it, a common cycling protocol is 5 days on and 2 days off.

Taking NACET with food is generally recommended as it can cause stomach upset when taken on an empty stomach.

Also, consult with your healthcare provider before starting any new supplement regimen.

The recommended daily dosage of NACET is 50-100 mg, taken twice daily. It's important to note that if you take NACET for more than two weeks, you may be able to increase the dosage.

However, you should always start with the smallest effective dose and increase gradually. It's important to note that there is no one-size-fits-all dosage for NACET, as it may vary depending on your needs and goals.

What Are The Side Effects Of NACET?

NACET is generally safe when taken as recommended. However, it may cause mild side effects, such as stomach upset, nausea, headache, and drowsiness. These side effects are typically mild and should subside after a few days of use.

nacet side effect

If you're new to NACET, we recommend starting with a lower dose and slowly increasing it over time to see how your body responds. If you experience any side effects, stop taking the supplement and consult your healthcare provider immediately.

In rare cases, NACET can cause side effects such as allergic reactions. These are typically rare and occur when the supplement is taken in large doses.

What Nootropics Are Similar To NACET?

If you're looking for an alternative to NACET, some potential nootropics, here are 3 that provide similar benefits:

  • N-Acetyl-Cysteine (NAC), a precursor to glutathione, is an important antioxidant in the body. Like NACET, NAC has been shown to have neuroprotective effects and may also help with mood disorders. NAC has poor bioavailability, meaning it is not easily absorbed in the body.
  • Alpha-Lipoic Acid (ALA) is both a water- and fat-soluble antioxidant. ALA has been shown to improve cognitive function and benefit those with diabetes or neuropathy.
  • Acetyl-L-Carnitine (ALCAR) is another nootropic that offers similar benefits as NACET. ALCAR has been shown to improve cognitive function and may also have neuroprotective effects.

While these nootropics are not identical to NACET, they share similar properties and can be used as alternatives depending on individual needs and preferences.

What Brain Supplements Can NACET Be Stacked With?

If you're looking for a brain supplement that can enhance the effects of NACET, NooCube might be your best bet. NooCube is a nootropic blend that contains several nootropic ingredients known to boost cognitive function, including choline.

Choline is an essential nutrient that plays a crucial role in brain health. It's a precursor to acetylcholine (ACh), a neurotransmitter involved in learning, memory, and attention. Increasing choline levels in the brain, Noocube can enhance the effects of other compounds like racetams, which rely on acetylcholine.

In addition to choline, Noocube contains other ingredients that can complement the effects of NACET. For example, it includes Huperzine A, which inhibits the breakdown of acetylcholine and thus prolongs its effects. It also contains Bacopa Monnieri, which has been shown to improve memory and reduce anxiety.(4)

Overall, if you're looking for a brain supplement to stack with NACET, Noocube is definitely worth considering. Its combination of choline and other cognitive-enhancing ingredients synergistically helps you maximize your NACET stack.

Frequently Asked Questions (FAQ)

Let's look at some of the most commonly asked questions about NACET.

How Long Does It Take For NACET To Work?

The time it takes for NACET to work can vary from person to person. Some people may notice a difference within a few days, while others may take several weeks to see results. It is important to note that NACET is not a quick fix and should be taken consistently over time for the best results.

How Does NACET Make You Feel?

NACET makes you feel alert and focused. It can also help to improve mood, reduce stress, and promote mental clarity. Thus, NACET will make you feel more energized and better able to focus on tasks.

What's The Half-Life Of NACET?

The half-life of NACET is approximately 5-6 hours. This means that it takes around 5-6 hours for half of the dose of NACET to be eliminated from the body.

Is It Safe To Use NACET?

NACET is generally considered safe when taken at recommended dosages (50-200 mg daily). However, as with any supplement, it is important to consult a healthcare professional before taking NACET.

Conclusion

So what do we know about NACET?

NACET is a nootropic compound that can improve cognitive function and reduce stress. It has antioxidant properties and can be stacked with other nootropics like NooCube. NACET has a half-life of 5-6 hours and is safe when taken at recommended dosages.

NACET has better bioavailability than NAC and can benefit those looking to improve their cognitive performance.

Overall, NACET is a powerful nootropic that has the potential to improve overall mental health and well-being.

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