Actovegin Review: Benefits, Dosage & Side Effects

Updated on January 12, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Aging is a constant thing in the world. And as we add up to our years, our bodies feel weaker, and our memories become poorer. Exercise is no longer that intense since it becomes harder to recover.

Suppose there could only be one supplement to work on these. Maybe Actovigen can do the wonders?

Why? Well, let us dive into this review.

Study Design: What is Actovegin?

Actovegin has demonstrated a good safety profile for the past 60 years in treating muscle injuries, diabetic neuropathy, and neurovascular conditions, consistently shown through large-scale clinical trials.

actovegin information

Actovegin, produced by an Austrian pharmaceutical company, has legitimate medical uses.

A drug from calf blood

It is a deproteinized extract of calf blood from calves younger than 8 months old. The compound has been studied as far back as the 1970s to treat peripheral artery disease and strokes.

Tests on brain ischemia model

A review of the published clinical studies of the drug showed test results on the treatment of cognitive disturbances of a group after stroke and even ulcers. In other studies, it has been shown to promote insulin-like activity like the stimulation of glucose transport in the body and glucose oxidation.

The said international, double-blind Actovegin study is vital to athletes trying to find ways to get more oxygen to working muscles. Its therapeutic use is mainly to improve oxygen uptake by tissues and improve glucose transport over a plasma membrane within the body.

This can result in aerobic oxidation, which gives a cell more energy and potentially enhances its function. Superoxide dismutase enzymes and magnesium are abundant in Actovegin.

How Does Actovegin Work?

Actovegin is a "highly pure hemodialysate recovered from vealer blood by ultrafiltration," according to Gulevsky et al.

It has been proven to promote glucose transport across a plasma membrane and oxygen uptake by tissues. This can lead to aerobic oxidation, which gives a cell more energy and perhaps improves its function.

The supplement has several active components that have yet to be identified. Possible explanations include the activity of inositol phosphate oligosaccharides (IPOs) and insulin-like effects after hypoxic injury, with a new review beginning to shed light on the anti-inflammatory role.

Actovegin has several active ingredients that are still unknown. According to a recent analysis, two possible mechanisms are the anti-inflammatory role of inositol phosphate oligosaccharides (IPOs) and insulin-like effects after hypoxia injury.

Actovegin prevents the generation of reactive oxygen species (ROS) by blood phagocytes in heart failure patients. It has also been demonstrated to protect human SK-N-SH neuroblastoma cells against hydrogen peroxide-induced necrosis compared with patients on placebo.

The preventive effects of Actovegin injectable therapy in muscle tears may be extrapolated from this decrease of ROS produced during an inflammatory process.

Benefits of Actovegin

Actovegin has been found in experiments to have insulin-like properties, such as increasing glucose transit in the body and glucose oxidation.

actovegin benefits

It is used to treat, control, prevent, and improve the symptoms of the following diseases, ailments, and illnesses:

  • Wound-healing impairment
  • Enhance performance
  • Stroke
  • Burns
  • Nutrition disturbances
  • Brain ischemia
  • Stroke
  • Diabetes
  • Skin grafting

According to Wadler, this might be good news for athletes. "Athletes are constantly looking for new strategies to supply more oxygen to their working muscles."

Actovegin Drug Experiences & Reviews Shared on Reddit

After several years of research studies and trials, these are what users have to say about Actovegin and its contents.

According to danarm:

"I have tried Actovegin pills. It certainly has a nootropic effect. About half an hour after taking two pills, drowsiness and tiredness disappear. I feel my mind is fresher and younger. Vision is improved, too. It's like the visual field is wider and brighter."

According to milliseconds:

"Actovegin relieves fatigue and presses your "refresh" button. Feeling refreshed and with more oxygen reaching tissues in your body, it may improve mental performance as well, don't you reckon?"

According to 00derper:

"I've tried it, just because I had it laying around too. It's something pretty good if you want to recover faster. It raises the oxygenation of tissues and lets the muscle heal faster. One injection and the doms of the day before would disappear. Powerlifters use it mostly in the gym world to keep up with their fixed training routine. Cons: Bad pip while injecting, but it lasts only 30 seconds."

Where to Find Actovegin for Sale?

Actovegin is available in injectables. Although there are restrictions in some countries, you can still buy this supplement through trusted vendors online.

It is often hard to find vendors selling natural supplements from the countries they are made from. Cosmic Nootropic is one website you can rely on when buying supplements like Actovegin.

Actovegin Dosage Based on Study

If you want to experience the benefits of Actovegin, you have to take the recommended dosage. This is available as an injectable in 40 mg/ml. Usually, a box contains 5 ampoules of 10 ml each.

You can inject 5 ml if you have mild metabolic disturbances. A 10 ml intravenous or intramuscular administration is recommended for severe metabolic disturbances. Do this 3-4 times a week. 

If you prefer the tablet, it is advisable to chew it instead of swallowing it. Take 1-2 tablets three times a day before meals and water. The treatment is for 4-6 weeks.

The supplement is not for those under 18 years of age.

How to Take Actovegin Drugs?

Actovegin has the tablet and the injectable forms. If you find it difficult to swallow the pill, you can opt for the intramuscular/intravenous administration of the supplement.

When taking the tablet, it is recommended to take it before meals. Chew it instead of swallowing, then drink a glass of water. The treatment for 4 to 6 weeks should give you the desired result.

On the one hand, the injectable should be administered 3 to 4 times a week, taking 5 or 10 ml depending on your need. For milf metabolic disturbances, take 5 ml and for severe metabolic disturbances, take 10 ml.

Actovegin Side Effects & Safety Test

The following is a list of potential adverse effects from any Actovegin components. This is not an exhaustive list.

actovegin side effects

These adverse effects can happen, but they don't always happen. Some of the adverse effects may be uncommon, yet they are dangerous. Contact your doctor if you have any of the following adverse effects, especially if they do not disappear.

  • headache
  • nausea
  • visual impairment
  • drowsiness

Do not use Actovegin if you have hypersensitivity to the components of the product and if you have an anaphylactic shock.

Frequently Asked Questions (FAQ)

Your questions answered.

Can Actovegin be used as a performance enhancer?

Yes, most users report that Actovegin can improve their performance. Some also report its efficacy if you have circulation and nutrition disturbances. However, do not use this without consulting your doctor first.

How long do I need to use Actovegin before seeing improvement in my conditions?

Most reports say that you should see results after two weeks of taking the supplement. Others report of 1 month before seeing improvement in their conditions. Our bodies react to medicines and supplements differently, so it depends on your body's reaction.

Does Actovegin injection have habit-forming functions?

Most medicines don't come with a potential for addiction or abuse. Usually, the government categorizes medications that can be addictive as controlled substances. So far, no users or reviews report that the product is habit-forming.

They equally share about the product because it aids in the considerable acceleration of muscle fiber synthesis in damaged muscle aiding muscle recovery. This is why athletes may find this helpful in the sporting world.

Does the International Olympic Committee approve Actovegin?

The IOC medical commission and the discipline committee said Actovegin, containing extracts of calf's blood, was banned as blood doping. It resurfaced, and studies were further conducted after the olympian from Russia was caught with the drug.

Actovegin Review: Conclusion

Actovegin is an effective product that can help your body recover from injuries. It enables the body to recover faster and recover better. It is available in injectable and tablet forms. It is also available in different strengths. Athletes prefer the injectable because it is easy to administer. It is also more effective than the tablet.

If you are looking for a supplement that can improve your recovery, then Actovegin is a good choice. It has helped a number of people who are looking to enhance their recovery.