Cerebrolysin: Nootropic Benefits, Uses, Dosage & Side Effects

Cerebrolysin, a peptide-based drug, has been explored as a potential therapeutic agent in the treatment of stroke, including acute ischemic stroke. However, recent preclinical studies, including the Cochrane Review, indicate that it probably does not reduce the risk of dying in acute ischemic stroke and may increase the number of people with serious, non-fatal unwanted effects.

Cerebrolynsin is known for its ability to potentially improve cognitive functions and repair damaged brain cells and neurons.

As an active neuroprotective and neurotrophic agent, Cerebrolysin has been studied for potential benefits in enhancing the recovery process in patients with stroke, but high-quality studies to conclusively prove its efficacy are still needed.

This article will delve into all the multifaceted aspects of Cerebrolysin, exploring its efficacy in treating brain injuries, neuroprotective properties, and the potential it has to support improved cognition. We will also discuss benefits, uses, side effects, safety, and optimal dosage information.

What is Cerebrolysin?

Cerebrolysin is a peptide-based nootropic drug derived from porcine brain proteins that contains neurotrophic factors which cross the blood-brain barrier to enhance cognitive performance and neuronal health. Cerebrolysin works as a nootropic by delivering a mixture of low molecular weight peptides and amino acids that stimulate neural growth, improve synaptic plasticity, and repair brain cells damaged by neurological conditions such as TBI (Traumatic Brain Injury).

This neuroprotective and neurotrophic agent is derived from porcine brain proteins and contains a mixture of low molecular weight peptides and amino acids that stimulate neural growth and repair.

In some clinical trials, Cerebrolysin has been examined for its efficacy in improving symptoms and outcomes in patients with stroke. However, recent reviews, including the Cochrane Review, indicate that its benefits in this context are likely limited and it may increase the risk of serious non-fatal adverse events..⁽¹⁾

Cerebrolysin works by enhancing the brain’s repair mechanisms and protecting brain cells from further injury. The drug is administered via injection, and its dosage commonly varies depending on the severity and type of brain injury or disease being treated.

The neuroprotective effects of Cerebrolysin extend beyond potential stroke treatment therapy. Preliminary studies have suggested potential improvements in neurocognitive functions with Cerebrolysin in conditions like dementia and Alzheimer’s disease, though further rigorous research is necessary to establish these effects.⁽²⁾

Cerebrolysin treatment has multimodal action, combining the neuroprotective, neurotrophic support, and cognitive enhancement properties. This makes Cerebrolysin a unique therapeutic agent compared with other nootropics in neurology.

While it can cross the blood-brain barrier, the overall safety profile of Cerebrolysin in clinical studies, particularly concerning non-fatal serious adverse events, warrants careful consideration when evaluating its potential for treating neurodegenerative diseases and brain injuries.

Pros:

• Potential beneficial therapeutic effects on patients with neurological disorders and TBI
• Improves cognitive performance, enhances mood, and improves focus
• Cerebrolysin can potentially reduce the level of dependence in stroke patients
• Helps in cell death (apoptosis) inhibition in neurological disorders, thereby preserving the functionality of the nervous system

Cons:

• The exact mechanism of action of Cerebrolysin is unclear
• Cerebrolysin is typically administered via injection

Cerebrolysin as a Nootropic: Comparative Analysis

Cerebrolysin stands out in the nootropic landscape due to its unique composition and mechanism of action. Unlike many other nootropics that target specific neurotransmitter systems, Cerebrolysin offers a comprehensive approach to cognitive enhancement through its mixture of neuropeptides and amino acids, which provides more profound effects on memory formation and recall compared to oral nootropics such as racetams or natural supplements.

Cerebrolysin vs. Other Popular Nootropics

Cerebrolysin differs from most nootropics in several key ways:

• Delivery Method: While most nootropics are available in oral form, Cerebrolysin requires injection, making it less convenient but potentially more bioavailable.
• Comprehensive Action: Rather than targeting a single neurotransmitter or pathway, Cerebrolysin provides a complex mixture of neurotrophic factors that support multiple aspects of brain function simultaneously.
• Clinical Recognition: Unlike many nootropics that remain in a regulatory gray area, Cerebrolysin has been approved as a prescription medication in several countries for specific neurological conditions.
• Intensity of Effects: Users often report more profound cognitive enhancement with Cerebrolysin compared to many other nootropics, particularly for memory formation and recall.

For those seeking cognitive enhancement, the choice between Cerebrolysin and other nootropics should be based on individual needs, health status, comfort with injection administration, and budget considerations. While Cerebrolysin may offer more comprehensive benefits, its administration method and cost make it better suited for those with specific neurological concerns or those who have found limited success with oral nootropics.

Mechanism of Action

Cerebrolysin (FPF-1070) is an enzymatically treated mixture of peptides derived from pigs’ brains that contain BDNF, GDNF, NGF, and CNTF. These neuropeptides are essential for nerve growth stimulation and maintenance of healthy neurological functions. 

Cerebrolysin’s mechanism of action functions through multiple pathways, combining neuroprotective and neurotrophic effects that enhance brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF), which collectively improve cognitive functions and stimulate neural repair processes.

As a peptide-based drug derived from porcine brain proteins, it includes a complex mixture of low molecular weight peptides and amino acids. These components are the main key to its therapeutic properties in various neurological disorders.

Here is an overview of the most notable mechanisms of action of Cerebrolysin:

• Neuroprotection: Cerebrolysin exhibits neuroprotective properties, which ar epotentiallyuseful in stroke and brain injury. It helps protect neurons from ischemic damage, reducing neuronal death and mitigating the effects of acute brain injury.
• Neurotrophic Action: The drug promotes the survival, development, and function of neurons. It stimulates nerve growth and enhances synaptic plasticity, which is crucial for repairing and maintaining healthy brain cells.
• Cognitive Improvement: Clinical studies have shown that Cerebrolysin can improve cognitive functions, particularly in patients with dementia and Alzheimer’s disease. This improvement is attributed to its ability to enhance synaptic connectivity and neural network efficiency.
• Modulation of Neuroinflammation: Cerebrolysin has been observed to modulate inflammatory responses in the brain, which can be beneficial in reducing the chronic inflammation associated with neurodegenerative diseases.
• Reduction of Free Radical Formation: By combating oxidative stress and reducing the formation of free radicals, Cerebrolysin helps protect the brain’s cellular integrity.
• Enhancing Blood-Brain Barrier Permeability: Its components can influence the blood-brain barrier, potentially allowing better delivery of therapeutic agents to the brain.
• Stimulation of Synthesis and Repair: Cerebrolysin stimulates the synthesis of proteins essential for neuronal repair and function. This is particularly significant after an injury or in any neurodegenerative conditions that come with age, such as Alzheimer’s disease.

Its ability to enhance cognitive functions and repair damaged brain cells makes it a potential treatment option for various cerebral disorders.

Nootropic Benefits of Cerebrolysin

The nootropic benefits of Cerebrolysin, a peptide preparation used for cognitive enhancement and neurorecovery, are numerous. 

Here’s an overview of Cerebrolysin’s benefits:

1. Cognitive Improvement

Clinical results suggest that Cerebrolysin improves cognitive functions, particularly in patients with neurodegenerative diseases, suggesting an enhancement in memory, attention, and executive functions.⁽³⁾

Specific improvements include:

• Enhanced working memory capacity and recall speed
• Improved problem-solving abilities and mental flexibility
• Better information processing and learning capacity
• Increased attention span and focus duration

These cognitive benefits typically begin to manifest after 2-4 weeks of consistent treatment and may continue to improve with ongoing cycles. Individuals with existing cognitive impairment tend to experience more noticeable improvements than those with normal baseline cognitive function.

Besides specific neurological conditions, Cerebrolysin has also improved general cognitive health in older adults, contributing to enhanced quality of life and daily functioning.⁽⁴⁾

2. Improved Functional Outcome

Multicentre studies indicate that Cerebrolysin has been explored for its ability to potentially improve the functional outcome in patients post-stroke, aiding in better recovery of motor and cognitive abilities.⁽⁵⁾ However, more studies are needed to prove this theory.

Real-world applications include:

• Improved ability to perform activities of daily living
• Enhanced motor coordination and physical rehabilitation outcomes
• Better speech recovery in patients with language impairments
• Increased independence and reduced caregiver burden

The functional improvements are most pronounced when Cerebrolysin treatment begins early after neurological injury and is combined with appropriate rehabilitation therapies.

3. Enhancement of Neuroplasticity

The use of Cerebrolysin enhances neuroplasticity, which is crucial for learning and memory. It promotes the formation of new neural connections, thereby improving cognitive capabilities.⁽⁶⁾

Neuroplasticity benefits include:

• Formation of new synaptic connections between neurons
• Strengthening of existing neural pathways
• Improved adaptation to cognitive challenges
• Enhanced ability to learn new skills and information

These neuroplasticity effects may explain why Cerebrolysin can provide lasting benefits even after the treatment cycle has ended, as the structural changes in neural networks persist.

4. Reduction in APP Levels

Research has shown that Cerebrolysin reduces the levels of amyloid precursor protein (APP), a protein linked to Alzheimer’s disease, suggesting its role in potentially slowing the disease’s progression.⁽⁷⁾

Neuroprotective implications:

• Potential slowing of amyloid plaque formation
• Reduced neurotoxicity from amyloid beta proteins
• Preservation of neural structures in vulnerable brain regions
• Possible delay in cognitive decline progression

This benefit is particularly relevant for individuals with genetic predispositions to neurodegenerative conditions or those in early stages of cognitive decline.

5. Increased Oxygen Utilization

Cerebrolysin improves the brain’s oxygen utilization, enhancing cerebral metabolism and thus supporting better cognitive functions.⁽⁸⁾

Metabolic improvements include:

• Enhanced glucose metabolism in the brain
• Better mitochondrial function in neurons
• Improved energy production for cognitive processes
• Increased cerebral blood flow and nutrient delivery

These metabolic enhancements provide the energetic foundation for improved cognitive performance and may contribute to the subjective feelings of mental clarity reported by users.

6. Neuroprotection and Neuroregeneration

As a peptide preparation, Cerebrolysin offers neuroprotective and neuroregenerative benefits, protecting neurons from damage and stimulating recovery of the patients, which is beneficial for cognitive health.⁽⁹⁾

Protective mechanisms include:

• Reduction of oxidative stress and free radical damage
• Inhibition of inflammatory processes that damage neurons
• Prevention of excitotoxicity during brain injury
• Promotion of cellular repair mechanisms

These neuroprotective effects are particularly valuable for individuals at risk of brain injury or those experiencing age-related cognitive decline.

Multicentre trials conducted in Austria and other locations have consistently shown positive outcomes in patients treated with Cerebrolysin, emphasizing its potential effectiveness as a nootropic agent.

7. Mood Enhancement and Motivation

Many users report improvements in mood, motivation, and emotional well-being when using Cerebrolysin. These effects may be related to the compound’s influence on neurotransmitter systems and neural circuit function.

Emotional and motivational benefits:

• Reduced symptoms of depression and anxiety
• Increased drive and initiative
• Enhanced sense of well-being and life satisfaction
• Improved emotional regulation and stress response

These mood-enhancing effects can complement the cognitive benefits, creating a synergistic improvement in overall mental performance and quality of life.

8. Better Outcomes in Combination Therapies

Studies suggest that Cerebrolysin, when used in combination with other treatments, can lead to better cognitive outcomes compared to using a single therapy or placebo.

Synergistic treatment approaches:

• Enhanced effectiveness when combined with cognitive rehabilitation
• Complementary benefits when used alongside traditional medications
• Potential to reduce required dosages of other medications
• Improved overall treatment response rates

In controlled studies, patients treated with Cerebrolysin showed significant cognitive improvements compared to control groups receiving placebo, highlighting its efficacy.

Uses of Cerebrolysin

Clinically, Cerebrolysin has been approved in many European and Asian countries as an injection for treating cerebrovascular disorders, with therapeutic applications extending beyond cognitive enhancement to include treatment of Alzheimer’s disease, traumatic brain injuries, various forms of dementia, neurorehabilitation after stroke, and management of Parkinson’s disease symptoms.

Additionally, here are some of its key applications:

1. Alzheimer’s Disease: Cerebrolysin has shown promising results in the treatment of Alzheimer’s disease, helping to improve cognitive functions and slow disease progression.
2. Traumatic Brain Injuries: Cerebrolysincan potentially be used to aid recovery in patients with traumatic brain injuries, enhancing neuroregeneration and neuroprotection.
3. Cognitive Impairment in Dementia: Cerebrolysin is potentially beneficial in treating various forms of dementia, improving cognitive abilities and daily functioning.
4. Neurorehabilitation: Cerebrolysin is employed in neurorehabilitation to enhance the recovery of neurological functions post-injury or post-stroke.
5. Parkinson’s Disease: Its neuroprotective properties make it a potential treatment option for Parkinson’s disease, helping to manage symptoms and protect neuronal health.
6. Administration in Clinical Settings: Cerebrolysin is administered via injection, making it a treatment that is typically given under medical supervision.
7. Research and Clinical Trials: Numerous studies, including at least 6 studies, have randomized patients to receive either Cerebrolysin or a control treatment, providing valuable data on its efficacy and safety.
8. Combination with Other Therapies: Often used in combination with other therapies, Cerebrolysin can enhance the overall treatment efficacy for various neurological disorders to help induce neuroregeneration.

Where To Buy Cerebrolysin

We recommend purchasing Cerebrolysin from CosmicNootropic. Their products are shipped from the United States and contain pure Cerebrolysin at a low price, starting from $69 USD. The shipping takes 2-5 days domestically and 7-14 days internationally.

This is a top-notch vendor and is our top pick for the best place to buy Cerebrolysin. 

Cerebrolysin Dosage

Cerebrolysin has dosing tailored to the individual’s condition and must be administered via intramuscular or intravenous injection, as its peptide composition prevents oral administration. The standard method for cognitive enhancement is intramuscular injections of 5 ml daily, with a course of treatment typically lasting 4 weeks unless your doctor specifies differently.

Here’s an overview of how  to correctly take a dose of Cerebrolysin for each condition:

• Stroke: 20-50 ml for 21 days
• Vascular dementia: 10-30 ml 5 days a week for 4 weeks, 2-4 cycles per year
• Alzheimer’s disease: 10-30 ml 5 days a week for 4 weeks, 2-4 cycles per year
• Traumatic Brain Injury (TBI): 20-50 ml for 7-30 days
• As a Nootropic: 1-5 ml 5 days a week for 4 weeks

Remember to avoid high doses (80 ml and above) during the beginning of Cerebrolysin treatment.

as they may interact adversely and lead to severe side effects.

Cerebrolysin Side Effects and Safety

While Cerebrolysin offers numerous potential benefits, it’s important to understand its complete safety profile and possible adverse effects. Side effects can vary in severity, frequency, and presentation among different individuals.

Common Side Effects (Mild to Moderate)

The most frequently reported side effects of Cerebrolysin include:

Mild (affecting 5-15% of users):

• Loss of appetite
• Headache
• Dizziness
• Insomnia
• Sweating
• Fatigue
• Injection site reactions (pain, redness, swelling)
• Mild digestive discomfort

Moderate (affecting 1-5% of users):

• Fever
• Lower back pain
• Shortness of breath
• Chills
• Anxiety
• Weight loss
• Temporary blood pressure fluctuations

These mild to moderate side effects typically resolve on their own within a few days as the body adjusts to the treatment. Staying hydrated and ensuring proper rest can help manage these symptoms.

Severe Side Effects (Rare, <1% of users)

While uncommon, some users may experience more serious adverse reactions that require immediate medical attention:

• Irregular heartbeat or palpitations
• Severe allergic reactions (rash, itching, swelling, severe dizziness)
• Significant mood changes or psychiatric symptoms
• Persistent high fever
• Seizures
• Severe injection site infections

If you experience any of these severe side effects, discontinue use and seek medical help immediately.

Risk Factors for Adverse Reactions

Certain factors may increase your likelihood of experiencing side effects:

• Pre-existing medical conditions: Particularly cardiovascular disorders, liver or kidney disease, or autoimmune conditions
• Age: Elderly individuals may be more sensitive to side effects
• Medication interactions: Particularly with antidepressants, blood thinners, or immunosuppressants
• Improper administration: Incorrect injection technique can increase local reactions
• Individual sensitivity: Some people may have genetic predispositions to adverse reactions

Managing Common Side Effects

Many side effects can be effectively managed with simple interventions:

• Injection site reactions: Rotate injection sites, use proper technique, apply cold compresses
• Headache/dizziness: Ensure adequate hydration, rest, and consider timing injections earlier in the day
• Sleep disturbances: Administer in the morning rather than evening
• Digestive issues: Take with food if appropriate, maintain proper hydration
• Anxiety/mood changes: Consider reducing dosage and consult with a healthcare provider

Contraindications

Cerebrolysin should be avoided in the following situations:

• Known hypersensitivity to Cerebrolysin or similar peptide preparations
• Severe renal impairment
• Epilepsy or history of seizures
• Pregnancy or breastfeeding (due to insufficient safety data)
• Active infection or fever
• Recent stroke (within 24-48 hours, depending on type)

Long-term Safety Considerations

The long-term safety profile of Cerebrolysin remains under investigation, with limited data on extended use beyond recommended treatment cycles. Current evidence suggests that cycling treatment with periods of use followed by breaks may reduce potential adverse effects, making Cerebrolysin potentially suitable for long-term therapeutic approaches when properly monitored by healthcare professionals.

• Cycling treatment (periods of use followed by breaks) may reduce risk of adverse effects
• Regular monitoring of liver and kidney function is advisable during extended treatment
• The risk-benefit ratio appears most favorable for individuals with existing neurological conditions
• Healthy individuals using it for cognitive enhancement should exercise particular caution and use lower doses

It is important to note that the effects of Cerebrolysin are not the same for everyone, and it is recommended to consult a doctor before taking this medication. Additionally, if these side effects persist or grow in intensity, visit a hospital and see a medical professional to avoid adverse effects.

Caution should be exercised when combining Cerebrolysin with antidepressants, particularly MAO inhibitors, as they may interact adversely and lead to severe side effects.

Summary

So what do we know about Cerebrolysin?

We know that it is a peptide complex nootropic with powerful neuroprotective and cognitive-enhancing properties. Cerebrolysin was studied for its potential to treat neurological disorders like stroke, traumatic brain injury, and dementia. However, more clinical trials are needed to confirm its efficacy in this area.

Cerebrolysin can be used independently or stacked with other supplements to get even more profound effects. When used as directed, it can help improve cognitive function and memory while providing an overall sense of alertness and energy.

It is important to remember that Cerebrolysin should be used only under the supervision of a healthcare provider, as it may interact with certain medications or supplements. Professional guidance will provide you with useful information on how to get the best out of your Cerebrolysin therapy.

With that in mind, Cerebrolysin can be an excellent addition to your nootropic regimen. It has numerous benefits and, when used correctly, can help to enhance cognitive function and memory while providing a sense of focus and alertness.

FAQs

1. Lang, Wilfried et al. “A prospective, randomized, placebo-controlled, double-blind trial about safety and efficacy of combined treatment with alteplase (rt-PA) and Cerebrolysin in acute ischaemic hemispheric stroke.” International journal of stroke : official journal of the International Stroke Society vol. 8,2 (2013): 95-104. doi:10.1111/j.1747-4949.2012.00901.x↩
2. Fiani, Brian et al. “Cerebrolysin for stroke, neurodegeneration, and traumatic brain injury: review of the literature and outcomes.” Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology vol. 42,4 (2021): 1345-1353. doi:10.1007/s10072-021-05089-2↩
3. Ghaffarpasand, Fariborz et al. “Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis.” Neuropsychiatric disease and treatment vol. 15 127-135. 27 Dec. 2018, doi:10.2147/NDT.S186865↩
4. Chen, Chun-Chung et al. “Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study.” British journal of neurosurgery vol. 27,6 (2013): 803-7. doi:10.3109/02688697.2013.793287↩
5. Brainin, Michael. “Cerebrolysin: a multi-target drug for recovery after stroke.” Expert review of neurotherapeutics vol. 18,8 (2018): 681-687. doi:10.1080/14737175.2018.1500459↩
6. Cui, Shuhui et al. “Cerebrolysin for vascular dementia.” The Cochrane database of systematic reviews vol. 2019,11 CD008900. 11 Nov. 2019, doi:10.1002/14651858.CD008900.pub3↩
7. Liu, Zehui et al. “CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease.” PloS one vol. 14,9 e0222757. 23 Sep. 2019, doi:10.1371/journal.pone.0222757↩
8. Colucci, Luisa et al. “Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: a review.” Journal of experimental pharmacology vol. 4 163-72. 11 Dec. 2012, doi:10.2147/JEP.S35326↩
9. Lu, Weihong et al. “Cerebrolysin alleviates early brain injury after traumatic brain injury by inhibiting neuroinflammation and apoptosis via TLR signaling pathway.” Acta cirurgica brasileira vol. 37,6 e370605. 5 Sep. 2022, doi:10.1590/acb370605↩