5 Best Caffeine-Free Nootropics in 2024 (Tested & Reviewed)

Updated on February 28, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Exploring the impact of caffeine-free nootropics on neural connections.

Are you looking for a way to enhance your cognitive performance without relying on caffeine or other aggressive stimulants?

Look no further than potent nootropics that don’t contain caffeine but still give you a mental and physical pep. These are known as smart drugs or cognitive enhancers. Nootropics have become increasingly popular in recent years. But with so many options out there, how do you choose the right one for your needs?

In this article, we’ve researched and tested the top five nootropics without caffeine content on the market. Whether you’re looking to improve your memory, focus, creativity, or energy levels, these supplements have got you covered. So, throw away that cup of coffee and read on to find the best nootropic for you.

Top Smart Drugs that are 100% Caffeine-Free

  • NooCube — Top-rated for focus and attention
  • Mind Lab Pro — Best for mental energy and concentration
  • L-Tyrosine — Great against oxidative stress
  • CDP Choline — Great for modulating neurotransmitters
  • Aniracetam — We love it for improved mood and reduce anxiety

How To Choose Products in This Category

Selecting the right non-caffeinated nootropic involves considering several factors that influence their effectiveness and compatibility with your cognitive health goals.

FactorDescriptionWhy It’s Important
Ingredient QualityThe purity and sourcing of the nootropic ingredients.High-quality ingredients ensure safety and efficacy.
EfficacyThe proven impact of the nootropics on cognitive functions.Ensures that the product delivers on its promises.
Side EffectsPotential adverse reactions or interactions.Minimizes health risks and discomfort.
SynergyHow well the nootropic works with others in a stack.Enhances overall cognitive benefits.
ValueBalance of cost against the benefits provided.Ensures a cost-effective cognitive enhancement.
  • Ingredient Quality: High-quality ingredients are crucial for ensuring that the nootropic is both safe and effective. Impurities or substandard sourcing can lead to reduced efficacy or even health risks.
  • Efficacy: The nootropic should have a proven track record of enhancing cognitive abilities. Reviews and clinical studies can be good indicators of a product’s effectiveness.
  • Side Effects: It’s important to consider the potential for side effects, as you want a nootropic that improves cognitive function without causing harm or discomfort.
  • Synergy: Some nootropics work better when combined with others. Ensuring that the ingredients complement each other can lead to better overall cognitive enhancement.
  • Value: Look for a nootropic that offers a good balance between cost and the cognitive benefits it provides. The most expensive option is not necessarily the best, and affordability without compromising quality is key.

Shortlist of Nootropics Containing Zero Caffeine 2024

According to our in-depth testing and research, the top nootropics are:

Another unique ingredient found in NooCube is Cat’s Claw, which is a vine from the Amazon that increases cellular regeneration. This supplement also has Huperzine A, which is very common in brain boosters.(2)

The ingredients in NooCube work together to provide functional cognitive support made by nature. NooCube contains Lutemax, which is derived from the marigold plant and includes lutein and two unique zeaxanthin isomers. Lutemax helps support areas of the brain responsible for information processing, including memory, listening comprehension, and visual acuity.



  • May not be as effective for everyone
  • Not recommended for nursing and pregnant women

NooCube has helped countless individuals get more accomplished in their daily lives, improving their focus, memory, and concentration while providing other added benefits such as better sleep, a calmer disposition throughout the day, and an overall better mood.

2. Mind Lab Pro

Mind Lab Pro is a brain booster supplement that aims to deliver a mental performance that fires on all cylinders. This nootropic supplement acts as a memory and mood booster to enhance focus, motivation, and drive. It is formulated to boost brain circulation, brain plasticity, and production of alpha brain waves for calm alertness and clarity.

One of the best things about Mind Lab Pro is its clean label. The supplement is made using premium grade research-backed ingredients that are ethically sourced. It is designed to help you perform at your peak all day, every day. The supplement has 11 brain-boosting nootropic ingredients that are expertly blended and precisely dosed. These ingredients work together to help you unlock your peak performance potential.


  • Enhances brainpower and neural efficacy
  • Regulates brain chemicals for optimum performance
  • Relieves stress and elevates mood


  • May cause headaches, nausea or insomnia in some people

Mind Lab Pro is gluten and lactose-free and doesn’t contain any GMO, caffeine, or pointless synthetic additives. Simply take 2-4 capsules a day with water, juice, coffee, or whatever you like, and uncap your true potential!

3. L-Tyrosin

L-Tyrosine is a naturally occurring amino acid and an important building block for neurotransmitters such as dopamine, norepinephrine, and epinephrine. It is known to improve cognitive performance, memory, and concentration. L-Tyrosine helps reduce stress, boost mood and reduce fatigue.

It supports healthy levels of cortisol and helps alleviate stress and anxiety.(3) L-Tyrosine has also been shown to improve physical performance by reducing fatigue and increasing endurance.

L-Tyrosine is widely available as a supplement and can be consumed on its own or as part of a nootropic stack. It is considered safe when taken in recommended doses, and side effects are rare. However, it is always advisable to consult a doctor before taking any dietary supplement.


  • Supports neurotransmitters needed for multitasking and peak mental performance
  • Boosts energy and motivation
  • Improves cognitive function and brain health
  • Helps reduce stress and improve mood


  • May interact with other medications or supplements
  • May take some time to show noticeable results

As a natural nootropic, L-Tyrosine has many promising benefits for improving cognitive and physical health. Whether you’re looking to improve your focus, reduce stress, or increase your endurance, L-Tyrosine could be an effective solution for you.

4. CDP Choline

CDP Choline, also known as Citicoline, is a dietary supplement that supports brain function. It is a natural compound found in the body and can also be obtained through the diet. CDP Choline is a potent source of choline, which is an essential nutrient for brain health. It is a precursor to acetylcholine, a neurotransmitter that is crucial for cognitive function, learning, and memory. CDP Choline has been found to improve focus, concentration, and memory in both healthy individuals and those with cognitive impairment.

CDP Choline also helps against age-related cognitive decline. Studies found that it improves cognitive function in people with Parkinson’s disease.(4) Additionally, CDP Choline has been shown to enhance brain metabolism and increase cerebral blood flow, which can further support brain health.

When it comes to the dosage, the recommended amount of CDP Choline is around 500 – 2000 mg per day. It is regarded as safe, with few reported side effects.


  • Optimizes brain pathways
  • Boosts neural regeneration and mental energy
  • Increases attention, focus and memory


  • Has potential for side effects such as stomach pain, headache, or insomnia

CDP Choline can enhance brain function and support cognitive health. It is a great addition to any nootropic stack and can be beneficial for people of all ages. As always, it is important to consult with a medical professional before adding any supplement to your routine.

5. Aniracetam

Aniracetam is a popular nootropic supplement that acts as a cognitive enhancer and mood booster without the stimulating effects of caffeine content. It was developed in Belgium in the 1970s and is believed to boost cognitive function by modulating neurotransmitters in the brain.

One of the key benefits of Aniracetam is its ability to boost memory, learning, and creativity. It helps in improving long-term memory and retaining new information by increasing the availability of the neurotransmitter acetylcholine in the brain.

Furthermore, Aniracetam plays a crucial role in mood enhancement, reducing anxiety levels, and improving overall well-being. It influences serotonin and dopamine receptors in the brain, which positively impacts mood and motivation.

Several studies have also shown its potential in improving brain health, especially in people suffering from cognitive impairment or Alzheimer’s.(5) Aniracetam helps modulate the activity of proteins called AMPA receptors, which are essential for learning and memory.


  • Improves cognitive function
  • Enhances learning and memory
  • Helps with stress and anxiety


  • Not suitable for people with certain medical conditions
  • May cause gastrointestinal discomfort

It is recommended to take Aniracetam with a source of choline to support the brain’s acetylcholine production and prevent headaches. Overall, Aniracetam is an effective and natural nootropic that offers a range of cognitive and mood-boosting benefits without the negative side effects of caffeine content.

How Do Nootropics Without Any Caffeine Work?

Caffeine-free nootropics are supplements that improve brain function by enhancing cognitive abilities such as memory, focus, and concentration. These supplements work by regulating the essential biochemical components within your brain to optimize mental performance causing no adverse side effects. Unlike caffeine which gives you a quick energy boost but leaves you feeling drained later on, these other nootropics provide a steady and sustained cognitive enhancement that lasts throughout the day.

These supplements are formulated with natural and clinically proven ingredients that offer multiple benefits, including protecting against screen fatigue, preventing neurodegeneration, optimizing brain functioning, and reducing anxiety and stress levels.

Different nootropics work in unique ways to stimulate various brain pathways, making the most of your brain’s networks and processes. They regulate essential components within your brain to optimize mental performance and offer multiple benefits, including improved focus, concentration, and memory.

What to Consider Before Buying These Types of Nootropics?

Before investing in no caffeine nootropics, it’s essential to reflect on several aspects to ensure you make a well-informed decision that aligns with your cognitive health objectives.

1. Personal Cognitive Goals

Understand your specific cognitive goals, such as improved memory, focus, or stress resilience. This will guide you in selecting a nootropic that targets your individual needs.

Identifying your desired outcomes will help you narrow down the vast array of caffeine-free nootropics to those that are most likely to support your personal cognitive goals.

2. Compatibility with Current Health Status

Consider your current health and any medical conditions that might influence the effectiveness or safety of nootropic supplements.

Certain ingredients might interact with medications or exacerbate existing health issues. Researching and understanding these aspects is crucial for a safe nootropic experience.

3. Lifestyle and Diet Compatibility

Reflect on how a nootropic’s dosage and regimen will fit into your daily routine and whether your diet provides sufficient support for cognitive health.

A nootropic should complement your lifestyle and dietary habits. Ensuring that you can maintain the recommended intake and that it doesn’t conflict with your daily activities is vital for consistency and effectiveness.

4. Scientific Research and Evidence

Review the scientific evidence backing the efficacy of the nootropic’s ingredients. Reliable research and studies add credibility to the claims made by the product.

Looking for peer-reviewed studies or clinical trials that support the use of the nootropics in question will provide confidence in their potential cognitive benefits.

By taking these factors into account, you can make a more informed decision when selecting the optimal nootropic to enhance your cognitive performance without the need for caffeine.

How We Selected this Shortlist of Brain and Body-Boosting Nootropics

We employed a comprehensive review process to identify the nootropics that met the requirement of having zero caffeine yet provided similar cognitive enhancement. Our evaluation took into account effectiveness, ingredients, brand reputation, transparency, manufacturing standards, user feedback, price, and overall value. By thoroughly examining these factors, we have curated a reliable and well-rounded list of the top nootropics available in this category.


We delved into clinical studies and user experiences to assess cognitive improvements, focusing on attention, memory, and mental clarity without relying on caffeination.


We carefully examined each formula, prioritizing evidence-based, natural, and high-quality ingredients that enhance cognitive performance without the need for caffeination.

Scientific Evidence

We referred to peer-reviewed research and meta-analyses to confirm the effectiveness of key ingredients in boosting cognitive function without caffeine.


We reviewed appropriate dosages and ingredient ratios, ensuring they comply with established research for maximum effectiveness without any stimulant effects.


We confirmed the safety of each ingredient, considering potential side effects and interactions, and ensuring compliance with regulatory guidelines. We prioritized FDA-approved ingredients.

Brand Reputation

We assessed the credibility and trustworthiness of each brand through customer reviews, expert recommendations, and company history.

Product Transparency

We valued full ingredient disclosure, including sources and concentrations, to allow informed consumer decision-making.

Manufacturing Process

We scrutinized manufacturing standards, giving preference to products made in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, placing emphasis on testimonials that detail cognitive improvements and overall satisfaction without caffeination.


We compared product prices to ensure they were competitive and in line with the quality and efficacy of that we (and you) expect.


We evaluated overall value, taking into account the balance of price, quality, and effectiveness to guarantee the best return on investment for consumers.

Caffeine-Free Nootropics in Summary

These nootropics offer a promising solution for individuals seeking cognitive enhancement without relying on caffeination. This article explored and evaluated the top five no caffeine nootropics on the market: NooCube, Mind Lab Pro, L-Tyrosine, CDP Choline, and Aniracetam.

NooCube stands out as a high-quality supplement that promotes brain health and cognitive function. Its blend of research-backed ingredients, including Alpha GPC and Cat’s Claw, work synergistically to improve memory, focus, and overall cognitive performance. Mind Lab Pro, another notable option, offers a clean label and premium-grade ingredients to boost mental performance, memory, and mood.

L-Tyrosine, a naturally occurring amino acid, supports neurotransmitter production and helps reduce stress and fatigue. CDP Choline acts as a potent source of choline, enhancing brain function, attention, and memory. Aniracetam, a popular cognitive enhancer, improves cognitive function, mood, and creativity without caffeine’s stimulating effects.

These alternative nootropics work by optimizing brain pathways, promoting neural regeneration, increasing brain energy, and supporting various cognitive functions. They are formulated with natural, clinically proven ingredients and are generally regarded as safe.

When selecting your nootropic for this purpose (or any purpose), factors such as effectiveness, ingredients, brand reputation, transparency, manufacturing standards, user feedback, price, and overall value should be considered.


Can I stack/combine caffeine-free supplements with other supplements?

Yes, these supplements/nootropics can be combined with other supplements to enhance their effects. It’s crucial to research potential interactions or consult a healthcare professional for guidance.

How long does it take for these products to work?

The onset of effects for caffeine-free products can vary. Some may produce noticeable benefits within hours, while others may require consistent use over weeks or months for optimal results.

Are non-caffeinated brain supplements suitable for students?

Non=caffeinated brain supplements can be a suitable choice for students seeking improved focus, memory, and stress management without the side effects of the world’s favorite drug. Always consult a healthcare professional before use, especially for minors.

Can I use these smart drugs for long-term cognitive enhancement?

Many caffeine-free smart drugs can be used long-term, but it’s essential to cycle (periodically pause use) some nootropics to maintain effectiveness and avoid potential negative effects. Consult a healthcare professional for guidance.

Sources, Studies, and Scientific Research
  1. Parker, Adam G., et al. “The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility.” Journal of the International Society of Sports Nutrition 12.sup1 (2015): P41. ↩
  2. Li, Jun, et al. “Huperzine A for Alzheimer’s disease.” Cochrane Database of Systematic Reviews 2 (2008). ↩
  3. Slominski, Andrzej, Michal A. Zmijewski, and John Pawelek. “L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions.” Pigment cell & melanoma research 25.1 (2012): 14-27. ↩
  4. Fioravanti, Mario, and Motokazu Yanagi. “Cytidinediphosphocholine (CDP‐choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.” Cochrane Database of Systematic Reviews 2 (2005). ↩
  5. Isaacson, Jeffry S., and Roger A. Nicoll. “Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus.” Proceedings of the National Academy of Sciences 88.23 (1991): 10936-10940. ↩