5 Best Caffeine-Free Nootropics in 2023 (Tested & Reviewed)

Updated on July 2, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
best caffeine free nootropics

What are the best caffeine-free nootropics?

Are you looking for a way to enhance your cognitive performance without relying on caffeine?

Look no further than nootropics, also known as smart drugs or cognitive enhancers. Nootropics have become increasingly popular in recent years. But with so many options out there, how do you choose the right one for your needs?

In this article, we've researched and tested the top five caffeine-free nootropics on the market. Whether you're looking to improve your memory, focus, creativity, or energy levels, these supplements have got you covered. So, throw away that cup of coffee and read on to find the best nootropic for you.

Best Caffeine-Free Nootropics

1. NooCube

NooCube is a high-quality nootropic supplement that helps to boost brain health and cognitive function. It is notable for being free of caffeine, gluten, and GMOs, making it suitable for most people. One of the key ingredients in NooCube is Alpha GPC, which is a proven brain enhancer that improves both memory and cognitive function.(1)

Another unique ingredient found in NooCube is Cat's Claw, which is a vine from the Amazon that increases cellular regeneration. This supplement also has Huperzine A, which is very common in brain boosters.(2)

The ingredients in NooCube work together to provide functional cognitive support made by nature. NooCube contains Lutemax, which is derived from the marigold plant and includes lutein and two unique zeaxanthin isomers. Lutemax helps support areas of the brain responsible for information processing, including memory, listening comprehension, and visual acuity.



  • May not be as effective for everyone
  • Not recommended for nursing and pregnant women

NooCube has helped countless individuals get more accomplished in their daily lives, improving their focus, memory, and concentration while providing other added benefits such as better sleep, a calmer disposition throughout the day, and an overall better mood.

2. Mind Lab Pro

Mind Lab Pro is a brain booster supplement that aims to deliver a mental performance that fires on all cylinders. This nootropic supplement acts as a memory and mood booster to enhance focus, motivation, and drive. It is formulated to boost brain circulation, brain plasticity, and production of alpha brain waves for calm alertness and clarity.

One of the best things about Mind Lab Pro is its clean label. The supplement is made using premium grade research-backed ingredients that are ethically sourced. It is designed to help you perform at your peak all day, every day. The supplement has 11 brain-boosting nootropic ingredients that are expertly blended and precisely dosed. These ingredients work together to help you unlock your peak performance potential.


  • Enhances brainpower and neural efficacy
  • Regulates brain chemicals for optimum performance
  • Relieves stress and elevates mood


  • May cause headaches, nausea or insomnia in some people

Mind Lab Pro is gluten and lactose-free and doesn't contain any GMO, caffeine, or pointless synthetic additives. Simply take 2-4 capsules a day with water, juice, coffee, or whatever you like, and uncap your true potential!

3. L-Tyrosin

L-Tyrosine is a naturally occurring amino acid and an important building block for neurotransmitters such as dopamine, norepinephrine, and epinephrine. It is known to improve cognitive performance, memory, and concentration. L-Tyrosine helps reduce stress, boost mood and reduce fatigue.

It supports healthy levels of cortisol and helps alleviate stress and anxiety.(3) L-Tyrosine has also been shown to improve physical performance by reducing fatigue and increasing endurance.

L-Tyrosine is widely available as a supplement and can be consumed on its own or as part of a nootropic stack. It is considered safe when taken in recommended doses, and side effects are rare. However, it is always advisable to consult a doctor before taking any dietary supplement.


  • Supports neurotransmitters needed for multitasking and peak mental performance
  • Boosts energy and motivation
  • Improves cognitive function and brain health
  • Helps reduce stress and improve mood


  • May interact with other medications or supplements
  • May take some time to show noticeable results

As a natural nootropic, L-Tyrosine has many promising benefits for improving cognitive and physical health. Whether you're looking to improve your focus, reduce stress, or increase your endurance, L-Tyrosine could be an effective solution for you.

4. CDP Choline

CDP Choline, also known as Citicoline, is a dietary supplement that supports brain function. It is a natural compound found in the body and can also be obtained through the diet. CDP Choline is a potent source of choline, which is an essential nutrient for brain health. It is a precursor to acetylcholine, a neurotransmitter that is crucial for cognitive function, learning, and memory. CDP Choline has been found to improve focus, concentration, and memory in both healthy individuals and those with cognitive impairment.

CDP Choline also helps against age-related cognitive decline. Studies found that it improves cognitive function in people with Parkinson's disease.(4) Additionally, CDP Choline has been shown to enhance brain metabolism and increase cerebral blood flow, which can further support brain health.

When it comes to the dosage, the recommended amount of CDP Choline is around 500 - 2000 mg per day. It is regarded as safe, with few reported side effects.


  • Optimizes brain pathways
  • Boosts neural regeneration and mental energy
  • Increases attention, focus and memory


  • Has potential for side effects such as stomach pain, headache, or insomnia

CDP Choline can enhance brain function and support cognitive health. It is a great addition to any nootropic stack and can be beneficial for people of all ages. As always, it is important to consult with a medical professional before adding any supplement to your routine.

5. Aniracetam

Aniracetam is a popular nootropic supplement that acts as a cognitive enhancer and mood booster without the stimulating effects of caffeine. It was developed in Belgium in the 1970s and is believed to boost cognitive function by modulating neurotransmitters in the brain.

One of the key benefits of Aniracetam is its ability to boost memory, learning, and creativity. It helps in improving long-term memory and retaining new information by increasing the availability of the neurotransmitter acetylcholine in the brain.

Furthermore, Aniracetam plays a crucial role in mood enhancement, reducing anxiety levels, and improving overall well-being. It influences serotonin and dopamine receptors in the brain, which positively impacts mood and motivation.

Several studies have also shown its potential in improving brain health, especially in people suffering from cognitive impairment or Alzheimer's.(5) Aniracetam helps modulate the activity of proteins called AMPA receptors, which are essential for learning and memory.


  • Improves cognitive function
  • Enhances learning and memory
  • Helps with stress and anxiety


  • Not suitable for people with certain medical conditions
  • May cause gastrointestinal discomfort

It is recommended to take Aniracetam with a source of choline to support the brain's acetylcholine production and prevent headaches. Overall, Aniracetam is an effective and natural nootropic that offers a range of cognitive and mood-boosting benefits without the negative side effects of caffeine.

How Do Caffeine-Free Nootropics Work?

Caffeine-free nootropics are supplements that improve brain function by enhancing cognitive abilities such as memory, focus, and concentration. These supplements work by regulating the essential biochemical components within your brain to optimize mental performance causing no adverse side effects. Unlike caffeine that gives you a quick energy boost but leaves you feeling drained later on, caffeine-free nootropics provide a steady and sustained cognitive enhancement that lasts throughout the day.

These supplements are formulated with natural and clinically proven ingredients that offer multiple benefits, including protecting against screen fatigue, preventing neurodegeneration, optimizing brain functioning, and reducing anxiety and stress levels.

Different nootropics work in unique ways to stimulate various brain pathways, making the most of your brain's networks and processes. They regulate essential components within your brain to optimize mental performance and offer multiple benefits, including improved focus, concentration, and memory.

How We Picked the Top Caffeine-Free Nootropics

We employed a comprehensive review process to identify the best caffeine-free nootropics for cognitive enhancement. Our evaluation took into account effectiveness, ingredients, brand reputation, transparency, manufacturing standards, user feedback, price, and overall value. By thoroughly examining these factors, we have curated a reliable and well-rounded list of the top caffeine-free nootropics available.


We delved into clinical studies and user experiences to assess cognitive improvements, focusing on attention, memory, and mental clarity without relying on caffeine.


We carefully examined each formula, prioritizing evidence-based, natural, and high-quality ingredients that enhance cognitive performance without the need for caffeine.

Scientific Evidence

We referred to peer-reviewed research and meta-analyses to confirm the effectiveness of key ingredients in boosting cognitive function without caffeine.


We reviewed appropriate dosages and ingredient ratios, ensuring they comply with established research for maximum effectiveness without any stimulant effects.


We confirmed the safety of each ingredient, considering potential side effects and interactions, and ensuring compliance with regulatory guidelines. We prioritized FDA-approved ingredients.

Brand Reputation

We assessed the credibility and trustworthiness of each brand through customer reviews, expert recommendations, and company history.

Product Transparency

We valued full ingredient disclosure, including sources and concentrations, to allow informed consumer decision-making.

Manufacturing Process

We scrutinized manufacturing standards, giving preference to products made in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, placing emphasis on testimonials that detail cognitive improvements and overall satisfaction without caffeine.


We compared product prices to ensure they were competitive and in line with the quality and efficacy of the caffeine-free nootropic.


We evaluated overall value, taking into account the balance of price, quality, and effectiveness to guarantee the best return on investment for consumers.


Caffeine-free nootropics offer a promising solution for individuals seeking cognitive enhancement without relying on caffeine. This article explored and evaluated the top five caffeine-free nootropics on the market: NooCube, Mind Lab Pro, L-Tyrosine, CDP Choline, and Aniracetam.

NooCube stands out as a high-quality supplement that promotes brain health and cognitive function. Its blend of research-backed ingredients, including Alpha GPC and Cat's Claw, work synergistically to improve memory, focus, and overall cognitive performance. Mind Lab Pro, another notable option, offers a clean label and premium-grade ingredients to boost mental performance, memory, and mood.

L-Tyrosine, a naturally occurring amino acid, supports neurotransmitter production and helps reduce stress and fatigue. CDP Choline acts as a potent source of choline, enhancing brain function, attention, and memory. Aniracetam, a popular cognitive enhancer, improves cognitive function, mood, and creativity without caffeine's stimulating effects.

These caffeine-free nootropics work by optimizing brain pathways, promoting neural regeneration, increasing brain energy, and supporting various cognitive functions. They are formulated with natural, clinically proven ingredients and are generally regarded as safe.

When selecting the best caffeine-free nootropic, factors such as effectiveness, ingredients, brand reputation, transparency, manufacturing standards, user feedback, price, and overall value should be considered.


Can I combine caffeine-free nootropics with other supplements?

Yes, many caffeine-free nootropics can be combined with other supplements to enhance their effects. It's crucial to research potential interactions or consult a healthcare professional for guidance.

How long does it take for caffeine-free nootropics to work?

The onset of effects for caffeine-free nootropics can vary. Some may produce noticeable benefits within hours, while others may require consistent use over weeks or months for optimal results.

Are caffeine-free nootropics suitable for students?

Caffeine-free nootropics can be a suitable choice for students seeking improved focus, memory, and stress management without the side effects of caffeine. Always consult a healthcare professional before use, especially for minors.

Can I use caffeine-free nootropics for long-term cognitive enhancement?

Many caffeine-free nootropics can be used long-term, but it's essential to cycle (periodically pause use) some nootropics to maintain effectiveness and avoid potential negative effects. Consult a healthcare professional for guidance.