8 Best Nootropic Peptides 2023 (+ Where to Buy Them)

Updated on May 26, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Do you want to maximize your mental performance?

Are you looking for ways to increase focus, alertness, and concentration?

Then look no further than nootropic peptides!

In this review, we’ll cover all the benefits of using these amazing compounds and tell you where to find them.

1. Semax

Semax is one of the most popular nootropic peptides. It is a synthetic analog of the naturally occurring neuropeptide ACTH and is used to improve cognitive abilities, memory and overall mental performance. Studies have shown that Semax boosts the production of nerve growth factor and brain-derived neurotrophic factor, both of which are key components in the development and maintenance of healthy neurons.

In addition, Semax has been found to protect against excitotoxic damage, improve learning and memory, and enhance focus and concentration. It is also believed to reduce inflammation in the body and may even be beneficial in treating depression.

2. Selank

Selank is a synthetic peptide that has been used as a treatment for anxiety, depression, and stress. It is derived from the brain-derived neurotrophic factor (BDNF) and is known to act on the nervous system by enhancing its plasticity.

Selank also increases the production of serotonin and gamma-aminobutyric acid (GABA), which are neurotransmitters responsible for regulating mood and anxiety. Studies have shown that Selank can reduce symptoms of generalized anxiety disorder, improve cognitive function, and help with sleep disturbances. Additionally, Selank has been found to be effective in treating social phobia.

3. Cerebrolysin

Cerebrolysin is a peptide derived from cow’s brain. It is used in the treatment of cognitive decline and age-related memory loss. It increases the production of neurotropic factors, which promote the growth of neurons and synapses.

Cerebrolysin can also improve the rate at which neurons are able to communicate with each other. This can lead to improved memory, learning and focus. Cerebrolysin has also been found to reduce anxiety and depression, as well as improve mood.

It is typically taken in doses of 5-10 mL per day, but this will vary depending on the individual's needs. As with any nootropic, it is important to consult with a doctor before taking Cerebrolysin.

4. Dihexa

Dihexa is a peptide drug that has been developed by researchers from Washington State University to help with cognitive functions related to trauma brain disorders, such as Alzheimer's Disease. Also known as N-hexanoic-Tyr-ile-(6) aminohexanoic amide and PNB-0408, Dihexa has been found to be seven orders of magnitude more potent than the brain-derived neurotrophic factor, and even ten million times stronger than the BDNF.

Its main function is to relieve and supplement people who are stricken by Alzheimer’s Disease (AD) to slow down the progression of the disease. It is offered in cream form in a 20mg/mL, provided in the form of a transdermal cream, and in capsules in 10 mg and 20 mg oral capsules. The average dose for Dihexa is between 8 and 45 milligrams, which you take orally.

5. FGL

FGL (Fibroblast Growth Factor) is a 15 amino acid peptide synthetically derived from the neural cell adhesion molecule (NCAM). It behaves as a fibroblast growth factor receptor agonist and activates the NCAM-FGFR signaling pathway, which is believed to have memory and cognition-enhancing effects.

FGL is thought to improve healing of neuronal tissues by decreasing oxidative stress-induced cell death, inhibiting neuronal degeneration and death, and stimulating activity-dependent delivery of glutamate receptors to synapses. FGL has also been shown to increase neurite outgrowth, synaptic transmission, and the formation of new synapses, making it a pharmacological cognitive enhancer.

6. PE-22-28

PE-22-28 is a peptide that has been shown to have a number of nootropic benefits, including improved cognitive performance, increased focus and concentration, enhanced memory, improved decision-making, and even improved mood. Studies have shown that PE-22-28 can help reduce anxiety and depression and can also increase dopamine levels in the brain.

This peptide can also help protect against neurological diseases such as Alzheimer's and Parkinson's. It may also increase the plasticity of the brain, which can help with learning and memory.

PE-22-28 has several nootropic benefits that can help improve cognitive performance and overall brain health.

7. Orexin A

Orexin A (also known as hypocretin-1) is a 33-amino-acid long neuropeptide that is located in the lateral hypothamalus of your brain and can be used to sustain wakefulness for longer periods of time throughout the day without feeling tired. Emerging research suggests that it can be a potent therapy for narcolepsy, as well as a way to enhance mental performance.

Orexin A helps to maintain alertness by stimulating other neurons to release alert neurotransmitters such as dopamine, serotonin, and norepinephrine, and activating orexin neurons, monoaminergic and cholinergic neurons in the hypothalamus/brainstem regions.

This helps to keep us awake and alert for longer periods of time throughout the day.

8. P21

P21 is a heavily modified peptide nootropic that was designed from CNTF antibodies. It works by inhibiting Leukaemia inhibiting factor (LIF), and has been shown to improve neurogenesis, BDNF levels, AMPA receptor protein levels, Phosphorylated GSK3B levels, Ki67 levels, DCX levels, PSD-95, NR1, MAP2, and pCREB.

It has also been shown to improve exploration time and discrimination index in rats with Alzheimer's disease. P21 has been shown to be an effective nootropic when combined with L-theanine and Ampakines, and has been used in studies at dosages of up to 2981 mcg per day for humans. Despite this, there is still no evidence of any side effects.

What are Nootropic Peptides?

Nootropic peptides are the highly functional parts of proteins used to communicate to the cells in our body to improve many functions including processing speed, healing, and decreasing inflammation. These peptides are specifically designed to increase the brain-derived nootropic factor and neuro growth factor. The most common nootropic peptides are Semax, Selank, Cerebrolysin, Dihexa, and FGL.

best nootropic peptides

These peptides have been studied for their potential to improve brain health and cognition. All of these peptides have the potential to improve learning and memory by increasing synaptic function. They can also help to reduce anxiety and depression by regulating neurotransmitters, as well as providing antioxidant protection and reducing inflammation. Additionally, these peptides can have positive effects on the cardiovascular system and metabolic health.

The Benefits of Nootropic Peptides

Nootropic peptides are highly functional parts of proteins which help to improve various functions within the body, such as improving processing speed, healing and decreasing inflammation. These peptides are designed to communicate with cells and improve their performance. Research has shown that many of these peptides can have a variety of positive impacts on the brain, such as improving learning and memory.

Nootropic peptides like Cerebrolysin, Dihexa, Selank, and Semax all work to increase the brain-derived neurotrophic factor (BDNF). This helps to improve synaptic plasticity, which is essential for learning and memory. Additionally, some of these peptides are also known to increase the levels of another peptide, called pinealon. This peptide is known to protect neurons from excitotoxic damage, making it an excellent choice for increasing cognitive functions.

Nootropic peptides may also help to improve focus and concentration. They have been found to increase the levels of acetylcholine, a neurotransmitter that is essential for focus and concentration. Additionally, some of these peptides have been found to reduce the levels of stress hormones in the body, which can help to improve focus and reduce anxiety.

Common Side Effects of Nootropic Peptides

Nootropic peptides are generally considered safe to use, but like any other drug, they can have some side effects. The most common side effects of nootropic peptides include headaches, nausea, dizziness, and fatigue. Nootropic peptides can also increase heart rate and blood pressure and can interact with other medications. Additionally, some nootropic peptides may cause allergic reactions in some people.

It is important to talk to your doctor before taking any nootropic peptide, as they can potentially cause serious side effects. It is also important to check the ingredients of any nootropic supplement you are considering taking and make sure there are no contraindications with any medications you may be taking.

Tips on Choosing the Right Nootropic Peptide

Choosing the right nootropic peptide can be a daunting task, as there are many to choose from. Before deciding which one is right for you, it is important to consider your individual needs and goals. Here are some tips to keep in mind when choosing the right nootropic peptide:

  1. Research the Different Types: It is important to understand the different types of nootropic peptides and their effects on the body before making a decision. This will ensure that you choose a peptide that is suited to your needs and goals.
  2. Consult with Professionals: Consulting with a doctor or pharmacist can help you determine which nootropic peptide is best for you. They can provide advice on potential side effects and interactions with other medications or supplements.
  3. Consider Your Budget: Different nootropic peptides come with different price tags, so it’s important to consider your budget before making a purchase. Do some research to compare prices and determine which peptide is most cost-effective for you.
  4. Read Reviews: Reading reviews from other users of nootropic peptides can help you make an informed decision about which one is best for you. Consider both positive and negative reviews to get a full understanding of the potential benefits and drawbacks of each peptide.

By following these tips, you can make sure that you are choosing the right nootropic peptide for your individual needs and goals.

Conclusion: The Pros and Cons of Nootropic Peptides

Nootropic peptides are a powerful and effective way to enhance cognitive function and improve overall brain health. They have been found to have neuroprotective and nootropic properties, helping improve overall cognitive performance. Although there are some potential side effects associated with these peptides, they are generally considered safe and effective when used properly.

When selecting a nootropic peptide, it is important to consult with a medical professional to ensure that you are taking the right type and dose for your specific needs. With the right information, you can make an informed decision that will help you maximize your cognitive potential.