8 Best Nootropic Peptides for the Brain in 2024 & Where to Buy Them

Updated on January 30, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Exploring nootropic peptides' impact on brain enhancement and purchase sources.

Do you want to maximize your mental performance?

Are you looking for ways to increase focus, alertness, and concentration?

Then look no further than nootropic peptides!

In this review, we’ll cover all the benefits of using these amazing compounds and tell you where to find them.

Best Nootropic Peptides for Cognitive Function, Memory, and Mental Health

  • Semax — Best for improving focus and memory
  • Selank — Best for enhancing cognitive abilities
  • Cerebrolysin — Great for enhancing brain’s executive functions
  • Dihexa — Great for enhancing brain’s synaptic plasticity
  • FGL — Great for aiding repair and growth of neurons
  • PE-22-28 — Best for boosting learning abilities
  • Orexin A — Best for enhancing wakefulness and alertness
  • P21 — Great for improving brain cell health

How to Choose the Best Nootropic Peptides?

Choosing the best nootropic peptides involves understanding several key factors that can impact their effectiveness and compatibility with your cognitive enhancement goals.

FactorDescriptionWhy It’s Important
PurityThe level of contaminants or impurities in the peptide.Ensures safety and efficacy.
SourceThe manufacturer or supplier of the peptide.Reliable sources provide quality assurance.
Mechanism of ActionHow the peptide works in the brain.Matches the peptide with your cognitive needs.
DosageThe amount of peptide to take for desired effects.Prevents overuse and optimizes results.
FormulationThe form in which the peptide is administered.Influences absorption and convenience.
  • Purity: It’s crucial to ensure that the peptides are of high quality and free from harmful contaminants that could negate their nootropic benefits or pose health risks.
  • Source: The credibility and reputation of the supplier can greatly influence the peptide’s quality. Reputable sources often have stringent quality control measures in place.
  • Mechanism of Action: Understanding the specific cognitive processes the peptide targets allows you to choose one that aligns with your particular cognitive enhancement goals.
  • Dosage: Proper dosage is key to achieving the desired nootropic effect without adverse side effects, and can vary based on individual tolerance and the peptide’s potency.
  • Formulation: The form, whether it’s an injectable, nasal spray, or pill, can affect the peptide’s bioavailability and how quickly it takes effect, as well as the ease of use.

The Best Nootropic Peptides of 2024

According our in-depth research and testing, the top nootropic peptides are:

1. Semax

Semax is one of the most popular nootropic peptides. It is a synthetic analog of the naturally occurring neuropeptide ACTH and is used to improve cognitive abilities, memory and overall mental performance. Studies have shown that Semax boosts the production of nerve growth factor and brain-derived neurotrophic factor, both of which are key components in the development and maintenance of healthy neurons.

In addition, Semax has been found to protect against excitotoxic damage, improve learning and memory, and enhance focus and concentration. It is also believed to reduce inflammation in the body and may even be beneficial in treating depression.

2. Selank

Selank is a synthetic peptide that has been used as a treatment for anxiety, depression, and stress. It is derived from the brain-derived neurotrophic factor (BDNF) and is known to act on the nervous system by enhancing its plasticity.

Selank also increases the production of serotonin and gamma-aminobutyric acid (GABA), which are neurotransmitters responsible for regulating mood and anxiety. Studies have shown that Selank can reduce symptoms of generalized anxiety disorder, improve cognitive function, and help with sleep disturbances. Additionally, Selank has been found to be effective in treating social phobia.

3. Cerebrolysin

Cerebrolysin is a peptide derived from cow’s brain. It is used in the treatment of cognitive decline and age-related memory loss. It increases the production of neurotropic factors, which promote the growth of neurons and synapses.

Cerebrolysin can also improve the rate at which neurons are able to communicate with each other. This can lead to improved memory, learning and focus. Cerebrolysin has also been found to reduce anxiety and depression, as well as improve mood.

It is typically taken in doses of 5-10 mL per day, but this will vary depending on the individual’s needs. As with any nootropic, it is important to consult with a doctor before taking Cerebrolysin.

4. Dihexa

Dihexa is a peptide drug that has been developed by researchers from Washington State University to help with cognitive functions related to trauma brain disorders, such as Alzheimer’s Disease. Also known as N-hexanoic-Tyr-ile-(6) aminohexanoic amide and PNB-0408, Dihexa has been found to be seven orders of magnitude more potent than the brain-derived neurotrophic factor, and even ten million times stronger than the BDNF.

Its main function is to relieve and supplement people who are stricken by Alzheimer’s Disease (AD) to slow down the progression of the disease. It is offered in cream form in a 20mg/mL, provided in the form of a transdermal cream, and in capsules in 10 mg and 20 mg oral capsules. The average dose for Dihexa is between 8 and 45 milligrams, which you take orally.

5. FGL

FGL (Fibroblast Growth Factor) is a 15 amino acid peptide synthetically derived from the neural cell adhesion molecule (NCAM). It behaves as a fibroblast growth factor receptor agonist and activates the NCAM-FGFR signaling pathway, which is believed to have memory and cognition-enhancing effects.

FGL is thought to improve healing of neuronal tissues by decreasing oxidative stress-induced cell death, inhibiting neuronal degeneration and death, and stimulating activity-dependent delivery of glutamate receptors to synapses. FGL has also been shown to increase neurite outgrowth, synaptic transmission, and the formation of new synapses, making it a pharmacological cognitive enhancer.

6. PE-22-28

PE-22-28 is a peptide that has been shown to have a number of nootropic benefits, including improved cognitive performance, increased focus and concentration, enhanced memory, improved decision-making, and even improved mood. Studies have shown that PE-22-28 can help reduce anxiety and depression and can also increase dopamine levels in the brain.

This peptide can also help protect against neurological diseases such as Alzheimer’s and Parkinson’s. It may also increase the plasticity of the brain, which can help with learning and memory.

PE-22-28 has several nootropic benefits that can help improve cognitive performance and overall brain health.

7. Orexin A

Orexin A (also known as hypocretin-1) is a 33-amino-acid long neuropeptide that is located in the lateral hypothamalus of your brain and can be used to sustain wakefulness for longer periods of time throughout the day without feeling tired. Emerging research suggests that it can be a potent therapy for narcolepsy, as well as a way to enhance mental performance.

Orexin A helps to maintain alertness by stimulating other neurons to release alert neurotransmitters such as dopamine, serotonin, and norepinephrine, and activating orexin neurons, monoaminergic and cholinergic neurons in the hypothalamus/brainstem regions.

This helps to keep us awake and alert for longer periods of time throughout the day.

8. P21

P21 is a heavily modified peptide nootropic that was designed from CNTF antibodies. It works by inhibiting Leukaemia inhibiting factor (LIF), and has been shown to improve neurogenesis, BDNF levels, AMPA receptor protein levels, Phosphorylated GSK3B levels, Ki67 levels, DCX levels, PSD-95, NR1, MAP2, and pCREB.

It has also been shown to improve exploration time and discrimination index in rats with Alzheimer’s disease. P21 has been shown to be an effective nootropic when combined with L-theanine and Ampakines, and has been used in studies at dosages of up to 2981 mcg per day for humans. Despite this, there is still no evidence of any side effects.

What are Nootropic Peptides?

Nootropic peptides are the highly functional parts of proteins used to communicate to the cells in our body to improve many functions including processing speed, healing, and decreasing inflammation. These peptides are specifically designed to increase the brain-derived nootropic factor and neuro growth factor. The most common nootropic peptides are Semax, Selank, Cerebrolysin, Dihexa, and FGL.

These peptides have been studied for their potential to improve brain health and cognition. All of these peptides have the potential to improve learning and memory by increasing synaptic function. They can also help to reduce anxiety and depression by regulating neurotransmitters, as well as providing antioxidant protection and reducing inflammation. Additionally, these peptides can have positive effects on the cardiovascular system and metabolic health.

The Benefits of Nootropic Peptides

Nootropic peptides are highly functional parts of proteins which help to improve various functions within the body, such as improving processing speed, healing and decreasing inflammation. These peptides are designed to communicate with cells and improve their performance. Research has shown that many of these peptides can have a variety of positive impacts on the brain, such as improving learning and memory.

Nootropic peptides like Cerebrolysin, Dihexa, Selank, and Semax all work to increase the brain-derived neurotrophic factor (BDNF). This helps to improve synaptic plasticity, which is essential for learning and memory. Additionally, some of these peptides are also known to increase the levels of another peptide, called pinealon. This peptide is known to protect neurons from excitotoxic damage, making it an excellent choice for increasing cognitive functions.

Nootropic peptides may also help to improve focus and concentration. They have been found to increase the levels of acetylcholine, a neurotransmitter that is essential for focus and concentration. Additionally, some of these peptides have been found to reduce the levels of stress hormones in the body, which can help to improve focus and reduce anxiety.

Common Side Effects of Nootropic Peptides

Nootropic peptides are generally considered safe to use, but like any other drug, they can have some side effects. The most common side effects of nootropic peptides include headaches, nausea, dizziness, and fatigue. Nootropic peptides can also increase heart rate and blood pressure and can interact with other medications. Additionally, some nootropic peptides may cause allergic reactions in some people.

It is important to talk to your doctor before taking any nootropic peptide, as they can potentially cause serious side effects. It is also important to check the ingredients of any nootropic supplement you are considering taking and make sure there are no contraindications with any medications you may be taking.

What to Consider Before Buying Nootropic Peptides?

Before you decide to purchase nootropic peptides, it’s important to evaluate several aspects to ensure you’re making an informed decision that aligns with your cognitive enhancement strategy.

1. Personal Cognitive Needs

Before buying nootropic peptides, assess your specific cognitive needs. Are you seeking to improve memory, focus, or perhaps enhance creativity? Different peptides have unique profiles and mechanisms of action that cater to various cognitive functions.

2. Potential Interactions

Consider any medications or supplements you are currently taking, as nootropic peptides could interact with them. This includes over-the-counter drugs, prescription medications, and even certain foods or drinks that might influence the efficacy or safety of the peptide.

3. Long-Term Goals

Reflect on your long-term cognitive enhancement goals. Are you looking for a temporary boost or sustained improvement? Some peptides may offer quick benefits, while others could support long-term neuroplasticity and brain health.

Research the legal status of the nootropic peptides you’re interested in. The regulatory environment varies by region and can change, so it’s important to stay informed. Additionally, consider ethical implications, such as fair competition in academic or professional settings.

5. Lifestyle Compatibility

Finally, think about how incorporating nootropic peptides into your routine will align with your lifestyle. This includes considering the method of administration, frequency of dosing, and any necessary storage conditions for the peptides.

Nootropic Peptides in Summary

Nootropic peptides are a powerful and effective way to enhance cognitive function and improve overall brain health. They have been found to have neuroprotective and nootropic properties, helping improve overall cognitive performance. Although there are some potential side effects associated with these peptides, they are generally considered safe and effective when used properly.

When selecting a nootropic peptide, it is important to consult with a medical professional to ensure that you are taking the right type and dose for your specific needs. With the right information, you can make an informed decision that will help you maximize your cognitive potential.