10 Best Nootropics for Anxiety (That Calm You Down Fast)

Updated on January 20, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

When we go through all kinds of struggles, we feel anxious; thus, some tend to resort to using the best nootropics for anxiety.

Anxiety could make us feel down and low. It is a common emotional condition.

At some point, we all feel fear when speaking in front of people.

We fear being judged, and overthinking about it, we become stressed.

It’s natural.

However, if these anxiety symptoms affect you so much that you can’t live a normal life, maybe you should do something about it.

Like, use nootropics for anxiety, perhaps?

Nootropics for anxiety specifically target generalized and social anxiety disorders by calming the brain to focus on better performance. Numerous benefits that improve brain function also come with these nootropics for social anxiety and generalized anxiety.

According to scientific studies and customer reviews, the 10 best nootropics for anxiety are:

1. NooCube

NooCube is a synergy of vitamins and amino acid ingredients that help improve mental energy, which is greatly affected by social anxiety. It enhances cognitive function, especially focus, alertness, memory, multitasking ability, and communication skills, by boosting the production of neurotransmitters such as acetylcholine, glutamate, dopamine, and serotonin.

Increased mental functions such as multitasking and concentration can avoid panic attacks and even elevate mood.

Some ingredients of NooCube that make all these effects possible are Alpha GPC (Alpha glycerylphosphorylcholine) that increases the neurotransmitter acetylcholine production. Huperzine A protects the acetylcholine from being broken down, and Bacopa Monnieri helps boost the production and growth of new neurons while repairing damaged ones.

2. Mind Lab Pro

Mind Lab Pro, also known as “social nootropics,” is a supplement that improves memory, focus, calmness, motivation, and many other cognitive functions. It is a plausible drug to treat, cure or prevent anxiety and stress symptoms because it can moderate cortisol levels, which can trigger stress and anxiety. Professional poker player David Williams is named as an ambassador of this nootropics.

Rhodiola Rosea, Bacopa monnieri, Phosphatidylserine, B Vitamins, and its other ingredients make Mind Lab Pro an effective anti-anxiety nootropic. Rhodiola Rosea is an adaptogen, and studies show that it effectively alleviates anxiety, depression, and stress. Bacopa monnieri is also an adaptogen that helps balance mood when facing stressful circumstances, and after prolonged use, can reduce anxiety symptoms.

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Mind Lab Pro is one of the most popular nootropics, and director David Wright stated that the terms memory pill and brain supplement are now starting to “sound flat and dated.”

Phosphatidylserine soothes social anxiety by reducing cortisol levels that contribute to high blood pressure and eventually social anxiety symptoms. Lastly, studies have stated that B Vitamins might help relieve anxiety and stress by reducing salivary cortisol secretion and keeping the cerebral healthy.

3. Brain Pill

Brain pill is a natural supplement that enhances cognitive performance by improving blood flow in the brain cells. Thus, the mind will calm down, and onsets of panic attacks, anxiety, and depression can be prevented. This substance helps brain fog, learning quickly, alertness, brain nutrition, and multitasking.

It contains Ginkgo Biloba, which prevents brain aging and expands the blood vessels for a better pathway for oxygen and other ingredients of the nootropic. It also has Cognizin, which improves metabolism and acetylcholine neurotransmitter production, leading to enhancement of brain health by as much as 15%.

L-Theanine, another ingredient, minimizes the level of anxiety by increasing GABA (gamma-Aminobutyric acid), a chief inhibitory neurotransmitter.

4. Performance Lab Mind

Performance Lab Mind increases the brain’s blood flow, which helps manifest its ingredients’ effects and benefits. These include improved memory, mood, alertness, and many other mental and body processes. It promotes a clearer mind, which can even positively affect your stress and anxiety. Performance Lab Mind has four primary natural ingredients.

Citicoline improves the mental energy and production of the chemical phosphatidylcholine needed to produce memory. Phosphatidylserine helps release neurotransmitters and contains DHA or Omega-3 fatty acids vital for cerebral health and regulating mood for managing stress and anxiety. L-Tyrosine can improve overall orientation, mood, and memory. Lastly, Maritime Pine Bark Extract improves focus, mood, and decision-making ability.

5. Qualia Mind

By supporting the health of neural pathways, Qualia Mind is effective in improving cerebral function. It is an anti-stress and anti-anxiety supplement because it helps you have a clearer mind and prevent panic attacks from happening. With its ability to boost dopamine production, it can lift your mood, improving depression and anxiety disorder.

Qualia Mind has Theobromine that increases alertness and lowers blood, which can help manage anxiety disorders. It also has Phosphatidylserine and B Vitamins that manage cortisol levels, DHA that helps regulate your mood, and several other ingredients that can improve cognitive function.

6. Alpha Brain

Alpha Brain is a type of nootropics for social anxiety and depression that can also improve memory, focus, and alertness. This kind of nootropics works by boosting the alpha waves. Research has shown that an increase in alpha waves might reduce anxiety and depression and improve creativity.

This substance contains ingredients like GPC, which the body transforms into acetylcholine, and Alpha GPC. Also, Oat Straw, a nootropic used to treat a person in holistic healing, is said to relieve anxiety, depression, and stress.

7. L-Theanine

A nootropic commonly found in green tea, L-Theanine promotes relaxation and improves alertness with increased dopamine, serotonin, and GABA. When combined with caffeine, your reaction time will increase, including your memory, and there is a reduction in fatigue.

Research has shown that L-Theanine can reduce symptoms of anxiety, such as increased heart rate and secretion of immunoglobulin A in saliva. However, it cannot be considered a prescription drug, even if it is similar to a sedative.

Studies stated that this substance is effective in improving sleep quality and anxiety if combined with antipsychotic treatment. For those experiencing depression, this type of nootropics is said to relieve the effects of anxiety and depression.

8. L-Tyrosine

L-Tyrosine is a kind of nootropic that prevents you from getting burnout even if stress is present. Stress exhausts your neurotransmitters, and with a low level of them, especially norepinephrine, the effect will be mental and body exhaustion.

This nootropic helps produce norepinephrine, ease stress, and improve attentiveness. It makes you feel alert without making you anxious, which is essential for those experiencing social anxiety.

9. Nicotine

A nootropic found in herbs, Nicotine, may be commonly known as one of the harmful nootropics, but with a small amount, it can improve your confidence and mentality. It also enhances short-term memory and reaction time. Nicotine’s most prevalent effect is immediate relaxation; that’s why it is used in various products like cigarettes and tobacco.

However, the food and drug administration does not recommend their use due to health reasons. Instead, you can use a spray that will give you enough amount that you will need to face your social anxiety.

10. Theacrine

Theacrine works similarly to caffeine, even at the molecular level. It keeps you awake and alert because of its structure that binds to the adenosine receptors. These receptors will be tricked into thinking that adenosine, the one that makes you sleepy, is bound to them when in fact, it is Theacrine. But why Theacrine instead of Caffeine?

This supplement does not make you jittery - it is helpful for those who have social anxiety because being jittery is a symptom of this disorder. According to Sheng et al. (2020), Theacrine also does not build tolerance, unlike caffeine.

Side Effects & Safety

These nootropics include safe ingredients that is why they contain little to no side effects. As of now, there have been no recent posts or reports indicating adverse effects experienced by consumers.

However, these nootropics are not intended to diagnose, treat, cure and completely prevent generalized and social anxiety. But they do stand as an alternative medicine to avoid negative aftereffects brought by pharmaceuticals.

Even if they do not pose any known risk within the recommended dosage, do not take past the dosage limit because they “may potentially be dangerous and deleterious to the human brain,” says Talih et al. (2015).


Nootropics for anxiety contain safe ingredients that work by crossing the blood-brain barrier to ease stress, depression, and anxiety. Most of these supplements do not only target anxiety but also other functions, contributing to a healthier mind. Many people experience anxiety, and it is high time to battle its effects.

This list of best nootropics for anxiety may give you the necessary ingredients and products you might need to help you take your stand against anxiety.