7 Best Nootropics for Bipolar Disorder 2024

Updated on January 29, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Exploring the impact of nootropics on bipolar disorder through neural enhancement.

Are you searching for ways to manage the cognitive challenges associated with bipolar disorder?

Navigating the world of nootropics can be daunting, especially when seeking safe and effective options for a condition as complex as bipolar disorder.

In this comprehensive article, we’ve leveraged the insights of Jacob Kovacs, a seasoned neuroscientist and nootropic specialist, along with our dedicated team of scientists, to provide you with well-researched recommendations.

Our independent researchers have meticulously evaluated each nootropic’s scientific backing, ensuring that the products we discuss are not only promising in theory but have shown real-world efficacy.

Join us as we explore the best nootropics for bipolar disorder, aiming to enhance your mental clarity and stability with the most credible, scientifically-supported options available.

Best Nootropic for Bipolar Disorder

  • Qualia Mind — Best for overall mental health and wellness
  • Lithium — Best against depressive and pessimistic thoughts
  • 5-HTP — Best to avoid depressive episodes
  • Omega-3 Fatty Acids — Great dietary supplement for overall brain health
  • Phenibut — Best for reducing anxiety and promoting relaxation
  • Uridine — Great for boosting memory and learning abilities
  • N-Acetyl-Cysteine — Best to protect cells from oxidative damage and reduce stress

How to Choose the Best Nootropics for Bipolar Disorder?

When selecting the best nootropics for bipolar disorder, it’s crucial to consider factors that ensure safety, efficacy, and compatibility with your individual health profile.

FactorDescriptionWhy It’s Important
Ingredient SafetyThe safety profile of each nootropic ingredient.Ensures that the nootropic will not cause adverse effects or exacerbate bipolar symptoms.
Scientific EvidenceResearch and clinical studies supporting the use of nootropics for bipolar disorder.Provides assurance that the nootropic has a basis in scientific research for efficacy in bipolar disorder management.
Interaction with MedicationsPotential interactions with prescription medications for bipolar disorder.Prevents negative interactions that could compromise the effectiveness of bipolar disorder treatments.
Side Effect ProfileThe likelihood and severity of potential side effects from the nootropic.Minimizes the risk of adverse reactions that could affect overall well-being and treatment adherence.
Manufacturer ReputationThe credibility and track record of the nootropic manufacturer.Increases confidence in the quality and purity of the nootropic product.
  • Ingredient Safety: It’s imperative to choose nootropics with a proven safety record, particularly for individuals with bipolar disorder, to avoid triggering mood episodes or other health complications.
  • Scientific Evidence: Select nootropics that have been backed by clinical trials and scientific studies, ensuring their potential effectiveness in managing bipolar disorder symptoms.
  • Interaction with Medications: Always evaluate the likelihood of nootropics interacting with current medications, as such interactions could negate the benefits of both the nootropics and the prescribed treatments.
  • Side Effect Profile: Consider the side effect profile of nootropics—opt for those with minimal and manageable side effects to maintain a high quality of life during supplementation.
  • Manufacturer Reputation: Research the manufacturer’s reputation for producing high-quality, reliable nootropic supplements to ensure you’re getting a product that’s as effective and safe as advertised.

The Best Nootropics for Bipolar Disorder of 2024

According to our in-depth research and testing, the best nootropics for bipolar disoder are:

1. Qualia Mind

Qualia Mind is an innovative cognitive enhancement supplement that has gained popularity for its ability to boost brain function and support mental performance. Developed by the experts at Neurohacker Collective, Qualia Mind is formulated with a blend of high-quality ingredients that have been scientifically researched and proven to enhance cognition. It is one of the most advanced nootropic stacks available on the market today.

What sets Qualia Mind apart is its commitment to providing a clean formula, free from toxic fillers, artificial colors, flavors, and preservatives. This makes it a safe and reliable option for individuals looking to improve their mental clarity, focus, and memory.


  • Enhances cognitive performance and overall mental wellness
  • Supports brain health and neurogenesis
  • Boosts mood and motivation
  • Improves memory and learning
  • Increases focus and attention


  • May not be suitable for individuals with certain medical conditions or taking specific medications
  • Some users may experience digestive discomfort or headaches
  • Requires taking multiple capsules per serving, which may be inconvenient for some individuals

If you’re looking to improve your cognitive function and boost your mood, Qualia Mind might be the ideal choice for you. Its science-centered formulation and carefully sourced ingredients make it a top contender in the world of nootropics. Give your brain the nourishment it craves and experience the powerful mood support Qualia Mind has to offer.

2. Lithium

Lithium is often associated with bipolar disorder, but it is gaining recognition as a beneficial nootropic for mood enhancement and overall brain health. Contrary to popular belief, lithium is a naturally occurring trace element found in nature and even in some foods. In low doses, lithium has a neuroprotective effect and acts as a mood enhancer, making it a valuable tool in modern psychiatry. Studies have shown that it reduces impulsivity, irritability, and suicidal thoughts in individuals with depression.(1) It is also known to induce the formation of brain cells, particularly in adults over 55 years old. Additionally, lithium has been linked to lower rates of suicide and violence in communities with higher levels of lithium in the groundwater.


  • Supports mood stability and mental well-being
  • Enhances cognitive function and memory
  • Promotes neuroprotection and brain health
  • Helps reduce symptoms of depression and anxiety
  • Plays a role in maintaining overall emotional balance


  • Requires careful dosing and monitoring due to potential toxicity at higher levels
  • Not suitable for individuals with kidney or heart problems
  • Possible side effects can include nausea, tremors, and drowsiness

It is important to note that when used as a supplement, the dosage of lithium is much lower than what is prescribed for bipolar disorder. Overall, lithium offers a safe and natural option for enhancing mood and promoting cognitive performance.

3. 5-HTP

5-HTP is a natural supplement that offers benefits for individuals with bipolar disorder. As a precursor to serotonin, a neurotransmitter that plays a role in mood regulation, 5-HTP increases serotonin levels and influences mood patterns. Some studies have shown that 5-HTP helps regulate mood and emotions, and alleviates symptoms of depression and anxiety.(2)

It’s important to consult with a healthcare professional before taking 5-HTP or any other supplements, as they can have potential side effects and may interact with other medications. It’s also crucial to note that 5-HTP alone is not a substitute for prescribed bipolar medications, and it should be used as an adjunct treatment under medical supervision.


  • Boosts serotonin levels, promoting mood regulation and a sense of well-being
  • Supports better sleep quality and regulates sleep patterns
  • Helps relieve anxiety
  • Supports cognitive function, including memory and learning
  • Helps with appetite control and weight management


  • May interact with certain medications, particularly those affecting serotonin levels
  • Can cause digestive issues such as nausea or stomach discomfort
  • May not be suitable for pregnant or breastfeeding women

Incorporating 5-HTP into a comprehensive treatment plan that includes therapy and medication would be beneficial in managing bipolar disorder symptoms, but further research is needed to fully understand its efficacy.

4. Omega-3 Fatty Acids

Omega-3 fatty acids have shown promising results in improving mood disorders such as bipolar disorder. These essential fatty acids, primarily found in fish oil and marine algae, have been studied extensively for their potential to prevent and treat depression and other mood disorders.

Omega-3s easily penetrate the brain cell membrane and interact with mood-related molecules, leading to improved mood stability.(3) Additionally, Omega-3s have anti-inflammatory actions, that help reduce symptoms of depression. Multiple clinical trials have examined the efficacy of omega-3 supplementation in people with depression, with most studies using omega-3s as an add-on therapy for those already taking antidepressants.(4)

While the results of these studies have been generally positive, there is some variability in the findings due to factors such as dose, ratio of EPA to DHA, and study design. However, meta-analyses suggest that omega-3s, particularly preparations with at least 60% EPA, are effective in improving mood disorders.


  • Essential for brain health and function
  • Promotes a healthy heart and cardiovascular system
  • Reduces inflammation in the body and supports joint health
  • Plays a role in maintaining overall mental well-being


  • May interact with certain blood-thinning medications
  • Not suitable for individuals with fish or shellfish allergies
  • High doses may increase the risk of bleeding

It is important to note that omega-3 supplementation should not replace traditional therapy for bipolar disorder, and individuals should always consult with their healthcare provider before starting any new treatment. Omega-3s are a promising natural option for improving mood disorders, but further research is needed to fully understand their mechanisms of action and long-term safety.

5. Phenibut

Phenibut is a nootropic supplement that is known for its ability to relieve anxiety, reduce stress, and improve mood. Derived from GABA, an inhibitory neurotransmitter, Phenibut works by reducing the overactivity of excitatory neurotransmitters in the brain. This helps to create a sense of calmness and relaxation, leading to an improved mood.

One of the main benefits of Phenibut is its anxiolytic properties. It helps to alleviate feelings of anxiety and fear by reducing the levels of stress-inducing neurotransmitters in the brain.(5) This is particularly beneficial for individuals who struggle with social anxiety or other anxiety-related disorders.

Another advantage of Phenibut is its ability to increase dopamine concentrations in the brain. Dopamine is a neurotransmitter that is associated with feelings of reward and motivation. By boosting dopamine levels, Phenibut enhances mood, energy, and motivation.


  • Promotes relaxation, calm state of mind and stress reduction
  • Enhances focus, mood, and sociability
  • Improves sleep quality and helps with insomnia


  • High potential for tolerance, dependency, and withdrawal symptoms
  • Not recommended for individuals with liver or kidney problems

It’s important to note that Phenibut should be used sparingly and not on a daily basis, as it can lead to dependency and withdrawal symptoms. It is always recommended to speak to a healthcare professional before starting any new supplement regimen.

6. Uridine

Uridine is a naturally occurring compound that has shown potential as a nootropic for bipolar disorder. It is a nucleotide base that is involved in the synthesis of RNA and plays a crucial role in various brain functions. Studies have suggested that uridine helps improve mood and alleviate symptoms associated with bipolar disorder. 

Uridine works by increasing the availability of dopamine and serotonin in the brain. These neurotransmitters play a key role in regulating mood and emotions. By enhancing their levels, uridine uplifts the mood and reduces symptoms of depression that are commonly experienced by individuals with bipolar disorder.(6)

Uridine has been found to have neuroprotective properties, meaning it helps protect brain cells from damage and maintain their function. This is particularly beneficial for individuals with bipolar disorder, as the condition is associated with cognitive decline and memory impairment.


  • Supports memory formation
  • Enhances neuroplasticity and synaptic connections in the brain
  • Boosts mental energy and focus
  • Plays a role in brain development


  • Some individuals may experience mild digestive discomfort
  • Not recommended for pregnant or breastfeeding women

While more research is needed to fully understand the effects of uridine on bipolar disorder, it shows promise as a natural supplement that supports overall brain health and improves mood. It is important to note that uridine should be used with therapy and medication prescribed by a healthcare professional, as it is not a substitute for professional treatment.

7. N-Acetylcysteine

N-Acetylcysteine (NAC) is a powerful antioxidant that has shown the potential for treating serious cognitive disorders like schizophrenia, bipolar disorder, severe depression, and anxiety. It acts by boosting glutathione and dopamine levels in the brain, reducing oxidative stress, and eliminating free radicals. NAC has neuroprotective properties that help reduce inflammation, oxidative damage, and modulate glutamate levels.(7) This positively impacts cognition, memory, and mood.

Many neurohackers have found that supplementing with NAC help improve their overall brain health and functioning. Its benefits include boosting cognitive performance, alleviating symptoms related to bipolar disorder, repairing traumatic brain injuries, and even improving symptoms related to chronic obstructive lung disease.(8) NAC is available in the form of capsules or tablets, and the recommended dosage is 500 mg, taken three times a day.


  • Has powerful antioxidant with neuroprotective properties
  • Boosts glutathione and dopamine levels in the brain
  • Reduces oxidative stress and eliminates free radicals
  • Helps improve cognitive performance and memory
  • Alleviates symptoms related to bipolar disorder and other cognitive disorders


  • May cause side effects such as nausea, diarrhea, or constipation in some people
  • Effectiveness may vary depending on individual response

It is safe and well-tolerated, besides some rare and minor side effects. Overall, NAC is a natural and effective way to support brain health and manage the symptoms of mood disorders.

How Do Nootropic for Bipolar Disorder Work?

Nootropics for Bipolar Disorder work by targeting various aspects of brain function to alleviate symptoms and improve overall mood. These supplements contain ingredients that have been scientifically studied and shown to have positive effects on cognitive function and mental well-being. For example, ingredients like Phosphatidylserine increases dopamine levels, helping improve mood and motivation. Lion’s Mane Mushroom increases serotonin levels and reduces anxiety and depression.

These nootropics work by supporting neurotransmitter balance, reducing inflammation, and providing essential nutrients for brain health. By addressing these underlying factors, they help stabilize mood, reduce symptoms of bipolar disorder, and enhance overall cognitive function. It is important to note that nootropics should not be considered a substitute for professional help, and therapy and medication remain the most reliable ways to manage bipolar disorder. However, for some individuals, these supplements can provide additional support and improve certain aspects associated with bipolar disorder.

What to Consider Before Buying Nootropics for Bipolar Disorder?

Before investing in nootropics for bipolar disorder, there are several key aspects to take into account to ensure that your choice aligns with your health goals and treatment plan.

1. Compatibility with Bipolar Disorder Management

Before adding any nootropic to your regimen, it is crucial to ensure that it complements your existing bipolar disorder management strategy. Consider how the nootropic might influence your mood cycles and symptom severity and whether it is intended for supportive use alongside conventional treatments.

2. Long-Term Sustainability

Evaluate the long-term sustainability of using nootropics, including the cost, the potential need for ongoing dosage adjustments, and the nootropic’s availability. It’s important to choose an option that you can realistically maintain over time to manage your bipolar disorder.

3. Risk of Dependency and Tolerance

Some nootropics carry a risk of dependency or tolerance, especially those affecting neurotransmitter levels directly. Assess this risk by researching the nootropic thoroughly and discussing it with your healthcare provider to prevent potential issues down the line.

4. Professional Healthcare Advice

While nootropics may offer supportive benefits for bipolar disorder, they are not a replacement for professional healthcare advice or treatment. It is essential to consult with a healthcare provider who understands your medical history and can guide you on the safe use of nootropics as part of your treatment plan.

5. Realistic Expectations

Set realistic expectations for what nootropics can achieve in the context of bipolar disorder. Understand that while they may provide cognitive support and mood stabilization, they are not a cure and should be viewed as one component of a comprehensive treatment approach.

How We Picked the Top Nootropics for Bipolar Disorder

Our selection of the best nootropics for bipolar disorder relied on a comprehensive review process. We evaluated factors like effectiveness, ingredient composition, brand credibility, transparency, manufacturing approach, consumer feedback, price, and value. All these elements were thoroughly analyzed to provide readers with a reliable list of the top nootropics for bipolar disorder.


We dived into clinical studies and user experiences to evaluate their impact on mood stability, cognitive function, and overall quality of life in bipolar disorder patients.


Each product’s formula was meticulously scrutinized, emphasizing on scientifically supported, natural, and high-grade ingredients that help manage bipolar disorder symptoms.

Scientific Evidence

We referred to peer-reviewed research and systematic reviews to validate the effectiveness of key ingredients in managing bipolar disorder.


We evaluated the recommended dosages and ingredient proportions, verifying they are in line with existing research for optimal results.


We ensured the safety of every ingredient, considering potential side effects and interactions, especially in the context of bipolar medication. Preference was given to ingredients approved by the FDA.

Brand Reputation

We assessed brand credibility and reliability based on customer reviews, expert endorsements, and the company’s track record.

Product Transparency

We appreciated full disclosure of ingredients, including their sources and amounts, promoting informed consumer choices.

Manufacturing Process

We investigated manufacturing standards, giving priority to products made in certified facilities adhering to Good Manufacturing Practices (GMP).

User Reviews

We sifted through real customer feedback, particularly testimonials highlighting improved mood stability and cognitive function.


We compared product prices, ensuring they are fair and commensurate with the quality and effectiveness of the nootropic.


We reviewed overall value, taking into account the balance of price, quality, and effectiveness to assure the best return on investment.

Nootropics for Bipolar Disorder in Summary

For individuals seeking alternative methods to manage bipolar disorder symptoms, incorporating certain nootropics into their treatment plan may offer potential benefits. Nootropics can be used to ease symptoms of mental disorders including bipolar disorder or schizophrenia. The best nootropics for bipolar disorder discussed in this blog post have shown promise in uplifting mood and improving overall well-being.

Qualia Mind stands out as a cutting-edge cognitive enhancement supplement that supports mental performance and provides a clean, science-centered formulation. Lithium, despite its association with bipolar disorder medication, offers a natural option for mood enhancement and brain health. 5-HTP, as a precursor to serotonin, has potential in regulating mood patterns, but further research is needed. Omega-3 fatty acids, particularly those high in EPA, show promise in improving mood disorders and have multiple mechanisms of action.

Phenibut, while effective for anxiety and mood improvement, should be used sparingly and under professional guidance to avoid dependency. Uridine has shown potential in improving mood and alleviating bipolar disorder symptoms, but it should be used in conjunction with therapy and medication. N-Acetylcysteine, a powerful antioxidant, positively impacts cognition, memory, and mood, and it has been found effective in managing symptoms of bipolar disorder.

It’s important to note that while these nootropics can provide additional support, they should not replace professional help, therapy, or medication. The effectiveness and safety of each individual’s treatment plan may vary, so it is crucial to consult with healthcare professionals before starting any new supplements. With the right approach and guidance, these nootropics may offer individuals with bipolar disorder a path towards improved mood stability, cognitive function, and overall well-being.

FAQs About Bipolar Disorder

Are there any side effects of using these nootropics?

Based on our testing, none of our testers reported any significant side effects from using these nootropics. However, it’s always recommended to consult with a healthcare professional before starting any new supplement regimen.

Can nootropics be paired with natural remedies to help in treating bipolar disorder?

There are several treatment options for bipolar disorder including medication for bipolar disorder, natural remedies, and alternative treatments. Prescription drugs such as lamotrigine and lithium orotate are recommended for people with bipolar disorder. Supplements may also help uplift mood, such as amino acids and fish oil supplements. Alternative treatments may help in managing the symptoms of bipolar disorder. Some alternative treatments for bipolar disorder include meditation, yoga, and acupuncture. However, it’s important to consult with a healthcare professional before using alternative treatments, as they may cause manic episodes or interact with medication for bipolar disorder.

Can nootropics cure bipolar disorder?

There is no cure for bipolar disorder, but there are several treatments available to manage the symptoms of the disorder. It’s important for patients with bipolar disorder to work closely with a healthcare professional to find the best treatment plan for their individual needs.

Can I take nootropics if I have other health conditions besides bipolar disorder?

Your ability to take nootropics will depend on your specific health conditions and medications. Always consult with your healthcare provider before starting any new supplements.

Can I build a tolerance to nootropics for bipolar disorder?

Depending on the specific nootropic, it’s possible to develop a tolerance over time. Regular breaks from use can help prevent this.

Sources, Studies, and Scientific Research
  1. Bergamelli, Emilio, et al. “The Impact of Lithium on Brain Function in Bipolar Disorder: An Updated Review of Functional Magnetic Resonance Imaging Studies.” CNS drugs 35.12 (2021): 1275-1287. ↩
  2. Maffei, Massimo E. “5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology.” International journal of molecular sciences vol. 22,1 181. 26 Dec. 2020, doi:10.3390/ijms22010181 ↩
  3. Bloch, M H, and J Hannestad. “Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis.” Molecular psychiatry vol. 17,12 (2012): 1272-82. doi:10.1038/mp.2011.100 ↩
  4. Marangell, Lauren B et al. “Omega-3 fatty acids in bipolar disorder: clinical and research considerations.” Prostaglandins, leukotrienes, and essential fatty acids vol. 75,4-5 (2006): 315-21. doi:10.1016/j.plefa.2006.07.008 ↩
  5. Mun, Monique, and Andrew Wong. “Kratom and phenibut: a concise review for psychiatric trainees.” American Journal of Psychiatry Residents’ Journal (2020). ↩
  6. Agarwal, Nivedita, et al. “Short‐term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31‐phosphorus magnetic resonance spectroscopy study at 4T.” Bipolar disorders 12.8 (2010): 825-833. ↩
  7. Nery, Fabiano G et al. “N-acetylcysteine as an adjunctive treatment for bipolar depression: A systematic review and meta-analysis of randomized controlled trials.” Bipolar disorders vol. 23,7 (2021): 707-714. doi:10.1111/bdi.13039 ↩
  8. Dean, Olivia et al. “N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action.” Journal of psychiatry & neuroscience : JPN vol. 36,2 (2011): 78-86. doi:10.1503/jpn.100057 ↩