5 Best Nootropics for Migraines & Headaches 2024 (That Really Work)

Updated on February 11, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Effective nootropic solutions for migraines and headaches explored in an article.

What are the best nootropics for headaches and migraines?

If you suffer from migraines, you know how debilitating they can be. The throbbing pain, sensitivity to light and sound, and nausea can significantly impact your daily life.

While there are various treatments available for migraines, one alternative approach that has gained popularity is the use of nootropics. Nootropics are substances that enhance cognitive function, and some have been found to have potential benefits for managing migraines.

In this article, we’ll explore the best nootropics for migraines that really work.

Best Nootropics for Migraines

  • Mind Lab Pro — Best supplement for migraine headaches
  • Vyvamind — Best nootropic stack for brain cell health
  • Magnesium — Greatly effective treatment for headache disorders
  • Melatonin — Great for regulating sleep cycle
  • Caffeine — Great for reducing the frequency of migraine

How to Choose the Best Nootropics for Migraines?

Choosing nootropics for migraines involves understanding their effects and ensuring quality. Safety, effectiveness, and personalized needs are key considerations.

  • Efficacy for Migraine Relief: Select nootropics with a proven track record in reducing migraine frequency or severity.
  • Scientific Research: Look for substances backed by clinical studies demonstrating benefits for migraine sufferers.
  • Safety Profile: Choose nootropics with minimal side effects and low toxicity levels.
  • Mechanism of Action: Understand how the nootropic works, ensuring it targets pathways relevant to migraines, such as cerebral blood flow or neurotransmitter modulation.
  • Dosage and Administration: Opt for nootropics with clear dosage guidelines that align with your needs and medical advice.
  • Potential Interactions: Check for interactions with current medications or other supplements you’re taking.
  • Formulation Quality: Prefer products from reputable manufacturers that provide pure, high-quality ingredients without unnecessary fillers or additives.
  • Personal Health Conditions: Consider your overall health, as some nootropics may not be suitable if you have certain conditions besides migraines.
  • Cost and Accessibility: Evaluate whether the cost is reasonable and if the product is readily available for purchase.
  • User Reviews and Testimonials: Read experiences from other migraine sufferers who have used the nootropics to gauge effectiveness and tolerability.
Factor to ConsiderDescriptionWhy It’s Important
IngredientsLook for nootropics with proven ingredients like magnesium, riboflavin (B2), and Coenzyme Q10.These ingredients have shown potential in reducing migraine frequency and severity.
Side EffectsConsider the potential side effects of each nootropic, as some may cause adverse reactions.To avoid exacerbating migraine symptoms or causing additional health issues.
DosageCheck the recommended dosage and ensure it aligns with clinical studies or expert recommendations.Proper dosage is crucial for efficacy and safety.
Formulation QualityChoose nootropics from reputable brands that use high-quality, pure ingredients and have good manufacturing practices.Ensures that the product is safe and contains what it claims to.
CostCompare the cost of different nootropics to find one that offers good value for money.To ensure the treatment is sustainable over time without financial strain.
Reviews and TestimonialsRead reviews and testimonials from other migraine sufferers who have used the nootropics.Provides insight into the real-world effectiveness of the product.
Physician’s OpinionConsult with a healthcare provider before starting any new supplement regimen.A physician can provide personalized advice based on your health history and current medications.
Clinical EvidenceResearch the level of clinical evidence supporting the use of the nootropic for migraines.To ensure that the product’s claims are backed by scientific research.
Interaction with MedicationsBe aware of any potential interactions with current medications you are taking.To prevent negative interactions that could worsen migraines or cause other health issues.
AccessibilityConsider how easy it is to purchase the nootropic, whether it requires a prescription, and if it is available in your region.Convenience and accessibility can affect long-term adherence to a treatment plan.

The Best Nootropics for Migraines of 2024

According to our extensive research and testing, the top nootropics for migraines are:

1. Mind Lab Pro

Mind Lab Pro is a popular nootropic supplement that contains a blend of natural ingredients designed to support brain health and function. It includes several essential nutrients and nootropic compounds that help alleviate migraines. One of its key ingredients is Citicoline, a compound that helps enhance brain energy, improve focus, and support overall cognitive health. There’s also Bacopa Monnieri, a herb that has been traditionally used for its cognitive-enhancing properties, including memory improvement.

Another nootropic ingredient, Lion’s Mane Mushroom, is known for its potential neuroprotective and neuroregenerative effects, which also help alleviate migraines. Although in rare cases Lion’s Mane Mushroom may also cause mild pressure headaches which is usually nothing to worry about. Mind Lab Pro also contains L-Theanine, which is an amino acid that promotes relaxation and helps reduce stress and anxiety, which can be triggers for migraines.


  • Enhances cognitive function and improves mental clarity
  • Boosts memory and focus
  • Increases overall brain health
  • Supports stress management and reduces anxiety


  • May take time to see noticeable effects for some users
  • Not suitable for pregnant or breastfeeding women
  • May interact with certain medications

Mind Lab Pro is a comprehensive nootropic supplement that targets multiple aspects of brain health, making it a suitable option for individuals seeking migraine relief.

2. Vyvamind

Vyvamind is another nootropic supplement formulated specifically to support brain health and reduce the frequency and severity of migraines. It contains a variety of ingredients that have shown promise in migraine management, including Vitamin B6 and B12, L-Tyrosine, Citicoline, L-Theanine and Caffein Anhydrous.

Citicoline is a powerful antioxidant that helps protect cells from oxidative damage and reduce the frequency and severity of migraines. Studies have shown that L-Tyrosine supplementation helps reduce migraine frequency and intensity. Methylcobalamin (Vitamin B12) plays a crucial role in nervous system function and has been found to reduce migraines in some individuals. Caffeine Anhydrous has anti-inflammatory properties and helps reduce the inflammation associated with migraines.


  • Improves mental energy and alertness
  • Enhances memory and concentration
  • Increases productivity and cognitive performance
  • Supports overall brain health and function


  • May cause side effects such as insomnia or headaches
  • Not suitable for individuals with certain medical conditions or sensitivities

Vyvamind combines these ingredients to provide a comprehensive approach to managing migraines and supporting overall brain health.

3. Magnesium

Magnesium is a mineral that plays a crucial role in various physiological processes, including nerve function and neurotransmitter regulation. Magnesium supplement have been studied extensively for their benefits in migraine management as they help prevent or treat migraine.

Research suggests that magnesium supplementation helps reduce the frequency and intensity of migraines. It works by relaxing blood vessels and reducing inflammation, both of which contribute to migraine symptoms. While magnesium can be obtained through diet, some individuals may require supplementation to reach optimal levels. It is important to consult with a healthcare professional to determine the appropriate dosage and form of magnesium for migraine management.

Magnesium has also been studied for its potential as an acute treatment for severe and difficult-to-treat migraines. It helps reduce pain during an attack by blocking pain-transmitting chemicals in the brain.(1) Daily oral magnesium supplementation has shown promise in preventing migraines that are related to menstruation, especially in individuals with premenstrual migraines.(2) This means that magnesium is particularly beneficial for those with irregular cycles or migraines triggered by hormonal changes.


  • Supports relaxation and better sleep quality
  • Helps reduce stress and anxiety
  • Improves mood and promotes a sense of calmness
  • Supports healthy brain function and cognitive performance


  • Can cause gastrointestinal side effects such as diarrhea or upset stomach
  • May interact with certain medications
  • Not recommended for individuals with kidney problems or kidney disease

While magnesium can be obtained through diet, some individuals may require supplementation to reach optimal levels. It is important to consult with a healthcare professional to determine the appropriate dosage and form of magnesium for migraine management.

4. Melatonin

Melatonin is a hormone that regulates sleep-wake cycles and plays a role in maintaining a healthy circadian rhythm. It is often used as a natural sleep aid but also has benefits for individuals with migraines. Research suggests that melatonin supplementation helps reduce the frequency and severity of migraines, particularly in individuals with sleep disturbances. It works by regulating neurotransmitters and reducing inflammation associated with migraines.

Research has shown that daily doses of melatonin, typically 3 mg, helps reduce the frequency of migraines. In one study, more than three-quarters of participants reported experiencing at least a 50% reduction in migraine attacks.(3)


  • Regulates sleep-wake cycles and promotes better sleep
  • Helps with insomnia and jet lag
  • Supports overall sleep quality and duration


  • May cause daytime drowsiness or grogginess
  • Can lead to vivid dreams or nightmares

Melatonin is safe when used short-term and under the guidance of a healthcare professional. This makes it a potentially favorable candidate for migraine therapy.

5. Caffeine

While excessive caffeine consumption can trigger migraines in some individuals, moderate amount of caffeine provides relief for others. Caffeine is a stimulant that constricts blood vessels and blocks certain neurotransmitters involved in pain signaling. It is commonly included in over-the-counter migraine medications for its potential to enhance the effectiveness of pain-relieving drugs.

Caffeine helps ease migraine pain by blocking the action of adenosine, a chemical that is involved in migraine mechanisms and pain signaling in the brain. Caffeine also enhances the effectiveness of some over-the-counter analgesics, such as aspirin, acetaminophen, and ibuprofen, by up to 40%.(4) 

Migraines can often cause fatigue and lethargy. Caffeine acts as a stimulant, increasing energy levels and promoting wakefulness. This is particularly beneficial for individuals experiencing migraines, as it can counteract the fatigue associated with the condition.


  • Increases alertness and energy levels
  • Improves focus and cognitive performance
  • Enhances physical endurance and performance
  • Provides a boost in mood and motivation


  • Can cause jitters, nervousness, or anxiety
  • May disrupt sleep patterns and lead to insomnia
  • May increase heart rate and blood pressure

However, it is important to note that caffeine should be used judiciously and may not be suitable for everyone. It is best to consult with a healthcare professional to determine if caffeine is a viable option for migraine management.

How Do Nootropics for Migraines Work?

Migraines are complex neurological disorders characterized by recurring headaches, often accompanied by symptoms such as nausea, sensitivity to light and sound, and visual disturbances. The exact cause of migraines is not fully understood, but factors like neurotransmitter imbalances, inflammation, oxidative stress, and impaired blood flow in the brain have been indicated to play a role.

Some nootropics have properties that address these underlying factors. These substances modulate neurotransmitter levels, reduce inflammation, provide neuroprotection against oxidative stress, and improve mitochondrial function—all of which are relevant to migraines.

Additionally, certain nootropics possess antioxidant and anti-inflammatory properties, which could help reduce the frequency and severity of migraines. They also support overall brain health and cognitive function.

It’s important to note that individual responses to nootropics vary, and their efficacy in migraine management is still being studied. If you experience migraines, it is crucial to consult with a healthcare professional for proper diagnosis and guidance on appropriate treatment options, including the potential use of nootropics.

What to Consider Before Buying Nootropics for Migraines?

Nootropics may offer relief from migraine symptoms, but choosing the right one requires careful consideration. It’s important to understand their effects and consult with healthcare professionals.

Safety Profile

Safety is paramount when selecting nootropics. Investigate each option’s potential side effects and interactions with other medications you may be taking. Some nootropics can cause adverse reactions, especially in individuals with specific health conditions or those using certain prescription drugs.

Research studies and clinical trials provide valuable safety information. Look for products that have been tested thoroughly and show a good safety record.

Efficacy Evidence

The effectiveness of a nootropic is crucial. Examine scientific research that supports claims made about the nootropic’s ability to alleviate migraine symptoms.

Real-world testimonials can also indicate efficacy. However, remember that individual experiences can vary greatly.

Ingredient Transparency

Knowing what’s in your nootropic is essential for avoiding harmful substances and allergens. Choose products with clear, detailed ingredient lists.

Reputable brands are usually transparent about their formulations. Avoid those that use proprietary blends without disclosing exact amounts of each ingredient.

Dosage Requirements

Correct dosing ensures maximum benefit while minimizing risks. Follow the manufacturer’s recommended dosage, and do not exceed it unless advised by a healthcare provider.

Some nootropics require consistent use over time to see results. Be prepared for this commitment before making a purchase.

Cost vs Quality

Price shouldn’t be the sole deciding factor, but it’s an important consideration. Higher cost doesn’t always mean better quality; conversely, cheap options might not be effective or safe.

Balance cost against quality by considering ingredients’ purity, brand reputation, and manufacturing standards.

Brand Reputation

A trustworthy brand builds confidence in its products’ quality and safety. Research company backgrounds, read user reviews, and check for any past issues related to product recalls or false advertising claims.

Look for brands that engage with their customers transparently on social media or other platforms.

How We Selected the Top Nootropics for Migraines

Our selection process for the best nootropics for migraines was multifaceted. We factored in effectiveness, ingredients, brand credibility, transparency, manufacturing process, customer reviews, pricing, and value. Each of these elements was thoroughly evaluated to offer our readers a well-rounded and trustworthy list of the best migraine-relieving nootropics.


To measure effectiveness, we studied clinical studies and user testimonials, focusing particularly on migraine frequency, intensity, and duration reduction.


We carefully analyzed each formula, giving priority to evidence-supported, natural, and high-quality ingredients known to mitigate migraine symptoms.

Scientific Evidence

To substantiate the effectiveness of the key ingredients in mitigating migraines, we referred to peer-reviewed research and meta-analyses.


We evaluated the right dosages and ingredient proportions, ensuring they are in line with the existing research for ultimate efficacy.


We confirmed the safety of each ingredient, considering potential side effects and interactions, and ensuring regulatory guidelines compliance. FDA-approved ingredients were given priority.

Brand Reputation

We assessed each brand’s credibility and reliability through customer feedback, expert recommendations, and the company’s track record.

Product Transparency

We favored products with full ingredient disclosure, including their sources and concentrations, to facilitate informed consumer choices.

Manufacturing Process

We investigated the manufacturing standards, preferring products produced in certified facilities that follow Good Manufacturing Practices (GMP).

User Reviews

We examined real customer feedback, placing importance on testimonials that report reduction in migraine frequency, intensity, and duration.


We compared the prices of various products, ensuring they were competitive and commensurate with the quality and efficacy of the nootropic.


We evaluated the overall value, considering the balance of price, quality, and effectiveness to guarantee the best return on investment.


While nootropics are not a cure for migraines, they provide relief and support brain health in individuals suffering from migraines. The 5 best nootropics for migraines discussed in this article—Mind Lab Pro, Vyvamind, Magnesium, Melatonin, and Caffeine—offer a range of benefits that help manage migraines. These substances target underlying factors such as neurotransmitter imbalances, inflammation, oxidative stress, and impaired blood flow in the brain, which are believed to contribute to migraines.

However, it is important to note that individual responses to nootropics can vary, and their efficacy in migraine management is still being studied. It is crucial to consult with a healthcare professional before incorporating any new supplements into your routine. They can provide proper diagnosis, guidance, and recommend suitable treatment options based on your specific needs.

When selecting the top nootropics for migraines, various factors were considered, including effectiveness, ingredients, brand credibility, transparency, scientific evidence, dosage, safety, manufacturing process, user reviews, price, and overall value. This comprehensive evaluation ensures that the recommended nootropics are reliable, safe, and potentially effective for individuals seeking relief from migraines.

Remember, managing migraines requires a comprehensive approach, and nootropics can be part of that strategy. By working closely with healthcare professionals and exploring different treatment options, individuals can find the relief they deserve and improve their overall well-being.

FAQs About Nootropics for Migraines

Are nootropics safe to use for migraines?

When used as directed, the nootropics mentioned in this article are safe for most individuals. However, it’s essential to consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications.

How long does it take for nootropics to work for migraines?

The time it takes for nootropics to work for migraines can vary depending on the individual and the specific substance being used. Some individuals may experience relief within a few days, while others may require several weeks of consistent use to notice a difference. It’s important to be patient and give the nootropics enough time to exert their effects.

Can I take multiple nootropics for migraines at the same time?

It’s generally safe to take multiple nootropics for migraines, as long as you follow the recommended dosages and guidelines. However, it’s always best to consult with a healthcare professional to ensure that there are no potential interactions or contraindications.

Are there any side effects associated with using nootropics for migraines?

The nootropics mentioned in this article are well-tolerated and have minimal side effects. However, some individuals may experience gastrointestinal upset, such as diarrhea or stomach cramps, when taking certain substances like magnesium or butterbur. If you experience any adverse effects, it’s important to discontinue use and consult with a healthcare professional.

Sources, Studies, and Scientific Research
  1. Mauskop, Alexander, and Jasmine Varughese. “Why all migraine patients should be treated with magnesium.” Journal of neural transmission 119 (2012): 575-579. ↩
  2. Sun-Edelstein, Christina, and Alexander Mauskop. “Role of magnesium in the pathogenesis and treatment of migraine.” Expert review of neurotherapeutics 9.3 (2009): 369-379. ↩
  3. Peres, M. F. P., et al. “Melatonin, 3 mg, is effective for migraine prevention.” Neurology 63.4 (2004): 757-757. ↩
  4. Lipton, Richard B., et al. “Caffeine in the management of patients with headache.” The journal of headache and pain 18.1 (2017): 1-11. ↩