7 Best Nootropics for Nerve Growth Factor (NGF) in 2024 – Top Brain Supplements

Updated on February 1, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Top brain supplements enhancing nerve growth factor for improved neural connections.

What are the best nootropics for nerve growth factor?

If you’re looking for a way to boost your cognitive abilities and improve your overall brain function, nootropics may be the answer.

Specifically, there are a variety of nootropics that are known to increase the production of NGF (nerve growth factor), which can enhance neuroplasticity and protect against cognitive decline. In this article, we’ll explore the best nerve growth factor supplements, how they work, and the research behind their effectiveness.

Whether you’re looking to improve your memory, focus, or overall brain power, these NGF-boosting nootropics are definitely worth considering.

Best Nootropics for Nerve Growth Factor

  • Nooceptin — Best for memory and recall
  • Lion’s Mane Mushroom — Best to reduce inflammation and oxidative stress in the brain
  • Semax — Great neuroprotectant to improve mood and reduce anxiety
  • ALCAR — Best for memory retention
  • Phosphatidylserine — Great for a versatile brain health support
  • Uridine — Best for supporting overall brain function and development
  • Noopept — Great for improving learning abilities

How to Choose the Best Nootropics for Nerve Growth Factor?

Selecting the most effective nootropics for enhancing nerve growth factor (NGF) necessitates understanding the various factors that contribute to their efficacy. Here are the top considerations to keep in mind.

FactorDescriptionWhy It’s Important
Mechanism of ActionThe biological process by which a nootropic enhances NGF.Understanding how a nootropic works can guide you to the right choice for your specific needs.
Scientific EvidenceResearch and clinical studies supporting a nootropic’s efficacy.Evidence-based choices ensure that the nootropic has been rigorously tested for its claims.
Ingredient QualityThe purity and source of the nootropic’s components.High-quality ingredients increase the likelihood of efficacy and reduce potential for side effects.
Dosage & SynergyThe amount and combination of nootropics ingested.Correct dosages are critical for effectiveness, and combining certain nootropics may offer synergistic benefits.
Safety & Side EffectsThe potential risks and adverse reactions associated with a nootropic.Ensuring the nootropic is safe for consumption minimizes health risks and unwanted side effects.
  • Mechanism of Action: A clear understanding of the mechanism of action is vital for predicting the potential benefits and tailoring your nootropic choices to your desired outcomes. For instance, some nootropics might directly stimulate NGF production, while others may protect neurons or assist in their repair.
  • Scientific Evidence: Nootropics backed by solid scientific evidence provide confidence in their ability to deliver on their promises. This can include peer-reviewed studies, clinical trials, and reputable testimonials.
  • Ingredient Quality: The purity and origin of ingredients can significantly influence the efficacy of a nootropic. High-quality ingredients ensure that you’re getting a product that is both effective and free from contaminants.
  • Dosage & Synergy: It’s crucial to follow the recommended dosages and consider the synergistic effects when combining nootropics. Some compounds may enhance the effects of others when taken together, which can be strategically used to support NGF.
  • Safety & Side Effects: Always opt for nootropics with a proven safety record, minimal side effects, and wide tolerability among users. The potential risks should be weighed against the expected benefits to make an informed decision.

The Best Nootropics for Nerve Growth Factor of 2024

According to our in-depth research and testing, the top nootropics for nerve growth factor (NGF) are:

1. Nooceptin

Nooceptin is a natural nootropic supplement that can significantly improve cognitive function by promoting nerve growth factor (NGF) production in the brain. This nootropic can boost NGF levels, which helps to support the growth and survival of nerve cells in the brain.

Nooceptin also contains other ingredients that can improve brain function, such as ginkgo biloba, panax ginseng, and Rhodiola rosea. These ingredients work together to enhance cognitive abilities like memory, focus, and mental clarity.(1) Nooceptin is a safe and effective nootropic supplement that can offer long-term benefits to consumers. It has been rigorously tested and proven to be effective in enhancing cognitive function.


  • Improves communication between healthy brain cells
  • Protects brain from oxidative damage
  • Promotes new brain cell generation
  • Decreases stress levels, anxiety, and fatigue


  • Takes time to work

Consumers can rest assured that they are taking a high-quality nootropic supplement that can help them perform better mentally and improve their overall brain health.

2. Lion’s Mane Mushroom

Lion’s Mane Mushroom is a popular nootropic that has been used for centuries in traditional Chinese medicine. It is well known for its cognitive-enhancing and neuroprotective effects. This nootropic works by stimulating the production of nerve growth factor (NGF), a protein that plays a crucial role in the growth, maintenance, and survival of nerve cells in the brain and other parts of the body.(2) By increasing NGF levels, Lion’s Mane Mushroom can help support healthy brain function, improve memory, concentration, and focus, reduce anxiety and depression, and protect the brain from age-related cognitive decline.

This powerful nootropic contains bioactive compounds like beta-glucans, erinacines, and hericenones, which have been shown to have potent antioxidant, anti-inflammatory, and immunity-boosting properties. Unlike other nootropics, Lion’s Mane Mushroom is generally considered safe and well-tolerated, with minimal side effects.


  • Stimulates neural growth
  • Helps improve cognitive function and memory recall
  • Reduces symptoms of anxiety and depression
  • Contains antioxidants that are beneficial for overall health


  • Possible allergic reactions for some individuals
  • May cause digestive discomfort in some cases

It can be consumed in various forms, including supplements, teas, and extracts, making it an easy and convenient option for anyone looking to boost their brainpower.

3. Semax

Semax is a nootropic drug known for its ability to enhance cognitive function and has been shown to increase neuroprotection. It is a synthetic version of a natural peptide found in the body that is known for stimulating the production of nerve growth factor (NGF). NGF is a protein that plays a critical role in the growth and maintenance of nerve cells. By increasing NGF levels, Semax can improve overall brain function, particularly in areas related to memory, attention, and learning.

It is also easy to use, as it can be administered as a nasal spray or injection. Studies have shown that Semax is also effective against various neurological disorders, including Alzheimer’s disease, stroke, and traumatic brain injury.


  • Enhances cognitive function, memory recall, and learning abilities
  • Improves mood and reduces symptoms of anxiety and depression
  • Boosts energy levels and helps with fatigue


  • May cause headaches or nausea in some individuals
  • Limited research on long-term effects and safety

Overall, Semax is a powerful nootropic that can enhance cognitive function and provide neuroprotection. Its unique mechanism of action, along with its low-risk profile, make it a popular choice among those looking to improve their mental performance.


Acetyl-L-carnitine (ALCAR) is a naturally occurring amino acid that has been shown to boost nerve growth factor (NGF) levels. ALCAR is able to cross the blood-brain barrier and reach the brain, where it enhances the health and function of nerve cells and their components, such as mitochondria. ALCAR also acts as an antioxidant and has anti-inflammatory properties that could contribute to its neuroprotective effects. Studies have suggested that ALCAR is beneficial for neurodegenerative conditions such as schizophrenia, Alzheimer’s, and Parkinson’s diseases, as well as cognitive impairments associated with aging and depression.(3)


  • Boosts energy levels and overall physical performance
  • Helps with brain metabolism and cognitive function
  • Protects against some age-related cognitive decline


  • May cause nausea in some individuals
  • Limited research on long-term effects and safety

ALCAR also has the potential to enhance energy metabolism, memory, and learning abilities. Dosages of ALCAR supplements may vary, but typical ranges are from 1 to 3 g per day. As with all supplements, it is important to consult with a healthcare provider before starting to take ALCAR.

5. Phosphatidylserine

Phosphatidylserine is a phospholipid that is naturally present in the body, especially in the brain. It is considered one of the best nootropics for nerve growth factor due to its ability to support brain function and promote neurogenesis, the generation of new brain cells. Phosphatidylserine is involved in the synthesis of acetylcholine, a neurotransmitter that is essential for learning and memory.(4) It also helps regulate cortisol levels, which can be a major contributor to stress and anxiety. Studies have shown that Phosphatidylserine can enhance memory and attention span in both young and elderly individuals, making it a popular ingredient in nootropic supplements.


  • Helps improve memory recall
  • Reduces symptoms of depression and anxiety
  • Reduces age-related cognitive decline


  • May cause digestive discomfort or insomnia in some cases

Overall, Phosphatidylserine can support brain health and function, making it a valuable addition to any nootropic stack focused on promoting nerve growth factor.

6. Uridine

Uridine is a naturally occurring nucleotide that is found in every living organism, including humans. It is a key component in the synthesis of RNA and is essential for the growth and repair of tissues in the body. Uridine has been shown to have many beneficial effects on the brain, including enhancing the production of nerve growth factor (NGF).(5) By promoting NGF production, uridine can help protect and maintain healthy nerve cells in the brain, leading to improved cognitive function and memory retention. Additionally, uridine has been found to work synergistically with omega-3 fatty acids, which are important for maintaining healthy neuron cell membranes.(6) This combination may help protect against cognitive decline and age-related brain disorders.


  • Enhances overall brain function
  • Has great neuroprotective effects


  • Limited research on long-term effects and safety
  • May induce nervousness

Overall, uridine is a potent nootropic that can have significant benefits for brain health and function when used as part of a comprehensive nootropic stack.

7. Noopept

Noopept is a synthetic nootropic commonly used for its cognitive-enhancing and neuroprotective properties. It promotes the production of nerve growth factor (NGF) in the brain, which plays a crucial role in the health of neurons. Noopept is also known to boost memory, focus, and mental clarity by enhancing the activity of neurotransmitters such as acetylcholine and glutamate.

It is a highly potent nootropic and is taken in small doses, usually 10-30 mg per day. Noopept has also been found to have antioxidant and anti-inflammatory effects, which can further protect the brain against damage and aging.


  • Enhances learning abilities
  • Helps improve mood
  • Boosts energy levels and helps with fatigue


  • Possible side effects such as headaches or stomach discomfort

Even though Noopept may improve your neural health, it is still recommended to consult a healthcare professional before taking Noopept or any other new supplement.

How Do Nootropics for Nerve Growth Factor Work?

Nootropics for NGF work by helping to increase the production and maintenance of neurons in the brain. NGF is a neurotrophic protein that is responsible for the development and health of neurons in the central and peripheral nervous systems. By increasing NGF levels, nootropics can help regulate neuron health and neurotransmitter levels, promote memory, and counteract cognitive decline.

By enhancing NGF levels, these nootropics can aid in cognitive function, mood, and overall brain health. They work by promoting communication and preservation of the sympathetic, sensory, and forebrain cholinergic neurons throughout the brain.

Further research is needed to fully understand how nootropics affect NGF levels and their impact on cognitive function. However, these natural supplements offer a promising approach to enhancing brain power and combating cognitive decline.

What to Consider Before Buying Nootropics for Nerve Growth Factor?

Before investing in nootropics aimed at boosting nerve growth factor, there are several key points to ponder. The following considerations will help ensure that the product you choose aligns with your health goals and lifestyle.

1. Personal Health Profile

It’s essential to take into account your individual health situation. Certain nootropics may interact with pre-existing conditions or medications, and what works for one person may not work for another.

2. Budget and Cost-Effectiveness

Nootropics can vary widely in price. Assess whether the potential benefits justify the cost and if the product provides good value for money over time.

3. Long-Term Sustainability

Consider if the nootropic is suitable for long-term use, as the effects on NGF may take time to manifest. Evaluate if you can maintain the regimen for the necessary duration.

4. Availability and Accessibility

Check the availability of the nootropic. Is it easily accessible from reputable sources? Can you obtain it regularly without significant inconvenience?

5. Company Reputation and Transparency

Research the manufacturer’s reputation. Companies that are transparent about their manufacturing processes, ingredient sourcing, and business practices are generally more reliable.

How We Picked the Top Nootropics for Nerve Growth Factor

Our thorough review process helped us find the best nootropics for boosting nerve growth factor (NGF) levels. We appraised factors such as efficacy, formula contents, company reputation, transparency, manufacturing process, user experiences, cost, and value. These aspects were thoroughly evaluated to provide our readers with a comprehensive and reliable list of the top nootropics for NGF enhancement.


We examined clinical studies and user testimonials to evaluate the efficacy of nootropics for increasing nerve growth factor production, emphasizing neural regeneration, synaptic plasticity, and cognitive function improvement.

Formula Contents

We scrutinized each formulation, highlighting evidence-based, natural, and high-quality components that promote increased NGF levels.

Scientific Evidence

We consulted peer-reviewed research and meta-analyses to confirm the effectiveness of the primary components in increasing nerve growth factor.


We analyzed the optimal dosages and proportions of ingredients, ensuring they were consistent with established scientific research for maximum potency.


We verified the safety of all components, considering potential side effects and interactions and checking for compliance with regulatory guidelines. We prioritize FDA-approved ingredients.

Company Reputation

We assessed brands’ credibility and trustworthiness by examining customer reviews, expert recommendations, and company background.

Product Transparency

Complete ingredient disclosure, along with their sources and concentrations, is valued to allow for well-informed consumer choices.

Manufacturing Process

We investigated manufacturing standards, giving preference to products made in certified facilities and following Good Manufacturing Practices (GMP).

User Experiences

Real customer feedback was analyzed, focusing on reports describing improvements in neural regeneration, cognitive function, and boosted NGF levels.


We compared the prices of different products, ensuring they were competitive and reflected the quality and efficacy of the nootropic.


We evaluated overall value by considering price, quality, and effectiveness to guarantee an optimal return on investment for consumers.

Nootropics for Nerve Growth Factor in Summary

The article discusses the importance of nerve growth factor (NGF) in cognitive function, mood, and inflammation. NGF is responsible for the development of new neurons and the maintenance of mature ones. Certain nootropics help increase low levels of NGF in the body, which can have positive effects on nerve health and cognitive function.

Nooceptin is a natural nootropic supplement that can promote NGF production and contains other ingredients that can improve brain function. Lion’s Mane Mushroom is another natural nootropic that stimulates NGF production and has cognitive-enhancing and neuroprotective effects. Semax is a synthetic peptide that increases NGF levels and can enhance cognitive function, mood, and energy levels. Alcar is a compound that can improve cognitive function, memory, and focus by increasing acetylcholine levels and promoting NGF synthesis.

Phosphatidylserine is a phospholipid that can support cognitive function and memory by enhancing NGF synthesis and preventing cognitive decline. Uridine is a nucleotide that can improve cognitive function and memory by enhancing NGF levels. Noopept is a synthetic peptide that can enhance cognitive function and memory by promoting NGF synthesis and neuroprotection.

It’s important to note that these effective nootropics have different mechanisms of action and may not work for everyone. It’s also important to follow the recommended dosage and consult a healthcare provider before starting any new supplement, especially if you have a medical condition or are taking medication.

FAQs Abut Nootropics for Nerve Growth Factor

Are nootropics for NGF safe?

Most nootropics for NGF are generally safe, but it’s essential to choose high-quality products, follow recommended doses, and consult a healthcare professional if you have any concerns or medical conditions.

How long does it take for nootropics to affect NGF levels?

A noticeable increase in NGF levels varies depending on individual factors, but generally, it takes several weeks of consistent use to experience significant results.

Can I combine different nootropics for NGF support?

Yes, combining various nootropics is known as “stacking” and can offer synergistic benefits. However, always research potential interactions and start with low doses to ensure safety and efficacy.

Can NGF supplements help with nerve damage?

NGF supplements may have therapeutic benefits for certain types of nerve damage, such as spinal cord injuries and diabetic neuropathy. By promoting nerve growth and repair, NGF supplements may help restore sensation and function in affected areas. However, more research is needed to determine the optimal dosing and duration of NGF supplements for these conditions.

Sources, Studies, and Scientific Research
  1. Pu, Wei-ling, et al. “Antiinflammatory effects of Rhodiola rosea L.: A review.” Biomedicine & Pharmacotherapy 121 (2020): 109552. ↩
  2. Lai, Puei-Lene et al. “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International journal of medicinal mushrooms vol. 15,6 (2013): 539-54. doi:10.1615/intjmedmushr.v15.i6.30 ↩
  3. Ferreira, Gustavo C, and Mary C McKenna. “L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain.” Neurochemical research vol. 42,6 (2017): 1661-1675. doi:10.1007/s11064-017-2288-7 ↩
  4. Donoso, Francisco, et al. “Neurobiological effects of phospholipids in vitro: Relevance to stress-related disorders.” Neurobiology of Stress 13 (2020): 100252. ↩
  5. Dobolyi, Arpád et al. “Uridine function in the central nervous system.” Current topics in medicinal chemistry vol. 11,8 (2011): 1058-67. doi:10.2174/156802611795347618 ↩
  6. Carlezon, William A Jr et al. “Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats.” Biological psychiatry vol. 57,4 (2005): 343-50. doi:10.1016/j.biopsych.2004.11.038 ↩